Pharmacology:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | Rundi |
| Veröffentlicht: |
Edinburgh [u.a.]
Churchill Livingstone
1999
|
| Ausgabe: | 4. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 830 S. |
| ISBN: | 0443059748 0443059942 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012766931 | ||
| 003 | DE-604 | ||
| 005 | 20020807 | ||
| 007 | t | ||
| 008 | 990916s1999 |||| 00||| run d | ||
| 020 | |a 0443059748 |9 0-443-05974-8 | ||
| 020 | |a 0443059942 |9 0-443-05994-2 | ||
| 035 | |a (OCoLC)245748759 | ||
| 035 | |a (DE-599)BVBBV012766931 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a run | |
| 049 | |a DE-355 |a DE-91 |a DE-19 |a DE-188 |a DE-578 | ||
| 050 | 0 | |a RM300 | |
| 082 | 0 | |a 615/.1 | |
| 084 | |a VT 5010 |0 (DE-625)147739: |2 rvk | ||
| 100 | 1 | |a Rang, H. P. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Pharmacology |c H. P. Rang ; M. M. Dale ; J. M. Ritter |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a Edinburgh [u.a.] |b Churchill Livingstone |c 1999 | |
| 300 | |a X, 830 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Pharmacology |2 cabt | |
| 650 | 0 | 7 | |a Pharmakologie |0 (DE-588)4045687-0 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Pharmakologie |0 (DE-588)4045687-0 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Dale, M. M. |e Verfasser |4 aut | |
| 700 | 1 | |a Ritter, J. M. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008681284&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008681284 | ||
Datensatz im Suchindex
| _version_ | 1804127434430218240 |
|---|---|
| adam_text | Contents
SECTION 1
GENERAL PRINCIPLES
1. How drugs act: general principles 2
Drugs in medicine 2
The binding of drug molecules to cells 3
Drug antagonism 13
Desensitisation and tachyphylaxis 16
2. How drugs act: molecular aspects 19
Targets for drug action 19
Receptor proteins 23
Receptor families: structure and signal transduction
mechanisms 24
Control of receptor expression 44
Receptors and disease 44
3. Method and measurement in pharmacology 47
Bioassay 47
Clinical trials 53
Measurement of toxicity 57
4. Absorption and distribution of drugs 61
Translocation of drug molecules 61
Drug disposition 68
Special drug delivery systems 75
5. Drug elimination and pharmokinetics 78
Drug metabolism 78
Renal excretion of drugs and drug metabolites 84
Biliary excretion and enterohepatic circulation 86
Pharmacokinetics 87
SECTION 2
CHEMICAL MEDIATORS
6. Chemical mediators and the autonomic nervous
system 94
Introduction 94
The peripheral nervous system 95
Some general principles of chemical transmission 100
Mechanisms of transmitter release 105
Termination of transmitter action 107
Basic steps in neurochemical transmission sites of drug action 108
7. Cholinergic transmission 110
Muscarinic and nicotinic actions of acetylcoline 110
Physiology of cholinergic transmission 113
Effects of drugs on cholinergic transmission 117
Drugs affecting muscarinic receptors 118
Drugs affecting autonomic ganglia 123
Neuromuscular blocking drugs 125
Drugs that enhance cholinergic transmission 130
8. Norodrenergic transmission 139
Classification of adrenoceptors 139
Physiology of adrenergic transmission 142
Drugs acting on adrenoceptors 146
Drugs that affect adrenergic neurons 156
9. Other peripheral mediators: 5 hydroxytryptamine and
purines 164
5 hydroxytryptamine 164
Purines 174
CONTENTS 10. Peptides and proteins as mediators 177
General principles of peptide pharmacology 177
Biosynthesis and regulation of peptides 181
Peptide antagonists 183
Proteins and peptides as drugs 184
Concluding remarks 186
11. Nitric oxide 188
Biosynthesis of nitric oxide and its control 188
Degradation and carriage of nitric oxide 191
Effects of nitric oxide 191
Therapeutic use of nitric oxide and nitric oxide donors 193
Inhibition of nitric oxide 193
Clinical conditions in which nitric oxide may play a part 194
12. Local hormones, inflammation and allergy 198
The acute inflammatory reaction and the immune response 199
Unwanted inflammatory and immune responses 209
The outcome of the inflammatory response 210
Mediators of inflammation and allergy 210
Potential therapies based on manipulation of the immune
response 225
13. Anti inflammatory and immunosuppressant drugs 229
Non steroidal anti inflammatory drugs (NSAIDs) 229
Antirheumatoid drugs 236
Drugs used in gout 239
Antagonists of histamine 240
Immunosuppressant drugs 242
Possible future developments 245
SECTION 3
DRUGS AFFECTING MAJOR ORGAN SYSTEMS
14. The heart 250
Physiology of cordiac function 250
Drugs that affect cardiac function 261
15. The vascular system 278
Control of vascular smooth muscle tone 279
Drugs that affect vascular smooth muscle contraction 286
16. Atherosclerosis and lipoprotein metabolism 301
Lipoproteins and other risk factors for atherosclerosis 301
Lipoprotein transport in the blood 302
Lipid lowering drugs 305
17. Haemostasis and thrombosis 310
Blood coagulation 311
Drugs that act on the coagulation cascade 314
Platelet adhesion and activation 320
Fibrinolysis (thrombolysis) 323
18. The haemopoietic system 328
Folic acid and vitamin B12 331
Haemopoietic growth factors 334
19. The respiratory system 338
The regulation of respiration 338
Drugs which affect respiration 339
Disorders of respiratory function 340
20. The kidney 351
The structure and function of the nephron 352
Drugs acting on the kidney 359
Drugs which alter the pH of the urine 367
Drugs which alter the excretion of organic molecules 367
21. The gastrointestinal system 370
The innervation and the hormones of the gastrointestinal tract 371
Gastric secretion 371
Vomiting 377
The motility of the gastrointestinal tract 380
Drugs for chronic inflammatory bowel disease 383
Drugs affecting the biliary system 383
22. The endocrine pancreas and the control of blood
glucose 385
Pancreatic islet hormones 385
Control of blood glucose 391
Diabetes mellitus 391
23. Obesity 399
Background 399
Definition of obesity 399
The homeostatic mechanisms controlling energy balance 400
Obesity as a health problem 404
The pathophysiology of obesity 404
Pharmacological approaches to the problem of obesity 406
24. The pituitary and adrenal cortex 409
The pituitary 409
Adrenal steroids 416
25. The thyroid 428
Synthesis, storage and secretion of thyroid hormones 428
Regulation of thryoid function 429
Actions of the thyroid hormones 430
Transport and metabolism 431
Abnormalities of thyroid function 431
Drugs used in diseases of the thyroid 432
26. The reproductive system 436
Endocrine aspects 436
Drugs used for contraception 447
The uterus 449
27. Bone metabolism 454
Bone structure and composition 454
Bone remodelling 454
Disorders of bone 460
Drugs used in bone disorders 460
SECTION 4
THE CENTRAL NERVOUS SYSTEM
28. Chemical transmission and drug action in the central
nervous system 464
Introduction 464
Chemical signalling in the nervous system 465
Targets for drug action 465
Drug action in the central nervous system 467
The classification of psychotropic drugs 468
Clinical use of psychotropic drugs 469
29. Amino acid transmitters 470
Excitatory amino acids (EAAs) 470
Gamma aminobutyric acid (GABA) 478
Glycine 480
30. Other transmitters and modulators 483
Noradrenaline 483
Dopamine 485
5 hyrdoxytryptamine 490
Acetylcholine 492
Histamine 495
Other CNS mediators 495
A final message 498
31. Neurodegenerative disorders 500
Introduction 500
CONTENTS
Mechanisms of neuronal death 500
Alzheimer s disease 504
Parkinson s disease 507
Huntingdon s disease 512
Neurodegenerative prion disease 513
32. General anaesthetic drugs 514
Physicochemical theories of anaesthesia 516
The effects of anaesthetics on the nervous system 517
Effects on the cardiovascular and respiratory systems 518
Inhalation anaesthetics 519
Individual inhalation anaesthetics 522
Intravenous anaesthetic agents 524
33. Anxiolytic and hypnotic drugs 528
The nature of anxiety and measurement of anxiolytic activity 528
Classification of anxiolytic and hypnotic drugs 529
Benzodiazepines 530
Benzodiazepine antagonists 536
Buspirone 537
Barbiturates 537
Other potential anxiolytic drugs 537
34. Antipsychotic drugs 539
The nature of schizophrenia 539
Antipsychotic drugs 542
35. Drugs used in affective disorders 550
The nature of affective disorders 550
The monoamine theory of depression 550
Antidepressant drugs 553
Mood stabilisers 564
36. Antiepileptic drugs and centrally acting muscle
relaxants 566
Epilepsy 566
Antiepileptic drugs 570
Muscle spasm and centrally acting muscle relaxants 577
37. Analgesic drugs 579
Neural mechanisms of pain sensation 579
Analgesic drugs 589
New approaches 602
38. Central nervous system stimulants and psychotomimetic
drugs 604
Convulsants and respiratory stimulants 604
Psychomotor stimulants 606
Psychotomimetic drugs 611
CONTENTS 39. Drug dependence and drug abuse 614
The nature of drug dependence 614
Nicotine and tobacco 618
Ethonol 623
Cannabis 630
40. Local anaesthetics and other drugs that affect ion
channels 634
Introduction 634
Sodium and potassium channels of excitable membranes 634
Drugs that affect sodium channels 638
Agents that affect potassium channels 644
SECTION 5
CHEMOTHERAPY OF INFECTIOUS AND
MALIGNANT DISEASE
41. Basic principles of chemotherapy 648
The molecular basis of chemotherapy 648
42. Cancer chemotherapy 663
The biology of cancer 664
General principles of action of cytotoxic onticancer drugs 668
Drugs used in concer chemotherapy 670
Resistance to anticancer drugs 680
Drug effects on the cell cycle and the possible clinical applications 68C
Treatment schedules 681
Techniques for dealing with emesis and myelosuppression 681
Possible future strategies for cancer chemotherapy 681
43. Antibacterial drugs 685
Antimicrobial agents which interfere with the synthesis or action
offolote 688
Beta lactam antibiotics 690
Antimicrobial agents affecting bacterial protein synthesis 696
Antimicrobial agents affecting topoisomerase II 700
Miscellaneous antibacterial agents 702
Antimycobacterial agents 703
Possible new antibacterial drugs 707
44. Antiviral drugs 708
Viral infection 708
General actions of antiviral drugs 713
Possible future developments in antiviral therapy 717
45. Antifungal drugs 720
Fungal infections 720
Drugs used for fungal infections 720
Potential new antifungal therapies 724
46. Antiprotozoal drugs 725
Host parasite interactions 725
Malaria 726
Antimalarial drugs 728
Pneumocystis pneumonia and its treatment 735
Amoebiasis and amoebicidal drugs 735
Leishmaniasis and leishmanicidal drugs 736
Trypanosomiasis and trypanosomicidal drugs 737
Toxoplasmosis and toxoplasmocidal drugs 737
New approaches to antiprotozoal therapy 737
47. Anthelminthic drugs 739
Helminth infections 739
Anthelminthic drugs 740
SECTION 6
GENERAL TOPICS
48. Individual variation and drug interaction 746
Effects of age 746
, Genetic factors 748
Idiosyncratic reactions 750
Effects of disease 751
Drug interactions 752
49. Harmful effects of drugs 757
Types of adverse drug reaction 757
Drug toxicity 760
50. Gene therapy 775
Technical aspects 776
Safety 779
Therapeutic aspects 780
APPENDIX
THE MAIN PHARMACOLOGICAL AGENTS 784
INDEX 791
|
| any_adam_object | 1 |
| author | Rang, H. P. Dale, M. M. Ritter, J. M. |
| author_facet | Rang, H. P. Dale, M. M. Ritter, J. M. |
| author_role | aut aut aut |
| author_sort | Rang, H. P. |
| author_variant | h p r hp hpr m m d mm mmd j m r jm jmr |
| building | Verbundindex |
| bvnumber | BV012766931 |
| callnumber-first | R - Medicine |
| callnumber-label | RM300 |
| callnumber-raw | RM300 |
| callnumber-search | RM300 |
| callnumber-sort | RM 3300 |
| callnumber-subject | RM - Therapeutics and Pharmacology |
| classification_rvk | VT 5010 |
| ctrlnum | (OCoLC)245748759 (DE-599)BVBBV012766931 |
| dewey-full | 615/.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.1 |
| dewey-search | 615/.1 |
| dewey-sort | 3615 11 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| edition | 4. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01398nam a2200397 c 4500</leader><controlfield tag="001">BV012766931</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20020807 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">990916s1999 |||| 00||| run d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0443059748</subfield><subfield code="9">0-443-05974-8</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0443059942</subfield><subfield code="9">0-443-05994-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)245748759</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012766931</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">run</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM300</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.1</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VT 5010</subfield><subfield code="0">(DE-625)147739:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Rang, H. P.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Pharmacology</subfield><subfield code="c">H. P. Rang ; M. M. Dale ; J. M. Ritter</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">4. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Edinburgh [u.a.]</subfield><subfield code="b">Churchill Livingstone</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">X, 830 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmacology</subfield><subfield code="2">cabt</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Pharmakologie</subfield><subfield code="0">(DE-588)4045687-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dale, M. M.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ritter, J. M.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008681284&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008681284</subfield></datafield></record></collection> |
| id | DE-604.BV012766931 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:33:17Z |
| institution | BVB |
| isbn | 0443059748 0443059942 |
| language | Rundi |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008681284 |
| oclc_num | 245748759 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-188 DE-578 |
| physical | X, 830 S. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Churchill Livingstone |
| record_format | marc |
| spelling | Rang, H. P. Verfasser aut Pharmacology H. P. Rang ; M. M. Dale ; J. M. Ritter 4. ed. Edinburgh [u.a.] Churchill Livingstone 1999 X, 830 S. txt rdacontent n rdamedia nc rdacarrier Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pharmakologie (DE-588)4045687-0 s DE-604 Dale, M. M. Verfasser aut Ritter, J. M. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008681284&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rang, H. P. Dale, M. M. Ritter, J. M. Pharmacology Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4045687-0 |
| title | Pharmacology |
| title_auth | Pharmacology |
| title_exact_search | Pharmacology |
| title_full | Pharmacology H. P. Rang ; M. M. Dale ; J. M. Ritter |
| title_fullStr | Pharmacology H. P. Rang ; M. M. Dale ; J. M. Ritter |
| title_full_unstemmed | Pharmacology H. P. Rang ; M. M. Dale ; J. M. Ritter |
| title_short | Pharmacology |
| title_sort | pharmacology |
| topic | Pharmacology cabt Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Pharmacology Pharmakologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008681284&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ranghp pharmacology AT dalemm pharmacology AT ritterjm pharmacology |