Epidemiology of childhood cancer:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Lyon
International Agency for Research on Cancer
1999
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| Schriftenreihe: | International Agency for Research on Cancer: IARC scientific publications
149 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 385 S. |
| ISBN: | 9283221494 |
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| 100 | 1 | |a Little, Julian |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Epidemiology of childhood cancer |c by Julian Little |
| 264 | 1 | |a Lyon |b International Agency for Research on Cancer |c 1999 | |
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| 650 | 4 | |a Tumors in children - Epidemiology | |
| 650 | 4 | |a Tumors in children - Etiology | |
| 650 | 4 | |a Kind | |
| 650 | 4 | |a Cancer in children |x Epidemiology | |
| 650 | 4 | |a Child | |
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Datensatz im Suchindex
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| adam_text | Contents
Foreword xiii
Acknowledgements xiv
Chapter 1. INTRODUCTION 1
Design issues 1
Case control studies 3
Cohort studies 6
Structure of the review 6
Hypotheses involving consideration of different possible routes of exposure 7
Childhood acute lymphocytic leukaemia of the B cell precursor type: Greaves hypothesis 7
Childhood leukaemia: the Kinlen hypothesis 7
Childhood acute lymphocytic leukaemia: maternal fertility problems 8
Childhood brain tumours: N nitroso compounds 8
Wilms tumour: overgrowth and fetal growth factors 9
Germ cell tumours: intra uterine exposure to maternal hormones 9
Chapter 2. DESCRIPTIVE EPIDEMIOLOGY ( Linda Sharp, Seonaidh Cotton and Julian Little) 10
Group I: Leukaemias 11
Geographical patterns 11
Acute lymphocytic leukaemia (ALL) 11
Acute non lymphocytic leukaemia (ANLL) 12
Chronic myeloid leukaemia (CML) 12
Age specific incidence and sex ratio 12
Acute lymphocytic leukaemia 12
Acute non lymphocytic leukaemia 13
Chronic myeloid leukaemia 13
Ethnic origin 13
Acute lymphocytic leukaemia 13
Acute non lymphocytic leukaemia 15
Socio economic status 15
Time trends 19
Clustering of leukaemia in space and time 23
Spatial clustering of leukaemia: no prior hypotheses about sources of putative hazard 28
Methods of analysing spatial clustering 28
Childhood leukaemia and non Hodgkin lymphoma in Britain, 1966 83 29
Other analyses of spatial clustering of leukaemia 33
Summary 36
Group II: Lymphomas and other reticuloendothelial neoplasms 36
Relative frequencies of lymphomas and lymphoma types 36
Hodgkin s disease 38
Geographical patterns 38
Age specific incidence and sex ratio 38
Ethnic origin 38
Socioeconomic status 39
Time trends 40
Burkitt s lymphoma 40
Geographical patterns 40
Age specific incidence and sex ratio 41
Time trends 41
Non Hodgkin lymphoma 42
Geographical patterns 42
Age specific incidence and sex ratio 42
Ethnic origin 42
Socioeconomic status 43
Time trends 43
Histiocytosis X 43
Clustering of lymphomas in space and time 43
Hodgkin s disease 43
Burkitt s lymphoma 47
Epidemiology of Childhood Cancer
Group HI: Central nervous system and miscellaneous intracranial and intraspinal neoplasms 47
Relative frequencies of histological types of central nervous system tumours 47
Factors pertinent to the interpretation of geographical variations and time trends 48
Geographical patterns 48
Ependymoma 49
Astrocytoma 49
Medulloblastoma 49
Age specific incidence and sex ratio 49
Ethnic origin 49
Socioeconomic status 50
Time trends 50
Group IV : Sympathetic and allied nervous system tumours 51
Neuroblastoma 51
Geographical patterns 51
Age specific incidence and sex ratio 52
Ethnic origin 52
Socioeconomic status 53
Time trends 53
Group V : Retinoblastoma 54
Geographical patterns 54
Age specific incidence and sex ratio 54
Ethnic origin 54
Laterality 55
Time trends 55
Group VI: Renal tumours 55
Wilms tumour 56
Geographical patterns 56
Age specific incidence and sex ratio 56
Ethnic origin 56
Laterality 57
Socioeconomic status 57
Time trends 57
Renal carcinoma 57
Group VII: Hepatic tumours 57
Geographical patterns 57
Age specific incidence and sex ratio 57
Ethnic origin 58
Time trends 58
Group VIII: Malignant bone tumours 58
Relative frequencies of bone tumour sub types 58
Osteosarcoma 58
Geographical patterns 58
Age specific incidence and sex ratio 59
Ethnic origin 59
Time trends 59
Skeletal sub site distribution 59
Ewing s sarcoma 59
Geographical patterns 59
Age specific incidence and sex ratio 59
Ethnic origin 59
Time trends 59
Skeletal sub site distribution 60
Chondrosarcoma 60
Group IX : Soft tissue sarcomas 60
All soft tissue sarcomas 60
Geographical variations 60
Age specific incidence and sex ratio 60
Ethnic variations 61
Time trends 61
Rhabdomyosarcoma 61
Geographical patterns 61
Age specific incidence and sex ratio 61
Ethnic variations 62
Time trends 62
Group X : Germ cell, trophoblastic and other gonadal neoplasms 62
Geographical patterns 62
Age specific incidence and sex ratio 63
Ethnic origin 63
Time trends 63
Gonadal carcinomas 64
Contents
Group XI: Carcinomas and other malignant epithelial neoplasms 64
Adrenocortical carcinoma 64
Thyroid carcinoma 64
Nasopharangeal carcinoma 64
Melanoma 65
All carcinomas 65
Clustering of malignancies other than leukaemia or lymphoma in space and time 65
Conclusions 66
Chapter 3. GENETIC FACTORS AND FAMILIAL AGGREGATION 67
Leukaemia 67
Concordance for childhood leukaemia in twins 67
Leukaemia and cancer in the families of children with leukaemia 68
Cancer in the offspring of patients treated for leukaemia in childhood 71
Other conditions in relatives of cases with childhood leukaemia 71
Second primary tumours in patients whose first primary tumour was leukaemia 72
Leukaemia and the major histocompatibility complex 72
Associations between leukaemia and other genetic markers 73
Mutation in the paternal gametes and childhood leukaemia in the offspring 73
Lymphoma 73
Concordance in twins 74
Cancer in the families of children with lymphoma 74
Second primary tumours 74
Tumours of the central nervous system 74
Concordance in twins 74
Cancer in the families of children with central nervous system tumours 74
Congenital anomalies in relatives of children with tumours of the central nervous system 76
Second primary tumours 76
Paternal age and CNS tumours in the offspring 77
Neuroblastoma 77
Concordance in twins 77
Cancer in families of cases with neuroblastoma 77
Other conditions in relatives of children with neuroblastoma 77
Second primary cancer 79
Paternal age and neuroblastoma in the offspring 79
Retinoblastoma 79
Concordance in twins 79
Cancer in families of cases of retinoblastoma 79
Second primary tumours 81
Environmental exposures and the occurrence of retinoblastoma mutations 81
Preconceptional exposures of the father 82
Exposures of maternal grandmother of index child before mother s birth 82
Preconceptional exposures of the mother 82
Wilms tumour 82
Concordance in twins 83
Cancer in relatives of cases with Wilms tumour 83
Paternal age and Wilms tumour 85
Congenital anomalies in relatives of patients with Wilms tumour 85
Liver tumours 85
Bone tumours 85
Osteosarcoma and genetic markers 85
Soft tissue sarcoma 87
Concordance in twins 87
Cancer in relatives of cases with soft tissue sarcoma 87
Second primary tumours 89
Other conditions in families of cases with soft tissue sarcoma 89
Paternal age and sarcomas 89
Gonadal and germ cell tumours 89
Epithelial tumours 89
Conclusions 89
Chapter 4. IONIZING RADIATION 90
Residential exposure 90
Effects of doses received after isolated episodes of exposure: the atomic bomb 90
explosions at Hiroshima and Nagasaki, August 1945
Offspring of women exposed during pregnancy 90
Other offspring of exposed individuals 91
Children who were exposed postnatally 91
Overall comment on data from Hiroshima and Nagasaki 92
Epidemiology of Childhood Cancer
Doses received after isolated episodes of exposure: accidents at nuclear plants 92
The Windscale reactor fire, October 1957 93
The Three Mile Island accident, March 1979 93
The Chernobyl accident, April 1986 94
The Chernobyl accident and childhood leukaemia 95
The Chernobyl accident and thyroid cancer in childhood 97
The Chernobyl accident and other types of childhood cancer 99
Fallout from weapons tests 99
Childhood leukaemia 99
Thyroid cancer in children 102
Proximity to nuclear installations 103
Nuclear reprocessing plants: Sellafield, West Cumbria 103
The initial investigations made by the Independent Advisory Group 103
Further work using cancer registries 104
Birth cohort study and incidence in schools in the area 104
Other studies 105
Nuclear reprocessing plants: Dounreay, Caithness 107
Nuclear reprocessing plants: La Hague, Normandy 108
Nuclear reprocessing plants: studies of groups of installations 109
Nuclear facilities of any type: studies of areas around groups of existing or proposed sites of installations 110
Other studies of areas around nuclear installations 116
Background radiation: terrestrial gamma radiation 116
Background radiation: radon 117
Conclusions regarding the effects of residential exposure to ionizing radiation 119
Parental occupational exposure 119
Paternal occupational exposure associated with the Sellafield nuclear plant in West Cumbria 119
Paternal occupational exposure associated with nuclear plants in Ontario, Canada 123
Paternal and maternal occupational exposure associated with the nuclear installation at La Hague, France 124
Paternal occupational exposure associated with nuclear plants in Scotland 125
Paternal and maternal occupational exposure associated with nuclear plants in
West Berkshire, Basingstoke and North Hampshire, England 126
Paternal occupational exposure associated with nuclear plants in Germany 127
Paternal occupational exposure associated with the nuclear plant at Tarapur, India 127
Parental occupational exposure to ionizing radiation other than from nuclear plants 127
Conclusions regarding paternal occupational exposure to ionizing radiation 131
Non occupational exposure 132
Maternal preconceptional exposure to diagnostic or therapeutic ionizing radiation 132
Paternal preconceptional exposure to diagnostic or therapeutic ionizing radiation 133
Maternal diagnostic exposure during pregnancy 134
Cohort studies 134
Case control studies 135
Other maternal exposure to ionizing radiation during the index pregnancy 143
Diagnostic and therapeutic exposure during the lifetime of the index child 143
Leukaemia 143
Brain tumours 143
Osteosarcoma 146
Thyroid cancer 146
Other types of childhood cancer 146
All types of childhood cancer combined 146
Other postnatal exposures to ionizing radiation of the index child 147
Conclusions regarding non occupational exposure to ionizing radiation 147
Chapter 5. ELECTROMAGNETIC FIELDS 148
Residential exposure 148
Description of studies which considered all types of childhood cancer 155
First Denver study (Wertheimer Leeper, 1979) 155
Second Denver study (Savitz et al., 1988, 1990) 155
Stockholm County study (Tomenius, 1986) 162
Taipei study (Lin Lu, 1989) 163
Yorkshire study (Myers et al, 1990) 163
Swedish study (Feychting Ahlbom, 1992, 1993) 163
Danish study (Olsen et al, 1993b) 164
Finnish study (Verkasalo et al, 1993) 164
Norwegian study (Tynes Haldorsen, 1997) 165
Description of studies which considered only leukaemia 165
Providence study (Fulton et al, 1980) 165
South London study (Coleman et al, 1989) 165
Los Angeles leukaemia study (London et al, 1991) 166
Tasmania study (Lowenthal et al, 1991) 167
Greek study (Petridou et al, 1993) 167
Contents
Mexico City study (Fajardo Gutierrez et al, 1993b) 167
Study in Wessex, England (Coghill et al, 1996) 168
Study in Lower Saxony, Germany (Michaelis et al., 1997b) 168
Multicentre study in USA (Linet et al, 1997) 168
Description of studies in which only brain tumours were considered 169
Seattle study (Gurney et al., 1996) 169
Los Angeles brain tumour study (Preston Martin et al, 1996a) 169
Synthesis of results leukaemia 170
Synthesis of results lymphoma 172
Synthesis of results brain tumours 172
Electromagnetic fields to which the general population is exposed other than from
electricity distribution and domestic appliances 173
Parental occupational exposure 174
Neuroblastoma 174
Tumours of the central nervous system 175
Leukaemia 176
All types of childhood cancer combined 177
Synthesis of results: parental occupational exposure 177
Conclusions 177
Chapter 6. EXPOSURES TO CHEMICALS AND DUSTS 178
Leukaemia 180
Pesticides 180
Leukaemia of all types combined 180
Acute leukaemia 181
ALL 181
ANLL 182
Summary 182
Agent Orange 182
Hydrocarbons, including benzene 184
Traffic 189
Solvents 189
Metal dusts and fumes 192
Industrial pollutants of all types 193
Wood dust 193
Insulation materials 193
Bracken spores 194
Lymphoma 194
Central nervous system tumours 195
Pesticides 195
Occupational exposure to N nitroso compounds 195
Paternal employment in the aerospace industry 198
Hydrocarbons 198
Other associations 198
Neuroblastoma 198
Retinoblastoma 200
Pesticides 200
Welding 200
Wilms tumour 200
Hydrocarbons 200
Lead 202
Boron 202
Pesticides 202
Hepatoblastoma 203
Osteosarcoma 203
Ewing s sarcoma 203
Soft tissue sarcoma 204
Conclusions 204
Chapter 7. INFECTION 206
Leukaemia 206
The Kinlen hypothesis: residence in areas with high levels of population mixing 206
Areas of population growth 206
Wartime evacuation 211
National service 212
Construction work 213
Commuting 216
Mass tourism 217
Migration during the index pregnancy or in childhood 217
Infections during the index pregnancy 217
Epidemiology of Childhood Cancer
Antibiotic use during the index pregnancy 218
Immunizations during the index pregnancy 221
Infection and related exposures during the lifetime of the index child 221
Serological evidence of infection 221
Infection in early life 224
Infection up to age of diagnosis 225
Chloramphenicol 226
Other antibiotics 226
Index child s contact with animals 226
Immunizations 227
Haematopoietic malignancies and BCG vaccination 227
Sibshipsize 231
Daycare 231
The lymphomas 232
Burkitt s lymphoma and postnatal infection with Epstein Barr virus 232
Studies in areas where Burkitt s lymphoma is endemic 232
Burkitt s lymphoma in areas of low and intermediate incidence 234
Hodgkin s disease and postnatal infection with Epstein Barr virus 234
Lymphoma and HIV infection of the index child 234
Non Hodgkin lymphoma and postnatal infection 234
Brain tumours 235
Maternal infection during pregnancy 235
Maternal polio vaccination during pregnancy 235
Maternal contact with animals during the index pregnancy 235
Contact of the index child with animals 235
Postnatal infection 236
Other types of childhood cancer 236
Neuroblastoma 236
Retinoblastoma and postnatal infection 236
Wilms tumour and maternal infection during pregnancy 236
Hepatoblastoma 236
Ewing s sarcoma and postnatal infection 236
Osteosarcoma 237
Soft tissue sarcoma and postnatal infection and immunization 237
Germ cell tumours and maternal infection during pregnancy 237
Germ cell tumours and postnatal exposures related to infection 237
All types of childhood cancer combined and immunization of the index child 237
All types of childhood cancer combined and postnatal exposures related to infection 240
Conclusions 240
Chapter 8. LIFESTYLE 242
Leukaemia 242
Maternal diet and vitamin supplement use during pregnancy 242
Breast feeding 243
Postnatal diet of the index child and use of vitamin supplements 243
Tobacco smoking by the mother 245
Tobacco smoking by the father 245
Exposure of child to tobacco smoke after birth 250
Smoking of marijuana and use of other recreational drugs 250
Alcohol 251
Lymphoma 251
Breast feeding 251
Tobacco smoking by the mother 253
Tobacco smoking by the father 253
Brain tumours 253
Maternal diet and vitamin supplement use during pregnancy 253
Breast feeding 261
Postnatal diet of the index child and use of vitamin supplements 261
Tobacco smoking by the mother 263
Tobacco smoking by the father 263
Exposure of the child to tobacco smoke after birth 263
Recreational drug use by the mother during pregnancy 263
Incense exposure during pregnancy 263
Alcohol consumption by the mother during pregnancy 268
Maternal use of hair colourants during the pregnancy 268
Use of other cosmetics during pregnancy 268
Use of dummies 268
Neuroblastoma 268
Maternal vitamin supplement use during pregnancy 268
Maternal consumption of caffeinated beverages 269
Contents
Tobacco smoking by the mother or father 269
Recreational drug use by the mother during pregnancy 269
Maternal alcohol consumption during pregnancy 269
Maternal use of hair colourants during pregnancy 269
Retinoblastoma 269
Wilms tumour 271
Maternal vitamin supplement use during pregnancy 271
Maternal consumption of caffeinated beverages during pregnancy 271
Tobacco smoking by the mother or father 271
Maternal alcohol consumption during pregnancy 271
Maternal use of hair colourants during pregnancy 273
Hepatoblastoma 273
Bone tumours 273
Soft tissue sarcoma 274
Germ cell tumours 276
Conclusions 276
Chapter 9. MATERNAL REPRODUCTIVE HISTORY, AND MATERNAL ILLNESS
AND RELATED DRUG USE 279
Haematopoietic malignancies 279
Maternal age 279
Birth order 279
Prior fetal loss 282
Other aspects of medical history of the mother before the index pregnancy 286
Maternal illness and use of medications during the index pregnancy 286
Threatened miscarriage and hormonal treatment during pregnancy 286
Oral contraceptives 286
Steroids other than gonadal hormones 288
Anaesthesia during labour 288
Other drugs 288
Ultrasound examinations 291
Central nervous system tumours 291
Maternal age 291
Birth order and prior fetal loss 291
Other aspects of medical history of the mother before the index pregnancy 293
Maternal illness and use of medications during the index pregnancy 293
Maternal epilepsy and use of anti epileptic drugs and barbiturates 293
Anaesthesia during pregnancy and labour 293
Nitrosatable drugs 296
Other maternal illnesses and medications used during pregnancy 296
Neuroblastoma 296
Maternal age, birth order and prior fetal loss 296
Other aspects of medical history of the mother before the index pregnancy 298
Pregnancy hypertension and diuretics 298
Hormone treatment 298
Phenytoin 299
Other neurally active drugs 299
Other maternal illnesses and medications used during pregnancy 299
Retinoblastoma 299
Wilms tumour 299
Maternal age, birth order and prior fetal loss 299
Other aspects of medical history of the mother before the index pregnancy 299
Pregnancy hypertension 301
Anaesthesia during labour 301
Other maternal illnesses and medications used during pregnancy 301
Hepatoblastoma 301
Bone tumours 301
Rhabdomyosarcoma 301
Maternal age and previous fetal loss 301
Maternal illness and medication use during pregnancy 302
Germ cell tumours 302
Clear cell adenocarcinoma of the vagina and cervix and diethylstilbestrol 302
Conclusions 303
Chapter 10. MEDICAL HISTORY OF THE INDEX CHILD 304
Perinatal and constitutional characteristics of the index child 304
Multiplicity 304
Congenital anomalies 306
Leukaemia 307
Lymphoma 314
Epidemiology of Childhood Cancer
Central nervous system tumours 314
Neuroblastoma 314
Retinoblastoma 315
Wilms tumour 315
Bone tumours 316
Soft tissue sarcoma 316
Germ cell tumours 317
Total childhood cancer 317
Birthweight 317
Leukaemia 318
Tumours of the central nervous system 318
Wilms tumour 318
Other types of childhood cancer 324
Other perinatal characteristics and related interventions 324
Length at birth 324
Apgar score 324
Jaundice 324
Photosensitizing lighting and leukaemia 325
Supplemental oxygen use 326
Vitamin K 326
Allergies 332
Injuries 332
Brain tumours and head injuries 332
Other types of childhood cancer 334
Epilepsy, seizures, barbiturates and tumours of the central nervous system 334
Other illnesses in the index child 336
Height 337
Conclusions 340
Chapter 11. CONCLUSIONS 342
The leukaemias 342
The lymphomas 345
Central nervous system tumours 345
Neuroblastoma 347
Wilms tumour 347
Other specific types of cancer 349
Final comments 350
REFERENCES 351
INDEX 379
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| genre | (DE-588)4056995-0 Statistik 1985-1995 gnd-content |
| genre_facet | Statistik 1985-1995 |
| id | DE-604.BV012598972 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:30:21Z |
| institution | BVB |
| isbn | 9283221494 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008556095 |
| oclc_num | 41310028 |
| open_access_boolean | |
| owner | DE-12 DE-29 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-29 DE-355 DE-BY-UBR |
| physical | XIV, 385 S. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | International Agency for Research on Cancer |
| record_format | marc |
| series | International Agency for Research on Cancer: IARC scientific publications |
| series2 | International Agency for Research on Cancer: IARC scientific publications |
| spelling | Little, Julian Verfasser aut Epidemiology of childhood cancer by Julian Little Lyon International Agency for Research on Cancer 1999 XIV, 385 S. txt rdacontent n rdamedia nc rdacarrier International Agency for Research on Cancer: IARC scientific publications 149 Epidemiologie gtt Kanker gtt Kinderen gtt Tumors in children - Epidemiology Tumors in children - Etiology Kind Cancer in children Epidemiology Child Infant Neoplasms epidemiology Neoplasms etiology Internationaler Vergleich (DE-588)4120509-1 gnd rswk-swf Epidemiologie (DE-588)4015016-1 gnd rswk-swf Kind (DE-588)4030550-8 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4056995-0 Statistik 1985-1995 gnd-content Krebs Medizin (DE-588)4073781-0 s Kind (DE-588)4030550-8 s Epidemiologie (DE-588)4015016-1 s DE-604 Internationaler Vergleich (DE-588)4120509-1 s International Agency for Research on Cancer: IARC scientific publications 149 (DE-604)BV000002423 149 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008556095&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Little, Julian Epidemiology of childhood cancer International Agency for Research on Cancer: IARC scientific publications Epidemiologie gtt Kanker gtt Kinderen gtt Tumors in children - Epidemiology Tumors in children - Etiology Kind Cancer in children Epidemiology Child Infant Neoplasms epidemiology Neoplasms etiology Internationaler Vergleich (DE-588)4120509-1 gnd Epidemiologie (DE-588)4015016-1 gnd Kind (DE-588)4030550-8 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4120509-1 (DE-588)4015016-1 (DE-588)4030550-8 (DE-588)4073781-0 (DE-588)4056995-0 |
| title | Epidemiology of childhood cancer |
| title_auth | Epidemiology of childhood cancer |
| title_exact_search | Epidemiology of childhood cancer |
| title_full | Epidemiology of childhood cancer by Julian Little |
| title_fullStr | Epidemiology of childhood cancer by Julian Little |
| title_full_unstemmed | Epidemiology of childhood cancer by Julian Little |
| title_short | Epidemiology of childhood cancer |
| title_sort | epidemiology of childhood cancer |
| topic | Epidemiologie gtt Kanker gtt Kinderen gtt Tumors in children - Epidemiology Tumors in children - Etiology Kind Cancer in children Epidemiology Child Infant Neoplasms epidemiology Neoplasms etiology Internationaler Vergleich (DE-588)4120509-1 gnd Epidemiologie (DE-588)4015016-1 gnd Kind (DE-588)4030550-8 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Epidemiologie Kanker Kinderen Tumors in children - Epidemiology Tumors in children - Etiology Kind Cancer in children Epidemiology Child Infant Neoplasms epidemiology Neoplasms etiology Internationaler Vergleich Krebs Medizin Statistik 1985-1995 |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008556095&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000002423 |
| work_keys_str_mv | AT littlejulian epidemiologyofchildhoodcancer |