Metabolic bone disease and clinically related disorders:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1998
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 811 S. zahlr. Ill. und graph. Darst. |
| ISBN: | 0120687003 |
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| 245 | 1 | 0 | |a Metabolic bone disease and clinically related disorders |c ed. by Louis V. Avioli ... |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1998 | |
| 300 | |a XVII, 811 S. |b zahlr. Ill. und graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Botziekten |2 gtt | |
| 650 | 2 | |a Maladies métaboliques | |
| 650 | 2 | |a Maladies osseuses | |
| 650 | 2 | |a Os et tissu osseux - Métabolisme | |
| 650 | 7 | |a Stofwisselingsziekten |2 gtt | |
| 650 | 4 | |a Bone Diseases | |
| 650 | 4 | |a Bone and Bones |x metabolism | |
| 650 | 4 | |a Bones |x Diseases | |
| 650 | 4 | |a Bones |x Metabolism |x Disorders | |
| 650 | 4 | |a Metabolic Diseases | |
| 700 | 1 | |a Avioli, Louis V. |d 1931-1999 |e Sonstige |0 (DE-588)171956095 |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008585100 | ||
Datensatz im Suchindex
| _version_ | 1804127293354803200 |
|---|---|
| adam_text | Co]
Contributors xi
Preface xv
Chapter 1 Embryology and Cellular
Biology of Bone
Lawrence G. Raisz and Gideon A. Rodan
I. Embryonic Skeletal Development 2
II. Limb Development and Pattern
Regulation 2
III. Bone Morphogenetic Proteins and
Development 4
IV. The Role of Parathyroid Hormone Related
Peptide in Development 4
V. Fibroblast Growth Factors and Skeletal
Development 4
VI. Cells of the Osteoblast Lineage 5
VII. The Osteoclast 9
VIII. Cell Cell Interaction in Bone
Remodeling 12
DC. Colony Stimulating Factors and Bone 13
X. The Transforming Growth Factor ft
Family 13
XI. Other Growth Factors (FGF, VEGF, PDGF, and
HGF) 15
XII. Cell Matrix Interactions 16
References 17
ntents
s
Chapter 2 The Nature of the Mineral
Phase in Bone: Biological and
Clinical Implications
Melvin J. Glimcher
I. Biological Functions of the Mineral
Phase 23
II. The General Nature of the Mineral Phase in Bone
and the Changes That Occur with Time 28
III. Postulated Phases Other Than Apatite as the Initial
Solid Ca P Mineral Phase Deposited in
Bone 29
IV. Crystal Size and Shape 32
V. Recent Studies of the Structure of Bone Apatites
and the Applications of These Data to Clinical and
Experimental Abnormalities and Diseases of
Bone 36
References 46
Chapter 3 Parathyroid Hormone and
Parathyroid Hormone Related Peptide in
Calcium Homeostasis, Bone Metabolism,
and Bone Development: The Proteins,
Their Genes, and Receptors
John T. Potts, Jr. and Harald Juppner
I. Introduction: Regulators of Mineral Ion
Homeostasis 52
II. Parathyroid Hormone 53
III. Parathyroid Hormone Related Peptide 67
IV. Receptors That Mediate Analogous and Distinct
Molecular Actions of PTH and PTHrP 73
V. Summary: Overall Biological Roles of PTH and
PTHrP and Their Cloned Receptors 82
References 83
v
i Chapter 4 Calcitonin
T. J. Martin, D. M. Findlay, J. M. Moseley,
and P. M. Sexton
I. Nature of Calcitonin 96
II. Chemistry 98
III. Biosynthesis 99
IV. Secretion and Metabolism 101
V. Actions of Calcitonin 102
VI. Calcitonin Receptor 108
VII. Calcitonin in Clinical Medicine 113
VIII. Summary 113
References 114
Chapter 5 Vitamin D Metabolism and
Biological Function
Michael F. Holick and John S. Adams
I. History of Vitamin D 124
II. Photobiology of Vitamin D3 127
III. Intestinal Absorption of Vitamin D 131
IV. Metabolism of Vitamin D to
25 Hydroxyvitamin D 132
V. Metabolism of 25 Hydroxyvitamin D to
1,25 Hydroxyvitamin D 135
VI. Alternative Metabolism of 25 Hydroxyvitamin D
and 1,25 Dihydroxyvitamin D 139
VII. Metabolism of Vitamin D2 141
VIII. Biological Actions of 1,25(OH)2D 142
IX. Biological Actions of 1,25(OH)2D in Tissues
Regulating Calcium Balance 144
X. Actions of Vitamin D Metabolites and Analogs
in Nonclassical Target Tissues 145
XI. Assays for Vitamin D and Its
Metabolites 148
XII. Conclusion 155
References 156
Chapter 6 Pathophysiology of Calcium,
Phosphate, and Magnesium Absorption
Roberto Civitelli, Konstantinos Ziambaras,
and Rattana Leelawattana
I. Calcium 165
II. Phosphate 183
III. Magnesium 190
References 195
Contents
Chapter 7 Disorders of Phosphate
Homeostasis
Keith Hruska and Anandarup Gupta ¦¦
I. Phosphate Homeostasis 207 i
II. Hypophosphatemia 216 ,
III. Hyperphosphatemia 226
References 230
Chapter 8 Bone Biopsies: A Modern
Approach
Marie Claude Monier Faugere, M. Chris Langub,
AND HARTMUT H. MALLUCHE
I. Function and Structure of the Skeleton 237
II. Bone Biopsies 244
III. Mineralized Bone Histology Techniques 247
IV. Molecular Bone Histology 249
V. Evaluation of Bone 251
VI. Indications For and Information Derived from
Bone Biopsies 256
VII. Information Derived from Molecular
Histology 267
References 269
Chapter 9 Noninvasive Assessment
of Bone
Martin Uffmann, Thomas P. Fuerst, Michael Jergas,
and Harry K. Genant
I. Introduction 275
II. Radiation Based Assessment of Bone 277
III. Assessment of Bone without Radiation 292
IV. Standardization and Quality Assurance in Dual
X Ray Absorptiometry 298
V. Clinical Applications 301
References 303
Chapter 10 Biochemical Markers of
Bone Turnover
Claus Christiansen, Christian Hassager,
AND BENTE JUEL RlIS
I. Introduction 313
II. Bone Matrix, Minerals, and Cells 314
III. Bone Turnover: Modeling and
Remodeling 314
IV. Biochemistry of Bone Turnover 315
V. Markers of Bone Formation 316
VI. Markers of Bone Resorption 318
VII. 24 Hour Variation in Markers of Bone
Turnover 321
Contents
VIII. Potential Use of Biochemical Markers 321
IX. Conclusions 324
References 324
Chapter 11 Osteomalacia and Related
Disorders
A. M. Parfitt
I. Bone Mineralization and the Mechanisms of
Osteoid Accumulation 328
II. Manifestations of Osteomalacia 338
III. Etiological Classification and Pathogenesis of
Osteomalacia 349
IV. Osteomalacia Resulting from Abnormal
Vitamin D Metabolism 354
V. Vitamin D and Age Related
Osteoporosis 360
VI. Osteomalacia Resulting from Abnormal
Phosphate Metabolism 361
VII. Osteomalacia with Normal Vitamin D and
Phosphate Metabolism 367
VIII. Therapeutic Intervention in
Osteomalacia 370
References 374
Chapter 12 Osteoporosis Pathogenesis
and Therapy
Michael Kleerekoper and Louis V. Avioli
I. Definition 387
II. Physiological Osteoporosis 389
III. Diagnostic Aids 390
IV. Classification 395
V. Management 397
References 406
Chapter 13 Primary
Hyperparathyroidism
John T. Potts, Jr.
I. Introduction 411
II. Etiology and Pathology 412
III. Clinical Features: Changing Clinical
Presentation 418
IV. Diagnosis and Differential Diagnosis 426
V. Medical Management of Hypercalcemia and
Hyperparathyroidism 431
VI. Summary 435
References 435
vii
Chapter 14 Renal Osteodystrophy
Eduardo Slatopolsky and James A. Delmez
I. Introduction 443
II. Secondary Hyperparathyroidism and Osteitis
Fibrosa 443
III. Osteomalacia 451
IV. Bone Histology 451
V. Clinical and Biochemical Features of Altered
Divalent Ion Metabolism 453
VI. Radiographic Features of Renal
Osteodystrophy 455
VII. Extraskeletal Calcifications 456
VIII. Therapeutic Approach to Renal
Osteodystrophy 456
References 460
Chapter 15 Surgical Treatment for
Hyperparathyroidism
Gerard M. Doherty and Samuel A. Wells, Jr.
I. History of Surgery for
Hyperparathyroidism 465
II. Primary Hyperparathyroidism: Preoperative
Evaluation 466
III. Primary Hyperparathyroidism: Conduct of the
Operation 469
IV. Primary Hyperparathyroidism: Management of
Patients with Persistent or Recurrent
Hyperparathyroidism 472
V. Operative Management of Patients with
Parathyroid Carcinoma 475
VI. Operative Management of Patients with Renal
Osteodystrophy 475
VII. Postoperative Management 475
References 477
Chapter 16 Familial Benign
Hypocalciuric Hypercalcemia and Other
Syndromes of Altered Responsiveness to
Extracellular Calcium
Edward M. Brown, Mei Bai, and Martin Pollak
I. Introduction 479
II. Syndromes of Extracellular Calcium
Resistance 480
III. Autosomal Dominant Hypocalcemia—A
Syndrome of Increased Responsiveness of Target
Tissues to Caj;+ 493
viii IV. Summary and Conclusions 496
References 496
Chapter 17 Hypoparathyroidism and
Pseudohypoparathyroidism
Michael A. Levine
I. Introduction 501
II. Pathophysiology of Hypocalcemia 502
III. Signs and Symptoms of Hypocalcemia 504
IV. Specific Causes of Functional
Hypoparathyroidism 505
V. Pseudohypoparathyroidism 510
VI. Diagnosis 519
VII. Treatment 521
VIII. Conclusion 522
References 522
Chapter 18 Bone Disease in
Hyperthyroidism
Douglas S. Ross
I. Grades of Hyperthyroidism 531
II. Overt Hyperthyroidism 532
III. Endogenous Subclinical
Hyperthyroidism 534
IV. Exogenous Subclinical Hyperthyroidism: Thyroid
Hormone Suppressive Therapy 535
V. Thyroid Hormone Replacement Therapy 539
VI. Treatment and Prevention of Thyroid Hormone
Mediated Bone Loss 539
VII. Conclusions 541
References 541
Chapter 19 Paget s Disease of Bone
Frederick R. Singer and Stephen M. Krane
I. Historical Aspects 545
II. Incidence and Epidemiology 545
III. Histopathology 547
IV. Focal Manifestations 554
V. Local Complications 562
VI. Metabolic Aspects of Paget s Disease 569
VII. Systemic Complications and Associated
Diseases 578
VIII. Drug Treatment 581
IX. Surgery 592
X. Etiology 593
References 596
Contents
Chapter 20 Sarcoidosis and Related
Disorders
Norman H. Bell
I. Granulomatous and Infectious Diseases 607
II. Lymphoma and Solid Tumors 613
III. Miscellaneous Diseases 614
References 615
Chapter 21 Bone Disease in
Rheumatological Disorders
Steven R. Goldring and Richard P. Polisson
I. Introduction 621
II. Rheumatoid Arthritis 622
III. Seronegative Spondyloarthropathies 626
IV. Systemic Lupus Erythematosus 628
V. Juvenile Rheumatoid Arthritis 628
References 633
Chapter 22 Hypercalcemia
of Malignancy
Gregory R. Mundy
I. Pathophysiology 637
II. Clinical Features 642
III. Treatment 643
References 646
Chapter 23 Osteogenesis Imperfecta
David W. Rowe and Jay R. Shapiro
I. Introduction 651
II. Perspective: Clinical Introduction 651
III. Clinical Features 657
IV. Pathophysiology 663
V. Collagen Biochemistry and Bone Cell Biology as
Related to OI 666
VI. Biochemical and Molecular Tools for the
Identification of Mutations in Patients
with OI 670
VII. Molecular Pathophysiology of OI 673
VIII. Therapy 678
IX. Future Diagnostic and Therapeutic
Directions 681
References 683
Contents
Chapter 24 Skeletal Disorders
Characterized by Osteosclerosis
or Hyperostosis
Michael P. Whyte
I. Introduction 697
II. Osteopetrosis 698
III. Carbonic Anhydrase II Deficiency 703
IV. Pycnodysostosis 705
V. Osteomesopyknosis 707
VI. Progressive Diaphyseal Dysplasia (Camurati
Engelmann Disease) 707
VII. Endosteal Hyperostosis 710
VIII. Osteopoikilosis 713
DC. Osteopathia Striata 715
X. Melorheostosis 716
XI. Mixed Sclerosing Bone Dystrophy 718
Xn. Fibrodysplasia Ossificans
Progressiva 719
Xin. Axial Osteomalacia 722
XIV. Fibrogenesis Imperfecta Ossium 726
XV. Fluorosis 728
XVI. Pachydermoperiostosis 729
XVII. Hepatitis C Associated
Osteosclerosis 731
XVIII. Other Disorders 731
References 732
ix
Chapter 25 Kidney Stones: Pathogenesis,
Diagnosis, and Therapy
Charles Y. C. Pak
I. Introduction 739
II. Hypercalcemia 740
III. Hyperuricosuria 747
IV. Hyperoxaluria 748
V. Hypocitraturia 750
VI. Gouty Diathesis 752
VII. Cystinuria 753
VIII. Infection with Urea Splitting
Organisms 755
IX. Conservative Management 755
References 756
Chapter 26 Metabolic Bone Disease
in Children
Francis H. Glorieux, Gerard Karsenty,
AND RAJESH V. THAKKER
I. Introduction 759
II. Skeletal Development 759
III. Rickets and Osteomalacia 764
References 777
Index 785
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| isbn | 0120687003 |
| language | English |
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| physical | XVII, 811 S. zahlr. Ill. und graph. Darst. |
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| spelling | Metabolic bone disease and clinically related disorders ed. by Louis V. Avioli ... 3. ed. San Diego [u.a.] Acad. Press 1998 XVII, 811 S. zahlr. Ill. und graph. Darst. txt rdacontent n rdamedia nc rdacarrier Botziekten gtt Maladies métaboliques Maladies osseuses Os et tissu osseux - Métabolisme Stofwisselingsziekten gtt Bone Diseases Bone and Bones metabolism Bones Diseases Bones Metabolism Disorders Metabolic Diseases Avioli, Louis V. 1931-1999 Sonstige (DE-588)171956095 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008585100&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metabolic bone disease and clinically related disorders Botziekten gtt Maladies métaboliques Maladies osseuses Os et tissu osseux - Métabolisme Stofwisselingsziekten gtt Bone Diseases Bone and Bones metabolism Bones Diseases Bones Metabolism Disorders Metabolic Diseases |
| title | Metabolic bone disease and clinically related disorders |
| title_auth | Metabolic bone disease and clinically related disorders |
| title_exact_search | Metabolic bone disease and clinically related disorders |
| title_full | Metabolic bone disease and clinically related disorders ed. by Louis V. Avioli ... |
| title_fullStr | Metabolic bone disease and clinically related disorders ed. by Louis V. Avioli ... |
| title_full_unstemmed | Metabolic bone disease and clinically related disorders ed. by Louis V. Avioli ... |
| title_short | Metabolic bone disease and clinically related disorders |
| title_sort | metabolic bone disease and clinically related disorders |
| topic | Botziekten gtt Maladies métaboliques Maladies osseuses Os et tissu osseux - Métabolisme Stofwisselingsziekten gtt Bone Diseases Bone and Bones metabolism Bones Diseases Bones Metabolism Disorders Metabolic Diseases |
| topic_facet | Botziekten Maladies métaboliques Maladies osseuses Os et tissu osseux - Métabolisme Stofwisselingsziekten Bone Diseases Bone and Bones metabolism Bones Diseases Bones Metabolism Disorders Metabolic Diseases |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008585100&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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