Update on dermatopathology:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1999
|
| Schriftenreihe: | Dermatologic clinics
17,3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X S., S. 445 - 721 Ill. |
Internformat
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| 245 | 1 | 0 | |a Update on dermatopathology |c Bruce R. Smoller, guest ed. |
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Datensatz im Suchindex
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UPDATIi ON DEKMAIOEATHOLOGY
CONTENTS
Preface xiii
Bruce R. Smoller
Update on the Cutaneous Manifestations of HIV Infection:
Clinical and Pathologic Features 445
Kent Aftergut and Clay J. Cockerell
Skin is the most commonly affected organ in patients with HIV. As such,
cutaneous manifestations of HIV infection have been the subject of intense
scrutiny as well as the topic of many articles. A broad range of infectious
and noninfectious skin lesions may develop during the course of the
disease. This article discusses the clinical and pathological cutaneous mani¬
festations of HIV infection.
Update on Inherited Bullous Dermatoses 473
M. Peter Marinkovich
Bullous diseases are becoming increasingly better understood owing to
the active research which has taken place in this field over the past
decade. Advances in understanding of bullous disease pathophysiology is
translating into clinical applications for diagnosis and therapy that will
greatly enhance the quality of care bullous disease patients may receive
now and in the future. This review focuses on the progress which has
been achieved in inherited bullous dermatoses.
Histopathologic and Immunohistochemical Diagnosis of Benign
and Malignant Fibrous and Fibrohistiocytic Tumors of the Skin 487
Hideko Kamino and Eduardo Salcedo
This article describes the histopathology and immunohistochemistry of
benign and malignant fibrous and fibrohistiocytic tumors. Some of the
benign fibrohistiocytic proliferation s have atypical variants which could
be misinterpreted as malignant processes. Key points for the diagnosis of
these entities based on routine histology and immunohistochemistry are
presented.
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Selected Cutaneous Vascular Neoplasms: A Review 507
Victor G. Prieto and Christopher R. Shea
This article reviews the pathology of benign, borderline, and malignant
vascular neoplasms of the skin. The classification of vascular lesions of
childhood is presented. Defined variants of hemangioma (including sinu¬
soidal, microvenular, glomeruloid, epithelioid, and targetoid hemosideric
hemangioma, as well as acquired tufted hemangioma and angiofibroma)
are discussed. Borderline hemangioendotheliomas are classified. Kaposi
sarcoma is reviewed with an update on the role of human herpesvirus
type 8 in its pathogenesis. Angiosarcoma and acquired progressive lymph
angioma are also discussed.
Clinical, Histopathologic, and Molecular Aspects of Cutaneous
Human Papillomavirus Infections 521
Nasim Fazel, Sharon Wilczynski, Lori Lowe, and Lyndon Su
Human papillomaviruses comprise a large family of double stranded DNA
viruses that are the etiologic agents of benign warts and anogenital can¬
cers. At least 82 different human papillomavirus types have been identified
and many remain yet uncharacterized. The development of new molecular
techniques in recent years has led to an increased understanding of human
papillomaviruses and their roles in carcinogenesis. Several clinicopatho
logic entities arising from human papillomavirus infection encountered by
the dermatologist are the subject of the article. The epidemiology, molecu¬
lar biology, clinical presentation, histologic findings, and treatment of each
disorder, where applicable, is discussed.
Recent Advances in the Pathology of Cutaneous Drug Eruptions 537
A. N. Crowson and C. M. Magro
Cutaneous reactions to drug therapy may be of either immunologic or
nonimmunologic etiology. It is important that the dermatologist and pa¬
thologist be familiar with these types of cutaneous reactions. This article
discusses the clinical features, pathogenesis, and histopathology of various
cutaneous drug eruptions.
Immunopathology of the Human Hair Follicle 561
Christine Jaworsky and Anita C. Gilliam
The hair follicle is a complex microorgan with a pivotal role in the immune
system of the skin. It is a reservoir of resident keratinocytes, melanocytes,
and Langerhans cells, that replenishes surface epithelium. It is also often
the earliest site of immune reactions in the skin. Follicular organization,
function, and alterations in disease states are discussed.
Cutaneous Lymphoma: Understanding the New Classification
Schemes 569
Lyn M. Duncan
Both the REAL and EORTC classification schemes classify lymphomas
according to their cell of origin. These schemata also incorporate clinical
features that allow for the distinction of some of these disorders. The
EORTC classification scheme for primary cutaneous tumors uses similar
terminology to that of the REAL classification and should allow for the
recognition of teleologically similar tumors in cutaneous and extracutane
ous sites. An understanding of the new lymphoma classification schemata
will enable dermatologists to present the appropriate information regard¬
ing prognosis, staging procedures, and therapeutic options to their patients
with cutaneous lymphoma.
Viii CONTENTS
Morphologic Spectrum of Cutaneous B cell Lymphomas 593
Christian A. Sander and Michael J. Flaig
Cutaneous B cell lymphomas represent a heterogenous group of entities
which show variation in histology, immunophenotype, and in prognosis.
In the current review the morphologic spectrum of cutaneous B cell lym¬
phomas comprising primary and secondary cutaneous B cell lymphomas
is discussed according to the REAL classification scheme.
Cutaneous T cell Lymphoma: Refinement in the Application of
Controversial Histologic Criteria 601
Earl J. Glusac, Philip E. Shapiro, and Jennifer Madison McNiff
The term cutaneous T cell lymphoma was originally coined to encompass
the spectrum of mycosis fungoides and Sezary syndrome. It has become
increasingly evident that the histopathologic diagnosis of CTCL can be
exceedingly challenging. A series of recent studies, however, have helped
clarify the nature of the histologic findings in CTCL. Recently reported
histologic data on mycosis fungoides, Sezary syndrome, and their variants
is emphasized in this article, with special focus given to the findings in
early lesions. A brief summary of lymphocyte immunophenotyping and
the role of T cell reception gene rearrangements in CTCL is included.
Recent Developments in the Pathology of Melanocytic
Neoplasia 615
Christopher R. Shea and Victor G. Prieto
This article selectively discusses clinically relevant aspects of the pathology
of cutaneous melanocytic neoplasms, from the literature of the past recent
years. Topics include the changing role of immunohistochemistry in diag¬
nosis, the controversies over dysplastic nevi, description of other special¬
ized variants of melanocytic nevi, diagnosis of melanocytic neoplasms of
acral skin, and melanoma occurring in childhood. Several variants of
melanoma including desmoplastic and spindle cell types, verrucous mela¬
noma, epidermotropic melanoma, and melanoma of the female genitalia
are reviewed. The issue of appropriate margins of resection for melanoma
and the use of Mohs Micrographic surgery for this tumor are considered.
Finally, a review of the sentinel node biopsy technique and of nodal nevi
is presented.
Update of Diagnostic and Prognostic Markers in Cutaneous
Malignant Melanoma 631
Jon A. Reed and Anthony P. Albino
To date, the single best predictor of clinical outcome in primary invasive
malignant melanoma has been the depth of tumor invasion; however, this
attribute alone cannot predict outcome with certainty for a given patient.
By studying the biology of tumor progression in melanoma, many biomo
lecules with possible prognostic value have been identified. This update
will review some of these markers and discuss their potential for use in a
clinical setting.
Sentinel Lymphadenectomy in the Management of Primary
Cutaneous Malignant Melanoma: An Update 645
Wain L. White and Brian W. Loggie
The management of lymph nodes in melanoma patients who have no
clinical evidence of nodal disease has changed dramatically with the
CONTENTS ix
development of selective lymph node biopsy. This procedure localizes the
node in a regional basin most likely to contain a metastasis (the sentinel
node) and averts the morbidity of unnecessary elective node dissection.
This update reviews the rationale for this procedure and describes the
methodology used by the surgeon and the pathologist. A progress report
highlights the promise and limitation of this procedure. Sentinel node
biopsy is currently the standard for staging select groups of melanoma
patients, but the field is rapidly evolving and may eventually be surpassed
by even newer molecular diagnostic techniques.
Use of the Polymerase Chain Reaction in the Evaluation of
Cutaneous T cell Infiltrates 657
Sabine Kohler and James L. Zehnder
Histologic evaluation of suspected cutaneous T cell neoplasia is challeng¬
ing. There is significant overlap with features of benign condition, and
neoplastic cells often occur in a reactive background. Recently, molecular
techniques using paraffin embedded tissue have been applied to the diag¬
nosis of cutaneous T cell infiltrates. These methods are useful for determin¬
ing whether a clonal population of T cells is present. The advantages and
limitation of molecular diagnostic methods in the diagnosis of cutaneous
T cell infiltrates are discussed.
Immunohistochemistry in Diagnostic Dermatopathology 667
Amy R. Hudson and Bruce R. Smoller
This article briefly reviews many immunohistochemical stains that have
been in use for years, emphasizing their diagnostic use and potential
pitfalls. Several newer immunostains are described in a more comprehen¬
sive fashion, including brief summaries from recently published studies.
Update on Immunoelectron Microscopy in Diagnostic
Dermatopathology and Cutaneous Biology 691
Gundula Schaumburg Lever
Immunoelectron microscopy for diagnostic dermatopathology is hardly
ever necessary. Immunoelectron microscopy, however, is very helpful in
the work up of interesting cases, for the study of genetic and autoimmune
bullous diseases and for basic science studies, particularly in conjunction
with molecular biology techniques. It is also very helpful for investigators
requiring double labeling.
Current Therapy
A Sherlockian Approach to Contact Dermatitis 705
Donald V. Besito
Identifying the etiology of allergic contact dermatitis requires detective
work. Not all allergic reactions are eczematous in appearance. The most
reliable clinical clue to the allergic nature of the dermatitis is its geographic
distribution. Patch testing provides the list of culprit allergens. The mys¬
tery is solved when the suspected allergen is found to be relevant and the
patient has been adequately instructed in allergen avoidance.
Index 715
Subscription Information Inside back cover
X CONTENTS
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| spelling | Update on dermatopathology Bruce R. Smoller, guest ed. Philadelphia [u.a.] Saunders 1999 X S., S. 445 - 721 Ill. txt rdacontent n rdamedia nc rdacarrier Dermatologic clinics 17,3 Maladies de la peau - Maladie Skin Diseases pathology Pathologie (DE-588)4044893-9 gnd rswk-swf Hautkrankheit (DE-588)4023852-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Hautkrankheit (DE-588)4023852-0 s Pathologie (DE-588)4044893-9 s DE-604 Smoller, Bruce R. Sonstige oth Dermatologic clinics 17,3 (DE-604)BV000004924 17,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008631111&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Update on dermatopathology Dermatologic clinics Maladies de la peau - Maladie Skin Diseases pathology Pathologie (DE-588)4044893-9 gnd Hautkrankheit (DE-588)4023852-0 gnd |
| subject_GND | (DE-588)4044893-9 (DE-588)4023852-0 (DE-588)4143413-4 |
| title | Update on dermatopathology |
| title_auth | Update on dermatopathology |
| title_exact_search | Update on dermatopathology |
| title_full | Update on dermatopathology Bruce R. Smoller, guest ed. |
| title_fullStr | Update on dermatopathology Bruce R. Smoller, guest ed. |
| title_full_unstemmed | Update on dermatopathology Bruce R. Smoller, guest ed. |
| title_short | Update on dermatopathology |
| title_sort | update on dermatopathology |
| topic | Maladies de la peau - Maladie Skin Diseases pathology Pathologie (DE-588)4044893-9 gnd Hautkrankheit (DE-588)4023852-0 gnd |
| topic_facet | Maladies de la peau - Maladie Skin Diseases pathology Pathologie Hautkrankheit Aufsatzsammlung |
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