Principles for the assessment of risks to human health from exposure to chemicals:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
1999
|
| Schriftenreihe: | Environmental health criteria
210 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 110 S. graph. Darst. |
| ISBN: | 9241572108 |
Internformat
MARC
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| 245 | 1 | 0 | |a Principles for the assessment of risks to human health from exposure to chemicals |
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| 490 | 1 | |a Environmental health criteria |v 210 | |
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| 650 | 7 | |a CHEMICALS |2 unbist | |
| 650 | 7 | |a ENVIRONMENTAL HEALTH |2 unbist | |
| 650 | 7 | |a Farmacologia |2 larpcal | |
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| 650 | 7 | |a Gezondheidseffecten |2 gtt | |
| 650 | 4 | |a Hygiène du milieu | |
| 650 | 7 | |a Risicoanalyse |2 gtt | |
| 650 | 4 | |a Risques pour la santé - Évaluation | |
| 650 | 4 | |a Toxicité | |
| 650 | 4 | |a Toxicologie - Relations dose-effet | |
| 650 | 4 | |a Environmental Exposure | |
| 650 | 4 | |a Environmental health | |
| 650 | 4 | |a Hazardous Substances |x adverse effects | |
| 650 | 4 | |a Health risk assessment | |
| 650 | 4 | |a Risk Assessment | |
| 650 | 4 | |a Toxicity testing | |
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Datensatz im Suchindex
| _version_ | 1813547437406552064 |
|---|---|
| adam_text |
CONTENTS
PRINCIPLES FOR THE ASSESSMENT OF RISKS TO
HUMAN HEALTH FROM EXPOSURE TO CHEMICALS
PREAMBLE vii
ABBREVIATIONS xx
1. SUMMARY 1
2. INTRODUCTION 5
3. HEALTH HAZARD IDENTIFICATION 7
3.1 Introduction 7
3.2 Human data 8
3.2.1 Criteria for establishing causality 10
3.3 Animal studies 13
3.4 In vitro studies 15
3.5 Structure activity relationships 16
4. DOSE RESPONSE 18
4.1 Introduction 18
4.2 Considerations in dose response assessment 20
4.2.1 Introduction 20
4.2.2 Inter and intra species considerations 20
4.2.2.1 Introduction 20
4.2.2.2 Species differences 21
4.2.2.3 Human variability 22
4.3 Non neoplastic (threshold) effects 22
4.3.1 Characterization of threshold 23
4.3.1.1 No observed adverse effect
level (NOAEL) 23
4.3.1.2 Benchmark dose/concentration 23
4.3.1.3 Lowest observed adverse effect
level 24
Hi
. ¦fui,w:ne
¦¦¦¦i:§¥\?fik ks *° Human Health from Exposure to Chemicals
K6in
. 4 3.2 Uncertainty factors 24
3£| S4J| Q uantitative risk assessment for neoplastic
_ Q IVI (i on threshold) effects 28
™_—T_™_7rJ4 2 introduction 28
"¦ ^ 4.4.2 Linear extrapolation 29
^ 4.4.3 Estimation of potency in the experimental
range 31
4.4.4 Two stage clonal expansion model 32
4.4.5 Proportional analyses carcinogenic and
non neoplastic effects 33
5. EXPOSURE ASSESSMENT 34
5.1 Definition of exposure and related terms 34
5.2 Exposure and dose 35
5.3 Approaches to quantification of exposure 40
5.3.1 Measurement at point of contact
(personal monitoring) 41
5.3.2 Scenario evaluation method (time activity
and monitoring/modelling) 41
5.3.3 Biomarkers of exposure/estimation of
internal dose 47
5.4 Variability and uncertainty 49
5.4.1 Assessing uncertainty 51
5.5 Exposure settings 51
5.5.1 Exposure in the general environment 51
5.5.2 Occupational settings 52
5.5.3 Consumer products 53
6. RISK CHARACTERIZATION AND IMPLICATIONS
FOR RISK MANAGEMENT 58
6.1 General considerations 58
6.2 Considerations in risk characterization 59
6.3 Considerations in risk management 62
6.3.1 Societal factors 62
6.3.2 Individual and population risks 63
6.3.3 Comparative risk 65
6.3.4 Risk perception 65
6.3.5 Risk and hazard communication 66
6.3.6 Economic factors 71
6.3.6.1 Cost benefit analyses 71
6.3.7 Political factors 72
6.3.8 Regulatory limits 73
6.4 Risk management options 75
6.4.1 Risk reduction 75
6.4.1.1 Technology based criteria 76
REFERENCES 77
APPENDIX 88
RESUME 101
RESUMEN 106 |
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| illustrated | Illustrated |
| indexdate | 2024-10-21T18:00:12Z |
| institution | BVB |
| isbn | 9241572108 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008678102 |
| oclc_num | 41672312 |
| open_access_boolean | |
| owner | DE-12 DE-Er8 |
| owner_facet | DE-12 DE-Er8 |
| physical | XX, 110 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Principles for the assessment of risks to human health from exposure to chemicals Geneva World Health Organization 1999 XX, 110 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 210 Blootstelling gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Farmacologia larpcal Gevaarlijke stoffen gtt Gezondheidseffecten gtt Hygiène du milieu Risicoanalyse gtt Risques pour la santé - Évaluation Toxicité Toxicologie - Relations dose-effet Environmental Exposure Environmental health Hazardous Substances adverse effects Health risk assessment Risk Assessment Toxicity testing Gesundheitsgefährdung (DE-588)4071808-6 gnd rswk-swf Risikoanalyse (DE-588)4137042-9 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 s Toxizitätstest (DE-588)4060540-1 s DE-604 Gesundheitsgefährdung (DE-588)4071808-6 s Risikoanalyse (DE-588)4137042-9 s Environmental health criteria 210 (DE-604)BV000011459 210 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008678102&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Principles for the assessment of risks to human health from exposure to chemicals Environmental health criteria Blootstelling gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Farmacologia larpcal Gevaarlijke stoffen gtt Gezondheidseffecten gtt Hygiène du milieu Risicoanalyse gtt Risques pour la santé - Évaluation Toxicité Toxicologie - Relations dose-effet Environmental Exposure Environmental health Hazardous Substances adverse effects Health risk assessment Risk Assessment Toxicity testing Gesundheitsgefährdung (DE-588)4071808-6 gnd Risikoanalyse (DE-588)4137042-9 gnd Toxizitätstest (DE-588)4060540-1 gnd Umweltchemikalie (DE-588)4117281-4 gnd |
| subject_GND | (DE-588)4071808-6 (DE-588)4137042-9 (DE-588)4060540-1 (DE-588)4117281-4 |
| title | Principles for the assessment of risks to human health from exposure to chemicals |
| title_auth | Principles for the assessment of risks to human health from exposure to chemicals |
| title_exact_search | Principles for the assessment of risks to human health from exposure to chemicals |
| title_full | Principles for the assessment of risks to human health from exposure to chemicals |
| title_fullStr | Principles for the assessment of risks to human health from exposure to chemicals |
| title_full_unstemmed | Principles for the assessment of risks to human health from exposure to chemicals |
| title_short | Principles for the assessment of risks to human health from exposure to chemicals |
| title_sort | principles for the assessment of risks to human health from exposure to chemicals |
| topic | Blootstelling gtt CHEMICAL SAFETY unbist CHEMICALS unbist ENVIRONMENTAL HEALTH unbist Farmacologia larpcal Gevaarlijke stoffen gtt Gezondheidseffecten gtt Hygiène du milieu Risicoanalyse gtt Risques pour la santé - Évaluation Toxicité Toxicologie - Relations dose-effet Environmental Exposure Environmental health Hazardous Substances adverse effects Health risk assessment Risk Assessment Toxicity testing Gesundheitsgefährdung (DE-588)4071808-6 gnd Risikoanalyse (DE-588)4137042-9 gnd Toxizitätstest (DE-588)4060540-1 gnd Umweltchemikalie (DE-588)4117281-4 gnd |
| topic_facet | Blootstelling CHEMICAL SAFETY CHEMICALS ENVIRONMENTAL HEALTH Farmacologia Gevaarlijke stoffen Gezondheidseffecten Hygiène du milieu Risicoanalyse Risques pour la santé - Évaluation Toxicité Toxicologie - Relations dose-effet Environmental Exposure Environmental health Hazardous Substances adverse effects Health risk assessment Risk Assessment Toxicity testing Gesundheitsgefährdung Risikoanalyse Toxizitätstest Umweltchemikalie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008678102&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000011459 |