Genetic immunization:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Kluwer Acad./Plenum
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 179S. Ill., graph. Darst. |
| ISBN: | 0306462265 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012824556 | ||
| 003 | DE-604 | ||
| 005 | 20010108 | ||
| 007 | t | ||
| 008 | 991025s2000 ad|| |||| 00||| eng d | ||
| 020 | |a 0306462265 |9 0-306-46226-5 | ||
| 035 | |a (OCoLC)42772940 | ||
| 035 | |a (DE-599)BVBBV012824556 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 050 | 0 | |a QR189.5.D53 | |
| 082 | 0 | |a 615.372 |2 22 | |
| 084 | |a XD 3000 |0 (DE-625)152551:12905 |2 rvk | ||
| 100 | 1 | |a Bona, Constantin A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Genetic immunization |c Constantin A. Bona ; Adrian I. Bot |
| 264 | 1 | |a New York [u.a.] |b Kluwer Acad./Plenum |c 2000 | |
| 300 | |a X, 179S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a DNA vaccines | |
| 650 | 4 | |a Immunization | |
| 650 | 4 | |a Vaccines, DNA | |
| 650 | 0 | 7 | |a Immunisierung |0 (DE-588)4161380-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Impfstoff |0 (DE-588)4026655-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a DNS |0 (DE-588)4070512-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Immunisierung |0 (DE-588)4161380-6 |D s |
| 689 | 0 | 1 | |a DNS |0 (DE-588)4070512-2 |D s |
| 689 | 0 | 2 | |a Impfstoff |0 (DE-588)4026655-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Bot, Adrian I. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008724774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008724774 | ||
Datensatz im Suchindex
| _version_ | 1804127500766281728 |
|---|---|
| adam_text | Contents
1. Approaches for Development of New Vaccines 1
1.1. Introduction 1
1.2. First Generation of Vaccines 2
1.3. Second Generation of Vaccines 4
1.3.1. Recombinant Protein Vaccines 5
1.3.2. Recombinant Vector Vaccines 5
1.3.3. Peptide Based Vaccines 6
1.3.4. T Cells Vaccines 7
1.3.5. DNA Vaccines 7
2. Genetic Vaccination: Routes and Formulations 11
2.1. Genetic Vaccines: Vectors 11
2.2. Administration of Genetic Vaccines 14
2.3. Formulations 17
3. Intrinsic Adjuvant Properties of Plasmid DNA 25
3.1. Introduction 25
3.2. Immunostimulatory Sequences of Plasmid DNA 26
3.3. Effect of ISS on Cells Involved in Innate Immunity 27
3.4. Effect of ISS on B Cells 28
3.5. Effect of ISS on 7 Cells 29
3.6. Effect of ISS on Cytokine Production 29
3.6.1. CpG ODN Induced Synthesis of Cytokines by CD4 T Cells 30
3.6.2. CpG ODN Induces the Secretion of IL 4 by fl Cells 30
3.6.3. Effect of CpG ODN on Production of Cytokines by Antigen
Presenting Cells 31
3.7. Mechanisms of Lymphocyte Activation by CpG ODN 31
vii
vijj CONTENTS }
4. Cellular Mechanisms Involved in the Immune Response Elicited
by Genetic Immunization 35
4.1. Introduction 35
4.2. Cellular Uptake of DNA 36
4.3. Cellular Mechanisms Involved in the Immune Response Induced by
Intradermal Genetic Immunization 37
4.4. Cellular Mechanisms Involved in the Immune Response Induced by
Intramuscular Genetic Immunization 43
5. Protective Immune Responses Elicited by Genetic Immunization against
Viruses 51
5.1. Introduction 51
5.2. Immune Responses against RNA Viruses Elicited by Genetic
Immunization 54
5.2! 1. Negative Sense Single Stranded RNA Viruses 54
5.2.1.1. Genetic Immunization against Influenza Virus 56
5.2.1.2. Genetic Immunization against Paramyxoviridae 59
5.2.1.3. Genetic Immunization against Other Single Stranded
RNA Viruses of Negative Sense 62
5.2.2. Genetic Vaccination against Single Stranded RNA Viruses of
Positive Sense 64
5.2.2.1. Genetic Immunization against Flaviviridae 64
5.2.2.2. Genetic Immunization against Other Single Stranded
RNA Viruses of Positive Sense 66
5.2.3. Genetic Immunization against Rotaviruses 67
5.2.4. Genetic Immunization against Retroviruses 68
5.3. Immune Responses against DNA Viruses Elicited by Genetic
Immunization 74
5.3.1. Genetic Vaccination against Hepadnaviridae 75
5.3.2. Genetic Vaccination against Herpesviridae 77
5.3.3. Genetic Vaccination against Papillomavirus 80
5.4. Immune Response Triggered by DNA Immunization Against
Nonconventional Viruses 81
5.5. Conclusions and Perspectives 82
6. Immune Responses Elicited by Genetic Immunization with Bacterial,
Fungal, or Parasitic Antigens 85
6.1. DNA Based Immunization with Bacterial or Fungal Antigens 85
6.1.1. Immunization with Plasmids Expressing Mycobacteria Antigens .. 86
6.1.2. Immunization with Plasmids Expressing Antigens from Other
Bacteria or Fungi 88
CONTENTS ix
6.2. DNA Based Immunization with Parasitic Antigens 90
6.2.1. Immunization with Plasmids Expressing Antigens from the Genus
Plasmodium 90
6.2.2. DNA Vaccination against Other Parasites 94
6.3. Conclusions and Perspectives 96
7. Autoimmunity, Allergy, and Genetic Vaccines 99
7.1. Bacterial DNA: Antigen and Immune Modulator 99
7.2. DNA Vaccines in Allergic Conditions 100
7.3. DNA Vaccination against Autoimmune Diseases 101
7.4. DNA Vaccines and Immune Mediated Pathology 105
7.5. Conclusions and Perspectives 107
8. Genetic Immunization against Tumors 109
8.1. Immunity against Tumors 109
8.2. Strategies to Elicit or Enhance Tumor Specific Immunity by Nucleic
Acid Based Delivery of Tumor Antigens Ill
8.2.1. Genetic Immunization with Expression Vectors Encoding Tumor
Idiotypes 112
8.2.2. Genetic Immunization with Expression Vectors Encoding Other
Tumor Derived Antigens 113
8.2.3. Genetic Immunization against Oncogenic Viruses 115
8.2.4. Genetic Immunization in Tumor Models Comprising Surrogate
Tumor Antigens 116
8.3. Induction or Enhancement of Tumor Specific Immunity by Nucleic
Acid Mediated Delivery of Cytokines or Other Immune Stimulators .... 117
8.4. Conclusions and Perspectives 119
9. Genetic Vaccination of Neonates 121
9.1. Characteristics of the Neonatal Immune System 121
9.2. Effects of Neonatal Genetic Immunization 126
9.2.1. Humoral Responses 127
9.2.2. CTL Responses 129
9.2.3. Cytokine Response 131
9.2.4. Augmentation of Protective Defensive Reactions by
Coimmunization of Neonates with Plasmids Encoding Antigens
Expressing Epitopes Recognized by B and 7 Cells 132
9.3. Effect of Maternal Antibodies on Immune Response of Neonates and
Infants 135
9.3.1. Protective Ability of Maternal Antibodies 135
x CONTENTS
I
9.3.2. Regulatory Properties of Maternal Antibodies via Idiotype
Interactions 136
9.3.3. Inhibitory Effect of Maternal Antibodies 137
9.3.4. Inhibitory Effect of Maternal Antibodies on Vaccination of Infants 138 r
9.4. Effect of Maternal Antibodies on Immune Response of Offspring Born
to Dams Immunized with Virus or Plasmid DNA 139
9.5. Effect of Maternal Antibodies on the Immune Response of Young and
Adult Animals Elicited by Genetic Immunization 140 I
Index 175
f
r
I
|
| any_adam_object | 1 |
| author | Bona, Constantin A. |
| author_facet | Bona, Constantin A. |
| author_role | aut |
| author_sort | Bona, Constantin A. |
| author_variant | c a b ca cab |
| building | Verbundindex |
| bvnumber | BV012824556 |
| callnumber-first | Q - Science |
| callnumber-label | QR189 |
| callnumber-raw | QR189.5.D53 |
| callnumber-search | QR189.5.D53 |
| callnumber-sort | QR 3189.5 D53 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | XD 3000 |
| ctrlnum | (OCoLC)42772940 (DE-599)BVBBV012824556 |
| dewey-full | 615.372 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.372 |
| dewey-search | 615.372 |
| dewey-sort | 3615.372 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01559nam a2200433 c 4500</leader><controlfield tag="001">BV012824556</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20010108 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">991025s2000 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0306462265</subfield><subfield code="9">0-306-46226-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)42772940</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012824556</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QR189.5.D53</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.372</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XD 3000</subfield><subfield code="0">(DE-625)152551:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bona, Constantin A.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetic immunization</subfield><subfield code="c">Constantin A. Bona ; Adrian I. Bot</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York [u.a.]</subfield><subfield code="b">Kluwer Acad./Plenum</subfield><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X, 179S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA vaccines</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vaccines, DNA</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Immunisierung</subfield><subfield code="0">(DE-588)4161380-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Impfstoff</subfield><subfield code="0">(DE-588)4026655-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Immunisierung</subfield><subfield code="0">(DE-588)4161380-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">DNS</subfield><subfield code="0">(DE-588)4070512-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Impfstoff</subfield><subfield code="0">(DE-588)4026655-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bot, Adrian I.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008724774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008724774</subfield></datafield></record></collection> |
| id | DE-604.BV012824556 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:34:20Z |
| institution | BVB |
| isbn | 0306462265 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008724774 |
| oclc_num | 42772940 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | X, 179S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Kluwer Acad./Plenum |
| record_format | marc |
| spelling | Bona, Constantin A. Verfasser aut Genetic immunization Constantin A. Bona ; Adrian I. Bot New York [u.a.] Kluwer Acad./Plenum 2000 X, 179S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier DNA vaccines Immunization Vaccines, DNA Immunisierung (DE-588)4161380-6 gnd rswk-swf Impfstoff (DE-588)4026655-2 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf Immunisierung (DE-588)4161380-6 s DNS (DE-588)4070512-2 s Impfstoff (DE-588)4026655-2 s DE-604 Bot, Adrian I. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008724774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bona, Constantin A. Genetic immunization DNA vaccines Immunization Vaccines, DNA Immunisierung (DE-588)4161380-6 gnd Impfstoff (DE-588)4026655-2 gnd DNS (DE-588)4070512-2 gnd |
| subject_GND | (DE-588)4161380-6 (DE-588)4026655-2 (DE-588)4070512-2 |
| title | Genetic immunization |
| title_auth | Genetic immunization |
| title_exact_search | Genetic immunization |
| title_full | Genetic immunization Constantin A. Bona ; Adrian I. Bot |
| title_fullStr | Genetic immunization Constantin A. Bona ; Adrian I. Bot |
| title_full_unstemmed | Genetic immunization Constantin A. Bona ; Adrian I. Bot |
| title_short | Genetic immunization |
| title_sort | genetic immunization |
| topic | DNA vaccines Immunization Vaccines, DNA Immunisierung (DE-588)4161380-6 gnd Impfstoff (DE-588)4026655-2 gnd DNS (DE-588)4070512-2 gnd |
| topic_facet | DNA vaccines Immunization Vaccines, DNA Immunisierung Impfstoff DNS |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008724774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bonaconstantina geneticimmunization AT botadriani geneticimmunization |