Apoptosis and its modulation by drugs: [with 12 tables]
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2000
|
| Schriftenreihe: | Handbook of experimental pharmacology
142 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 478 S. Ill., graph. Darst. |
| ISBN: | 3540661212 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV012827951 | ||
| 003 | DE-604 | ||
| 005 | 20000223 | ||
| 007 | t | ||
| 008 | 991019s2000 gw ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 957212305 |2 DE-101 | |
| 020 | |a 3540661212 |9 3-540-66121-2 | ||
| 035 | |a (OCoLC)42660082 | ||
| 035 | |a (DE-599)BVBBV012827951 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-355 |a DE-19 |a DE-12 |a DE-188 |a DE-578 | ||
| 050 | 0 | |a QH671 | |
| 050 | 0 | |a QP905 | |
| 082 | 0 | |a 616.07/8 |2 21 | |
| 084 | |a XI 1701 |0 (DE-625)152977:12907 |2 rvk | ||
| 084 | |a QV 4 |2 nlm | ||
| 245 | 1 | 0 | |a Apoptosis and its modulation by drugs |b [with 12 tables] |c contributors G. Bauer ... Ed. R. G. Cameron ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2000 | |
| 300 | |a XXV, 478 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 142 | |
| 650 | 7 | |a Apoptosis |2 cabt | |
| 650 | 7 | |a Drug Effects |2 cabt | |
| 650 | 7 | |a Celdood |2 gtt | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Apoptosis |x drug effects | |
| 650 | 4 | |a Pathology, Cellular | |
| 650 | 0 | 7 | |a Cytokine |0 (DE-588)4205701-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Cytotoxin |0 (DE-588)4148716-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Sauerstoffradikal |0 (DE-588)4179211-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Apoptosis |0 (DE-588)4291096-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 0 | 1 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 2 | 1 | |a Cytokine |0 (DE-588)4205701-2 |D s |
| 689 | 2 | |5 DE-604 | |
| 689 | 3 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 3 | 1 | |a Sauerstoffradikal |0 (DE-588)4179211-7 |D s |
| 689 | 3 | |5 DE-604 | |
| 689 | 4 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 4 | 1 | |a Cytotoxin |0 (DE-588)4148716-3 |D s |
| 689 | 4 | |5 DE-604 | |
| 700 | 1 | |a Cameron, Ross G. |d 1949- |e Sonstige |0 (DE-588)121309231 |4 oth | |
| 700 | 1 | |a Bauer, Georg |e Sonstige |4 oth | |
| 830 | 0 | |a Handbook of experimental pharmacology |v 142 |w (DE-604)BV002390716 |9 142 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008727739&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008727739 | ||
Datensatz im Suchindex
| _version_ | 1804127505231118336 |
|---|---|
| adam_text | Contents
CHAPTER 1
Incidence of Apoptosis and Its Pathological and Biochemical
Manifestations
R. Cameron and G. Feuer. With 6 Figures 1
A. Apoptosis: Characteristics and Scope 1
B. Cell Death 2
C. Features of Necrosis 4
I. Occurrence 4
II. Morphology 5
III. Biochemistry 5
D. Features of Apoptosis 6
I. Occurrence 6
II. Morphology 6
III. Biochemistry 7
E. Activation of Apoptosis 9
F. Incidence of Apoptosis 12
I. Physiological Conditions 12
1. Embryonic and Fetal Development 12
2. Cell Turnover in Adult Tissues 12
3. Involution of Adult Tissues 13
II. Pathological Conditions 13
1. Regression of Hyperplasia 13
2. Pathological Atrophy 13
3. Drugs 14
4. Toxic Chemicals 14
5. Chemical Carcinogens and Cancer Chemotherapy
Agents 15
6. Radiation and Hyperthermia 16
III. Disease Conditions 16
1. Cell Mediated Immunity 16
2. Ischemia 18
3. Neurodegenerative Disorders 19
4. Blood Cell Disorders 20
5. Malignant Neoplasms 21
XIV Contents
6. Viral Infection 21
7. Expression of Apoptosis in Other Diseases 22
G. Conclusions 23
References 24
CHAPTER 2
Molecular Cellular and Tissue Reactions of Apoptosis and
Their Modulation by Drugs
R. Cameron and G. Feuer 37
A. Introduction 37
B. Molecular Mediators of Apoptosis 37
I. TNF Receptor Family 37
II. Bcl 2 Gene Family 39
III. Caspases 41
IV. Cytokines 42
V. Co Stimulatory Molecules 42
VI. Perforin and Granzyme B 43
VII. Protein Kinase C 43
VIII. Reactive Oxygen Species 43
IX. Glutathione 44
X. Inhibitor Polypeptides 44
C. Cell Specific Pathways of Apoptosis 44
I. Immune System 44
1. T Cells 44
2. B Cells (and Plasma Cells) 45
3. Macrophages (and Dendritic Cells) 46
4. Eosinophils 46
5. Neutrophils 47
II. Nervous System 47
1. Neuronal Cells 47
III. Liver Cells 47
1. Hepatocytes 47
2. Kupffer Cells 48
IV. Malignant Cells 48
1. Leukemia (and Lymphoma) 48
2. Carcinoma 48
D. Tissue Specific Reactions Involving Apoptosis 49
I. Inflammation and Hypersensitivity 49
II. Cancer (and Carcinogenesis) 51
III. Neurodegenerative Disorders 51
IV. Autoimmune Disorders 52
E. Potential of Modulation of Molecular, Cellular
or Tissue Reactions by Drugs 52
Contents XV
I. Immunosuppressive Drugs 52
II. Chemotherapeutic Drugs 52
III. Natural Substances 52
References 53
CHAPTER 3
Hepatocyte Apoptosis Triggered by Natural Substances
(Cytokines, Other Endogenous Molecules and Foreign Toxins)
D. Pessayre, G. Feldmann, D. Haouzi, D. Fau, A. Mokeau,
and M. Neuman. With 4 Figures 59
A. Introduction 59
B. Fas Mediated Apoptosis 60
I. Fas Ligand 60
II. Fas 61
III. Fas Signal Transduction in Lymphoid Cells 61
1. Caspase Activation 61
2. Permeabilization of Mitochondrial Membranes 63
3. Modulation by Caspase 8 Decoys (FLIPs), Cellular
Inhibitors of Apoptosis (c IAPs), Members of the
Bcl 2 Family and Other Factors 65
4. Orientation of Cell Death Towards Apoptosis
and/or Necrosis 67
5. Efflux of Reduced Glutathione and Other Effects 67
6. Fas Signaling Independent of Fas Ligand 67
IV. Role of Fas in the Control of the Immune System 68
V. Fas Induced Hepatocyte Apoptosis 69
1. Agonistic Anti Fas Antibodies 69
2. Activated Lymphocytes 71
3. Fratricidal Killing 72
4. Basal Hepatic Apoptosis 73
C. Tumor Necrosis Factor a Mediated Cell Death 74
I. TNF a 74
II. TNF a Receptors and Signal Transduction 75
III. Hepatotoxicity of TNF a in Experimental Models 76
IV. Role of TNF a in Human Liver Injury 78
D. Transforming Growth Factor /? and Activins 78
E. Small Endogenous Molecules 81
I. Ceramide, Sphingosine 1 phosphate.
and Phosphatidylserine 81
II. Retinoic Acid 82
III. Bile Acids 83
IV. Extracellular ATP and Adenosine 86
V. Nitric Oxide 86
XVI Contents
F. Foreign Toxins 86
G. Conclusions and Perspectives 90
References 91
CHAPTER 4
The Role of C type Protein Kinases in Apoptosis
M. Lucas. With 5 Figures 109
A. PKC Isozymes 109
B. PKC and Apoptosis 110
C. Caspases and PKC 112
D. Apoptosis Versus Mitosis 112
E. Cell Cycle, CDK and PKC Inhibitors 114
F. Capacitative Calcium Entry and Apoptosis 115
G. PKC Implication in the Sphingomyelin Pathway to Apoptosis ... 120
References 123
CHAPTER 5
How Does Programmed Cell Death Contribute
to AIDS Pathogenesis?
M. L. Gougeon. With 4 Figures 127
A. Introduction 127
I. The Pathogenesis of HIV Disease 127
II. CD4 T Cell Homeostasis in HIV Infection 128
B. PCD in HIV Infection 129
I. Influence of HIV 1 Genes on the Induction
of Apoptosis 129
II. Peripheral T Lymphocytes from HIV Infected Subjects
are Prematurely Primed for Apoptosis 130
III. Relationship Between Apoptosis
and Immune Activation 132
IV. Relevance of PCD to Disease Progression
and AIDS Pathogenesis 133
C. Molecular Control of HIV Induced Apoptosis 134
I. Negative Regulation of Bcl 2 Expression. Consequences
on the Anti Viral Cytotoxic Function 134
II. Upregulation of the CD95 System 135
III. Possible Effectors of CD95 Mediated Apoptosis.
Consequences on CD4 T Cell Depletion 136
IV. Other Cell Death Genes Involved in HIV Induced
Apoptosis 138
D. Interrelation of HIV Induced Apoptosis and Cytokines 138
Contents XVII
I. Dysregulation of Cytokine Synthesis in HIV Infection .... 138
II. The Disappearance of Thl cells Is Related to
Their Priming for Apoptosis 139
III. Regulation of HIV Induced Apoptosis by Cytokines 140
E. PCD and T Cell Renewal. Influence of HA ART 142
F. Concluding Remarks 143
References 144
CHAPTER 6
Apoptotic Cell Phagocytosis
J. Savill and C. Bebb. With 3 Figures 151
A. Introduction 151
B. Tissue Consequences of Cell Death 151
I. Necrosis and Incitement of Inflammatory Injury 151
II. Silent and Anti Inflammatory Cell Clearance by
Apoptosis 152
III. Provocation of Immune Responses During Clearance
of Apoptotic Cells 154
IV. Resolving the Clearance Paradox for Apoptotic Cells 156
C. Molecular Mechanisms by Which Phagocytes Recognise Cells
Undergoing Apoptosis 158
I. Eat Me Signals Displayed by Apoptotic Cells 158
1. Exposure of Phosphatidylserine 158
2. Sites Which Bind Bridging Proteins 160
3. Carbohydrate Changes on Apoptotic Cells 161
4. Intercellular Adhesion Molecule (ICAM) 3 162
II. Phagocyte Receptors for Apoptotic Cells 162
1. Thrombospondin Receptors: av/33 and CD 36 163
2. Scavenger Receptors 165
3. CD14 165
4. Phosphatidylserine Receptors (PSRs) 166
5. Complement Receptors 166
6. Murine ABC1 and C. Elegans CED 7 Proteins 167
7. Intraphagocyte Signalling; CED 5 and CED 6 167
III. Why So Many Recognition Mechanisms? 168
D. Perturbations of Clearance in Disease 168
I. Clq Deficiency 169
II. Antiphospholipid Autoantibodies 170
E. Promotion of Safe Clearance 170
I. Glucocorticoids 171
II. Other Factors 171
F. Conclusions and Future Prospects 171
References 172
XVIII Contents
CHAPTER 7
T Cell Apoptosis and Its Role in Peripheral Tolerance
R. Cameron and L. Zhang 179
A. Introduction 179
B. Phenotypically Different Types of Apoptosis
of T Lymphocytes 179
I. Activation Induced Cell Death 179
II. Veto Cell Phenomenon 179
III. Programmed Cell Death 180
IV. Activation Induced Cell Death of Human Peripheral
T Cells 180
C. Molecules Involved in T Cell Apoptosis 180
I. TNF Receptor Family 180
II. Bcl 2 Family 181
III. Caspases 182
D. Regulators of T Cell Apoptosis 182
I. Cytokines (IL 2, IL 4, Interferon gamma, etc.) 182
II. Co Stimulatory Molecules (B7, CD28, CTLA 4, etc.) 182
III. Effect of Viral Infection 183
E. Mechanisms Involved in Peripheral Tolerance 183
I. Clonal Deletion 183
1. Bacterial Superantigen Induced AICD 183
2. Alloantigen Induced AICD 184
3. Clonal Anergy 185
II. Suppression, Regulatory (Suppressor) T Cells 185
III. Immune Deviation (Thl to Th2 Switching) 186
F. Role of T Cell Apoptosis in Oral Tolerance
and Autoimmunity 187
G. Role of T Cell Apoptosis in Transplantation Tolerance 188
I. Mechanisms of Transplantation Tolerance 188
II. Potential of Immunosuppressive Drugs to Modulate T Cell
Apoptosis and Induce Transplantation Tolerance 190
H. Apoptosis and Immune Privilege 190
I. Conclusions 191
References 191
CHAPTER 8
Apoptosis of Nerve Cells
A. M. Woodgate and M. Dragunow 197
A. Introduction 197
I. Programmed Cell Death 199
B. Apoptosis in the Brain 199
Contents XIX
I. Alzheimer s Disease 199
II. Parkinson s Disease 200
III. Cerebral Ischemia 201
IV. Status Epilepticus 201
V. Huntington s Disease 202
VI. Other Brain Disorders 202
C. Models of Neuronal Apoptosis 202
I. Developmental Nerve Cell Death 202
II. Degenerative Nerve Cell Death 203
D. Biochemical Apoptosis Pathways in Neurons 204
I. The Inducible Transcription Factors 204
II. The Role of the ITFs in Apoptosis 204
1. During CNS Development 204
2. Degenerative Nerve Cell Death 205
3. Evidence of a Role for c Jun and c Fos
in Apoptotic Nerve Cell Death 206
4. How Might c Jun Mediate Neuronal Apoptosis? 206
a. Upstream Mediators 206
b. Downstream Mediators 207
III. The Caspase Family 208
1. Evidence of a Role for Caspases in Apoptotic Nerve
Cell Death 209
a. Developmental Nerve Cell Death 209
b. Degenerative Nerve Cell Death 209
2. Which Caspases Mediate Apoptotic Nerve Cell
Death? 210
3. Regulation of Apoptosis by the Caspases 211
IV. The Bcl 2 Family 212
1. Regulation of Bcl 2 Related Genes 212
2. Evidence of a Role for Bcl 2 Related Genes
in the Nervous System 213
a. Developmental Nerve Cell Death 213
b. Degenerative Nerve Cell Death 214
3. How Does Bcl 2 Exert Its Neuroprotective Effects? 215
V. Cell Cycle Regulators 215
1. Evidence of a Role for p53 in Neuronal Apoptosis 216
2. How Does p53 Mediate Neuronal Apoptosis? 217
3. Cyclins and Cyclin Dependent Kinases 217
E. Conclusion 218
References 218
CHAPTER 9
Use of p53 as Cancer Cell Target for Gene Therapy
C. Thiede, T.D. Kim, and A. Neubauer. With 2 Figures 235
XX Contents
A. Introduction 235
B. Genetic Changes in Tumor Development 236
C. The p53 Tumor Suppressor Gene 236
I. p53: From Structure to Function 236
II. p53 and Induction of Apoptosis 239
III. Alterations of p53 in Human Cancers 240
IV. p53 Homologues 241
D. p53 and Gene Therapy 241
I. Introduction 241
II. Gene Therapy: General Remarks 242
III. Rationale for p53 Targeting in Gene Therapy 242
IV. Trials Reconstituting Wild Type p53 242
1. Adenoviruses 243
2. Retroviruses 243
3. Non Viral Gene Delivery Systems 243
4. In Vitro Data and Preclinical Trials 244
5. Clinical Trials 245
V. The ONYX 015 Virus 247
VI. Future Directions 248
E. Summary 250
References 250
CHAPTER 10
Antioxidants: Protection Versus Apoptosis
Y. Delneste, E. Roelandts, J. Y. Bonnefoy, and P. Jeannin 257
A. Introduction 257
B. Apoptosis and the Cellular Redox Status 258
I. Exogenous ROS or Oxidants can Trigger Apoptosis 259
II. Apoptosis is Associated with an Alteration
of the Redox Status 259
III. The Antioxidant Activity of the Apoptosis Inhibitor
Molecule Bcl 2 260
IV. Are ROS Really Involved in Apoptosis? 261
C. Anti Apoptotic Properties of Antioxidants: Mechanisms
of Action 262
I. ROS Scavenging and Reducing Activities
of Antioxidants 262
II. Replenishment of Intracellular GSH Levels 262
III. Thiol Antioxidants Induce the Shedding
of Membrane Fas 263
Contents XXI
IV. Thiol Antioxidants can Modulate the Generation
of Second Messengers and the Expression Activation
of Transcription Factors 265
1. Modulation of Signaling Molecules 265
2. Modulation of Transcription Factors 266
D. Conclusions and Therapeutic Perspectives 267
References 267
CHAPTER 11
Reactive Oxygen Species and Apoptosis
G. Bauer, S. Dormann, I. Engelmann, A. Schulz, and M. Saran.
With 3 Figures 275
A. Introduction 275
B. Reactive Oxygen Species: Shotgun or Precision Tool? 276
C. Interdependencies of ROS 278
D. Physiological Sources of ROS 279
E. ROS and Apoptosis 281
I. ROS Dependent Apoptosis Under Physiological
and Pathophysiological Conditions 281
II. Evidence for the Role of ROS During Induction
and Execution of Apoptosis 282
III. Induction and Inhibition of Apoptosis by NO 285
IV. Peroxynitrite: An Efficient Apoptosis Inducer 287
V. Glutathione: Key Element for the Regulation
of Apoptosis 289
VI. Mitochondria: Target and Source for ROS
During Apoptosis Induction 290
VII. Ceramides: First Class Second Messengers 291
F. Tumor Necrosis Factor: Apoptosis Induction Through Versatile
Use of ROS 293
G. Apo/Fas Mediated Apoptosis: ROS Involved
in Synergistic Pathways 294
H. p53 Mediated Apoptosis: ROS Action Through Several
Subsequent Steps 294
I. TGF Beta: Central Roles for ROS 295
I. ROS, Apoptosis and Tumorigenesis 296
I. Intercellular Induction of Apoptosis: Elimination
of Transformed Cells Through Diverse Extracellular
and Intracellular ROS Dependent Signaling Steps 296
II. NO Mediated Control of Tumorigenesis 299
III. Sensitivity of Transformed Cells Against Natural
Antitumor Mechanisms 300
References 302
XXII Contents
CHAPTER 12
Clearance of Apoptotic Lymphocytes by Human Kupffer Cells.
Phagocytosis of Apoptotic Cells in the Liver: Role of Lectin
Receptors, and Therapeutic Advantages
L. Dim. With 4 Figures 319
A. Introduction 319
I. Apoptotic Cells: Fast Food for Phagocytes 319
B. Recognizing Death: Phagocytosis of Apoptotic Cells
in the Liver 321
I. Liver Apoptosis 321
II. Hepatic Lectin Like Receptors 322
III. Kupffer Cells Phagocytic Activity 325
C. Human Kupffer Cells Removal of Apoptotic Lymphocytes 330
I. Lymphocyte Cell Surface Modifications 330
II. Kupffer Cells Recognition and Phagocytosis
of Apoptotic Lymphocytes 332
D. Concluding Remarks and Future Perspectives 333
References 336
CHAPTER 13
Drug Induced Apoptosis of Skin Cells and Liver
M. Neuman, R. Cameron, N. Shear, and G. Feuer.
With 8 Figures 343
A. Prevalence of Drug Induced Apoptosis 343
B. Methotrexate Induced Apoptosis 343
I. Apoptosis of Hepatocytes In Vivo 344
II. Apoptosis of Hepatocytes In Vitro 344
1. Initial Studies 344
2. Effects of Co exposures of Hepatocytes
with Methotrexate and Ethanol 345
III. Apoptosis of Skin Cells In Vitro 347
C. Acetaminophen Induced Apoptosis of Hepatocytes
and Skin Cells In Vitro 348
D. Valproic Acid Induced Apoptosis of Hepatocytes In Vitro 350
E. Conclusion 353
References 353
CHAPTER 14
Apoptosis and Eosinophils
H. U. Simon. With 6 Figures 357
A. Introduction 357
Contents XXIII
B. Characteristics and Measurements of Apoptotic Eosinophils 357
C. Role of Delayed Eosinophil Apoptosis for the Development
of Eosinophilia in Allergic Tissues 360
D. Role of Tyrosine Kinases Activation in Cytokine Mediated
Antiapoptosis 361
E. The MEK ERK MAP Kinase Pathway Does Not Mediate
Antiapoptotic Signals Initiated Via the IL 5 Receptor 362
F. The Effects of Glucocorticoids on Eosinophil Apoptosis 363
G. Role of CD95 Ligand/CD95 Molecular Interactions
in the Regulation of Eosinophil Apoptosis 364
H. Nitric Oxide, but Not Eosinophil Hematopoietins,
Mediates CD95 Resistance 365
I. Role of Sphingomyelinase Mediated Pathways
in CD95 Signaling 366
J. Role of Tyrosine Kinase Activation in CD95 Signaling 368
K. Concluding Remarks 369
References 370
CHAPTER 15
Thymocyte and B Cell Death Without DNA Fragmentation
T. Itoh, M. Nakamura, H. Yagi, H. Soga, and T. Ishii.
With 19 Figures 375
A. Introduction 375
B. Functional and Structural Characteristics of the Thymus 375
I. Differentiation of Thymocytes 375
II. Thymocyte Selection 377
III. Thymocyte Death 377
C. Functional and Structural Characteristics
of the Germinal Center 386
I. Affinity Maturation of B Cells 386
II. B Cell Selection 390
III. B Cell Death 390
D. Summary 392
E. Prospects 394
References 395
CHAPTER 16
Antigen Receptor Induced Death of Mature B Lymphocytes
T. Defrance, M. Berard, and M. Casamayor Palleja.
With 2 Figures 399
A. Introduction 399
XXIV Contents
B. Antigen Receptor Induced Death and Maintenance
of Peripheral B Cell Tolerance 400
I. BCR Induced Apoptosis of Germinal Center B Cells 400
II. BCR Induced Apoptosis of Virgin and Memory
B Cells 405
C. Antigen Receptor Induced Death and Homeostatic Regulation
of the Mature B Cell Compartment 406
D. Positive and Negative Signaling Through the BCR 408
I. Biochemical Events Associated with the Alternative BCR
Signaling Pathways 408
II. Parameters Affecting the Outcome of BCR Signaling 410
1. Physical Properties of the Ag 410
2. Costimulatory Signals 411
a. Activated Complement Fractions 411
b. T Cells and Microbial Factors 412
E. Molecular Control of the Apoptosis Sensitivity Threshold
in Mature B Cells 412
I. Developmental Regulation of the Survival Genes 413
II. Activation Induced Regulation of the Survival Genes 415
F. The Executioners of the BCR Apoptotic Pathway 416
I. Early Transduction Events 416
II. The Caspase Cascade 417
G. Concluding Remarks 419
References 420
CHAPTER 17
Modulation of Apoptosis and Maturation
of the B Cell Immune Response
G. Koopman. With 4 Figures 429
A. Introduction 429
B. Antigen Dependent B Cell Maturation in Secondary
Lymphoid Organs 430
I. Anatomical Organization of the B Cell Immune
Response 430
II. The Germinal Center Microenvironment 431
1. Cellular Composition of the Germinal Center 431
2. B Cell Subpopulations 431
III. Ig Switching and Somatic Hypermutation 434
C. Cell Surface Molecules Involved in Regulation of B Cell
Maturation and Apoptosis 435
I. The TNF/NGF Receptor Family 435
II. Adhesion Molecules 437
D. Regulation of B Cell Maturation 438
Contents XXV
I. The Initiation of the B Cell Immune Response, Formation
of Centroblasts 438
II. Differentiation of Centroblasts into Centrocytes 440
III. Differentiation of Centrocytes into Memory
and Plasma Cells 440
E. Regulation of B Cell Survival 442
I. Apoptosis Regulation by Antigen and Follicular Dendritic
Cells 442
II. Apoptosis Regulation by T Cells 444
III. Triple Check Hypothesis of B Cell Selection 446
References 448
CHAPTER 18
The Neuroprotective and Neuronal Rescue Effect of ( ) Deprenyl
K. Magyar and B. Szende. With 3 Figures 457
A. Summary 457
B. Introduction 457
C. Clinical Benefits of ( ) Deprenyl Treatment 458
D. Effect of ( ) Deprenyl Against Oxidative Stress 459
E. Selegiline Induced Neuroprotection Against Toxic Insults 459
F. Apoptosis in Neurodegenerative Diseases 462
G. Effect of Deprenyl on Neuronal Apoptosis 463
H. Possible Mode of Action of ( ) Deprenyl on Apoptosis 466
References 467
Subject Index 473
|
| any_adam_object | 1 |
| author_GND | (DE-588)121309231 |
| building | Verbundindex |
| bvnumber | BV012827951 |
| callnumber-first | Q - Science |
| callnumber-label | QH671 |
| callnumber-raw | QH671 QP905 |
| callnumber-search | QH671 QP905 |
| callnumber-sort | QH 3671 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | XI 1701 |
| ctrlnum | (OCoLC)42660082 (DE-599)BVBBV012827951 |
| dewey-full | 616.07/8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/8 |
| dewey-search | 616.07/8 |
| dewey-sort | 3616.07 18 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02591nam a2200697 cb4500</leader><controlfield tag="001">BV012827951</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20000223 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">991019s2000 gw ad|| |||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">957212305</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540661212</subfield><subfield code="9">3-540-66121-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)42660082</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012827951</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH671</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QP905</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.07/8</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 1701</subfield><subfield code="0">(DE-625)152977:12907</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">QV 4</subfield><subfield code="2">nlm</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Apoptosis and its modulation by drugs</subfield><subfield code="b">[with 12 tables]</subfield><subfield code="c">contributors G. Bauer ... Ed. R. G. Cameron ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXV, 478 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">142</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Apoptosis</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Drug Effects</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Celdood</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Apoptosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Apoptosis</subfield><subfield code="x">drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pathology, Cellular</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Cytokine</subfield><subfield code="0">(DE-588)4205701-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Cytotoxin</subfield><subfield code="0">(DE-588)4148716-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Sauerstoffradikal</subfield><subfield code="0">(DE-588)4179211-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="1"><subfield code="a">Cytokine</subfield><subfield code="0">(DE-588)4205701-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="3" ind2="0"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2="1"><subfield code="a">Sauerstoffradikal</subfield><subfield code="0">(DE-588)4179211-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="4" ind2="0"><subfield code="a">Apoptosis</subfield><subfield code="0">(DE-588)4291096-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="4" ind2="1"><subfield code="a">Cytotoxin</subfield><subfield code="0">(DE-588)4148716-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="4" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cameron, Ross G.</subfield><subfield code="d">1949-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)121309231</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bauer, Georg</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">142</subfield><subfield code="w">(DE-604)BV002390716</subfield><subfield code="9">142</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008727739&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008727739</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012827951 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:34:25Z |
| institution | BVB |
| isbn | 3540661212 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008727739 |
| oclc_num | 42660082 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| physical | XXV, 478 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Apoptosis and its modulation by drugs [with 12 tables] contributors G. Bauer ... Ed. R. G. Cameron ... Berlin [u.a.] Springer 2000 XXV, 478 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 142 Apoptosis cabt Drug Effects cabt Celdood gtt Apoptosis Apoptosis drug effects Pathology, Cellular Cytokine (DE-588)4205701-2 gnd rswk-swf Cytotoxin (DE-588)4148716-3 gnd rswk-swf Sauerstoffradikal (DE-588)4179211-7 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Apoptosis (DE-588)4291096-1 s Pharmakologie (DE-588)4045687-0 s DE-604 Cytokine (DE-588)4205701-2 s Sauerstoffradikal (DE-588)4179211-7 s Cytotoxin (DE-588)4148716-3 s Cameron, Ross G. 1949- Sonstige (DE-588)121309231 oth Bauer, Georg Sonstige oth Handbook of experimental pharmacology 142 (DE-604)BV002390716 142 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008727739&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Apoptosis and its modulation by drugs [with 12 tables] Handbook of experimental pharmacology Apoptosis cabt Drug Effects cabt Celdood gtt Apoptosis Apoptosis drug effects Pathology, Cellular Cytokine (DE-588)4205701-2 gnd Cytotoxin (DE-588)4148716-3 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Pharmakologie (DE-588)4045687-0 gnd Apoptosis (DE-588)4291096-1 gnd |
| subject_GND | (DE-588)4205701-2 (DE-588)4148716-3 (DE-588)4179211-7 (DE-588)4045687-0 (DE-588)4291096-1 (DE-588)4143413-4 |
| title | Apoptosis and its modulation by drugs [with 12 tables] |
| title_auth | Apoptosis and its modulation by drugs [with 12 tables] |
| title_exact_search | Apoptosis and its modulation by drugs [with 12 tables] |
| title_full | Apoptosis and its modulation by drugs [with 12 tables] contributors G. Bauer ... Ed. R. G. Cameron ... |
| title_fullStr | Apoptosis and its modulation by drugs [with 12 tables] contributors G. Bauer ... Ed. R. G. Cameron ... |
| title_full_unstemmed | Apoptosis and its modulation by drugs [with 12 tables] contributors G. Bauer ... Ed. R. G. Cameron ... |
| title_short | Apoptosis and its modulation by drugs |
| title_sort | apoptosis and its modulation by drugs with 12 tables |
| title_sub | [with 12 tables] |
| topic | Apoptosis cabt Drug Effects cabt Celdood gtt Apoptosis Apoptosis drug effects Pathology, Cellular Cytokine (DE-588)4205701-2 gnd Cytotoxin (DE-588)4148716-3 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Pharmakologie (DE-588)4045687-0 gnd Apoptosis (DE-588)4291096-1 gnd |
| topic_facet | Apoptosis Drug Effects Celdood Apoptosis drug effects Pathology, Cellular Cytokine Cytotoxin Sauerstoffradikal Pharmakologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008727739&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT cameronrossg apoptosisanditsmodulationbydrugswith12tables AT bauergeorg apoptosisanditsmodulationbydrugswith12tables |