Toxicology of the human environment: the critical role of free radicals
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Taylor & Francis
2000
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 494 S. graph. Darst. |
| ISBN: | 0748409165 |
Internformat
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| 245 | 1 | 0 | |a Toxicology of the human environment |b the critical role of free radicals |c ed. by Christopher J. Rhodes |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Taylor & Francis |c 2000 | |
| 300 | |a XVI, 494 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Free radicals (Chemistry) | |
| 650 | 4 | |a Toxicology | |
| 650 | 4 | |a Electron Spin Resonance Spectroscopy | |
| 650 | 4 | |a Electron paramagnetic resonance spectroscopy | |
| 650 | 4 | |a Environmental Exposure |x adverse effects | |
| 650 | 4 | |a Environmental Pollutants |x toxicity | |
| 650 | 4 | |a Environmental toxicology | |
| 650 | 4 | |a Free Radicals |x adverse effects | |
| 650 | 4 | |a Free radicals (Chemistry) |x Toxicology | |
| 650 | 4 | |a Nitroxides |x Toxicology | |
| 650 | 4 | |a Spin Trapping | |
| 650 | 0 | 7 | |a Umwelttoxikologie |0 (DE-588)4121813-9 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Umwelttoxikologie |0 (DE-588)4121813-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Rhodes, Christopher J. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008859501&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804127700610187264 |
|---|---|
| adam_text | Contents
List of contributors xi
List of abbreviations xiv
1 Introduction 1
CHRISTOPHER J. RHODES
PARTI
Spin trapping 5
2 Chemistry of spin trapping 7
RHEAL A. TOWNER
2.1 Introduction 7
2.2 Types of spin trap 11
2.3 Selection criteria 15
2.4 Structural assignment considerations 17
2.5 Conclusions 19
3 Spin trapping: problems and artefacts 25
LENNART EBERSON
3.1 Introduction 25
3.2 The redox reactivity of spin traps and reagents involved in the
radical cation mechanism; inverted spin trapping 26
3.3 The Forrester Hepburn mechanism; nucleophilic
addition oxidation 31
3.4 Detection of spin adducts in biochemical/biological systems 40
3.5 Cycloaddition as a possible cause of artefacts 41
4 In vivo spin trapping from chemistry to toxicology 49
RONALD P. MASON
5 Ex vivo detection of free radicals 71
ALDO TOMASI, ANNA IANNONE, MARCO FERRARI AND
VALENTINA QUARESIMA
5.1 Background 71
5.2 Ex vivo spin trapping of short lived free radicals 72
5.3 Nitrogen monoxide (nitric oxide, NO , NO) 78
5.4 Conclusion 82
PART II
Nitroxides 89
6 The metabolism of nitroxides in cells and tissues 91
HAROLD M. SWARTZ AND GRAHAM S. TIMMINS
6.1 Introduction and overview 91
6.2 Reduction of nitroxides in mammalian cells 93
6.3 Cellular oxidation of hydroxylamines 99
6.4 The toxicity of nitroxides 99
6.5 Applications of the metabolism of nitroxides 100
7 Clinical uses of nitroxides as superoxide dismutase mimics 113
JAMES B. MITCHELL, MURALI C. KRISHNA, AMRAM SAMUNI, PERIANNAN
KUPPUSAMY, STEPHEN M. HAHN, AND ANGELO RUSSO
7.1 Introduction 113
7.2 Structural features and chemical properties of nitroxides 114
7.3 In vitro and in vivo toxicity 118
7.4 In vitro radioprotection by nitroxides 122
7.5 In vivo radioprotection by nitroxides 124
7.6 Protection against redox cycling chemotherapy drugs 128
7.7 Nitroxides as functional imaging probes 131
7.8 Summary 132
8 Nitroxide skin toxicity 139
JURGEN FUCHS
Abstract 139
8.1 Introduction 140
8.2 Materials and methods 141
8.3 Results 145
8.4 Discussion 147
8.5 Conclusion 148
PART III
Toxic role of specific agents 153
9 Biological oxidations catalyzed by iron released from ferritin 155
CHRISTOPHER A. REILLY AND STEVEN D. AUST
9.1 Introduction 155
9.2 Iron catalyzed oxidations 155
9.3 Biological sources of catalytic iron 164
9.4 Antioxidant defences for iron mediated toxicity 174
9.5 Conclusions 181
10 The toxicology of iron 191
RODNEY BILTON
10.1 Introduction 191
10.2 Human conditions and diseases involving iron toxicity 197
10.3 From oxygen via iron to the hydroxyl radical 201
11 The role of free radicals in the toxicology of airborne particulate
pollutants 209
PETER EVANS
11.1 Introduction 209
11.2 Silica toxicity 210
11.3 Coal 211
11.4 Asbestos 212
11.5 Man made mineral fibres 215
11.6 Zeolites 216
11.7 Smoke 217
11.8 Traffic air pollution 219
11.9 Nutritional and physiological antioxidants 222
11.10 Pharmacological antioxidants 223
11.11 Conclusion 224
12 Free radical mechanisms of ethanol toxicity 235
EMANUELE ALBANO
12.1 Introduction 235
12.2 Mechanisms involved in causing oxidative damage
by alcohol 236
12.3 Free radical mediated processes in organ damage
by alcohol 244
12.4 Role of free radical mediated mechanisms in
alcohol toxicity 248
12.5 Conclusions 252
13 The role of cytokines in the inflammatory response 265
CARMEN M. ARROYO
13.1 Introduction 265
13.2 Activation of TNF a by THP 1 exposed to H MG 266
13.3 Nitrosyl chloride in keratinocytes exposed to HD 273
14 Duplicity of thiols and thiyl radicals: protector and foe 285
CHRISTOPHER J. RHODES
Abstract 285
14.1 Introduction 285
14.2 Background to the muon spectroscopy technique 286
14.3 Experimental section 287
14.4 Structural studies of thiyl radicals 287
14.5 Reactivity of thiyl radicals 290
14.6 Evidence for actual biological significance of thiyl radicals 293
14.7 Conclusions 296
15 Synergistic effect of carbon tetrachloride and 1,2 dibromoethane 301
GIUSEPPE POLI, MANUELA ARAGNO, ELENA CHIARPOTTO, SIMONETTA
CAMANDOLA AND OLIVIERO DANNI
15.1 Introduction 301
15.2 Carbon tetrachloride and 1,2 dibromoethane interactions 301
15.3 Conclusions 306
16 Reactive oxygen species in physiology and toxicology 311
NALINI KAUL AND HENRY JAY FORMAN
Abstract 311
16.1 Production of free radicals 312
16.2 Biological sources of free radicals 314
16.3 Toxicity of reactive oxygen species 316
16.4 Oxidant stress and signaling 320
16.5 Oxidative stress and inflammation 325
16.6 Oxidative stress in apoptosis, necrosis and cell growth 327
16.7 Oxidative stress and carcinogenesis 328
PART IV
Free radicals in specific disease states 337
17 The role of free radicals in chemical carcinogenesis 339
JOSEPH R. LANDOLPH
Abstract 339
17.1 Introduction 340
17.2 Stimulation of the arachidonic acid cascade, oxygen radical
generation, and chemical carcinogenesis 342
17.3 Metabolism of poly cyclic aromatic hydrocarbons, free radicals,
and chemical carcinogenesis 346
17.4 Metal induced free radical generation and metal salt
carcinogenesis 347
17.5 Endogenous oxygen radical generation and carcinogenesis 353
17.6 Conclusions 354
18 Free radical involvement in cardiovascular and respiratory diseases 363
FRANK J. KELLY
Abstract 363
18.1 Heart disease 363
18.2 Lung diseases 365
PARTV
Free radicals in the diet 371
19 NMR evaluation of thermally induced peroxidation in culinary oils 373
MARTIN GROOTVELD, CHRISTOPHER J.L. SILWOOD AND
ANDREW W.D. CLAXSON
19.1 Introduction 373
19.2 Materials and methods 375
19.3 Results 378
19.4 Discussion 390
PART VI
Chemical models 395
20 The structure and electronic properties of oxy intermediates in the
enzymatic cycle of cytochrome P450s 397
DAN HARRIS
20.1 Introduction 397
20.2 Theoretical and technical aspects 402
20.3 Results and discussion 404
20.4 Conclusions 414
21 Spin trapping applications to photochemical and
photobiological problems 421
COLIN F. CHIGNELL
21.1 Introduction 421
21.2 Photochemistry of photosensitizers 421
21.3 Free radical and EPR 423
21.4 Spin trapping in photochemical systems 429
21.5 Spin trapping of oxygen centered radicals 431
21.6 Spin trapping of radicals from photosensitizing chemicals 433
22 Thermodynamic considerations of free radical reactions 437
JOHN BUTLER
22.1 Introduction 437
22.2 Reduction 437
22.3 Oxidation 438
22.4 pH dependence of reduction potentials 438
22.5 Measurement of reduction potentials 441
22.6 Redox enzymes 442
22.7 Drugs, oxygen and metals 444
23 The use of QSAR for the prediction of free radical toxicity 453
MARK T.D. CRONIN AND THUY T. TRAN
23.1 Introduction 453
23.2 Identification of compounds likely to form free radicals 454
x Contents
23.3 Acute toxicity 456
23.4 Skin sensitisation 463
23.5 Teratogenicity 464
23.6 Mutagenicity 466
23.7 Conclusions 468
Index 473
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| indexdate | 2024-07-09T18:37:31Z |
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| language | English |
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| physical | XVI, 494 S. graph. Darst. |
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| spelling | Toxicology of the human environment the critical role of free radicals ed. by Christopher J. Rhodes 1. publ. London [u.a.] Taylor & Francis 2000 XVI, 494 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Free radicals (Chemistry) Toxicology Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Environmental Exposure adverse effects Environmental Pollutants toxicity Environmental toxicology Free Radicals adverse effects Free radicals (Chemistry) Toxicology Nitroxides Toxicology Spin Trapping Umwelttoxikologie (DE-588)4121813-9 gnd rswk-swf Umwelttoxikologie (DE-588)4121813-9 s DE-604 Rhodes, Christopher J. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008859501&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Toxicology of the human environment the critical role of free radicals Free radicals (Chemistry) Toxicology Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Environmental Exposure adverse effects Environmental Pollutants toxicity Environmental toxicology Free Radicals adverse effects Free radicals (Chemistry) Toxicology Nitroxides Toxicology Spin Trapping Umwelttoxikologie (DE-588)4121813-9 gnd |
| subject_GND | (DE-588)4121813-9 |
| title | Toxicology of the human environment the critical role of free radicals |
| title_auth | Toxicology of the human environment the critical role of free radicals |
| title_exact_search | Toxicology of the human environment the critical role of free radicals |
| title_full | Toxicology of the human environment the critical role of free radicals ed. by Christopher J. Rhodes |
| title_fullStr | Toxicology of the human environment the critical role of free radicals ed. by Christopher J. Rhodes |
| title_full_unstemmed | Toxicology of the human environment the critical role of free radicals ed. by Christopher J. Rhodes |
| title_short | Toxicology of the human environment |
| title_sort | toxicology of the human environment the critical role of free radicals |
| title_sub | the critical role of free radicals |
| topic | Free radicals (Chemistry) Toxicology Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Environmental Exposure adverse effects Environmental Pollutants toxicity Environmental toxicology Free Radicals adverse effects Free radicals (Chemistry) Toxicology Nitroxides Toxicology Spin Trapping Umwelttoxikologie (DE-588)4121813-9 gnd |
| topic_facet | Free radicals (Chemistry) Toxicology Electron Spin Resonance Spectroscopy Electron paramagnetic resonance spectroscopy Environmental Exposure adverse effects Environmental Pollutants toxicity Environmental toxicology Free Radicals adverse effects Free radicals (Chemistry) Toxicology Nitroxides Toxicology Spin Trapping Umwelttoxikologie |
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