Verfügbarkeit: Experimental and clinical neurotoxicology

Experimental and clinical neurotoxicology:

Gespeichert in:

Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	New York [u.a.] Oxford Univ. Press 2000
Ausgabe:	2. ed.
Schlagworte:	Neurotoxicologie Environmental Pollutants > toxicity Nervous System Diseases > chemically induced Nervous System > drug effects Nervous system > Diseases Neurotoxicology Neurotoxikologie
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XL, 1310 S. graph. Darst.
ISBN:	0195084772

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245	1	0	\|a Experimental and clinical neurotoxicology \|c ed. by Peter S. Spencer ...
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650		4	\|a Environmental Pollutants \|x toxicity
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Datensatz im Suchindex

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adam_text	Contents PART ONE FUNDAMENTALS OF EXPERIMENTAL AND CLINICAL NEUROTOXICOLOGY Chapter One Biological Principles of Chemical Neurotoxicity 3 Peter S. Spencer VULNERABILITY OF THE NERVOUS SYSTEM 3 Extraneural Factors 4 Exposure, Dose and Response 4 Biotransformation 6 Species, Genotype, Gender, Nutrition, Age 6 Factors Associated with the Nervous System 7 Neural Microenvironment 7 Architectural and Functional Specialization 10 Nature and Progress of the Neurotoxic Response 12 VULNERABILITY OF NEURONS AND THEIR PROCESSES 13 Somal DNA 13 Protein Synthesis and Enzyme Inhibition 13 Mitochondria and Energy State 14 Vitamin Function 15 Physiological Ions 17 G Proteins 17 Excitable Membrane 18 Sodium Ion (Na+) Channels 18 Potassium Ion (K+) Channels 20 Chloride Ion (C ~) Channels 21 Calcium Ion (Ca2+) Channels 22 lonophores 23 Neurotransmitter Systems 23 Exocytosis 23 Acetylcholine 24 Glutamate/Aspartate 27 GAB A 31 Glycine 32 v Catecholamines 32 Serotonin 34 Neuropeptides 35 Cannabinoid Receptors 37 Purinoceptors and Adenosine Receptors 37 Axonal Transport 37 Vesicles 39 Cytoskeletal Proteins 39 VULNERABILITY OF NEUROGLIA AND MYELIN 40 Astrocytes and Ependymal Cells 40 Oligodendrocytes and Schwann Cells 40 SYSTEM VULNERABILITY TO CHEMICALS 41 Special Senses 41 Olfaction 42 Gustation 43 Vision 43 Balance and Audition 43 Sensorimotor Function 44 Principal Sensory Pathway 45 Pain Pathways 45 Principal (Voluntary) Motor Pathway 46 Cerebellum 46 Basal Ganglia 47 Autonomic (Involuntary) Motor System 48 Hypothalamus, Hippocampus and Limbic System 49 DEVELOPMENTAL NEUROTOXICITY 50 Sensitive Periods of Neural Development 50 Fetal and Newborn Toxic Syndromes 51 CNS AND PNS CHEMICAL ONCOGENESIS 53 SELECTED BIBLIOGRAPHY 54 Chapter Two Human Neurotoxic Disease 55 Herbert H. Schaumburg CAUSATION CRITERIA FOR IDENTIFICATION OF NEUROTOXICITY 55 CARDINAL TENETS OF NEUROTOXIC DISEASE 56 Strong Dose response Relationship 56 Proximity to Exposure 56 Improvement Usually Follows Cessation of Exposure 56 Multiple Clinical Syndromes May Result from Different Exposures to a Single Toxin 56 Asymptomatic Disease 56 Modulation by Bystander Chemicals 57 Chemical Formula May Not Predict Toxicity 57 Age, Pre existing Conditions or Genetic Variation in Metabolism Occasionally Modulate the Effects of a Neurotoxin 57 THE NATURE OF NEUROTOXIC DISEASE 57 Neurotoxic Clinical Syndromes (corresponds generally to Clinical Neurotoxicity Rating Scale for substances in A Z catalogue section) 57 Pseudo Neurotoxic Syndromes 57 Physical Dependence/Addiction/Abuse 58 Psychobiological Reactions 59 Acute Encephalopathy Syndromes (Cortical Subcortical Neuronal Encephalopathy/ Leukoencephalopathy) 59 Neuroleptic Malignant Syndrome 61 Malignant Hyperthermia Syndrome 61 Chronic Encephalopathy Syndromes 61 Dementia 62 Seizure Disorders 62 Headache Syndromes 63 Pyramidal Syndrome 63 Extrapyramidal Syndromes 64 Cerebellar Syndromes 65 Hydrocephalus 65 Benign Intracranial Hypertension (Pseudotumor Cerebri) 65 Aseptic Meningitis 65 Encephalomalacia (stroke) 65 Tremor 65 Neural Visual System 66 Neural Auditory and Vestibular Systems (Ototoxicity) 66 Olfaction and Taste 67 Myelopathy (Spinal Cord) 68 Peripheral Neuropathy 68 Sensory Neuronopathy Syndrome 69 Cranial Neuropathy 70 Ion Channel Syndromes 70 Neuromuscular Transmission Syndromes 71 Myopathy 71 Specific Syndromes and Scenarios Strongly Associated with Neurotoxins 72 ASSESSMENT OF NEUROTOXIC DISEASE IN INDIVIDUALS 73 Methods and Procedures 73 History 74 Physical Examination 74 Neuropsychological Tests 74 Specialized Laboratory Tests 75 Illustrative Clinical Vignettes 76 Pseudo Neurotoxic Syndromes 76 Neurotoxic PNS Syndromes 77 Neurotoxic CNS Syndromes 77 ASSESSMENT OF NEUROTOXIC DISEASE IN LARGE POPULATIONS 78 Study Design 78 Methods and Procedures 79 Questionnaire 79 Quantitative Sensory Testing 79 Tremor Analysis 79 Computer administered Neurobehavioral Testing 79 Biological Markers 79 Data Analysis 80 Large population Screening Scenarios 81 Chapter Three Aspects of Veterinary Neurotoxicology 83 Anthony A. Frank, Linda L. Blythe and Peter S. Spencer Host Factors 83 NONBIOLOGICAL NEUROTOXIC FACTORS 84 Feed, Chemicals, and Water 84 Metals, Metalloids and Other Elements 85 • Arsenic 85 • Boron 85 • Lead 85 • Mercurials 85 • Molybdenum intoxication/copper deficiency 86 • Selenium 86 • Sulfide/Sulfate induced Polioencephalomalacia 86 Fungicides, Pesticides, Herbicides, Baits, and Repel lants 87 • 4 Aminopyridine 87 • Bromethalin 87 • a Chloralose 88 • N,N Diethyl m toluamide fenvalerate 88 • Fluoroacetate 88 • d Limonene 88 • Metaldehyde 88 • Strychnine 88 BIOLOGICAL NEUROTOXIC FACTORS 89 Bacteria 89 • Clostridium perfringens Type D 89 • Corynebacterium rathayi 89 Blue green Algae 89 Fungal Neurotoxins 90 Tremorgens 90 Other Myconeurotoxins 91 Neurotoxic Plants 92 Neurodegenerative Disorders 93 Optic Nerve Damage 93 Extrapyramidal and Movement Disorders 93 Motoneuron and Locomotor Disorders 94 Neuronal Storage Disorders 95 Strychnine like and Other Convulsant Effects 96 Effects on Cholinergic Neurotransmission: Anticholinesterase Effects 97 Nicotinic Receptor Blockade 97 Nicotine like Toxins 97 Disorders of Striated Muscle 97 Disorders of Cardiac Muscle 99 PART TWO SUBSTANCES WITH NEUROTOXIC POTENTIAL NEUROTOXIC SUBSTANCES Criteria for Neurotoxicity 109 Absinthe (Wormwood) 109 Albert C. Ludolph and Herbert H. Schaumburg Acacia berlandieri Benth. 110 Albert C. Ludolph Acetone 111 Herbert H. Schaumburg Acetyl Ethyl Tetramethyl Tetralin 112 Peter S. Spencer 3 Acetylpyridine 116 Hans Kolbe Acetylsalicylic Acid 118 Peter C.Mabie y Acivicin 121 Herbert H. Schaumburg Aconitine 122 Peter S. Spencer Acromelic Acid 123 Albert C. Ludolph Acrylamide 124 V Bruce G. Gold and Herbert H. Schaumburg Acrylonitrile 133 Kevin M. Crofton and Mary Beth Center Acyclovir 135 Herbert H. Schaumburg Agaritine 136 Peter S. Spencer Agatoxins 137 Albert C, Ludolph L Alanosine A 138 Albert C. Ludolph Allyl Chloride 139 Fengsheng He Allylglycine 140 Albert C. Ludolph Almitrine Bimesilate 141 Herbert H. Schaumburg Aluminum and Its Compounds 142 Peter S. Spencer Amanita Toxins 151 Albert C. Ludolph Amantadine 153 John D. Rogers a Aminoadipic Acid 153 Albert C. Ludolph e Aminocaproic Acid 154 Daniel M. Rosenbaum 1 Amino 3 Chloro 2 Propanol 156 Peter S. Spencer Aminoglycoside Antibiotics (Streptomycin) 156 Herbert H. Schaumburg 6 Aminonicotinamide 161 Hans Kolbe a Aminopyridine 165 Albert C. Ludolph Amiodarone 166 Steven Herskovitz Amoscanate 169 Georg J. Krinke Amphetamines and Related Compounds 170 Alfred Heller, Lisa Won, and Philip C. Hoffmann Amphotericin B 192 Herbert H. Schaumburg Amsacrine 193 Albert C. Ludolph A MTX 194 Albert C. Ludolph Amyl Alcohols 194 Herbert H. Schaumburg Anabasine 195 Albert C. Ludolph Anatoxins 196 Wayne W. Carmichael and Edward G. Hyde Anisatin 199 Peter S. Spencer Anthranilic Acid and Derivatives 199 Albert C. Ludolph Antillatoxin 199 William H. Gerwick and Thomas F. Murray Apamin and Hymenoptera Venoms 200 Zarife Sahenk and Jerry R. Mendell Arsenic 203 Anthony J. Windebank 1 Aryl 3,3 Dialkyltriazenes 207 Peter S. Spencer L Asparaginase 208 Herbert H. Schaumburg Aspartame 209 Bennett A. Shaywitz Atropine 212 Brent T. Burton Avermectins 214 Albert C. Ludolph Azacitidine 216 Herbert H. Schaumburg Azoles 217 Herbert H. Schaumburg Baclofen 219 Herbert H. Schaumburg Barbiturates 219 Joseph Maytal and Shlomo Shinnar Barium 225 Steven Herskovitz Batrachotoxin and Related Compounds 227 Peter S. Spencer Benzalkonium Chloride 228 Peter S. Spencer Benzene 228 Herbert H. Schaumburg Benzene Hexachloride 229 Herbert H. Schaumburg Benzimidazole 230 Herbert H. Schaumburg Benzodiazepines 231 Howard A. Crystal and Herbert H. Schaumburg Bicuculline 235 Albert C. Ludolph Bismuth 236 Mark Forest Gordon Black Widow Spider Venom 239 Alfredo Gorio and Anna Maria Di Giulio Botulinum Neurotoxin 243 Phyllis L. Bieri Bradykinin Analogs 252 Tom Piek Brevetoxins 254 Albert C. Ludolph Bromide 255 Peter C. Mabie Bromocriptine 257 John D. Rogers p Bromophenylacetylurea 258 Richard M. LoPachin and Ellen J. Lehning p Bromophenylisothiocyanate 260 John L. O Donoghue Buspirone 260 Herbert H. Schaumburg 2 Butenenitrile 261 Kevin M. Crofton and Mary Beth Genter 3 Butenenitrile 263 Kevin M. Crofton and Mary Beth Genter Buthotus hottentota 265 Albert C. Ludolph 2 f Butylazo 2 hydroxy 5 methylhexane 265 Thomas L. Kurt yV Butylbenzenesulfonamide 268 Albert C. Ludolph 6 ferf Butyl 3 methyl 2,4 dinitroanisole 269 Peter S. Spencer y^Butyrolactone 271 Peter S. Spencer Butyrophenones 272 Matthias Riepe Cadmium 276 J. Michael Schroder Calycanthine 280 Albert C. Ludolph Canatoxin 280 Albert C. Ludolph Cannabis 281 John CM. Brust Cantharidin 284 Herbert H. Schaumburg Capsaicin and Analogs 284 Rainer Amann and Peter Holzer Captopril 288 Herbert H. Schaumburg Carbamates 289 Donald J. Ecobichon Carbamazepine 298 Carol Eisenberg, Mark J. Sinnett, and Shlomo Shinnar Carbolines/lsoquinolines 304 Michael A. Collins and Edward J. Neafsey Carbon Disulfide 315 Doyle G. Graham and William M. Valentine Carbon Monoxide 318 Howard A. Crystal and Myron D. Ginsberg Carbon Tetrachloride 330 John L. O Donoghue Carboxyatractyloside 333 Albert C. Ludolph Carmustine 334 William C. Welch and Paul L. Kornblith Cassava 338 Hans Rosling and Thorkild Tylleskar Catha edulis 344 Matthias Riepe Cephalosporins 345 Libor Velfsek and Solomon L. Mosh6 Ceruleotoxin 348 Albert C. Ludolph CGS 21595 349 Georg J. Krinke Charatoxin 350 Albert C. Ludolph Charybdotoxin 351 Albert C. Ludolph Cheilanthes sieberi 352 Albert C. Ludolph Chelidonium majus 353 Albert C. Ludolph Chloral Hydrate 353 Herbert H. Schaumburg Chloramphenicol 354 Herbert H. Schaumburg Chlordecone 355 John R. Taylor, John B. Selhorst, Vincent P. Calabrese, and Martha Neff Smith Chlorhexidine Gluconate 363 Herbert H. Schaumburg Chlorinated Cyclodienes 364 Peter S. Spencer and Herbert H. Schaumburg 6 Chloro 6 Deoxyglucose 371 Peter S. Spencer (2 Chloroethyl) N ethyl 2 bromo benzylamine 372 Albert C. Ludolph 2 Chloropropionic Acid 373 John L. O Donoghue Chloroquine 375 William A. Meier Ruge and Herbert H. Schaumburg Chlorpromazine and Other Neuroleptics 379 Arnold E. Merriam Cicutoxin 385 Albert C. Ludolph Ciguatoxin 386 Jerry G. Kaplan Cimetidine 391 Herbert H. Schaumburg Cinnarizine 391 John D. Rogers Cisplatin 392 Anthony J. Windebank Clioquinol 396 Herbert H. Schaumburg Clioxanide 401 Albert C. Ludolph Clofibrate 401 Bryon A. Kakulas Clonidine 403 Herbert H. Schaumburg Clozapine 404 Albert C. Ludolph Clupeotoxin 406 Albert C. Ludolph and Peter S. Spencer Cobra Venom 407 Albert C. Ludolph Cocaine 408 Randall Berliner Colchicine 413 Herbert H. Schaumburg Conium maculatum 415 Albert C. Ludolph and Peter S. Spencer Conotoxins 417 Lourdes J. Cruz and Baldomero M. Olivera Corticosteroids 420 Byron A. Kakulas Cotyledon Spp. 423 Albert C. Ludolph Crotalaria Spp. 423 Albert C. Ludolph Crotamine 424 Albert C. Ludolph Crotoxin 425 Albert C. Ludolph Cuprizone 426 Thomas W. Bouldin Cyanides and Related Compounds 428 John Tor Agbidye and Peter S. Spencer Cycasin, Methylazoxymethanol and Related Compounds 436 Peter S. Spencer, Glen Kisby, Valerie S. Palmer, and Peter Obendorf Cyclobenzaprine 447 Herbert H. Schaumburg Cycloleucine 448 Henry C. Powell Cyclopentolate 451 Herbert H. Schaumburg Cycloserine 452 Herbert H. Schaumburg and Peter S. Spencer Cyclosporine 453 Matthias Riepe and Herbert H. Schaumburg Cyclotrimethylenetrinitramine 455 Steven A. Sparr L Cysteine 457 John W. Olney Cytarabine 458 Mark F. Mehler Dactinomycin (Actinomycin D) 463 Herbert H. Schaumburg Dapsone 464 Ludwig Guttmann Datura stramonium 466 Albert C. Ludolph Delphinium Spp. 467 Albert C. Ludolph Dendroaspis angusticeps Toxins 469 Frank Bretschneider and Albert C. Ludolph 20,25 Diazacholesterol 472 Jorge N. Larocca Dichloroacetic Acid 474 Peter S. Spencer Dichloroacetylene 476 Herbert H. Schaumburg Dichlorodiphenyltrichloroethane and Derivatives 478 Peter S. Spencer and Herbert H. Schaumburg 2,4 Dichlorophenoxyacetic Acid 483 Herbert H. Schaumburg Dideoxycytidine and Other Nucleoside Analogs 486 Joseph C. Arezzo Diethylbenzene 490 Peter S. Spencer N,/V Diethyl /n toluamide and Other Dialkylamides 492 Peter S. Spencer Digitalis and Other Cardiac Glycosides 497 Daniel M. Rosenbaum Dihydro j8 erythroidine 499 Albert C. Ludolph /V,N Dimethylaminopropionitrile 499 Alan Pestronk Dimethyl Sulfate 502 Peter S. Spencer Diphenyl 503 Peter S. Spencer Diphtheria Toxin 505 Herbert H. Schaumburg, Dennis A. Aquino, and Kenneth R. Einberg Dipiperidinoethane 511 Albert C. Ludolph Disulfiram 512 John CM. Brust 2,4 Dithiobiuret 514 John L. O Donoghue Dizocilpine 517 Albert C. Ludolph Domoic Acid 518 Neil R. Cashman and F. Cendes Doxorubicin and Related Anthracyclines 529 Peter S. Spencer Enflurane 534 Herbert H. Schaumburg Erabutoxins 534 Albert C. Ludolph Ergot Alkaloids 535 Lawrence C. Newman and Richard B. Lipton Erythromycin 537 Herbert H. Schaumburg Ethacrynic Acid 538 Herbert H. Schaumburg Ethambutol 539 Peter S. Spencer Ethanol 541 John CM. Brust Ethchlorvynol 558 Herbert H. Schaumburg Ethidium Bromide 558 Peter S. Spencer Ethionamide 560 Herbert H. Schaumburg Ethylcholine Aziridinium 561 Peter S. Spencer Ethylene Glycol 562 Herbert H. Schaumburg Ethylene Oxide 563 Akio Ohnishi Euphorbia Spp. 566 Thomas Meyer and Albert C. Ludolph Fasciculins 567 Albert C. Ludolph Fentanyl 568 John CM. Brust Flecanide and Other Class 1 c Antiarrhythmic Agents 569 Steven A. Sparr Fludarabine 571 Mark F. Mehler Flumazenil 574 Herbert H. Schaumburg Flunarazine 574 John D. Rogers Fluoroacetic Acid 575 Hans Kolbe Fluoroquinolones 578 Herbert H. Schaumburg 5 Fluorouracil 579 Mark F. Mehler Fluoxetine and Other Serotonin Reuptake Blockers 582 Arnold E. Merriam Fumitremorgen 584 Albert C. Ludolph Fumonisin 586 Albert C. Ludolph Funnel Web Spider Toxins 587 Albert C. Ludolph and Peter S. Spencer Furaltadone 588 Herbert H. Schaumburg Furosemide 589 Herbert H. Schaumburg Galactose 590 Andrew P. Mizisin and Henry C. Powell Ganciclovir 595 Steven A. Sparr Gangliosides 598 Horst Wietholter Gasoline 600 Herbert H. Schaumburg Germanium Dioxide 600 Herbert H. Schaumburg Germine 602 Albert C. Ludolph Gila Monster Venom 603 Albert C. Ludolph Ginseng 603 Herbert H. Schaumburg Glutamic Acid 604 John W. Olney and Albert C. Ludolph Glutethimide 610 Albert C. Ludolph o Glycerotoxins 611 Albert C. Ludolph and Frank Bretschneider Glycine 612 Thomas L. Slamovits Gold Salts 614 Steven Herskovitz Gossypol 615 Fengsheng He Grammostola spatulata 617 Albert C. Ludolph Grayanotoxins 617 Albert C. Ludolph Griseofulvin 618 Herbert H. Schaumburg Gyromitrin 619 Albert C. Ludolph Halothane 621 Herbert H. Schaumburg Helichrysum Spp. 621 Helge Volkel and Albert C. Ludolph n Heptane 622 Herbert H. Schaumburg Heroin 623 John CM. Brust Hexachlorobenzene 626 Henry A. Peters, Derek J. Cripps, Ayhan Gocmen, and George T. Bryan Hexachlorophene 630 Mitchell Steinschneider 2,4 Hexadiene 1 nitrile 632 John L. O Donoghue Hexamethylmelamine 632 Herbert H. Schaumburg n Hexane, Metabolites, and Derivatives 633 Anthony P. DeCaprio Histrionicotoxins 648 Alexander Storch and Albert C. Ludolph Holothurins and Holotoxins 649 Peter S. Spencer Hydralazine 650 Glen Kisby Hydrazine 652 Glen Kisby Hydrogen Sulfide 655 D. Gary Rischitelli and Herbert H. Schaumburg Hydrophiidae Toxins 658 Albert C. Ludolph 6 Hydroxydopamine 659 Hans Georg Baumgarten and Zarko Grozdanovic a Hydroxytoluene 667 Peter S. Spencer Hymenoxys richardsonii 669 Helge Volkel and Albert C. Ludolph Hypoglycine 669 Peter S. Spencer Iberiotoxin 673 Albert C. Ludolph Ibotenic Acid 673 Albert C. Ludolph Ibuprofen 674 Herbert H. Schaumburg Ifosfamide 675 Steven A. Sparr /3,/3 Iminodipropionitrile 678 Bruce G. Gold Indolealkylamines 680 Albert C. Ludolph Indomethacin 681 Steven A. Sparr Interferon or 683 Herbert H. Schaumburg lodoacetate 684 Albert C. Ludolph and Peter S. Spencer lohexol and Other Radiographic Contrast Agents 685 George Lantos Ipomoea Spp. 689 Matthias W. Riepe Isoflurane 690 Herbert H. Schaumburg Isoniazid 690 J. Michael Schroder Isopropanol 697 Herbert H. Schaumburg Isoxazololes 698 Matthias W. Riepe Janthitrems 700 Albert C. Ludolph JSTX 3 701 Nobufumi Kawai Kaliotoxin 703 Albert C. Ludolph Kallstroemia hirsutissima 703 Alexander Storch and Albert C. Ludolph Kalmia latifolia 704 Albert C. Ludolph Karwinskia humboldtiana 705 Roy O. Weller Lead, Inorganic 708 Deborah A. Cory Schlecta and Herbert H. Schaumburg Lead, Organic 720 Herbert H. Schaumburg Leiurotoxin 721 Albert C. Ludolph Leptinotoxin H 722 Albert C. Ludolph Levamisole 722 Herbert H. Schaumburg Levodopa 723 John D. Rogers Lidocaine and Related Local Anesthetics 726 Michael W. Kalichman and Henry C. Powell Lincomycin 736 Steven Herskovitz Lithium 737 Klaus Windgassen Lobeline 741 John CM. Brust Lophotoxin and Other Gorgonian Toxins 742 Albert C. Ludolph Lovastatin 743 Herbert H. Schaumburg Lupinus Spp. 744 Thomas Meyer and Albert C. Ludolph Lysergide 745 Arnold E. Merriam Lysolecithin 747 Thomas W. Bouldin Maitotoxin 750 Albert C. Ludolph Mamba Snake Venom 751 Albert C. Ludolph Mandaratoxin 752 Albert C. Ludolph Manganese 752 Nai Shin Chu, Chin Chang Huang, and Donald B. Calne Margatoxin 756 Albert C. Ludolph Measles Vaccine 756 Neil L. Rosenberg Mechlorethamine 757 Herbert H. Schaumburg Mefloquine 759 Steven A. Sparr Meperidine 761 John CM. Brust 3 Mercaptopropionic Acid 762 Peter S. Spencer Mercury and Mercury Compounds 763 / v M. Anthony Verity and Ted A. Sarafian Mescaline 770 John CM. Brust Methadone 772 John CM. Brust Methanol 773 Albert C Ludolph Methaqualone 780 John CM. Brust Methionine Sulfoximine 781 Mohammad I. Sabri Methohexital Sodium 784 Albert C Ludolph Methotrexate 785 Raul Francisco Valenzuela and Fred H. Hochberg Methoxyflurane 789 Herbert H. Schaumburg /5 /V Methylamino L Alanine 789 Glen Kisby Methyl Bromide 794 Steven Herskovitz Methyl Chloride 796 Peter S. Spencer Methylene Chloride 798 Richard D. Stewart and Herbert H. Schaumburg 3,4 Methylenedioxymethamphetamine 802 William Slikker Jr. and Herbert H. Schaumburg Methyl Ethyl Ketone 807 Herbert H. Schaumburg 3,3 Methyliminobis(/V Methylpropylamine) 807 Peter S. Spencer Methyl Iodide 807 Peter S. Spencer Methyllycaconitine 809 Albert C. Ludolph Methyl Methacrylate 810 Steven Herskovitz MPTP and Analogs 812 Donato A. Di Monte and J. William Langston Methylxanthines 819 Albert C. Ludolph Methysergide 821 Herbert H. Schaumburg Metoclopramide 822 Steven A. Sparr Metrizamide 825 Steven Herskovitz Metronidazole 827 Steven Herskovitz Misonidazole 828 Steven Herskovitz Mitotane 830 Herbert H. Schaumburg MMR Vaccine 830 Neil L. Rosenberg Mojave Toxin 832 Albert C. Ludolph Morphine and Related Opiates 833 John CM. Brust Mumps Vaccine 836 Neil L. Rosenberg Mustard Warfare Agents and Related Substances 837 Peter S. Spencer, Jeffrey L. Daniels, and Glen Kisby Muzolimine 848 Herbert H. Schaumburg Myristica fragrans 849 Frank Bretschneider and Albert C. Ludolph Nalidixic Acid 852 Steven A. Sparr Naphthalene 854 John D. Rogers 1 Naphthylacetyl Spermine 854 Nobufumi Kawai Naproxen 855 Herbert H. Schaumburg Neosurugatoxin 857 Albert C. Ludolph Nereistoxin and Related Compounds 858 William R. Kem Nicotine 860 y John CM. Brust .S Nifedipine 862 Steven A. Sparr Nitrobenzene 864 John L. O Donoghue Nitrofurantoin 866 Herbert H. Schaumburg Nitrogen Trichloride 869 John L. O Donoghue 3 Nitropropionic Acid and Related Compounds 870 Fengsheng He and Albert C. Ludolph Nitroprusside 875 Herbert H. Schaumburg Nitrosoureas 876 Glen Kisby Nitrous Oxide 882 Stephen N. Scelsa Noxiustoxin 889 Albert C. Ludolph and Peter S. Spencer Ochratoxins 891 Albert C. Ludolph and Peter S. Spencer Okadaic Acid 892 Peter S. Spencer Organic Solvent Mixtures 894 Herbert H. Schaumburg and Peter S/Spencet Organophosphorus Compounds 898 Marcel lo Lotti ^ /J /V Oxalylamino L Alanine 926 Jacques Hugon, Albert C. Ludolph, and Peter S. Spencer Oxotremorine 939 Albert C. Ludolph and Peter S. Spencer Oxybate 939 Peter S. Spencer Palytoxin 940 Alexander Storch and Albert C. Ludolph Pandinus imperator Toxin 942 Albert C. Ludolph and Peter S. Spencer Paraquat 943 Herbert H. Schaumburg Parmelia molliuscula 944 Albert C. Ludolph Pelamitoxin 944 Albert C. Ludolph Pemoline 944 Herbert H. Schaumburg Penicillamine 946 Steven Herskovitz Penicillins 948 Libor Velfsek and Solomon L. Moshe Penitrems and Other Tremorgens 951 Albert C. Ludolph and Peter S. Spencer Pennyroyal Oil 963 Peter S. Spencer Pentaborane 964 Steven A. Sparr 2,4 Pentanedione 966 Peter S. Spencer Pentazocine 967 Herbert H. Schaumburg Pentenenitrile 968 Mary Beth Genter and Kevin M. Crofton Perhexilene Maleate 969 Steven Herskovitz Pertussis Vaccine 971 Neil L. Rosenberg Pfiesteria piscicida 975 Edward D. Levin, Howard Glasgow Jr., Donald E. Schmechel, Nora Deamer Melia, and JoAnn Burkholder Phalaris Spp. 977 Alexander Storch and Albert C. Ludolph Phencyclidine 979 Daniel C. Javitt Phenelzine and Other Monoamine Oxidase Inhibitors 985 Arnold E. Merriam Phenol 987 Herbert H. Schaumburg Phenytoin 988 Allison Mann, Mark J. Sinnett and Shlomo Shinnar Philanthotoxin 999 Tom Piek Physalia Toxin 1000 Michael K. Pugsley and Michael J.A. Walker Phytolacca Spp. 1003 Albert C. Ludolph Picrotoxin 1004 Albert C. Ludolph and Peter S. Spencer Piper methysticum 1005 Albert C. Ludolph Piperazine 1006 Steven A. Sparr orPlecteurys tristis Toxins 1008 Albert C. Ludolph and Peter S. Spencer Podophyllotoxin and Related Compounds 1008 Fung Chow Chui Polio Virus Vaccine 1010 Neil L. Rosenberg Polychlorinated Biphenyls 1013 Herbert H. Schaumburg Polymyxin 1015 Herbert H. Schaumburg Poneratoxin 1016 Tom Piek Praziquantel 1017 Steven A. Sparr n Propanol 1019 Peter S. Spencer Propranolol and Other /3 Adrenergic Receptor Antagonists 1019 Steven A. Sparr Propylene Glycol 1024 Brent T. Burton Pseudomonas Toxins 1025 Albert C. Ludolph Psilocybin and Psilocin 1026 John CM. Brust Pteridium aquilinum 1027 Albert C. Ludolph and Peter S. Spencer Pyrethroids 1028 Henk P.M. Vijverberg Pyridoxine/Vitamin B6 1044 Herbert H. Schaumburg Pyrimethamine 1048 Herbert H. Schaumburg Pyriminil 1048 Albert C. Ludolph and Peter S. Spencer Pyrithione 1050 Zarife Sahenk and Jerry R. Mendel I Quinacrine 1055 Byron A. Kakulas Quinidine 1056 Herbert H. Schaumburg Quinine 1057 Steven Herskovitz 3 Quinuclidinyl Benzilate 1058 Peter S. Spencer Rabies Vaccine 1064 Neil L. Rosenberg Reserpine 1067 John D. Rogers Rhodactis howesii 1068 Albert C. Ludolph Ricin 1068 Herbert H. Schaumburg and Peter S. Spencer Rotenone 1070 Matthias Riepe Rubella Vaccine 1071 Neil L. Rosenberg Sarin, Other Nerve Agents , and their Antidotes 1073 Peter S. Spencer, Barry W. Wilson, and Edson X. Albuquerque Saxitoxin 1093 Richard G. Pellegrino Scombroid Fish (Histamine) 1096 Albert C. Ludolph and Peter S. Spencer Scorpion Toxins (a and /3) 1097 Albert C. Ludolph and Peter S. Spencer Sea Anemone Toxins 1099 Albert C. Ludolph Selenium 1100 Dennis J. Blodgett and Bernard S. Jortner Shiga Toxin 1103 Albert C. Ludolph and Peter S. Spencer Silicone 1104 Neil L. Rosenberg Smallpox Vaccine 1106 Neil L. Rosenberg Sodium Azide 1107 Mohammad I. Sabri Spirogermanium 1110 Herbert H. Schaumburg Stichodactyla Spp. 1111 Albert C. Ludolph and Peter S. Spencer Stipa robusta 1112 Frank Bretschneider and Albert C. Ludolph Stonefish Venom 1112 Albert C. Ludolph and Peter S. Spencer Strychnine 1114 Charles N. Allen Styrene 1116 John L. O Donoghue Succinylcholine 1121 Phyllis L. Bieri Sulfasalazine 1122 Herbert H. Schaumburg Sulfonamides 1124 Steven Herskovitz Suramin Sodium 1125 Herbert H. Schaumburg Swainsonine 1127 Steven U. Walkley Tacrolimus 1131 Herbert H. Schaumburg, Albert C. Ludolph, and Bruce G. Gold Taicatoxin 1133 Albert C. Ludolph and Peter S. Spencer Taipoxin 1134 Albert C. Ludolph Taxoids 1135 Stuart C. Apfel Tellurium 1140 Kenneth R. Reuhl and Marianne A. Polunas Tetanospasmin 1143 John W. Griffin and George Oyler Tetrachlorodibenzodioxin 1148 Marie Haring Sweeney and David A. Dankovic 1,1,2,2 Tetrachloroethane 1151 John L. O Donoghue Tetrachloroethylene 1154 John L. O Donoghue Tetracyclines 1158 Steven A. Sparr Tetramethylthiuram Disulfide 1160 John L. O Donoghue Tetrodotoxin 1162 Toshio Narahashi Thalicarpine 1163 Peter S. Spencer Thalidomide 1165 Herbert H. Schaumburg Thallium 1168 Luigi Manzo Thiophene 1177 John L. O Donoghue Thymidine 1179 Herbert H. Schaumburg Tick Saliva 1180 Rainer Gothe Tityustoxin 1182 Albert C. Ludolph and Peter S. Spencer Toluene 1183 Herbert H. Schaumburg Toluene 2,4 Diisocyanate 1190 Herbert H. Schaumburg Toxaphene and Constituents 1191 Peter S. Spencer Toxic Oil 1193 Alberto Portera Scinchez and Manuel Posada de la Paz Tremetone 1196 Albert C. Ludolph Triamcinolone 1197 Byron A. Kakulas 1,1,1 Trichloroethane 1198 John L. O Donoghue Trichloroethylene 1202 Herbert H. Schaumburg Tricyclic Antidepressants 1203 Arnold E. Merriam Triethyltin 1206 Georg j. Krinke Trihexyphenidyl Hydrochloride 1209 John D. Rogers Trimethaphan Camsylate 1209 Herbert H. Schaumburg Trimethobenzamide Hydrochloride 1210 Herbert H. Schaumburg Trimethyltin 1211 Georg J. Krinke Triparanol 1214 Herbert H. Schaumburg Trithiozine 1215 Steven Herskovitz L Try ptophan 1216 Herbert H. Schaumburg and Neil L. Rosenberg rf Tubocurarine 1219 Phyllis L. Bieri ValproicAcid 1222 Carol Eisenberg, Mark J. Sinnett, and Shlomo Shinnar Vecuronium Bromide 1226 Steven Herskovitz Veratridine 1228 Albert C. Ludolph Vidarabine 1229 Herbert H. Schaumburg Vigabatrin 1230 Herbert H. Schaumburg Vinca Alkaloids 1232 Herbert H. Schaumburg Vinyl Chloride 1236 Peter S. Spencer Vinyltoluene 1239 Herbert H. Schaumburg Vitamin A 1239 Mitchell Steinschneider Volkensin 1241 Albert C. Ludolph Water 1243 Herbert H. Schaumburg Yellow Star Thistle 1244 Dwijendra N. Roy and Peter S. Spencer Zidovudine 1246 Enrica Arnaudo Zimeldine 1253 Neil L. Rosenberg Zolpidem 1255 Albert C. Ludolph APPENDIX 1 1257 APPENDIX 2 1269 INDEX 1277
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discipline	Medizin
edition	2. ed.
format	Book
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illustrated	Illustrated
indexdate	2024-07-09T18:35:49Z
institution	BVB
isbn	0195084772
language	English
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physical	XL, 1310 S. graph. Darst.
publishDate	2000
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spelling	Experimental and clinical neurotoxicology ed. by Peter S. Spencer ... 2. ed. New York [u.a.] Oxford Univ. Press 2000 XL, 1310 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neurotoxicologie gtt Environmental Pollutants toxicity Nervous System Diseases chemically induced Nervous System drug effects Nervous system Diseases Neurotoxicology Neurotoxikologie (DE-588)4457830-1 gnd rswk-swf Neurotoxikologie (DE-588)4457830-1 s DE-604 Spencer, Peter S. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008785731&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Experimental and clinical neurotoxicology Neurotoxicologie gtt Environmental Pollutants toxicity Nervous System Diseases chemically induced Nervous System drug effects Nervous system Diseases Neurotoxicology Neurotoxikologie (DE-588)4457830-1 gnd
subject_GND	(DE-588)4457830-1
title	Experimental and clinical neurotoxicology
title_auth	Experimental and clinical neurotoxicology
title_exact_search	Experimental and clinical neurotoxicology
title_full	Experimental and clinical neurotoxicology ed. by Peter S. Spencer ...
title_fullStr	Experimental and clinical neurotoxicology ed. by Peter S. Spencer ...
title_full_unstemmed	Experimental and clinical neurotoxicology ed. by Peter S. Spencer ...
title_short	Experimental and clinical neurotoxicology
title_sort	experimental and clinical neurotoxicology
topic	Neurotoxicologie gtt Environmental Pollutants toxicity Nervous System Diseases chemically induced Nervous System drug effects Nervous system Diseases Neurotoxicology Neurotoxikologie (DE-588)4457830-1 gnd
topic_facet	Neurotoxicologie Environmental Pollutants toxicity Nervous System Diseases chemically induced Nervous System drug effects Nervous system Diseases Neurotoxicology Neurotoxikologie
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008785731&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT spencerpeters experimentalandclinicalneurotoxicology

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