DNA recombination and repair:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
1999
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Frontiers in molecular biology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 236 S. Ill., graph. Darst. |
| ISBN: | 0199637075 0199637067 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012957111 | ||
| 003 | DE-604 | ||
| 005 | 20031114 | ||
| 007 | t | ||
| 008 | 000125s1999 ad|| |||| 00||| eng d | ||
| 020 | |a 0199637075 |9 0-19-963707-5 | ||
| 020 | |a 0199637067 |9 0-19-963706-7 | ||
| 035 | |a (OCoLC)41503892 | ||
| 035 | |a (DE-599)BVBBV012957111 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-19 | ||
| 050 | 0 | |a QH467 | |
| 082 | 0 | |a 572.8/6459 |2 21 | |
| 245 | 1 | 0 | |a DNA recombination and repair |c ed. by Paul J. Smith ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 1999 | |
| 300 | |a XIX, 236 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Frontiers in molecular biology | |
| 650 | 4 | |a ADN - Réparation | |
| 650 | 4 | |a Recombinaison génétique | |
| 650 | 4 | |a DNA Repair | |
| 650 | 4 | |a DNA repair | |
| 650 | 4 | |a Genetic recombination | |
| 650 | 4 | |a Recombination, Genetic | |
| 650 | 0 | 7 | |a DNS |0 (DE-588)4070512-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a DNS-Reparatur |0 (DE-588)4150347-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Rekombination |0 (DE-588)4049338-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a DNS |0 (DE-588)4070512-2 |D s |
| 689 | 0 | 1 | |a Rekombination |0 (DE-588)4049338-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a DNS-Reparatur |0 (DE-588)4150347-8 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Smith, Paul J. |d 1953- |e Sonstige |0 (DE-588)128505583 |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008824028&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008824028 | ||
Datensatz im Suchindex
| _version_ | 1804127649843380224 |
|---|---|
| adam_text | Contents
List of contributors xv
Abbreviations xvii
1 Molecular processing of DNA folding anomalies in
Escherichia coli 1
DAVID R. F. LEACH
1. Introduction 1
2. Folding anomalies in DNA 1
2.1 Hairpin DNA 1
2.2 Pseudo hairpin DNA and S DNA 2
2.3 H DNA, *H DNA, and nodule DNA 4
2.4 Z DNA 6
2.5 Quadruplex DNA 6
3. Deletions at direct repeats stimulated by closely spaced inverted
repeats 6
4. Duplications and inversions stimulated by closely spaced inverted
repeats 8
5. Deletions and amplifications of triplet repeats 9
6. Inhibition of DNA replication and initiation of homologous
recombination by SbcCD protein 9
7. Conclusions 10
Acknowledgements 11
References 12
2 Double strand break repair and V(D)J recombination 16
BELINDA K. SINGLETON AND PENNY A. JEGGO
1. Introduction 16
2. V(D)J recombination 16
2.1 Recognition and cleavage of the signal sequences 17
2.2 Processing and joining the dsbs 17
f
x CONTENTS
3. Mechanisms of DNA double strand break repair 19
3.1 Homologous recombination 19
3.2 Single strand annealing 22
3.3 Non homologous end joining (NHEJ) 22
4. Identification of the genes involved in NHEJ 25
4.1 DNA dependent protein kinase, DNA PK 25
4.2 XRCC4 and DNA ligase IV 26
4.3 Yeast as a model system 27
5. The phenotypes of mammalian mutants defective in NHEJ 27
6. Conclusions 30
References 31
3 Translesion replication 38
CHRISTOPHER LAWRENCE AND ROGER WOODGATE
1. Introduction 38
2. Tranlesion replication in E. coli 40
2.1 Translesion replication is usually a strategy of last resort 40
2.2 Most translesion replication is dependent upon the Umu proteins 41
2.3 Umu dependent TR is regulated with exquisite precision 42
2.4 Formation of the mutasome and translesion replication 45
2.5 The Umu proteins are generalized elongation factors 47
2.6 Translesion replication in the absence of Umu proteins 48
3. Translesion replication in yeast 50
3.1 Genes important for TR and their mutant phenotypes 50
3.2 Regulation of translesion replication 51
3.3 Molecular and enzymatic analysis of REV gene function 53
4. The mutagenic properties of DNA damage 55
5. Comparisons, speculations, and TR in humans 56
References 58
4 Mismatch repair and cancer 66
P. KARRAN and M. BIGNAMI
1. Introduction 66
2. Bacterial mismatch repair 67
2.1 The identification of bacterial mismatch repair genes 67
2.2 The biochemistry of mismatch repair in Escherichia coli 68
CONTENTS xi
3. Human mismatch repair 69
3.1 Identification of human mismatch repair genes 69
3.2 Microsatellite instability and mutator effects in repair defective human
cells 71
3.3 The biochemistry of the human mismatch repair pathway 78
3.4 An alternative mismatch repair pathway 81
4. Mismatch repair defects in mouse models 82
4.1 Mice as models for HNPCC 84
5. Mismatch repair defects and susceptibility to therapeutic agents 84
6. Important areas for the future 87
6.1 Mismatch repair, transcription coupled excision repair, and
recombinational repair 87
6.2 Adaptive responses and reduced mismatch repair efficiency 88
6.3 Epigenetic effects on mismatch repair genes 88
6.4 Mismatch repair cell cycle checkpoints and apoptosis 89
References 90
5 Enzymology of human nucleotide excision repair 99
HANSPETER NAEGELI
1. Introduction 99
2. Human NER factors and general strategies 100
3. The human genetic framework: xeroderma pigmentosum 102
4. The biochemical framework: in vitro reconstitution of human NER
activity 103
4.1 XPA 103
4.2 RPA 106
4.3 XPA HHR23B 107
4.4 TFIIH 108
4.5 XPF ERCC1 and XPG 110
4.6 RFC, PCN A, DN A Pol e, and DN A ligase I 112
5. The substrate discrimination problem 112
5.1 Heterogeneity of DNA damage recognition 113
5.2 Damaged DNA binding proteins 114
5.3 Shielding from excision repair 116
5.4 The damaged DNA binding function of XPA protein 117
5.5 The role of multiprotein assembly in damage recognition 119
6. Bipartite substrate discrimination in human NER 120
6.1 Analysis of substrate discrimination using C4 backbone modifications 120
1
xii CONTENTS
6.2 Significance of bipartite recognition in mutagenesis and carcinogenesis 123
6.3 A potential sensor of defective Watson Crick hybridization 125
6.4 A potential sensor of defective deoxyribonucleotide chemistry 126
7. Conclusions 128
Acknowledgements 129
References 129
6 Transcription coupled and global genome repair in
yeast and humans 138
MARCEL TIJSTERMAN, RICHARD A. VERHAGE, and JAAP BROUWER
1. Introduction 138
2. Techniques 139
2.1 Gene specific repair analysis 139
2.2 Nucleotide specific repair analysis 139
2.3 Nucleotide excision repair in vitro 141
3. Transcription coupled nucleotide excision repair 141
3.1 General features of RNA polymerase II transcription 144
3.2 TFIIH: required for RNA pol II transcription and nucleotide excision
repair 145
3.3 Coupling NER to transcription in E. coli: a paradigm for eukaryotes? 146
3.4 Transcription coupled repair in humans 146
3.5 Transcription coupled repair in the yeast Saccharomyces cerevisiae 148
3.6 Molecular mechanisms of TCR in eukaryotes 150
4. Global genome nucleotide excision repair 152
4.1 XP C and repair of non transcribed DNA 154
4.2 Rad7 and Radl6 and repair of non transcribed DNA 155
5. Connections between NER and other repair pathways 157
5.1 NER and direct reversal by DNA photolyases 158
5.2 NER and mismatch repair 158
5.3 Nucleotide and base excision repair 158
Acknowledgements 159
References 159
7 The ATM gene and stress response 166
MARTIN F. LAVIN and KUM KUM KHANNA
1. Introduction 166
CONTENTS xiii
2. Ataxia telangiectasia 167
3. Cloning of ATM 169
3.1 Mutation analysis 170
3.2 ATMcDNA 171
3.3 Genomic organization of ATM 172
4. The ATM protein 172
4.1 Detection and importance for radiosensitivity 172
4.2 Cellular localization 173
5. ATM gene family 175
5.1 DNA dependent protein kinase 176
5.2 Atr (ataxia felangiectasia and rad3 related) 177
6. Mouse models 178
7. Role of ATM in cell cycle control 179
7.1 G,/S phase checkpoint 179
7.2 S phase and G2/M checkpoints 183
7.3 Cell cycle and radiosensitivity 185
8. Role of ATM in meiosis 186
9. Integrated view of the role of ATM 187
References 190
8 p53 and the integrated response to DNA damage 202
PAUL J. SMITH and CHRISTOPHER J. JONES
1. Introduction 202
2. DNA damage: induction and processing 202
3. DNA damage induction by anticancer agents 205
3.1 Alkylating agents 205
3.2 Antibiotics: parallels with ionizing radiation 206
3.3 DNA topoisomerase inhibitors 207
4. Cellular responses to stress and the role of p53 209
4.1 p53 and cycle arrest 210
4.2 p53 and nucleotide excision repair 213
5. p53 as a damage sensor in replicative senescence 214
5.1 Replicative senescence and telomeric clocks? 214
5.2 Telomeres: form and function 215
5.3 Telomerase 216
5.4 p53 and replicative senescence 216
xiv CONTENTS
5.5 Nature of the p53 activating signal at senescence and the role of DNA
repair pathways? 217
6. Human cancer prone disorders 220
6.1 Perspective 220
6.2 Germline disorders involving dominant proto oncogenes and dominant
tumour suppressor genes 221
7. Conclusions 222
References 223
Index 233
|
| any_adam_object | 1 |
| author_GND | (DE-588)128505583 |
| building | Verbundindex |
| bvnumber | BV012957111 |
| callnumber-first | Q - Science |
| callnumber-label | QH467 |
| callnumber-raw | QH467 |
| callnumber-search | QH467 |
| callnumber-sort | QH 3467 |
| callnumber-subject | QH - Natural History and Biology |
| ctrlnum | (OCoLC)41503892 (DE-599)BVBBV012957111 |
| dewey-full | 572.8/6459 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8/6459 |
| dewey-search | 572.8/6459 |
| dewey-sort | 3572.8 46459 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. publ. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01812nam a2200505 c 4500</leader><controlfield tag="001">BV012957111</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20031114 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">000125s1999 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0199637075</subfield><subfield code="9">0-19-963707-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0199637067</subfield><subfield code="9">0-19-963706-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)41503892</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012957111</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH467</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.8/6459</subfield><subfield code="2">21</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">DNA recombination and repair</subfield><subfield code="c">ed. by Paul J. Smith ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. publ.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford [u.a.]</subfield><subfield code="b">Oxford Univ. Press</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIX, 236 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers in molecular biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ADN - Réparation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Recombinaison génétique</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA Repair</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA repair</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic recombination</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Recombination, Genetic</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">DNS-Reparatur</subfield><subfield code="0">(DE-588)4150347-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Rekombination</subfield><subfield code="0">(DE-588)4049338-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Rekombination</subfield><subfield code="0">(DE-588)4049338-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">DNS-Reparatur</subfield><subfield code="0">(DE-588)4150347-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smith, Paul J.</subfield><subfield code="d">1953-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)128505583</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008824028&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008824028</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012957111 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:36:43Z |
| institution | BVB |
| isbn | 0199637075 0199637067 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008824028 |
| oclc_num | 41503892 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM |
| owner_facet | DE-12 DE-19 DE-BY-UBM |
| physical | XIX, 236 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| series2 | Frontiers in molecular biology |
| spelling | DNA recombination and repair ed. by Paul J. Smith ... 1. publ. Oxford [u.a.] Oxford Univ. Press 1999 XIX, 236 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frontiers in molecular biology ADN - Réparation Recombinaison génétique DNA Repair DNA repair Genetic recombination Recombination, Genetic DNS (DE-588)4070512-2 gnd rswk-swf DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf Rekombination (DE-588)4049338-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content DNS (DE-588)4070512-2 s Rekombination (DE-588)4049338-6 s DE-604 DNS-Reparatur (DE-588)4150347-8 s Smith, Paul J. 1953- Sonstige (DE-588)128505583 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008824028&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | DNA recombination and repair ADN - Réparation Recombinaison génétique DNA Repair DNA repair Genetic recombination Recombination, Genetic DNS (DE-588)4070512-2 gnd DNS-Reparatur (DE-588)4150347-8 gnd Rekombination (DE-588)4049338-6 gnd |
| subject_GND | (DE-588)4070512-2 (DE-588)4150347-8 (DE-588)4049338-6 (DE-588)4143413-4 |
| title | DNA recombination and repair |
| title_auth | DNA recombination and repair |
| title_exact_search | DNA recombination and repair |
| title_full | DNA recombination and repair ed. by Paul J. Smith ... |
| title_fullStr | DNA recombination and repair ed. by Paul J. Smith ... |
| title_full_unstemmed | DNA recombination and repair ed. by Paul J. Smith ... |
| title_short | DNA recombination and repair |
| title_sort | dna recombination and repair |
| topic | ADN - Réparation Recombinaison génétique DNA Repair DNA repair Genetic recombination Recombination, Genetic DNS (DE-588)4070512-2 gnd DNS-Reparatur (DE-588)4150347-8 gnd Rekombination (DE-588)4049338-6 gnd |
| topic_facet | ADN - Réparation Recombinaison génétique DNA Repair DNA repair Genetic recombination Recombination, Genetic DNS DNS-Reparatur Rekombination Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008824028&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT smithpaulj dnarecombinationandrepair |