Adenosine receptors and Parkinson's disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Academic Press
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 275 S. Ill., graph. Darst. |
| ISBN: | 0124004059 |
Internformat
MARC
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| 245 | 1 | 0 | |a Adenosine receptors and Parkinson's disease |c ed. by Hiroshi Kase ... |
| 264 | 1 | |a San Diego [u.a.] |b Academic Press |c 2000 | |
| 300 | |a XVIII, 275 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Adenosine | |
| 650 | 4 | |a Parkinson's disease - Treatment | |
| 650 | 4 | |a Adenosine |x Antagonists |x Therapeutic use | |
| 650 | 4 | |a Adenosine |x Receptors | |
| 650 | 4 | |a Parkinson Disease |x drug therapy | |
| 650 | 4 | |a Parkinson's disease | |
| 650 | 4 | |a Receptors, Purinergic P1 |x antagonists & inhibitors | |
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| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Kase, Hiroshi |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008707359 | ||
Datensatz im Suchindex
| _version_ | 1804127474384109568 |
|---|---|
| adam_text | CONTENTS
Contributors xiii
Preface xvii
1 Introductory Remarks: Adenosine A2A Receptor
Antagonists: A Novel Approach to the Treatment of
Parkinson s Disease
Hiroshi Kase
I. A View of the Action of Adenosine in the Stratum 5
A. Adenosine A2A Receptor Functions in Normal and Disease States 6
B. New Aspects of Adenosine A2A Receptor Function 7
C. Intracellular Signal Transduction of Presynaptic A2A Receptors
in the Striatum 9
D. Adenosine AM Function in the Parkinsonian State 9
E. Adenosine and Dopamine Receptors 10
F. L Dopa induced Dyskinesias and AM Receptors 11
References 13
2 Localization of Adenosine Receptors in Brain
and Periphery
Sarah J. Augood, Piers C. Emson, and David G. Standaert
I. Adenosine 17
II. Receptor Subtypes 18
A. Adenosine At Receptors 18
B. Adeonsine Aja Receptors 21
C. Adenosine Aa Receptors 22
v
Vi Contents
D. Adenosine A3 Receptors 23
III. Summary 27
References 27
3 Medicinal Chemistry of Adenosine Receptors in Brain
and Periphery
Junichi Shimada and Fumio Suzuki
I. Introduction 31
II. A1 Adenosine Receptor Antagonists 32
A. Structure Activity Relationships 32
B. Pharmacology of A! Receptor Antagonists 34
III. A2A Adenosine Receptor Antagonists 36
A. Structure Activity Relationship 36
B. Photoisomerization of 8 Styrylxanthines 39
C. Pharmacology of AM Receptor Antagonists 41
IV. Conclusion 42
References 43
4 Overview of the Physiology and Pharmacology of
Adenosine in the Peripheral System
Afeira Karasawa
I. Metabolism, Receptors, and Modulation of Adenosine 51
II. Peripheral Nervous System 54
III. Cardiovascular System 55
IV Renal Effects 58
V. Respiratory and Pulmonary System 60
VI. Gastrointestinal System 62
VII. Inflammation and Immune System 63
VIII. Endocrine and Exocrine Effects 65
IX. Concluding Remarks 67
References 67
5 Biochemical Characterization of Adenosine Agonists
and Antagonists
Hiromi Nonaka and Michio Ichimura
I. Introduction 77
II. Ligands for Adenosine Receptor Subtypes 78
A. Binding Characterization of Adenosine Receptor Ligands 80
Contents vii
III. Signal Transduction 89
A. Aj Receptor 89
B. A2A Receptor 90
C. A2B Receptor 93
D. A3 Receptor 95
IV Biochemical Basis of the Use of Au Antagonists in
Parkinson s Disease 96
V Conclusion 99
References 99
6 Physiology of Adenosine Receptors in the Striatum
Akihisa Mori and Tomomi Shindou
I. Introduction 107
II. Striatal Cell Subtypes 108
III. The Striatal Medium Spiny Neurons 109
IV. A2A Receptor Mediated Suppression of GABAergic
Transmission onto Medium Spiny Neurons 110
A. Aia Receptor Suppression of IPSPs and IPSCs in Medium
Spiny Neurons 111
B. Presynaptic AM Receptor Modulation 111
C. Physiological Significance of AM Receptor Modulation of
GABAergic Synaptic Transmission in Medium Spiny Neurons 114
V Adenosine Receptor Modulation of Glutamatergic Synaptic
Transmission in the Striatum 117
VI. Influence of Adenosine Receptor Activation on Membrane
Properties of Medium Spiny Neurons 118
VII. Antiparkinsonian Effects of A2A Receptor Antagonists 119
VIII. Conclusion 123
References 124
7 Regulation of Neurotransmitter Release in Basal Ganglia
by Adenosine Receptor Agonists and Antagonists in Vitro
and in Vivo
Peter J. Richardson and Masako Kurokawa
I. Introduction 129
II. Methodology 130
III. The Adenosine A! Receptor in the Basal Ganglia 132
A. Localization of the A! Receptor 132
B. Mechanism of Action of the Adenosine A! Receptor 133
Viii Contents
C. A! Receptor Modulation of ACh Release 133
D. A! Receptor Modulation of GABA Release 134
E. A! Receptor Modulation of Dopamine Release 135
F. A! Receptor Modulation of Glutamate Release 135
IV. The Adenosine A2 Receptors in the Basal Ganglia 136 :
A. Localization of the A2 Receptors 136 ¦
B. Mechanism of Action of the A2 Receptors 137 ;
C. Aja Receptor Modulation of ACh Release 137
D. Aja Receptor Modulation of GABA Release 140
E. A2 Receptor Modulation of Dopamine Release 141 ]
F. A2 Receptor Modulation of Glutamate Release 141 j
V Relevance of the AM Receptor to the Therapy of |
Parkinson s Disease 142 I
References 144 !
8 Control of Gene Expression in Basal Ganglia by
Adenosine Receptors
Alistair K. Dixon and Peter J. Richardson
I. Introduction 149
A. Neuropeptide Gene Expression 150
B. Immediate Early Gene Expression 151
II. Effect of CGS15943A on Proenkephalin mRNA Levels in
Dopamine Depleted Striatum 153
III. Effect of A2 and A1 Adenosine Receptor Antagonism on
Levels of Striatal Peptide Gene Expression 157
IV Discussion 162
A. Effect of CGS15943A in Unilaterally Lesioned Rat Striatum 162
B. Effect of KF17837 in Striatum of Rats Treated with Eticlopride 164
References 167
9 Knockout Mice in the Study of Dopaminergic Diseases
Shiro Aoyama, Hiroshi Kase,Ja Hyun Baik, and Emiliana Borrelli
I. Introduction 171
II. D2 like Receptors 173
A. Dopamine D2 Receptor 173
B. Two Isoforms of D2 Receptor 175
C. D3 Receptor 175
D. D4 Receptor 176
III. Drlike Receptors 177
A. D! Receptor 177
B. D5 Receptor 178
Contents ix
IV Dopamine Dl and D2 Receptor Interactions in Basal Ganglia 178
V Dopamine and Adenosine 180
VI. D2 Receptor Deficient Mice 182
VII. Adenosine A^ Receptor Deficient Mice 184
VIII. Animal Models of Neuropathologies: D2 Receptor Deficient
Mice and Parkinson s Disease 185
References 186
10 Effects of Adenosine Receptors
Shizuo Shiozaki, Shunji Ichikawa, Joji Ndkamura, and Yoshihisa Kwwana
I. Introduction 193
II. The Role of Adenosine Ax Receptor in the CNS
in Cognition 194
A. Distribution of Adenosine Ai Receptor in CNS 194
B. Cognition 194
III. Role of Adenosine AM Receptor in CNS 199
A. Distribution of Aja Receptor in CNS 199
B. Behavioral Phenotype in A2A Receptor KO Mice 200
C. Sleep 201
D. Adenosine A2A Receptor and Motor Function 201
IV Conclusion 205
V Methods 205
A. Spontaneous Electroencephalogram 205
B. Internal Capsule Lesion 206
C. Locomotor Activity 206
D. Data Analysis and Statistics 207
Acknowledgments 207
References 207
11 Actions of Adenosine Antagonists in Primate Model of
Parkinson s Disease
Tomoyuki Kanda and Peter Jenner
I. Introduction 211
II. Action of MPTP on Motor Behavior in Common Marmosets 212
III. Effects of Adenosine Receptor Ligands on Motor
Dysfunction in MPTP Treated Common Marmosets 214
A. Adenosine A! Receptor Antagonist DPCPX 214
B. Adenosine A2A Receptor Antagonist KW 6002 214
C. Adenosine A2A Receptor Agonist APEC 217
IV Effect of Adenosine A^ Receptor Antagonist KW 6002 on
L Dopa induced Dyskinesias 219
X Contents
V Effect of Chronic Administration of Adenosine A2A
Receptor Antagonist KW 6002 221
VI. Comparison of the Antiparkinsonian Activity of L Dopa and
AiA Antagonist KW 6002 222
VII. Conclusion 224
Acknowledgments 225
References 225
12 Selective Adenosine A2A Receptor Antagonism as an
Alternative Therapy for Parkinson s Disease
A. Had) Tahar, R. Grondin, L. Grtgoire, P.]. Bedard, A. Mori, and H. Rose
I. Introduction 229
II. Materials and Methods 232
A. Animals 232
B. Drug Treatments 232
C. Motor Assessment 233
D. Statistical Analysis 233
III. Results 234
A. Locomotion 234
B. Improvement in Disability and Dyskinesias 235
IV. Discussion 236
V Conclusion 240
References 240
13 Neurobiology of Adenosine Receptors
Masahiro Nomoto
I. Introduction 245
A. Adenosine in the Basal Ganglia 246
B. Effects of Caffeine or Other Methylxanthines on
Parkinson s Disease 246
C. Effects of Caffeine or Other Methylxanthines on
Essential Tremor 248
D. Effects of Caffeine or Other Methylxanthines on Other
Movement Disorders 248
E. Levels of Adenosine and Other Nucleosides in
Neurological Disorders 249
E Effects of Xanthines or L Dopa on Other Neurological
Disorders . 251
References 251
I
Contents xi
14 The Relevance of Adenosine A2A Antagonists to the
Treatment of Parkinson s Disease: Concluding Remarks
Peterjenner
Introduction 257
Striatal Output Pathways and Parkinson s Disease 259
Alterations in Striatal Output Pathways Following the
Occurrence of Dyskinesia 260
Final Comments 261
Acknowledgments 262
References 262
Index 265
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| spelling | Adenosine receptors and Parkinson's disease ed. by Hiroshi Kase ... San Diego [u.a.] Academic Press 2000 XVIII, 275 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Adenosine Parkinson's disease - Treatment Adenosine Antagonists Therapeutic use Adenosine Receptors Parkinson Disease drug therapy Parkinson's disease Receptors, Purinergic P1 antagonists & inhibitors Parkinson-Krankheit (DE-588)4044683-9 gnd rswk-swf Adenosinrezeptor (DE-588)4327002-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Parkinson-Krankheit (DE-588)4044683-9 s Adenosinrezeptor (DE-588)4327002-5 s DE-604 Kase, Hiroshi Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008707359&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Adenosine receptors and Parkinson's disease Adenosine Parkinson's disease - Treatment Adenosine Antagonists Therapeutic use Adenosine Receptors Parkinson Disease drug therapy Parkinson's disease Receptors, Purinergic P1 antagonists & inhibitors Parkinson-Krankheit (DE-588)4044683-9 gnd Adenosinrezeptor (DE-588)4327002-5 gnd |
| subject_GND | (DE-588)4044683-9 (DE-588)4327002-5 (DE-588)4143413-4 |
| title | Adenosine receptors and Parkinson's disease |
| title_auth | Adenosine receptors and Parkinson's disease |
| title_exact_search | Adenosine receptors and Parkinson's disease |
| title_full | Adenosine receptors and Parkinson's disease ed. by Hiroshi Kase ... |
| title_fullStr | Adenosine receptors and Parkinson's disease ed. by Hiroshi Kase ... |
| title_full_unstemmed | Adenosine receptors and Parkinson's disease ed. by Hiroshi Kase ... |
| title_short | Adenosine receptors and Parkinson's disease |
| title_sort | adenosine receptors and parkinson s disease |
| topic | Adenosine Parkinson's disease - Treatment Adenosine Antagonists Therapeutic use Adenosine Receptors Parkinson Disease drug therapy Parkinson's disease Receptors, Purinergic P1 antagonists & inhibitors Parkinson-Krankheit (DE-588)4044683-9 gnd Adenosinrezeptor (DE-588)4327002-5 gnd |
| topic_facet | Adenosine Parkinson's disease - Treatment Adenosine Antagonists Therapeutic use Adenosine Receptors Parkinson Disease drug therapy Parkinson's disease Receptors, Purinergic P1 antagonists & inhibitors Parkinson-Krankheit Adenosinrezeptor Aufsatzsammlung |
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