Bile acids and cholestasis: (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Kluwer
1999
|
| Schriftenreihe: | Falk Symposium
108 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 291 S. Ill., graph. Darst. |
| ISBN: | 079238752X |
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Datensatz im Suchindex
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| adam_text | Contents
Preface xiii
List of Principal Authors x
1 Adolf Windaus Prize Lecture
Intestinal bile acid transport: molecules, mechanisms,
and malabsorption 1
P. A. Dawson
SECTION 1: BIOSYNTHESIS AND METABOLISM OF
BILE ACIDS
2 The regulation of different bile acid biosynthetic pathways
and their quantitative contribution to bile acid synthesis 31
Z ft Vlahcevic, P. B. Hylemon, ft 7: Stravitz,
D. M. Heuman and W. M. Pandak
3 Signal transduction pathways regulating cholesterol
7a hydroxylase transcription by bile acids 39
ft T. Stravitz, Z. ft Vlahcevic and P. B. Hylemon
4 Transcriptional regulation of the cholesterol
7a hydroxylase gene (CYP7A) by nuclear hormone
receptors bound to the bile acid response elements
(BARE) 51
J. Y. L. Chiang, D. Stroup, M. Crestani and A. Sadeghpour
5 Regulation by bile acids of hepatic sterol 12a hydroxylase
(CYP12) and cholic acid synthesis in the rat 59
W. M. Pandak, P. B. Hylemon, I. Bjorkhem, G. Eggertsen,
K. Redford and Z. ft Vlahcevic
V
CONTENTS
6 A novel biosynthetic pathway to cholic acid in cultured
human hepatocytes 65
M. Axelson, B. Mbrk, K. Garmark, I. Bjorkhem, E. Ellis
and C. Einarsson
SECTION II: TRANSPORT OF BILE ACIDS
7 Substrate specificity of Na+/bile acid cotransporters and
identification of substrate binding sites 77
W. Kramer, S. Stengelin, K. H. Baringhaus and K. Sauber
8 Evidence for an additional sinusoidal bile salt transport
system 86
W. Schmider, H. E. Blum, A. Dietrich, W. Gerok,
B. Hagenbuch, G. Kurz, P. J. Meier, D. Schwab and
B. Stieger
9 Regulation of basolateral bile acid transport proteins in
human liver 95
G. A. Kullak Ublick, M. Oswald, P. J. Meier, U. Beuers
and G. Paumgartner
10 Effect of cholestasis on ileal bile acid transport in the rat 102
P. Sauer, A. Stiehl, B. A. Fitscher, D. Riedel, C. Benz,
P. Kloters Plachky, S. Stengelin, W. Stremmel and
W. Kramer
11 ATP dependent hepatocellular conjugate export
pumps of the MRP family 106
D. Keppler, J. Konig, D. Rostand Y. Cui
12 The role of the canalicular bile salt efflux pump in the
pathogenesis of cholestasis 111
P. J. Meier Abt, T. Gerloff, K. Fattinger and B. Stieger
13 The role of the bile salt export pump (BSEP) in genetic
cholestasis 115
R J. Thompson and S. Strautnieks
14 The molecular expression of the bile salt export pump,
sister of P glycoprotein (spgp), in experimental models
of cholestasis 123
J. M. Lee, M. Trauner, C. J. Soroka, B. Stieger, P. J. Meier
andJ. L Boyer
vi
CONTENTS
15 Defects in hepatobiliary lipid secretion 129
M. de Vree, P. Bosma, R. Ottenhoff, A. K. Groen and
R.P.J. OudeElferink
16 Regulation of canalicular conjugate export pump by
osmolarity, endotoxin and glucocorticoids in rat liver 137
D. Haussinger, R. Kubitz, F. Schliess, M. Wettstein,
U. Warskulat, A. K. Kurz, N. Saha and
S. vom Dahl
SECTION III: BIOLOGICAL EFFECTS OF BILE ACIDS
AND CHOLESTASIS
17 Cellular and molecular response of hepatic bile salt
transporters to cholestatic liver injury 145
J. L Boyer, J. M. Lee, M. Trauner, C. J. Soroka,
C. Gartung and S. J. Karpen
18 Concentration dependent modulation of cytosolic free
calcium and protein kinase C by taurolithocholic acid in
isolated rat hepatocytes 151
U. Beuers, I. Probst, C. Soroka, J. L Boyer,
G. A. Kullak Ublick and G. Paumgartner
19 Role of guanine nucleotide binding protein (Gs) in the
impaired hepatic modulation of cAMP formation by
hormones and bile acids in cholestasis 156
B. Bouscarel, Y. Matsuzaki, M. Le, T. W. Gettys,
S. Ceryak and H. Fromm
20 Trophic effects of taurocholate on the bile secretory
phenotype of WIF B hepatoma cells 166
E. M. Konieczko andJ. M. Crawford
21 Role of Fas in glycochenodeoxycholate induced
hepatocyte apoptosis 172
W. A. Faubion, M. E. Guicciardi, S. F. Bronk, P. J. Roberts
and G. J. Gores
22 Effect of tauroursodeoxycholic acid and
S adenosylmethionine on bile acid induced apoptosis in
primary rat hepatocytes 179
C. Bern, S. Angermuller, P. Kldters Plachky, P. Sauer,
W. Stremmel and A. Stiehl
vii
CONTENTS
23 Taurohyodeoxycholic acid prevents taurochenodeoxycholic
acid induced cholestasis in rat: modulation of cytochrome
P450 system 184
A. Roda, M. Paolini, F. Piazza, M. Baraldini, E. Speroni,
M. C. Guerra, L. Pozzetti and G. Cantelli Forti
24 Organelle blockade: another mechanism for the
cytoprotective effect of ursodeoxycholic acid conjugates
in the hepatocyte 191
A. F. Hofmann, F. Holzinger, H. T. Ton Nu, C. Cerre,
H. Z. Yeh and C. D. Schteingart
25 Elevated plasma bile salt levels without cholestasis in
mdr2 P glycoprotein deficient mice due to impaired
NaMaurocholate transporting protein (Ntcp) function 203
P. J. Voshol, N. R. Koopen, R. Havinga, H. Wolters,
R. P. J. Oude Elferink, B. Hagenbuch, A. K. Groen and
F. Kuipers
SECTION IV: BILE ACIDS IN DISEASE
26 A mutation in the oxysterol 7a hydroxylase gene causes
severe liver disease and highlights the quantitative
importance of the acidic pathway for bile acid synthesis
in humans 213
K. D. R. Setchell, M. Schwarz, N. C. O Connell,
E. G. Lund, D. L. Davis, R. Lathe, R. J. Sokoland
D. W. Russell
27 The canalicular bile salt export pump BSEP is not
expressed in livers of PFIC 2 patients 220
M. Mullen G. J. E. J. Hooiveld, O. Mol, H. Koning,
A. Gouw, F. Kuipers, H. van Goor and P. L M. Jansen
28 Functional and genetic studies of biliary cholesterol
secretion in inbred mice: evidence for a primary role of
sister to P glycoprotein, the canalicular bile salt export
pump, in cholesterol gallstone pathogenesis 224
F. Lammert, D. Q. H. Wang, D. E. Cohen, B. Paigen and
M. C. Carey
SECTION V: BILE ACIDS IN THERAPY
29 Effect of ursodeoxycholic acid on cholestatic features
and complications of primary biliary cirrhosis 231
R. P. Jazrawi, A. Verma, H. A. Ahmed and T. C. Northfield
viii
CONTENTS
30 Primary biliary cirrhosis autoimmune hepatitis overlap
syndrome: features and response to therapy 247
R. Poupon, O. Chazouilleres and R. E. Poupon
31 Electron microscopic study on antifibrotic effects of
ursodeoxycholate treatment in primary biliary
cirrhosis 254
M. G. Neuman, R. G. Cameron, N. H. Shear and
L M. Blendis
32 Ursodeoxycholic acid and glucocorticoids in the
treatment of primary biliary cirrhosis 270
U. Leuschner, J. Schlichting, M. Leuschner, G. Herrmann,
K. P. MaierandS. Strahl
33 Bile acid therapy for paediatric cholestasis 276
C. Colombo
34 Transit induced changes in colonic bacteriology, bile acid
metabolizing enzymes and luminal pH influence
deoxycholic acid metabolism 284
L A. Thomas, T. Bathgate, M. J. Veysey, N. Smeeton,
G. L French, G. M. Murphy and R. H. Dowling
Index 287
ix
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| spelling | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 ed. by G. Paumgartner ... Dordrecht [u.a.] Kluwer 1999 XIII, 291 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Falk Symposium 108 Cholestase (DE-588)4147858-7 gnd rswk-swf Gallensäuren (DE-588)4155851-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1998 Titisee Ort gnd-content Cholestase (DE-588)4147858-7 s DE-604 Gallensäuren (DE-588)4155851-0 s Paumgartner, Gustav Sonstige oth International Bile Acid Meeting 15 1998 Titisee-Neustadt Sonstige (DE-588)1241709-9 oth Falk Symposium 108 (DE-604)BV000001125 108 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008687607&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 Falk Symposium Cholestase (DE-588)4147858-7 gnd Gallensäuren (DE-588)4155851-0 gnd |
| subject_GND | (DE-588)4147858-7 (DE-588)4155851-0 (DE-588)1071861417 |
| title | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 |
| title_auth | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 |
| title_exact_search | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 |
| title_full | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 ed. by G. Paumgartner ... |
| title_fullStr | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 ed. by G. Paumgartner ... |
| title_full_unstemmed | Bile acids and cholestasis (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 ed. by G. Paumgartner ... |
| title_short | Bile acids and cholestasis |
| title_sort | bile acids and cholestasis xv international bile acid meeting proceedings part i of the gastrointestinal week titisee 1998 held in titisee germany oct 12 13 1998 |
| title_sub | (XV International Bile Acid Meeting) ; proceedings ; Part I of the Gastrointestinal Week Titisee 1998) held in Titisee, Germany, Oct. 12-13, 1998 |
| topic | Cholestase (DE-588)4147858-7 gnd Gallensäuren (DE-588)4155851-0 gnd |
| topic_facet | Cholestase Gallensäuren Konferenzschrift 1998 Titisee Ort |
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| volume_link | (DE-604)BV000001125 |
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