Imaging of hypoxia: tracer developments
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Kluwer
1999
|
| Schriftenreihe: | Developments in nuclear medicine
33 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 180 S. Ill. |
| ISBN: | 0792355296 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV012774702 | ||
| 003 | DE-604 | ||
| 005 | 19991209 | ||
| 007 | t | ||
| 008 | 990922s1999 a||| |||| 00||| eng d | ||
| 020 | |a 0792355296 |9 0-7923-5529-6 | ||
| 035 | |a (OCoLC)40311520 | ||
| 035 | |a (DE-599)BVBBV012774702 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 050 | 0 | |a RC103.A4 | |
| 082 | 0 | |a 616.2 |2 21 | |
| 084 | |a YC 2614 |0 (DE-625)153203:12920 |2 rvk | ||
| 245 | 1 | 0 | |a Imaging of hypoxia |b tracer developments |c ed. by Hans-Jürgen Machulla |
| 264 | 1 | |a Dordrecht |b Kluwer |c 1999 | |
| 300 | |a XII, 180 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Developments in nuclear medicine |v 33 | |
| 650 | 4 | |a Anoxemia |x Radionuclide imaging | |
| 650 | 4 | |a Anoxia |x radionuclide imaging |v Congresses | |
| 650 | 4 | |a Radiopharmaceuticals |x diagnostic use |v Congresses | |
| 650 | 4 | |a Tomography, Emission-Computed |x methods |v Congresses | |
| 650 | 0 | 7 | |a Radioindikator |0 (DE-588)4176829-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Hypoxie |0 (DE-588)4133549-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Hypoxie |0 (DE-588)4133549-1 |D s |
| 689 | 0 | 1 | |a Radioindikator |0 (DE-588)4176829-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Machulla, Hans-Jürgen |d 1942- |e Sonstige |0 (DE-588)144006650 |4 oth | |
| 830 | 0 | |a Developments in nuclear medicine |v 33 |w (DE-604)BV000008632 |9 33 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008687345&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008687345 | ||
Datensatz im Suchindex
| _version_ | 1804127443835944960 |
|---|---|
| adam_text | Table of Contents
Preface ix
List of Contributors xi
Color Figures xiii
1 Hypoxia: An Introduction
Leonard I. Wiebe and H. Jiirgen Machulla
1 Definitions of Hypoxia 1
2 Predictive Assays for Tissue Hypoxia 2
2.1 The Design of Predictive Assays 2
2.2 Predictive Assays based on the Measurement of Tissue Hypoxia 3
3 Hypoxia in Selected Pathologies 4
3.1 Oncology 4
3.2 Cardiovascular Disease 6
3.3 Cerebrovascular Disease 7
3.4 Diabetes 10
3.5 Infection 10
3.6 Wound Healing and Organ Transplantation 11
3.7 Joint Hypoxia 11
3.8 Other Cutaneous and Mucosal Pathologies 12
4 Aspects of Cellular Metabolism in Hypoxia 13
5 Radiotherapy and Hypoxia ] 4
5.1 Radiobiological Hypoxia 14
5.2 Radiosensitizers 15
5.3 Hypoxic Binding of 2 Nitroimidazoles 15
6 Further Reading 16
v
vi
2 The Biology of Technetium Based Hypoxic Tissue
Localising Compounds
Adrian D. Nunn
1 Introduction 19
2 Oxygen concentrations in tissues 20
3 Oxygen levels required for trapping of nitroimidazoles 21
3.1 Individual cells 22
3.2 Isolated perfused hearts 23
3.3 Myocardium in vivo 26
3.4 Conclusions 27
4 Row levels required for trapping 28
4.1 Myocardium 28
4.2 Brain 30
4.3 Conclusions 30
5 Trapping mechanisms 31
6 Imaging/Kinetics 34
6.1 Brain 34
6.2 Heart 34
6.3 Tumours 35
7 Comparison to other metabolic imaging agents 36
8 Toxicity 38
8.1 Toxicity of therapeutic nitroimidazoles. 38
8.2 Pharmacokinetics of therapeutic nitroimidazoles. 40
8.3 Assessment of toxicity of diagnostic doses. 41
3 Basic Chemistry of 2 Nitroimidazoles (Azomycin Derivates)
Christa E. Mutter
1 Introduction 47
2 Imidazole 48
3 2 Nitroimidazole (Azomycin) 48
3.1 Preparation of 2 nitroimidazole 49
3.2 Chemical properties of 2 nitroimidazole 50
3.3 Reactivity of 2 nitroimidazole 50
4 5 Substituted 2 nitroimidazoles 54
5 2 Nitroimidazole nucleosides and analogs 54
5.1 Azomycin riboside 54
5.2 Azomycin nucleosides 55
5.3 Azomycin nucleoside analogs 55
vii
4 Molecular Design Approaches of Hypoxia Tracers
Gerd Folkers, Frank Alber, Oliver Kuonen and Alfred Men
1 Introduction 61
1.1 Modelling of Ligand Protein Interaction Complexes 62
1.2 The QSAR Approach 65
1.3 Threedimensional QSAR and Pseudoreceptors 66
2 Material and Methods 67
3 Results 70
3.1 Molecular electrostatic potentials 70
3.2 Formation of Radicals 71
4 Outlook 73
5 Syntheses of PET Tracers for the Determination of Hypoxia
John Grierson and Marianne Pan
1 Syntheses of [18F]FMISO 75
2 Synthesis of alternative [18F] labelled agents for hypoxia imaging 80
3 Summary and future directions 81
6 Quantifying Hypoxia with Radiolabeled Fluoromisonidazole:
Pre Clinical and Clinical Studies
Janet S. Rasey, Gary V. Martin and Kenneth A. Krohn
1 Introduction 85
1.1 Rational approach 85
1.2 Properties of fluromisonidazole that make it a useful tracer 87
1.3 Development of FMISO as a PET tracer: From cells in vitro to patient imaging 87
2 Cell Monolayers and Spheroids in Culture 88
2.1 Cell monolayer studies 88
2.2 Spheroid Studies 89
2.3 Isolated myocyte studies 90
3 Studies in Animals 90
3.1 Mice 90
3.2 Rats 95
3.3 Tumor studies in dogs 98
3.4 Heart studies in dogs 100
4 Patient Studies 103
4.1 Tumor studies 103
4.2 Heart studies 11 j
5 Summary and Conclusions 1 ] 3
viii
7 Detection of Liver Hypoxia by [18F]FIuoromisonidazole and
Application in Liver Transplant Disorders
Morand Piert and H. Jiirgen Machulla
1 Introduction ] 19
2 Liver tissue hypoxia in transplant dysfunctions 119
2.1 Hypoxia and rejection 119
2.2 Hypoxia and immunosuppressive therapy 120
2.3 Differential diagnoses in transplant dysfunctions ] 21
3 Material and methods 121
4 Results 122
5 Discussion 125
6 Conclusion 126
8 The Evaluation of Hypoxia in Diabetes
John R. Mercer and Hui Liu
1 Introduction 129
2 Microangiopathy in Diabetic Patients 130
2.1 Biochemical Processes and Pathways 130
2.2 Structural and Functional Changes 131
3 The Diabetic Foot 132
3.1 Assessment of Hypoxia in the Diabetic Foot 133
4 Imaging and Nuclear Medicine Methods in the Evaluation 138
of Tissue Hypoxia in Diabetes
4.1 Non Radionuclide Imaging 138
4.2 Radiopharmaceuticals and Diabetic Hypoxia 139
5 Conclusions 145
9 Radiohalogenated Nitroimidazoles for Single photon
Scintigraphic Imaging of Hypoxic Tissues
Leonard 1. Wiebe
1 Rational Design of Hypoxia specific Radiotracers 155
1.1 The oxygen effect and chemical radiosensitizers 155
1.2 Nitroimidazole radiosensitizer design 155
1.3 Metabolism of 2 nitroimidazoles 157
2 Radiohalogenated Imidazole based Radiopharmaceuticals forSPECT 158
and Planar Imaging
2.1 Hypoxia tracers labelled with 82Br. 158
2.2 Radioiodinated 4(5) nitroimidazole analogues 159
2.3 Radioiodinated 2 NitroimidazoIes 160
2.4 Azomycin Nucleosides 163
3. Discussion o
|
| any_adam_object | 1 |
| author_GND | (DE-588)144006650 |
| building | Verbundindex |
| bvnumber | BV012774702 |
| callnumber-first | R - Medicine |
| callnumber-label | RC103 |
| callnumber-raw | RC103.A4 |
| callnumber-search | RC103.A4 |
| callnumber-sort | RC 3103 A4 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | YC 2614 |
| ctrlnum | (OCoLC)40311520 (DE-599)BVBBV012774702 |
| dewey-full | 616.2 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.2 |
| dewey-search | 616.2 |
| dewey-sort | 3616.2 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01830nam a2200457 cb4500</leader><controlfield tag="001">BV012774702</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">19991209 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">990922s1999 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0792355296</subfield><subfield code="9">0-7923-5529-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)40311520</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012774702</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC103.A4</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.2</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YC 2614</subfield><subfield code="0">(DE-625)153203:12920</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Imaging of hypoxia</subfield><subfield code="b">tracer developments</subfield><subfield code="c">ed. by Hans-Jürgen Machulla</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Dordrecht</subfield><subfield code="b">Kluwer</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 180 S.</subfield><subfield code="b">Ill.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Developments in nuclear medicine</subfield><subfield code="v">33</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anoxemia</subfield><subfield code="x">Radionuclide imaging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anoxia</subfield><subfield code="x">radionuclide imaging</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Radiopharmaceuticals</subfield><subfield code="x">diagnostic use</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tomography, Emission-Computed</subfield><subfield code="x">methods</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Radioindikator</subfield><subfield code="0">(DE-588)4176829-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Hypoxie</subfield><subfield code="0">(DE-588)4133549-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)1071861417</subfield><subfield code="a">Konferenzschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Hypoxie</subfield><subfield code="0">(DE-588)4133549-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Radioindikator</subfield><subfield code="0">(DE-588)4176829-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Machulla, Hans-Jürgen</subfield><subfield code="d">1942-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)144006650</subfield><subfield code="4">oth</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Developments in nuclear medicine</subfield><subfield code="v">33</subfield><subfield code="w">(DE-604)BV000008632</subfield><subfield code="9">33</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008687345&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008687345</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content |
| genre_facet | Aufsatzsammlung Konferenzschrift |
| id | DE-604.BV012774702 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:33:26Z |
| institution | BVB |
| isbn | 0792355296 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008687345 |
| oclc_num | 40311520 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XII, 180 S. Ill. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Kluwer |
| record_format | marc |
| series | Developments in nuclear medicine |
| series2 | Developments in nuclear medicine |
| spelling | Imaging of hypoxia tracer developments ed. by Hans-Jürgen Machulla Dordrecht Kluwer 1999 XII, 180 S. Ill. txt rdacontent n rdamedia nc rdacarrier Developments in nuclear medicine 33 Anoxemia Radionuclide imaging Anoxia radionuclide imaging Congresses Radiopharmaceuticals diagnostic use Congresses Tomography, Emission-Computed methods Congresses Radioindikator (DE-588)4176829-2 gnd rswk-swf Hypoxie (DE-588)4133549-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Hypoxie (DE-588)4133549-1 s Radioindikator (DE-588)4176829-2 s DE-604 Machulla, Hans-Jürgen 1942- Sonstige (DE-588)144006650 oth Developments in nuclear medicine 33 (DE-604)BV000008632 33 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008687345&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Imaging of hypoxia tracer developments Developments in nuclear medicine Anoxemia Radionuclide imaging Anoxia radionuclide imaging Congresses Radiopharmaceuticals diagnostic use Congresses Tomography, Emission-Computed methods Congresses Radioindikator (DE-588)4176829-2 gnd Hypoxie (DE-588)4133549-1 gnd |
| subject_GND | (DE-588)4176829-2 (DE-588)4133549-1 (DE-588)4143413-4 (DE-588)1071861417 |
| title | Imaging of hypoxia tracer developments |
| title_auth | Imaging of hypoxia tracer developments |
| title_exact_search | Imaging of hypoxia tracer developments |
| title_full | Imaging of hypoxia tracer developments ed. by Hans-Jürgen Machulla |
| title_fullStr | Imaging of hypoxia tracer developments ed. by Hans-Jürgen Machulla |
| title_full_unstemmed | Imaging of hypoxia tracer developments ed. by Hans-Jürgen Machulla |
| title_short | Imaging of hypoxia |
| title_sort | imaging of hypoxia tracer developments |
| title_sub | tracer developments |
| topic | Anoxemia Radionuclide imaging Anoxia radionuclide imaging Congresses Radiopharmaceuticals diagnostic use Congresses Tomography, Emission-Computed methods Congresses Radioindikator (DE-588)4176829-2 gnd Hypoxie (DE-588)4133549-1 gnd |
| topic_facet | Anoxemia Radionuclide imaging Anoxia radionuclide imaging Congresses Radiopharmaceuticals diagnostic use Congresses Tomography, Emission-Computed methods Congresses Radioindikator Hypoxie Aufsatzsammlung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008687345&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008632 |
| work_keys_str_mv | AT machullahansjurgen imagingofhypoxiatracerdevelopments |