Intracellular bacterial vaccine vectors: immunology, cell biology, and genetics
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Wiley-Liss
1999
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 267 S. Ill. |
| ISBN: | 0471172782 |
Internformat
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| 245 | 1 | 0 | |a Intracellular bacterial vaccine vectors |b immunology, cell biology, and genetics |c ed. by Yvonne Paterson |
| 264 | 1 | |a New York [u.a.] |b Wiley-Liss |c 1999 | |
| 300 | |a XVI, 267 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Antigène bactérien - immunologie | |
| 650 | 7 | |a Antigènes bactériens - Immunologie |2 ram | |
| 650 | 2 | |a Immunité cellulaire | |
| 650 | 7 | |a Immunité cellulaire |2 ram | |
| 650 | 2 | |a Vaccins antibactériens | |
| 650 | 7 | |a Vaccins antibactériens |2 ram | |
| 650 | 4 | |a Vaccins antimicrobiens | |
| 650 | 2 | |a Vaccins à ADN | |
| 650 | 7 | |a Vaccins à l'ADN |2 ram | |
| 650 | 4 | |a Antigens, Bacterial |x immunology | |
| 650 | 4 | |a Bacterial Vaccines | |
| 650 | 4 | |a Bacterial vaccines | |
| 650 | 4 | |a Immunity, Cellular | |
| 650 | 4 | |a Immunity, Mucosal | |
| 650 | 4 | |a Vaccines, DNA | |
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Datensatz im Suchindex
| _version_ | 1804127256055906304 |
|---|---|
| adam_text | CONTENTS
Preface xi
Contributors xv
CHAPTER 1 THE RELATIONSHIP BETWEEN INTRA
CELLULAR BACTERIAL LIFE STYLES
AND IMMUNE RESPONSIVENESS TO
BACTERIAL DELIVERED ANTIGENS 1
Yvonne Paterson
1.1 Introduction 1
1.2 Role of the Macrophage and Phagolysosome in
Intracellular Bacterial Infections 2
1.3 Counterimmune Mechanisms 3
1.4 Exploiting Current Concepts of Immune Defense for
Vaccinology 8
1.5 Inert Bacterial Products as Vectors 12
1.6 Intracellular Bacteria as Vectors for DNA Vaccines 13
1.7 Concluding Remarks 14
1.8 References 15
y
Vi CONTENTS
PART I THE BIOLOGY AND IMMUNOLOGY
OF INTRACELLULAR BACTERIAL
VECTORS 25
CHAPTER 2 THE IMMUNE RESPONSE TO
MYCOBACTERIA 27
Douglas B. Young and Jelle E. R. Thole
2.1 Introduction 27
2.2 Mycobacteria and the Macrophage 28
2.3 Processing of Mycobacterial Antigens 32
2.4 CD4 T Cell Responses 36
2.5 CD8 T Cells 37
2.6 Other T Cell Subsets 38
2.7 Humoral Immune Responses 39
2.8 Protection Versus Pathology 40
2.9 Toward New Vaccines 41
2.10 References 43
CHAPTER 3 MUCOSAL IMMUNE DEFENSE: THE
Salmonella typhimurium MODEL 51
Toby K. Eisenstein
3.1 Introduction 51
3.2 The Secretory Immune System 54
3.2.1 Anatomic Structure and Production of slgA 54
3.2.2 Functions of slgA 56
3.2.3 Cell Trafficking and Mucosal IgA
Responses 57
3.2.4 Interconnections Between Serum and
Secretory Antibody Compartments 60
3.2.5 Origin of B Cells in the Gastrointestinal
Tract and Induction of Lymphocyte IgA
Production: Role of T Cells in Regulation
of IgA Responses 62
3.2.6 Intraepithelial T Cells 64
CONTENTS Vii
3.2.7 Cross regulation Between the Systemic and
Mucosal Immune Systems and Oral
Tolerance 64
3.2.8 Summary of the Roles of T Cells in the Gut 66
3.3 Salmonella: Infection and Immunity 66
3.3.1 Overview 66
3.3.2 Pathogenesis of S. typhi and S. typhimurium 69
3.3.3 Systemic Immunity to Salmonella 70
3.3.4 Early Events in Immunity to Salmonella
Infection: Cytokines, NK Cells, and
Macrophages 74
3.3.5 Attenuated Salmonella Vaccines Induce
Systemic Immunosuppression in Mice 76
3.3.6 Immunity to Oral Salmonella Infection 77
3.4 Summary and Conclusions 86
3.5 References 87
CHAPTER 4 CELL BIOLOGY AND IMMUNE
RESPONSE TO Listeria
monocytogenes, AN INTRACELLULAR
PATHOGEN 111
Sujata Vijh and Eric G. Pamer
4.1 Introduction 111
4.2 Infections Caused by Listeria monocytogenes 112
4.3 Epidemiology of Listeria monocytogenes Infections 112
4.4 Listeria monocytogenes Microbiology 113
4.5 Pathogenesis and cell biology of Listeria
monocytogenes Infections 114
4.6 The Immune Response to Listeria monocytogenes
Infection 117
4.7 Early Responses to Listeria monocytogenes Infection 117
4.8 T lymphocyte responses to Listeria monocytogenes 120
4.9 Cytokines and Soluble Mediators of Host Defense 121
4.9.1 Interferon Y 122
4.9.2 Tumor Necrosis Factor a 123
4.9.3 Interleukin 1 123
Viii CONTENTS
4.9.4 Interleukin 12 124
4.9.5 Interleukin 6 125
4.9.6 Interleukin 4, Interleukin 10, and
Interleukin 13 125
4.9.7 NF kB and NF IL6 Transcription Factors 126
4.9.8 Nitric Oxide 127
4.9.9 Summary of Innate Responses to L.
monocy to genes 127
4.10 Antigen Specificity of T lymphocytes 128
4.10.1 MHC Class II Restricted T Cells 128
4.10.2 MHC Class la Restricted CTL 129
4.10.3 Efficiency of MHC Class I Antigen
Processing 131
4.10.4 Magnitude and Kinetics of MHC Class
la Restricted CTL Responses 133
4.10.5 MHC Class Ib Restricted CTL 133
4.11 Conclusion 135
4.12 References 136
PART II VACCINE STRATEGIES USING LIVE
RECOMBINANT INTRACELLULAR
BACTERIA 149
CHAPTER 5 RECOMBINANT BCG VACCINES 151
Anna Aldovini and Richard Young
5.1 Introduction and Overview of Recombinant BCG
as a Vaccine Vehicle 151
5.2 Mycobacteria as Hosts for Molecular Genetics 152
5.2.1 DNA Vectors and Transformation 152
5.2.2 Genome Manipulation in Mycobacteria 155
5.3 Expression of Foreign Protein in Mycobacteria 156
5.3.1 Expression of Antigens 156
5.3.2 Expression of Cytokines 158
CONTENTS IX
5.4 In Vivo Experimentation with Recombinant BCG 159
5.4.1 Persistence and Stability 159
5.4.2 Immunogenicity 159
5.4.3 Protective Immunity Elicited by
Recombinant BCG Vaccines in Animal
Models 160
5.4.4 Safety 161
5.5 Perspectives 162
5.5.1 Recombinant BCG for Immune Modulation 162
5.5.2 Recombinant Mycobacteria as Improved
Vaccines Against Tuberculosis 162
5.6 Conclusions 163
5.7 References 164
CHAPTER 6 MUCOSAL VACCINATION WITH
Salmonella VACCINE VECTORS 171
David M. Hone, Mohamed T. Shata,
David W. Pascual and George K. Lewis
6.1 Introduction 171
6.2 Lessons from the Past to the Present 178
6.2.1 Laboratory Animal Studies with Salmonella
Vectors; Establishing the Paradigm 178
6.2.2 Properties of Immunogenic Salmonella
Vectors 180
6.2.3 Improved Passenger Antigen Expression
Systems 182
6.2.4 Evaluation of Attenuated Typhi Strains in
Volunteers 185
6.2.5 Evaluation of Prototype Salmonella Vectors
in Volunteers 193
6.3 Future Directions 194
6.3.1 Salmonella Vaccine Vectors Targeted
Against Specific Pathogens 194
6.3.2 Typhi Vectors for Using Typhoid Endemic
Regions 195
X CONTENTS
6.3.3 Salmonella and Shigella DNA Vaccine
Vectors: A New Paradigm 196
6.4 Conclusions 200
6.5 References 200
CHAPTER 7 THE USE OF Listeria monocytogenes
RECOMBINANTS AS VACCINE
VECTORS IN INFECTIOUS AND
NEOPLASTIC DISEASE 223
Larry Weiskirch and Yvonne Paterson
7.1 Introduction 223
7.2 Listeria monocytogenes Induces Efficient Antigen
Processing and Presentation 224
7.3 Vaccines for the Induction of Cell Mediated
Immunity: The Importance of APCs 226
7.4 Listeria monocytogenes Is a Potent Inducer of
Thl Type Responses 228
7.5 The Immune Response to Oral Infection With
Listeria monocytogenes: Are Antibodies Important? 230
7.6 Rationale for the Use of Listeria monocytogenes as
an Experimental Live Vaccine Vector 231
7.7 Efficacy of Listeria monocytogenes as a Live
Vaccine Vector 232
7.8 Antiviral Responses Induced by Recombinant
Listeria monocytogenes Vaccines 233
7.9 Antitumor Immune Responses Induced by Listeria
monocytogenes 235
7.10 Genetic Strategies Used to Generate Recombinant
Vaccine Strains of Listeria monocytogenes 238
7.11 Features of Vaccination with Live Listeria
monocytogenes 243
7.12 Practical Limitations and Safety Concerns of
Listeria B sed Vaccines 244
7.13 Conclusions 247
7.14 References 248
Index 261
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| spelling | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics ed. by Yvonne Paterson New York [u.a.] Wiley-Liss 1999 XVI, 267 S. Ill. txt rdacontent n rdamedia nc rdacarrier Antigène bactérien - immunologie Antigènes bactériens - Immunologie ram Immunité cellulaire Immunité cellulaire ram Vaccins antibactériens Vaccins antibactériens ram Vaccins antimicrobiens Vaccins à ADN Vaccins à l'ADN ram Antigens, Bacterial immunology Bacterial Vaccines Bacterial vaccines Immunity, Cellular Immunity, Mucosal Vaccines, DNA Bakterieller Impfstoff (DE-588)4216344-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bakterieller Impfstoff (DE-588)4216344-4 s DE-604 Paterson, Yvonne Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008560236&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics Antigène bactérien - immunologie Antigènes bactériens - Immunologie ram Immunité cellulaire Immunité cellulaire ram Vaccins antibactériens Vaccins antibactériens ram Vaccins antimicrobiens Vaccins à ADN Vaccins à l'ADN ram Antigens, Bacterial immunology Bacterial Vaccines Bacterial vaccines Immunity, Cellular Immunity, Mucosal Vaccines, DNA Bakterieller Impfstoff (DE-588)4216344-4 gnd |
| subject_GND | (DE-588)4216344-4 (DE-588)4143413-4 |
| title | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics |
| title_auth | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics |
| title_exact_search | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics |
| title_full | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics ed. by Yvonne Paterson |
| title_fullStr | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics ed. by Yvonne Paterson |
| title_full_unstemmed | Intracellular bacterial vaccine vectors immunology, cell biology, and genetics ed. by Yvonne Paterson |
| title_short | Intracellular bacterial vaccine vectors |
| title_sort | intracellular bacterial vaccine vectors immunology cell biology and genetics |
| title_sub | immunology, cell biology, and genetics |
| topic | Antigène bactérien - immunologie Antigènes bactériens - Immunologie ram Immunité cellulaire Immunité cellulaire ram Vaccins antibactériens Vaccins antibactériens ram Vaccins antimicrobiens Vaccins à ADN Vaccins à l'ADN ram Antigens, Bacterial immunology Bacterial Vaccines Bacterial vaccines Immunity, Cellular Immunity, Mucosal Vaccines, DNA Bakterieller Impfstoff (DE-588)4216344-4 gnd |
| topic_facet | Antigène bactérien - immunologie Antigènes bactériens - Immunologie Immunité cellulaire Vaccins antibactériens Vaccins antimicrobiens Vaccins à ADN Vaccins à l'ADN Antigens, Bacterial immunology Bacterial Vaccines Bacterial vaccines Immunity, Cellular Immunity, Mucosal Vaccines, DNA Bakterieller Impfstoff Aufsatzsammlung |
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