Estrogens and antiestrogens: 1 Physiology and mechanisms of action of estrogens and antiestrogens
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1999
|
| Schriftenreihe: | Handbook of experimental pharmacology
135,1 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVI, 407 S. Ill., graph. Darst. |
| ISBN: | 3540650164 |
Internformat
MARC
| LEADER | 00000nam a2200000 cc4500 | ||
|---|---|---|---|
| 001 | BV012712917 | ||
| 003 | DE-604 | ||
| 005 | 20140404 | ||
| 007 | t | ||
| 008 | 990812s1999 ad|| |||| 00||| eng d | ||
| 020 | |a 3540650164 |9 3-540-65016-4 | ||
| 035 | |a (OCoLC)247288850 | ||
| 035 | |a (DE-599)BVBBV012712917 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-19 |a DE-12 |a DE-188 |a DE-578 | ||
| 084 | |a XI 1700 |0 (DE-625)152977:12905 |2 rvk | ||
| 084 | |a QV 4 |2 nlm | ||
| 245 | 1 | 0 | |a Estrogens and antiestrogens |n 1 |p Physiology and mechanisms of action of estrogens and antiestrogens |c ed. M. Oettel ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1999 | |
| 300 | |a XXVI, 407 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 135,1 | |
| 490 | 0 | |a Handbook of experimental pharmacology |v ... | |
| 700 | 1 | |a Oettel, Michael |d 1939- |e Sonstige |0 (DE-588)13725931X |4 oth | |
| 700 | 1 | |a Alves, Stephen E. |e Sonstige |4 oth | |
| 700 | 1 | |a Anderson, Elizabeth |e Sonstige |4 oth | |
| 773 | 0 | 8 | |w (DE-604)BV012712897 |g 1 |
| 830 | 0 | |a Handbook of experimental pharmacology |v 135,1 |w (DE-604)BV002390716 |9 135,1 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008641921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
Datensatz im Suchindex
| _version_ | 1805075462495404032 |
|---|---|
| adam_text |
Contents
CHAPTER 1
History of Estrogen Research
C. Lauritzen 1
A. The Classical Experiments of Extirpation
and Reimplantation 1
I. Ovarian Extracts 1
B. Isolation of Estrogens 1
C. Analysis of the Steroid Structure; Nomenclature
and Standardization 2
D. Partial and Total Synthesis of Estrogens 2
E. Localization of the Estrogen Production 2
F. Estrogens in Body Fluids and Tissues 3
G. Estrogens in Food 3
H. Estrogen Determination 4
I. Estradiol Effects at the Target Organs 4
I. Vagina and Endometrium 4
II. Breasts 4
III. Hypothalamus and Pituitary 4
J. Biogenesis and Metabolism of Estrogens 5
K. Physiological Effects of Estrogens 5
I. Genomic Actions 5
II. Non genomic Actions 6
L. Mechanism of Action of Estrogens 6
M. Effects on Lipids 6
N. Effects on Coagulation 7
O. Estrogens in Pregnancy 7
P. Fetal Endocrinology 7
Q. Estrogens for Treatment 7
I. Preparations 7
II. Treatment of Cycle Anomalies, Bleeding Disturbances
and Dysmenorrhea 8
R. Side Effects of Estrogens 8
S. Treatment in Pregnancy 8
T. Treatment of Climacteric Complaints 8
XII Contents
U. Estrogens and Carcinogenesis 9
V. Estrogens and Life Expectancy 9
References 10
Part 1: Chemistry of Estrogens and Antiestrogens
CHAPTER 2
Steroidal Estrogens
G. Neef 17
A. Introduction 17
B. Total Synthesis 18
C. Partial Synthesis 20
I. Ring A Substitution 21
II. Ring B Substitution 25
III. Ring C Substitution 28
IV. Ring D Substitution 30
V. The Periphery 33
D. Labeling of Estradiol and its Derivatives 34
E. Bioconversions of Estrogens 35
References 35
CHAPTER 3
Non steroidal Estrogens
J.A. Dodge and CD. Jones 43
A. Introduction 43
B. Structural Classifications of Non Steroidal Estrogens 44
I. 1,2 Diarylethanes and Ethylenes 44
1. Diethylstilbestrol (DES), hexestrol (HES) and
Analogs 44
2. Structure Activity Relationships 45
3. DES Metabolites 46
II. Flavones and Isoflavones 47
III. Macrolactones 47
IV. Alkylphenols and Arylphenols 49
V. Non Aromatic Estrogens 49
VI. Miscellaneous Non Steriodal Templates 50
C. Conclusions 50
References 50
CHAPTER 4
Antiestrogens and Partial Agonists
E. von Angerer. With 17 Figures 55
[
Contents XIII
A. Introduction 55
B. Triphenylethylene Derivatives 56
I. Tamoxifen 56
II. Triphenylethylene Derivatives Related to Tamoxifen 57
III. Fixed Ring Analogues of Tamoxifen 61
IV. 1,2,3 Triarylpropenone Derived Antiestrogens 63
C. Diphenylethylene Derivatives 66
I. 1,1 Diphenylethylene Derived Agents 66
II. 1,2 Diphenylethylene Derivatives 67
III. 2 Phenylindoles and Related Heterocycles 68
D. Steroidal Compounds 70
I. 7a Substituted Estradiol Derivatives 70
II. 11/3 Substituted Estradiol Derivatives 72
E. Conclusion 74
References 75
CHAPTER 5
Structure Activity Relationships
E. von Angerer. With 2 Figures 81
A. Introduction 81
B. Estrogens and Antiestrogens with a Modified
Steroid Structure 82
I. Modifications of the A Ring 84
II. Modifications of the D Ring 84
III. Modifications of the B Ring 85
IV. Modifications of the C Ring 87
V. Conclusion 87
C. Non Steroidal Estrogens and Antiestrogens 90
I. Derivatives of Diethylstilbestrol 90
II. 2 Phenylindole Derivatives 91
III. 2 Phenylbenzo[b]thiophene Derivatives 94
IV. Triphenylethylene Derivatives 94
V. 2,3 Triphenyl 2H l Benzopyrans and
Related Structures 98
VI. Conclusion 100
References 101
Part 2: Molecular Biology of Estrogenic Action
CHAPTER 6
Structure and Function of the Estrogen Receptor
A.K. Hmi and W. Wahli. With 3 Figures Ill
XIV Contents
A. Introduction Ill
B. Structure of the Estrogen Receptor Ill
I. The A/B Domain 112
II. The DNA Binding Domain 112
III. The Ligand Binding Domain 115
C. ER Functions and Transcription 116
I. ER DNA Binding Properties 116
II. ER Ligand Independent Activity 117
III. Ligand Dependent Transcriptional Activity 117
D. ER Isotype Diversity Generates Specificity 120
I. ERa and ER/3 Heterodimerization 120
II. Tissue Distribution and Ligand Binding 120
III. ERa and ER/3 Differential Activity 121
E. ERa Knock Out Mouse: A Functional Model 122
F. Future Directions 122
References 123
CHAPTER 7
Estrogen Regulated Genes
A. Weisz 127
A. Introduction 127
B. Transcriptional Control of Gene Activity by Estrogens 129
I. Molecular and Cellular Determinants of
Gene Responses to Estrogens 130
1. The Estrogen Receptors 130
2. Estrogen Reponsive Gene Elements 132
a) Estrogen Response Elements and
Other Estrogen Responsive DNA Elements 132
b) Target Gene Promoters 135
3. The Target Cell Environment 135
C. Non transcriptional Control of Gene Activity by Estrogens 137
I. Post transcriptional Effects of Estrogens 138
II. Extra Genomic Effects of Estrogens 139
References 139
CHAPTER 8
Regulation of Constitutive and Inducible Nitric Oxide Synthase
by Estrogen
K. Kauser and G.M. Rubanyi. With 6 Figures 153
A. Introduction 153
B. Isoenzymes of NOS 153
I. Nitric Oxide Synthase I 154
Contents XV
II. Nitric Oxide Synthase II 154
III. Nitric Oxide Synthase III 155
C. Regulation of NOS Isoenzymes by 17/J Estradiol 155
I. Inhibition of NOS II Activity by 17i3 Estradiol 155
II. Upregulation of Endothelial NOS III Activity by
17/3 Estradiol 156
1. Gender Difference and the Effect of 17/J Estradiol on
Endothelial Function 158
2. Potential Mechanism of Estrogen Induced Increased
Endothelial NO Production 159
a) NOS III Gene Expression 159
b) NOS III Enzyme Activity 161
c) Bioactivity of NO 162
3. Role of the Estrogen Receptor in the Regulation
of NOS III 162
4. Role of Increased Endothelial NO in
the Anti Atherosclerotic Effect of 17/3 Estradiol 164
D. Summary 165
References 166
CHAPTER 9
Non Genomic Effects of Estrogens
V.D. Ramirez and J. Zheng . With 5 Figures 171
List of Abbreviations 171
A. Introduction 172
B. Evidence for Fast Estradiol Evoked Biological Responses 173
I. Central Biological Responses 173
1. Fast Estradiol Effects on the Catecholamine
System 173
2. Fast Estradiol Effects on the Hippocampus 174
3. Fast Estradiol Effects on Other Areas of the
Central Nervous System 176
II. Peripheral Biological Responses 177
C. Evidence for Specific Estradiol Binding Sites in
Cellular Membranes 180
I. Central Sites 180
II. Peripheral Sites 181
D. Evidence for Diverse Protein Estrogen Binders 182
I. Estrogen Binders in Plasmalemmal Microsomal
Fractions 182
II. Estrogen Binders in Mitochondrial Lysosomal
Fractions 184
III. Estrogen Binders from Other Origins 184
XVI Contents
E. Diverse Mechanisms in the Fast Actions of Estradiol 186
I. Channel Regulator 187
1. Ca2+ Channels 187
2. Others 187
II. Transduction Activator 188
1. Cyclic Adenosine Monophosphate (cAMP) 188
2. Phospholipase C (PLC) 188
3. Mitogen Activated Protein Kinase (MAPK) 188
III. Metabolic Regulator 189
1. ATPase/ATP Synthase 189
2. Glyceraldehyde 3 Phosphate Dehydrogenase
(G3PD) 190
3. Others 191
F. Overview and Concluding Remarks 192
I. The Continuum Theory 192
References 193
CHAPTER 10
Molecular Mechanisms of Antiestrogen Action
L.T. Seery, J.M.W. Gee, O.L. Dewhurst, and R.I. Nicholson 201
A. Introduction 201
B. Key Elements in Estrogen Receptor Signalling Important
for Antiestrogen Action 202
C. Molecular Actions of Antiestrogens 204
I. Effects of Antiestrogens on Binding to the Receptor,
Dimerisation and Nuclear Localisation 205
II. Effects of Antiestrogens on Estrogen Receptor (ER)
Estrogen Response Element (ERE) Binding and
Subsequent Transcriptional Activation 205
1. Altered ER ERE Binding Efficiency 205
2. Changes in ER Conformation Influence
AF 2 Activity 206
3. Effects Enabled by AF 1 and the Phenomenon
of AF l/AF 2 Promoter Dependency 206
4. Effects Enabled by the Cellular Levels of
Co Activators/Co Repressors 207
5. Effects on Ligand Independent ERE
Transactivation 207
6. Effects Enabled by Promoter Elements and
ERE Sequence 208
7. Effects Enabled by ER Sub Type 208
III. Effects on Ap 1 and NF xB Mediated
Transactivation 208
Contents XVII
IV. Effects on Antiestrogen Specific Response
Elements 209
V. Effects on ER Degradation 209
VI. Non ER Action of Antiestrogens 209
D. Modifying Effects of the Normal Cellular Phenotype on
Antiestrogen Response 210
E. Modifying Effects of the Cancer Cell Phenotype on
Antiestrogen Response 212
F. Conclusions 213
References 213
Part 3: Biosynthesis and Metabolism of Endogenous Estrogens
CHAPTER 11
Estrogen Transforming Enzymes
MJ. Reed and A. Purohit. With 2 Figures 223
A. Introduction 223
B. Metabolism of Estradiol by 17/3 Hydroxysteroid
Dehydrogenase Type 2 (HSD2) 223
I. 17/7HSD Superfamily 223
II. Tissue Distribution 225
III. Regulation of 17/JHSD2 226
C. Cytochrome P450 Mono Oxygenase Hydroxylation of
Estrogens 227
I. Cytochrome P4s,)S 227
II. C2 and C16a Hydroxylation of Estrogens 227
1. Effect of 2 or 16a Hydroxylation on
Metabolite Estrogenicity 227
2. Modulation by Thyroid Hormones, Body Weight and
Diet 227
3. Effect of Smoking on C2/C16a Hydroxylation 228
4. C2/C16a Hydroxylation and Breast Cancer 229
5. Induction of C2 Hydroxylation by lndole 3
Carbinol 229
6. C2/C16a Hydroxylation in Different Ethnic Groups . 230
7. Effect of Pesticides on C2/C16a Estrogen
Hydroxylation 231
8. Inhibition of C2 Hydroxylation 231
9. Estrogen 2 Hydroxylation by Placental Aromatase 231
D. Catechol Estrogens and Carcinogenesis 232
E. Estrogen Sulphates 233
I. Estrogen Sulphate Formation 233
II. Biological Role of Estrogen Sulphation 233
III. Regulation of Estrogen Sulphation 234
XVIII Contents
F. Estrogen Glucuronides 235
G. Lipoidal Estrogens 235
H. Conclusions 237
References 237
CHAPTER 12
Metabolism of Endogenous Estrogens
T.H. Lippert, H. Seeger, and A.O. Mueck. With 3 Figures 243
A. Introduction 243
I. Estradiol Breakdown Mechanisms 243
II. Sex Differences in Estradiol Metabolism 246
III. Catechol Estrogen Metabolism 248
B. Estrogen Metabolism and Disease 249
I. Breast Cancer 251
II. Endometrial Cancer 252
III. Cervical Cancer 253
IV. Prostate Cancer 253
V. Papilloma of the Larynx 254
VI. Liver Disease 254
VII. Lupus Erythematosus 255
VIII. Disease of the Thyroid 255
IX. Weight Changes 256
X. Depression 256
XI. Osteoporosis 257
C. Drugs 257
D. Lifestyle 259
E. Pregnancy 261
I. Changes in Metabolism During Pregnancy 264
References 265
Part 4: Physiology and Pathophysiology of Estrogens
CHAPTER 13
Phylogeny of Estrogen Synthesis, Extragenital Distribution of
Estrogen Receptors and Their Development Role
L. Sobek and V.K. Patchev 275
A. Phylogeny of Estrogen Synthesis 275
B. Extragenital Distribution of Estrogen Receptors and
Their Functional Significance 276
I. Breast 276
Contents XIX
II. Bone 276
III. Gastrointestinal Tract 277
IV. Cardiovascular System 278
V. Immune System 278
VI. Pituitary 279
VII. Central Nervous System 280
VIII. Membrane Bound ERs 281
C. Hormonal Regulation of ER Synthesis 282
I. Estrogens 282
II. Thyroid Hormones 283
III. Progesterone 283
IV. Androgens 283
V. Glucocorticoids 284
VI. Neurotransmitters 284
D. Developmental Role of ERs as Exemplified by Hormone
Dependent Brain Differentiation 285
References 288
CHAPTER 14
Female Reproductive Tract
C. Hegele Hartung. With 4 Figures 299
A. Embryology of the Reproductive Tract 299
B. Sex Differentiation 300
I. Genetic Sex 300
II. Gonadal Sex ' 301
1. Male 301
2. Female 302
III. Somatic Sex 302
1. Male Sex Differentiation 302
2. Female Sex Differentiation 303
3. Estrogens and Sex Differentiation 304
C. Estrogens and Ovary 304
D. Fallopian Tubes 305
I. Steroidal Regulation 305
E. Uterus 306
I. Estrogen Regulation 307
II. Estrogens and Uterine Pathology 309
F. Cervix 309
I. Estrogen Regulation 309
G. Vagina 310
I. Estrogens and Vaginal Pathology 310
References 310
XX Contents
CHAPTER 15
Estrogen and Brain Function: Implications for Aging
and Dementia
S.E. Alves and B.S. McEwen 315
List of Abbreviations 315
A. Introduction 315
B. Current Views on Estrogen's Mechanism of Action 316
C. Non Reproductive Brain Functions Influenced by Estrogen 317
I. Cognition (Learning and Memory) 317
1. Basal Forebrain Cholinergic System 317
2. Hippocampal y Aminobutyric Acid (GABA)
Interneurons 318
3. Hippocampal CA1 Pyramidal Neurons 318
II. Psychological Function 319
1. Midbrain Serotonergic Neurons 319
III. Sensorimotor Performance 321
1. Nigrostriatal Dopaminergic System 321
IV. Non Neuronal Functions: "Brain Maintenance" 322
1. Glial Cells 322
2. Endothelial Cells of the Blood Brain Barrier (BBB) 323
D. Summary 324
References 324
CHAPTER 16
Cardiovascular System
M. Birkhauser. With 4 Figures 329
A. Introduction 329
B. Cardioprotective Mechanism of Estrogens 331
I. Indirect Action on the Cardiovascular System by
a Change of the Lipid Balance 331
1. Atherogenic Lipoproteins 331
2. High Density Lipoprotein 332
3. Lipoprotein (a) 332
4. Influence of Estrogen Replacement Therapy and
HRT on the Lipid Profile 333
II. Direct Effect of Estrogens on the Vascular Wall 333
C. Influence of Progesterone and Progestagens 337
D. Conclusion 338
References 338
CHAPTER 17
Immune System
E. Nagy, E. Baral, and I. Berczi. With 1 Figure 343
Contents XXI
A. Introduction 343
B. Effect on Primary Lymphoid Tissue 343
I. The Effect of Estrogens 343
1. The Bone Marrow 343
2. The Thymus 344
C. Effect on Immune Function 344
I. The Effect of Estrogens 344
1. Receptors 344
2. Cytokines 344
3. Humoral Immunity 345
4. Cell Mediated Immunity 345
5. Inflammation 345
II. The Effect of Anti Estrogens 346
1. Lymphocytes 346
2. Humoral Immunity 346
3. Cell Mediated Immunity 346
4. Inflammation 347
D. Conclusions 347
References 348
CHAPTER 18
Male Reproductive Function
M. Simoni and E. Nieschlag 353
A. Introduction 353
B. Source of Estrogen in the Male 353
C. Localization of the Estrogen Receptor in the
Male Genital Tract 353
D. Function of Estrogens in the Male 355
I. Bone Maturation 355
II. Testicular Function 355
III. Prostate 357
IV. Behavior 358
E. Conclusions 358
References 359
CHAPTER 19
The Effect of Estrogens and Antiestrogens on the Urogenital Tract
A. Hextall and L. Cardozo. With 2 Figures 363
A. Introduction 363
B. Pathophysiology 363
I. Hormonal Influences on the Urogenital Tract 363
II. The Effect of Ageing on the Bladder 364
XXII Contents
C. Estrogen and Urinary Incontinence 365
I. Epidemiological Studies 365
II. Estrogen and the Continence Mechanism 367
III. Estrogens for Stress Incontinence 368
IV. Estrogens for Urge Incontinence 370
D. Estrogen for Recurrent Urinary Tract Infections 370
E. Estrogen for Vaginal Atrophy 371
F. Antiestrogens and the Urogenital Tract 372
G. Conclusions 373
References 373
CHAPTER 20
Effects of Estrogens on Various Endocrine Regulations
F. Gomez 379
A. The Complexity of Estrogen's Action on Various Tissues 379
I. Introduction 379
II. Estrogen Receptor Mediated Tissue Specificity 379
III. Sex Hormone Binding Globulin Mediated
Estrogenic Action 380
B. Estrogens and the Thyroid 381
I. Sexual Dimorphism in Thyroid Disease 381
II. The Effect of Estrogens in Thyroid Enlargement 381
III. Thyroid Dysfunction 382
IV. Thyroid Hormone Binding Globulin 382
V. Thyrotropin Regulation 383
C. Estrogens and the Adrenal Glands 384
I. Sexual Dimorphism in Adrenal Disease? 384
II. Regulation of Adrenal Sex Steroid Precursors 384
III. Anti toxic Properties of the Adrenal Glands 385
IV. Corticosteroid Binding Globulin 386
V. Corticotropin Regulation 386
D. Estrogens and the Phosphocalcic Metabolism 387
I. Bone Remodeling and Calcium Kinetics 387
II. Parathyroid Hormone 389
III. Vitamin D 390
References 391
Subject Index 397
Contents of Companion Volume 135/11
Part 5: Pharmacology of Estrogens and Antiestrogens
CHAPTER 21
In Vitro and In Vivo Models to Characterise Estrogens
and Antiestrogens
K. H. Fritzemeier and C. Hegele Hartung 3
CHAPTER 22
Estrogen Receptor (3 in the Pharmacology of Estrogens
and Antiestrogens
G. Kuiper, M. Warner, and J. A. Gustafsson 95
CHAPTER 23
Interrelationship of Estrogens with Other Hormones or
Endocrine Systems
N. Navizadeh and EZ. Stanczyk 105
CHAPTER 24
Mammary Gland
G. Soderqvist and B. von Schoultz 113
CHAPTER 25
Cardiovascular System
G. Samsioe 129
CHAPTER 26
Bone
B. Winding, H. J0rgensen, and C Christiansen 141
CHAPTER 27
Central Nervous System
R. Gallo, M. Stomati, A. Spinetti, F. Petraglia, and
A.R. Genazzani 151
XXIV Contents of Companion Volume 135/11
CHAPTER 28
Liver Inclusive Protein, Lipid and Carbohydrate Metabolism
L. Sahlin and B. von Schoultz 163
CHAPTER 29
Pharmacology of Antiestrogens
A.E. Wakeling 179
CHAPTER 30
Oncology
E.V. Jensen 195
CHAPTER 31
Hormonal Resistance in Breast Cancer
S.R.D. Johnston, E. Anderson, M. Dowsett, and A. Howell 205
CHAPTER 32
Pharmacology of Inhibitors of Estrogen Biosynthesis
A.S. Bhatnagar and W.R. Miller 223
CHAPTER 33
Pharmacology of Inhibitors of Estrogen Metabolizing Enzymes
M.J. Reed and A. Purohit 231
CHAPTER 34
Pharmacology of Different Administration Routes Oral vs
Transdermal
R. Sitruk Ware 247
Part 6: Kinetics and Toxicology of Estrogens and Antiestrogens
CHAPTER 35
Pharmacokinetics of Exogenous Natural and Synthetic Estrogens
and Antiestrogens
W. Kuhnz, H. Blode, and H. Zimmermann 261
Contents of Companion Volume 135/11 XXV
CHAPTER 36
Toxicology of Estrogens and Antiestrogens
H. ZlMMERMANN 323
CHAPTER 37
Estrogens and Sexually Transmitted Diseases
M. Doren 353
Part 7: Clinical Application and Potential of Estrogens
and Antiestrogens
CHAPTER 38
Hormonal Contraception
H. Kuhl 363
CHAPTER 39
Hormone Replacement Including Osteoporosis
H.L. J0rgensen and B. Winding 409
CHAPTER 40
Gynaecological Disorders
G. Samsioe 423
CHAPTER 41
Oncology
R.Q. Wharton and S.K. Jonas 431
CHAPTER 42
Cardiology
E.F. Mammen 447
CHAPTER 43
Urogenital Ageing and Dermatology
M. Doren 461
CHAPTER 44
Geriatric Neurology and Psychiatry
V.W. Henderson 473
XXVI Contents of Companion Volume 135/11
CHAPTER 45
Estrogens and Antiestrogens in the Male
M. Oettel 505
Part 8: Comparative Endocrinology
CHAPTER 46
Comparative Aspects of Estrogen Biosynthesis and Metabolism and
the Endocrinological Consequences in Different Animal Species
H.H.D. Meyer 575
CHAPTER 47
Therapeutic Use of Estrogens in Veterinary Medicine
M. Oettel 603
Part 9: Estrogens, Antiestrogens, and the Environment
CHAPTER 48
Environmental Estrogens
S. Makela, S.M. Hyder, and G.M. Stancel 613
Subject Index 665 |
| any_adam_object | 1 |
| author_GND | (DE-588)13725931X |
| building | Verbundindex |
| bvnumber | BV012712917 |
| classification_rvk | XI 1700 |
| ctrlnum | (OCoLC)247288850 (DE-599)BVBBV012712917 |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 cc4500</leader><controlfield tag="001">BV012712917</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20140404</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">990812s1999 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540650164</subfield><subfield code="9">3-540-65016-4</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)247288850</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012712917</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-188</subfield><subfield code="a">DE-578</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 1700</subfield><subfield code="0">(DE-625)152977:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">QV 4</subfield><subfield code="2">nlm</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Estrogens and antiestrogens</subfield><subfield code="n">1</subfield><subfield code="p">Physiology and mechanisms of action of estrogens and antiestrogens</subfield><subfield code="c">ed. M. Oettel ...</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXVI, 407 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">135,1</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">...</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oettel, Michael</subfield><subfield code="d">1939-</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)13725931X</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alves, Stephen E.</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Anderson, Elizabeth</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="w">(DE-604)BV012712897</subfield><subfield code="g">1</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Handbook of experimental pharmacology</subfield><subfield code="v">135,1</subfield><subfield code="w">(DE-604)BV002390716</subfield><subfield code="9">135,1</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008641921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield></record></collection> |
| id | DE-604.BV012712917 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T05:41:47Z |
| institution | BVB |
| isbn | 3540650164 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008641921 |
| oclc_num | 247288850 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-12 DE-188 DE-578 |
| physical | XXVI, 407 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Estrogens and antiestrogens 1 Physiology and mechanisms of action of estrogens and antiestrogens ed. M. Oettel ... Berlin [u.a.] Springer 1999 XXVI, 407 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 135,1 Handbook of experimental pharmacology ... Oettel, Michael 1939- Sonstige (DE-588)13725931X oth Alves, Stephen E. Sonstige oth Anderson, Elizabeth Sonstige oth (DE-604)BV012712897 1 Handbook of experimental pharmacology 135,1 (DE-604)BV002390716 135,1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008641921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Estrogens and antiestrogens Handbook of experimental pharmacology |
| title | Estrogens and antiestrogens |
| title_auth | Estrogens and antiestrogens |
| title_exact_search | Estrogens and antiestrogens |
| title_full | Estrogens and antiestrogens 1 Physiology and mechanisms of action of estrogens and antiestrogens ed. M. Oettel ... |
| title_fullStr | Estrogens and antiestrogens 1 Physiology and mechanisms of action of estrogens and antiestrogens ed. M. Oettel ... |
| title_full_unstemmed | Estrogens and antiestrogens 1 Physiology and mechanisms of action of estrogens and antiestrogens ed. M. Oettel ... |
| title_short | Estrogens and antiestrogens |
| title_sort | estrogens and antiestrogens physiology and mechanisms of action of estrogens and antiestrogens |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008641921&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV012712897 (DE-604)BV002390716 |
| work_keys_str_mv | AT oettelmichael estrogensandantiestrogens1 AT alvesstephene estrogensandantiestrogens1 AT andersonelizabeth estrogensandantiestrogens1 |