The use of drugs in food animals: benefits and risks
"The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the food animal industry. The book discusses the potential for antibiotic resistance to develop in or be transferred to pathogens that can cause disease in humans. It also provides analysis and insight into...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, DC
National Acad. Pr.
1999
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the food animal industry. The book discusses the potential for antibiotic resistance to develop in or be transferred to pathogens that can cause disease in humans. It also provides analysis and insight into the monitoring of drug use in food animals as well as the monitoring of drug residues in animal-derived food products. The book also discusses how drug use may be minimized with new approaches in food animal production management, including nutrition, vaccination, and genetic strategies."--BOOK JACKET. |
| Beschreibung: | XXI, 253 S. graph. Darst. |
| ISBN: | 0309054346 |
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| 245 | 1 | 0 | |a The use of drugs in food animals |b benefits and risks |c Committee on Drug Use in Food Animals ... . |
| 264 | 1 | |a Washington, DC |b National Acad. Pr. |c 1999 | |
| 300 | |a XXI, 253 S. |b graph. Darst. | ||
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| 520 | 1 | |a "The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the food animal industry. The book discusses the potential for antibiotic resistance to develop in or be transferred to pathogens that can cause disease in humans. It also provides analysis and insight into the monitoring of drug use in food animals as well as the monitoring of drug residues in animal-derived food products. The book also discusses how drug use may be minimized with new approaches in food animal production management, including nutrition, vaccination, and genetic strategies."--BOOK JACKET. | |
| 650 | 7 | |a Residues |2 cabt | |
| 650 | 7 | |a Antibiotics |2 cabt | |
| 650 | 7 | |a Aliments - Contamination |2 ram | |
| 650 | 7 | |a Aliments - Teneur en médicaments vétérinaires |2 ram | |
| 650 | 4 | |a Aliments d'origine animale - Contamination | |
| 650 | 7 | |a Aliments d'origine animale - Toxicologie |2 ram | |
| 650 | 4 | |a Animaux destinés à l'alimentation - Maladies - Chimiothérapie | |
| 650 | 4 | |a Antibiotics in veterinary medicine - United States | |
| 650 | 4 | |a Antibiotiques en médecine vétérinaire | |
| 650 | 7 | |a Antibiotiques en médecine vétérinaire |2 ram | |
| 650 | 4 | |a Food animals - Diseases - Chemotherapy - United States | |
| 650 | 4 | |a Food of animal origin - Contamination - United States | |
| 650 | 4 | |a Médicaments vétérinaires | |
| 650 | 4 | |a Médicaments vétérinaires - Résidus dans les aliments | |
| 650 | 4 | |a Veterinary drug residues - United States | |
| 650 | 4 | |a Veterinary drugs - United States | |
| 650 | 4 | |a Animal Diseases |x drug therapy | |
| 650 | 4 | |a Anti-Bacterial Agents | |
| 650 | 4 | |a Antibiotics in veterinary medicine | |
| 650 | 4 | |a Drug Residues | |
| 650 | 4 | |a Food Contamination | |
| 650 | 4 | |a Food animals |x Diseases |x Chemotherapy | |
| 650 | 4 | |a Food of animal origin |x Contamination | |
| 650 | 4 | |a Veterinary Drugs | |
| 650 | 4 | |a Veterinary drug residues | |
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Datensatz im Suchindex
| _version_ | 1804127422741741568 |
|---|---|
| adam_text | Executive Summary 1
The Committee Process, 3
Food Animal Drug Use, 4
Approval and Oversight of Food Animal Drugs, 5
Monitoring of Drug Residues, 6
Resistance to Antibiotic Drugs, 6
Conclusions, 9
Major Recommendations, 10
Development, Approval, and Availability of Food Animal Drugs, 10
Resistance to Antibiotic Drugs, 11
Alternatives to Drug Use in Food Animals, 11
1 Drugs Used in Food Animals: Background and Perspectives 12
The Role of This Report, 13
Review of Previous Reports, 15
The Antibiotic Issue, 19
A Possible Scenario, 20
The Emergence of Antibiotics in Our Lives, 20
Food Animal Antibiotic Resistance and Human Health, 22
2 Food Animal Production Practices and Drug Use 27
Overview, 27
The Poultry Industry, 29
An Integrated Industry, 30
History and Trends in Drug Use, 31
xv
;CVj CONTENTS
Routes of Drug Administration, 34
Feed, 34
One Day of Age Injection, 34
Water Medication, 34
Growth Promotion, 38
Disease Control, 38
Salmonella Control, 38
Escherichia coli Control, 39
Clostridium Control, 39 !
The Swine Industry, 40 ;
Disease Control and Use of Drugs and Chemicals, 41
Growth and Metabolic Performance, 42
The Dairy Industry, 44
Disease Control and Prophylactic Treatments, 45
Therapeutic Treatment of Disease, 45
Antibiotic Drug Use, 47
Production Enhancers, 48
The Beef Industry, 48
Disease Prevention, 50
Trends in Drug Use, 50
Therapeutic Drug Use, 51
Vaccinations, 53
The Veal Industry, 53
The Sheep Industry, 54
Minor Species, 56
The Aquaculture Industry, 56
Quality Assurance Programs and Animal Health Maintenance, 60
Poultry Quality Assurance Programs, 60
Pork Quality Assurance Programs, 61
Dairy Quality Assurance Programs, 63
Beef Quality Assurance Program, 67
Summary of Findings, 68
3 Benefits and Risks to Human Health 69
Overview, 69
Prevention, 71
Treatment, 72
Benefits of Antibiotic Use, 73
Possible Hazards of Antibiotic Use, 75
Antibiotic Resistance as a Human Health Risk, 76
Antibiotic Resistance Trends, 78
Human Health Risks from Drug Residues in Foods, 81
Antibiotic Toxicities, 83
Allergenicity, 84
I
CONTENTS xvii
Relative Risks: Residues versus Microbial Contamination, 85
Summary of Findings, 86
4 Drug Development, Government Approval, and the
Regulatory Process 88
Overview, 88
Restructuring the Regulatory and Approval Process, 91
Reforming the Regulatory Process, 95
The Animal Medicinal Drug Use Clarification Act, 96
The Animal Drug Availability Act, 99
Human Health Risk, Residues, and Approval, 100
Perspectives on Developing Drugs, 101
Worldwide Harmonization of the Animal Drug Approval Process, 104
Summary of Findings and Recommendations, 106
Recommendations, 107
5 Drug Residues and Microbial Contamination in Food:
Monitoring and Enforcement 110
Drug Residue Standards and Screening, 111
Tracking Drug Residues in Food, 113
Drug Residues in Meat and Poultry, 115
Drug Residues in Fish and Seafood, 119
Drug Residues in Milk, 119
The Grade A Pasteurized Milk Ordinance, 121
Drug Residue Testing in Milk, 122
Drug Monitoring in Milk, 124
Unresolved Dairy Testing Issues, 125
Food Borne Pathogens and Contamination of Food, 126
Determination of Pathogens, 127
A Nine Year Survey of Reported Food Borne Dlness, 133
Integrating Issues of Residues and Microbial Contamination, 137
Summary of Findings and Recommendations, 140
Recommendations, 141
6 Issues Specific to Antibiotics 142
Development and Functionality of Antibiotic Drugs, 143
Identifying and Screening Antibiotics, 145
Bacterial Resistance, 148
Antibiotic Resistant Bacteria and Animal Management, 150
Subtherapeutic versus Therapeutic Use of Drugs, 153
Human and Veterinary Clinical Implications of Antibiotic Resistance, 161
Cases to Test the System, 166
The Fluoroquinolones Issue, 168
The Virginiamycin Issue, 175
xviii CONTENTS
Summary of Findings and Recommendations, 176
Recommendations, 177
7 Costs of Eliminating Subtherapeutic Use of Antibiotics 179
Considerations in Determining the Effect of a Ban, 180
Definition of Subtherapeutic Use, 180
Measurement Choice, 180
Viable Antibiotic Substitutes, 182
Total Versus Partial Ban, 182
Consumer Behavior, 183
Results of Economic Analysis and Conclusions, 184
Appendix, 186
Technical Notes for Table 7 1, 186
Chicken Data, 186
Turkey Data, 187
Beef Data, 187
Pork Data, 187
8 Approaches to Minimizing Antibiotic Use in Food Animal
Production 188
Animal Management, 190
Ambient Temperature and Heat Stress, 190
Overcrowding and Behavioral Stress, 193
Vaccination Strategies to Prevent Disease, 193
DNA Vaccination, 195
Beneficial Microbial Cultures, Probiotics, and Competitive
Exclusion Alternatives, 195
Biosecurity, 197
Fly Control, 199
Moisture, Mud, and Manure, 199
Enhancing Natural Mediators of Immune Function, 200
Killed Bacterial Adjuvants: Biomodulation of Cytokine
and Immune Function, 202
Nutrition, 202
Disease Eradication 206
Genetics, 207
Recommendations, 208
References 210
About the Authors 235
Index 239
Tables and Figures
TABLES
1 1 Summary of Previous Major Reports on Food Animal Antibiotics, 16
2 1 Coccidiostats Approved for Use in Broilers, Turkeys, and Layers, 32
2 2 Major Claims of Antibiotics Approved for Use in Chickens and
Turkeys, 32
2 3 Cost of Drug and Vaccine Use in Broilers from 1989 to 1994, 35
2 4 Turkey Medication and Vaccine Cost Analysis, 36
2 5 Cost of Medication and Vaccination Used for Turkeys and Broilers in the
United States, 37
2 6 Major Claims of Antibiotics Approved for Use in Hogs, 42
2 7 Major Claims of Chemotherapeutics Approved for Use in Hogs, 43
2 8 Intramammary Antibiotics Approved for Dairy Cattle, 45
2 9 Distribution of Health Costs per Cow by Functional Category, 46
2 10 Estimated Annual Losses Caused by Mastitis, 47
2 11 Major Claims for Systemic Antimicrobials Approved for Use in Beef and
Dairy Cattle, 52 J¥,_ .
2 12 Steroid Products Labeled for Improved Growth and/or Feed Efficiency in
Cattle, 53
2 13 Major Claims of Antibacterials Approved for Use in Sheep, 53
2 14 Major Claims for Drugs Approved for Use in Minor Species, 57
2 15 FDA Approved New Drugs for Use in Aquaculture, 59
xix
XX TABLES AND FIGURES
3 1 The Effect of Implementation of a Veterinary Preventive Medicine
Scheme on Offal and Carcass Rejections from 12 Finishing Farms, 76
4 1 Food Animal Populations in the United States, 102
4 2 Comparative Value of FDA Regulated Industries, 102
4 3 Annual Sales of Animal Drugs, 103
5 1 FSIS Animal Drug Residue Test Results, 118
5 2 Drug Residue Analysis Results for Grade A and Non Grade A Milk, 121
5 3 Survey Report of Microbiological Hazards in Swine, 128
5 4 Survey Report of Microbiological Hazards in Cattle, 130
5 5 Survey Report of Microbiological Hazards in Lamb, 132
5 6 Survey Report of Microbiological Hazards in Poultry, 134
6 1 E. coli Resistance to TMP SMX, 163
6 2 Resistance of TMP SMX Resistant E. coli Isolates to Other
Antimicrobial Agents, 164
6 3 Antimicrobial Resistance of E. coli Strains Isolated from
Enteritis in Calves in the United States, Canada, and France, 165
6 4 Antibiotic Resistance in Salmonella from Animals, Percentage of
Cultures Showing Resistance, 165
6 5 Antibiotic Resistance in Salmonella typhimurium from Animals,
Percentage of Cultures Showing Resistance, 167
7 1 Approximate Annual Costs of a Ban on Subtherapeutic Antibiotic Use
in Four Domestic Retail Markets, 185
8 1 Efficacy of Recombinant Bovine IFN y against E. coli Mastitis, 201
8 2 Effect of GCSF on Blood and Milk Leukocyte Profiles and Efficacy
against Staphylococcus aureus Mastitis, 201
8 3 Blood Selenium, GSH Px, and Serum Vitamin E of Cows from Low and
High SCC Herds, 204
FIGURES
4 1 CVM Organizational Structure, 90
4 2 Comparison of the Traditional and Re Engineered Approval
Processes, 92
4 3 Effect of Re Engineering the Approval Process on the Time to
Approve New Animal Drug Applications, 93
4 4 Trends in Animal Drug Approvals since 1990, 94
j
i
TABLES AND FIGURES xxi
5 1 Seasonally of Reported Cases of Food Borne Disease as Monitored
Across the Seven Sentinel Organisms at All Locations, 137
6 1 Salmonella DT 104 Ciprofloxacin Resistant Human Isolates Confirmed
in the United Kingdom, 173
|
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| id | DE-604.BV012756018 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:33:06Z |
| institution | BVB |
| isbn | 0309054346 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008673450 |
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| publisher | National Acad. Pr. |
| record_format | marc |
| spelling | The use of drugs in food animals benefits and risks Committee on Drug Use in Food Animals ... . Washington, DC National Acad. Pr. 1999 XXI, 253 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier "The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the food animal industry. The book discusses the potential for antibiotic resistance to develop in or be transferred to pathogens that can cause disease in humans. It also provides analysis and insight into the monitoring of drug use in food animals as well as the monitoring of drug residues in animal-derived food products. The book also discusses how drug use may be minimized with new approaches in food animal production management, including nutrition, vaccination, and genetic strategies."--BOOK JACKET. Residues cabt Antibiotics cabt Aliments - Contamination ram Aliments - Teneur en médicaments vétérinaires ram Aliments d'origine animale - Contamination Aliments d'origine animale - Toxicologie ram Animaux destinés à l'alimentation - Maladies - Chimiothérapie Antibiotics in veterinary medicine - United States Antibiotiques en médecine vétérinaire Antibiotiques en médecine vétérinaire ram Food animals - Diseases - Chemotherapy - United States Food of animal origin - Contamination - United States Médicaments vétérinaires Médicaments vétérinaires - Résidus dans les aliments Veterinary drug residues - United States Veterinary drugs - United States Animal Diseases drug therapy Anti-Bacterial Agents Antibiotics in veterinary medicine Drug Residues Food Contamination Food animals Diseases Chemotherapy Food of animal origin Contamination Veterinary Drugs Veterinary drug residues Veterinary drugs Fütterungsantibiotikum (DE-588)4327257-5 gnd rswk-swf Nutztiere (DE-588)4042839-4 gnd rswk-swf Tierarzneimittel (DE-588)4134081-4 gnd rswk-swf Risiko (DE-588)4050129-2 gnd rswk-swf Nutztiere (DE-588)4042839-4 s Tierarzneimittel (DE-588)4134081-4 s Risiko (DE-588)4050129-2 s DE-604 Fütterungsantibiotikum (DE-588)4327257-5 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008673450&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The use of drugs in food animals benefits and risks Residues cabt Antibiotics cabt Aliments - Contamination ram Aliments - Teneur en médicaments vétérinaires ram Aliments d'origine animale - Contamination Aliments d'origine animale - Toxicologie ram Animaux destinés à l'alimentation - Maladies - Chimiothérapie Antibiotics in veterinary medicine - United States Antibiotiques en médecine vétérinaire Antibiotiques en médecine vétérinaire ram Food animals - Diseases - Chemotherapy - United States Food of animal origin - Contamination - United States Médicaments vétérinaires Médicaments vétérinaires - Résidus dans les aliments Veterinary drug residues - United States Veterinary drugs - United States Animal Diseases drug therapy Anti-Bacterial Agents Antibiotics in veterinary medicine Drug Residues Food Contamination Food animals Diseases Chemotherapy Food of animal origin Contamination Veterinary Drugs Veterinary drug residues Veterinary drugs Fütterungsantibiotikum (DE-588)4327257-5 gnd Nutztiere (DE-588)4042839-4 gnd Tierarzneimittel (DE-588)4134081-4 gnd Risiko (DE-588)4050129-2 gnd |
| subject_GND | (DE-588)4327257-5 (DE-588)4042839-4 (DE-588)4134081-4 (DE-588)4050129-2 |
| title | The use of drugs in food animals benefits and risks |
| title_auth | The use of drugs in food animals benefits and risks |
| title_exact_search | The use of drugs in food animals benefits and risks |
| title_full | The use of drugs in food animals benefits and risks Committee on Drug Use in Food Animals ... . |
| title_fullStr | The use of drugs in food animals benefits and risks Committee on Drug Use in Food Animals ... . |
| title_full_unstemmed | The use of drugs in food animals benefits and risks Committee on Drug Use in Food Animals ... . |
| title_short | The use of drugs in food animals |
| title_sort | the use of drugs in food animals benefits and risks |
| title_sub | benefits and risks |
| topic | Residues cabt Antibiotics cabt Aliments - Contamination ram Aliments - Teneur en médicaments vétérinaires ram Aliments d'origine animale - Contamination Aliments d'origine animale - Toxicologie ram Animaux destinés à l'alimentation - Maladies - Chimiothérapie Antibiotics in veterinary medicine - United States Antibiotiques en médecine vétérinaire Antibiotiques en médecine vétérinaire ram Food animals - Diseases - Chemotherapy - United States Food of animal origin - Contamination - United States Médicaments vétérinaires Médicaments vétérinaires - Résidus dans les aliments Veterinary drug residues - United States Veterinary drugs - United States Animal Diseases drug therapy Anti-Bacterial Agents Antibiotics in veterinary medicine Drug Residues Food Contamination Food animals Diseases Chemotherapy Food of animal origin Contamination Veterinary Drugs Veterinary drug residues Veterinary drugs Fütterungsantibiotikum (DE-588)4327257-5 gnd Nutztiere (DE-588)4042839-4 gnd Tierarzneimittel (DE-588)4134081-4 gnd Risiko (DE-588)4050129-2 gnd |
| topic_facet | Residues Antibiotics Aliments - Contamination Aliments - Teneur en médicaments vétérinaires Aliments d'origine animale - Contamination Aliments d'origine animale - Toxicologie Animaux destinés à l'alimentation - Maladies - Chimiothérapie Antibiotics in veterinary medicine - United States Antibiotiques en médecine vétérinaire Food animals - Diseases - Chemotherapy - United States Food of animal origin - Contamination - United States Médicaments vétérinaires Médicaments vétérinaires - Résidus dans les aliments Veterinary drug residues - United States Veterinary drugs - United States Animal Diseases drug therapy Anti-Bacterial Agents Antibiotics in veterinary medicine Drug Residues Food Contamination Food animals Diseases Chemotherapy Food of animal origin Contamination Veterinary Drugs Veterinary drug residues Veterinary drugs Fütterungsantibiotikum Nutztiere Tierarzneimittel Risiko |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008673450&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |