Inorganic polyphosphates: biochemistry, biology, biotechnology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1999
|
| Schriftenreihe: | Progress in molecular and subcellular biology
23 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XV, 317 S. Ill., graph. Darst. |
| ISBN: | 3540653031 |
Internformat
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| 245 | 1 | 0 | |a Inorganic polyphosphates |b biochemistry, biology, biotechnology |c Heinz C. Schröder ... (eds.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1999 | |
| 300 | |a XV, 317 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Progress in molecular and subcellular biology |v 23 | |
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Datensatz im Suchindex
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| adam_text | Contents
Inorganic Poly phosphate: A Molecule of Many Functions
A. Kornberg
1 Introduction 1
2 Metachromatic Granules Are Inorganic PolyP 2
3 Occurrence and Enzymology of PolyP 2
4 Biosynthesis of PolyP 5
5 Functions of PolyP 8
5.1 ATP Substitute and Energy Source 8
5.2 A Reservoir for P; 9
5.3 Chelator of Metal Ions 9
5.4 Buffer Against Alkali 9
5.5 Channel for DNA Entry 10
5.6 Regulator for Stress and Survival 10
5.7 Regulator of Development 11
5.8 Cell Capsule 11
6 PolyP in Animal Cells and Tissues 11
7 Prebiotic Role of PolyP 12
8 Industrial Applications of PolyP 13
8.1 Depollution of P; in the Environment 13
8.2 Antibacterial Action 13
8.3 PolyP Kinase as an Antimicrobial Target 13
8.4 Source of ATP (NTPs) 14
8.5 Insulating Fibers 15
9 Summary 15
References 16
Research in Inorganic Polyphosphates: The Beginning
P. Langen
1 From the Last Decade of the Previous Century to the Middle
of the Present One: The Discovery of Polyphosphates
in Yeast and Other Microorganisms and the Elucidation
of Their Structure 19
2 Polyphosphate Synthesis. How and Where Does it Start? 21
References 24
VIII Contents
Metabolism and Function of Polyphosphates in Bacteria and Yeast
I.S. Kulaev, T.V. Kulakovskaya, N.A. Andreeva, and L.P. Lichko
1 Introduction 27
2 Polyphosphates and Enzymes of Their Metabolism
in Prokaryotes 27
3 Polyphosphates and Enzymes of Their Metabolism
in Lower Eukaryotes 30
4 Exopolyphosphatases of Yeast Cells: Compartmentation
and Properties 33
References 40
Inorganic Polyphosphate in Eukaryotes:
Enzymes, Metabolism and Function
H.C. Schroder, B. Lorenz, L. Kurz, and W.E.G. Miiller
1 Introduction 45
2 Occurrence of PolyP in Eukaryotic Cells 45
2.1 Variations in Cellular PolyP Content 48
2.2 Subcellular Localization 49
3 PolyP Dependent Enzymes 49
3.1 PolyP Synthesis: Polyphosphate Kinase 50
3.2 PolyP Degradation: Polyphosphatases 51
3.2.1 Exopolyphosphatases 52
3.2.2 Endopolyphosphatases 58
3.3 Further PolyP Dependent Enzymes 59
4 PolyP Binding Proteins 60
5 Biological Functions of PolyP 60
5.1 Energy Source 61
5.2 Phosphate Reserve and Phosphate Donor for Kinases 61
5.3 Regulator of Cellular Enzymes 62
5.4 Regulator of Levels of Intracellular Adenylate Nucleotides 62
5.5 Regulator of DNA Histone Interaction and Other Functions
in the Cell Nucleus 63
5.6 Formation of Calcium Channels Across Membranes 64
5.7 Chelator for Divalent Cations and Counterion
for Basic Molecules 65
5.8 Regulator of Cellular Stress Response 66
5.9 Antibacterial and Antiviral Agent 67
6 PolyP Metabolism During Ageing and Development 67
7 Changes in PolyP Metabolism During Apoptosis 69
8 PolyP in Human Bone Formation 70
9 PolyP and Disease 72
10 Concluding Remarks 74
References 74
Contents IX
Cyclic Condensed Metaphosphates in Plants
and the Possible Correlations Between Inorganic Polyphosphates
and Other Compounds
R. Niemeyer
1 Nomenclature and Structure of Inorganic Condensed
Phosphates 83
1.1 Linear Condensed Polyphosphates 83
1.2 Cyclic Condensed Metaphosphates 84
1.3 Ultraphosphates 84
2 Extraction Methods of Condensed Inorganic Phosphates 84
2.1 Hydrolysis Free Extraction Method as a Prerequisite
for Metabolic Investigation 84
2.2 Hydrolysis Free Extraction, Separation and Identification
of Metaphosphates Together with Inositol Phosphates
and Nucleic Acids 85
3 Radioactivity Pattern of Condensed Phosphates
and Inositol Phosphates After Fractionation on Slab Gels 87
4 Quantitative Distribution of Incorporated 32P Orthophosphate
in Six Different Fractions 92
5 The Metabolic Model of Condensed Phosphates 94
References 98
Polyphosphate Glucokinase
N.F.B. Phillips, P.C. Hsieh, and T.H. Kowalczyk
1 Introduction 101
2 An Historical Perspective 102
2.1 Involvement of PolyP Glucokinase in Metabolism 102
3 Multiple Forms of PolyP Glucokinase
and Molecular Weight Characterization 103
4 Bifunctionality 104
5 PolyP and ATP Glucokinase Activities Are Catalyzed
by a Single Enzyme 105
6 PolyP and ATP Have Separate Binding Sites 105
7 The Glucose Phosphorylating Center Is Common
for Both PolyP and ATP 106
7.1 Kinetic Evidence 106
7.1.1 Substrate Competition 106
7.1.2 Affinity Labeling with Nudeotide Analogs 107
7.2 Structural Evidence 107
8 Mechanism of the PolyP Glucokinase Reaction 109
8.1 Mechanism of the Mycobacterial Enzyme 109
8.1.1 Kinetic Mechanism of the PolyP Dependent Reaction 109
8.1.2 Kinetic Mechanism of the ATP Dependent Reaction 109
X Contents
8.2 Kinetic Mechanism of the P. shermanii Enzyme 110
8.3 Mechanism of PolyP Utilization:
Processivity vs Nonprocessivity 110
8.4 Preferential Utilization of Long Chains Over Short Chains
Is Due to Better Binding Affinities
Rather than Faster Catalysis or Product Release 112
8.5 Influence of Glycerol on Kinetic Parameters 114
9 Which Reaction Is Favorable in M. tuberculosis? 114
10 Cloning and Expression of the PolyP Glucokinase Gene
from M. tuberculosis 115
11 Characterization of the PolyP Glucokinase Gene 116
12 Identification of Substrate Binding Domains
of PolyP Glucokinase and Other ATP Hexokinases 116
13 Proposed Substrate Binding Domains of PolyP Glucokinase... 117
13.1 The ATP Binding Site 117
13.2 The Adenosine Site 117
13.3 The Glucose Binding Site 118
13.4 The PolyP Binding Site 119
14 Evolutionary Significance of PolyP Glucokinase 119
14.1 Transition from PolyP to ATP as the Phosphoryl Donor
in Glucose Phosphorylation 119
14.2 Bifunctional PolyP Glucokinase May be an Intermediate
in the Evolution of Hexokinases and Glucokinases 120
15 Concluding Remarks 121
References 122
Cytoplasmic Inorganic Pyrophosphatase
A.A. Baykov, B.S. Cooperman, A. Goldman, and R. Lahti
1 Introduction 127
2 Catalytic Properties 128
2.1 Substrate and Metal Activator Specificity 128
2.2 Pyrophosphate Synthesis 129
2.3 Oxygen Exchange 129
2.4 Inhibitors 130
3 Pyrophosphatase Gene 130
3.1 Cloning the Gene 130
3.2 Expressing the Genes and Producing Enzyme Variants 131
3.3 Conservation of Enzyme Primary Structure 131
4 Three Dimensional Structure 134
4.1 Monomeric Structure 135
4.2 Active Site Structure 136
4.3 Oligomeric Structure 138
4.4 The Role of Oligomeric Structure in Catalysis
and Thermostability 139
Contents XI
5 Mechanism of Catalysis of Water Attack on PP; 140
5.1 Assignment of PI and P2 142
5.2 Consistency with Model Studies 142
5.3 The General Acid 143
5.4 The Nucleophilic Water 143
5.5 Relaxation at the Active Site: Alternative Mechanisms 144
References 145
Polyphosphate/Poly (R) 3 hydroxybutyrate Ion Channels
in Cell Membranes
R.N. Reusch
1 Introduction 151
2 Inorganic Polyphosphates: Cation Attraction, Selection,
and Transport 152
3 Poly (R) 3 Hydroxybutyrate) 153
3.1 Low Molecular Weight Poly (R) 3 Hydroxybutyrate
in Bacterial Membranes 154
3.2 Poly (R) 3 Hydroxybutyrate as an Amphiphilic Salt Solvent... 158
3.3 Poly (R) 3 Hydroxybutyrate Ion Channels
in Planar Lipid Bilayers 160
4 Polyphosphate/Poly (R) 3 Hydroxybutyrate Complexes
in Bacterial Membranes 162
4.1 Selectivity for Calcium 162
4.2 Models for the Structure of PolyP/Poly (R) 3 Hydroxybutyrate
Membrane Complexes 163
5 Polyphosphate/Poly (R) 3 Hydroxybutyrate Complexes
in Planar Lipid Bilayers 166
5.1 E. coli PolyP/Poly (R) 3 Hydroxybutyrate Complexes
as Ion Channels 166
5.2 Completely Synthetic PolyP/Poly (R) 3 Hydroxybutyrate
Complexes as Ion Channels 169
5.3 Cation Selectivity of PolyP/Poly (R) 3 Hydroxybutyrate
Channels 170
5.4 Blockage of PolyP/Poly (R) 3 Hydroxybutyrate Channels 171
5.5 How Do PolyP/Poly (R) 3 Hydroxybutyrate Channels Work?.. 172
6 Polyphosphate/Poly (R) 3 Hydroxybutyrate Complexes
as Calcium Pumps 173
7 Polyphosphate/Poly (R) 3 Hydroxybutyrate Complexes
as DNA Channels? 175
8 Evolutionary Aspects and Concluding Remarks 177
References 178
XII Contents
Inorganic Polyphosphate Regulates Responses of Escherichia coli
to Nutritional Stringencies, Environmental Stresses and Survival
in the Stationary Phase
N.N. Rao and A. Kornberg
1 Introduction 183
2 Nutritional Stringencies and Environmental Stress 183
2.1 Phosphate Limitation: phoB and pho Regulon 184
2.2 Amino Acid and Phosphate Limitation 185
2.3 (p)ppGpp and in Vivo Synthesis of PolyP 185
2.4 Accumulation of PolyP is Due to Inhibition
of Exopolyphosphatase by (p)ppGpp 186
2.5 Nitrogen Starvation: rpoN 186
2.6 Nutritional Shift from Rich to Minimal Medium
and the Reverse 186
2.7 Osmotic Stress 186
3 Stationary Phase Adaptations 187
3.1 Heat Sensitivity 187
3.2 Response to Oxidative Stress and Sensitivity to Menadione ... 187
3.3 Sensitivity to UV and Osmotic Challenge 188
3.4 HPII Expression 189
3.5 Reduced Survival and Growth Defects 189
4 PolyP and Induction of rpoS Expression 189
4.1 Transcription of katE is not Induced in Cells Lacking PolyP... 190
4.2 Transcription of rpoS Gene 190
4.3 Cellular Levels of RpoS in PolyP Minus Cells 191
5 PolyP Binding Proteins and Metal Complexes 191
5.1 PolyP Binding Proteins 191
5.2 Heavy Metals and Polyamines 191
5.3 Metal PolyP Complexes and Membrane Potential 192
6 Summary 192
References 193
From Polyphosphates to Bisphosphonates
and Their Role in Bone and Calcium Metabolism
H. Fleisch
1 Introduction 197
2 Pyrophosphates and Polyphosphates 197
3 Bisphosphonates 200
3.1 Chemistry 200
3.2 Physicochemical Effects 200
3.3 Biological Effects 201
3.3.1 Inhibition of Bone Resorption 201
3.3.2 Inhibition of Calcification 208
Contents XIII
3.4 Pharmacokinetics 209
4 Discussion 210
5 Further Information 210
References 210
Methods for Investigation of Inorganic Polyphosphates
and Polyphosphate Metabolizing Enzymes
B. Lorenz and H.C. Schroder
1 Introduction 217
2 Preparation of Inorganic Polyphosphates 217
2.1 Chemical Synthesis 217
2.2 Radiolabeled Polyphosphates 219
2.3 Enzymatic Synthesis 220
2.4 Synthesis by Living Cells or Organisms 220
3 Isolation of Polyphosphates from Cells and Tissues 221
3.1 Isolation Procedures 221
4 Analysis of Polyphosphates and Measuring
of Enzyme Activities 223
4.1 Basic Dyes 224
4.2 Determination of Orthophosphate Using Ammonium
Molybdate 224
4.3 Radioassays 225
4.4 Fura 2 Method 226
4.5 Enzymatic Assays 227
4.6 Detection of Polyphosphates in Whole Cells and Tissues 230
5 Separation of Polyphosphates and Determination
of Their Chain Lengths 230
5.1 Thin Layer Chromatography 231
5.2 Ion Exchange Chromatography 231
5.3 High Performance Liquid Chromatography 231
5.4 Gel Electrophoresis 233
5.5 Gel Filtration 234
5.6 Other Methods for Determination of Chain Lengths 235
References 236
Definitive Enzymatic Assays in Polyphosphate Analysis
D. Ault Riche and A. Kornberg
1 Introduction 241
2 Enzymes Used in Assays of PolyP 242
2.1 PolyP Kinase (PPK) 242
2.2 Exopolyphosphatase (PPX) 243
2.3 Other Enzymes 244
3 Purification and Assay of Recombinant PPK 245
XIV Contents
4 Purification and Assay of Recombinant PPX 246
5 Rapid Preparation of 32P PolyP 247
6 Estimating PolyP in Biological Samples 248
6.1 Radioactive Assay of PolyP with PPX 248
6.2 Non radioactive Assay of PolyP with PPK 249
6.3 High Throughput (HTP) Assay of PolyP 249
7 Future Directions in Assay Development 250
References 251
Study of Polyphosphate Metabolism in Intact Cells
by 31 P Nuclear Magnetic Resonance Spectroscopy
K.Y. Chen
1 Introduction 253
2 Phosphorus NMR 254
2.1 Basic Principles of NMR 254
2.2 Phosphorus NMR 255
3 Polyphosphates 256
3.1 Inorganic and Organic 256
3.2 Metabolism, Regulation, and Function 256
4 Use of Phosphorus NMR to Study Polyphosphate
in Intact Cells 257
4.1 NMR Apparatus and Sample Preparations 257
4.2 Specific Information Gained on PolyP
from Phosphorus NMR 259
4.3 Eubacteria 260
4.3.1 Escherichia coli 260
4.3.2 Propionibacterium acnes 261
4.3.3 Acinetobacter johnsonii 263
4.4 Lower Eukaryotes 263
4.4.1 Yeast 263
4.4.2 Neurospora crassa 266
4.4.3 Physarum polycephalum 268
4.4.4 Aspergillus terreus 269
4.4.5 Algae 269
4.5 Plant and Animal Cells 270
5 Conclusions 270
References 271
Contents XV
Polyphosphate Accumulating Bacteria and Enhanced Biological
Phosphorus Removal
G.J.J. Kortstee and H.W. van Veen
1 Introduction 275
2 Chemistry of Inorganic Condensed Phosphates 276
3 Functions of PolyP in Bacteria 277
3.1 Energy Source 277
3.2 Acquisition of Competence 279
3.3 Uptake of Ca2+ 280
4 Biosynthesis and Biodegradation of PolyP
in Acinetobacter spp 281
4.1 Biosynthesis 281
4.2 Biodegradation 283
5 Phosphate Transport in Acinetobacter johnsonii 210A 285
5.1 Uptake and Efflux 285
5.2 Pi Efflux as an Energy Recycling Mechanism 287
6 Enhanced Biological Phosphorus Removal (EBPR) 288
6.1 The Process 288
6.2 The Biochemical Model 290
6.3 The Bacteria Involved 292
7 Conclusions and Outlook 293
References 294
Genetic Improvement of Bacteria for Enhanced Biological Removal
of Phosphate from Wastewater
H. Ohtake, A. Kuroda, J. Kato, and T. Ikeda
1 Introduction 299
2 Strategy of Genetic Improvement of Escherichia coli 300
3 Rate Limiting Step for PolyP Accumulation 301
4 PolyP Accumulation Capacity 304
5 PolyP Accumulation in Klebsiella aerogenes 306
6 Concluding Remarks 309
References 309
Subject Index 313
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012555836 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:29:36Z |
| institution | BVB |
| isbn | 3540653031 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008525523 |
| oclc_num | 468480079 |
| open_access_boolean | |
| owner | DE-703 DE-12 DE-634 DE-11 DE-188 |
| owner_facet | DE-703 DE-12 DE-634 DE-11 DE-188 |
| physical | XV, 317 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Springer |
| record_format | marc |
| series | Progress in molecular and subcellular biology |
| series2 | Progress in molecular and subcellular biology |
| spelling | Inorganic polyphosphates biochemistry, biology, biotechnology Heinz C. Schröder ... (eds.) Berlin [u.a.] Springer 1999 XV, 317 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in molecular and subcellular biology 23 Literaturangaben Polyphosphates - Biotechnologie ram Polyphosphates - Effets physiologiques ram Polyphosphates - Métabolisme ram Polyphosphates Physiologie (DE-588)4045981-0 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Polyphosphate (DE-588)4175289-2 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polyphosphate (DE-588)4175289-2 s DE-604 Biochemie (DE-588)4006777-4 s Physiologie (DE-588)4045981-0 s Biotechnologie (DE-588)4069491-4 s Schröder, Heinz C. 1951- Sonstige (DE-588)120765039 oth Progress in molecular and subcellular biology 23 (DE-604)BV002534931 23 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008525523&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Inorganic polyphosphates biochemistry, biology, biotechnology Progress in molecular and subcellular biology Polyphosphates - Biotechnologie ram Polyphosphates - Effets physiologiques ram Polyphosphates - Métabolisme ram Polyphosphates Physiologie (DE-588)4045981-0 gnd Biotechnologie (DE-588)4069491-4 gnd Polyphosphate (DE-588)4175289-2 gnd Biochemie (DE-588)4006777-4 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4069491-4 (DE-588)4175289-2 (DE-588)4006777-4 (DE-588)4143413-4 |
| title | Inorganic polyphosphates biochemistry, biology, biotechnology |
| title_auth | Inorganic polyphosphates biochemistry, biology, biotechnology |
| title_exact_search | Inorganic polyphosphates biochemistry, biology, biotechnology |
| title_full | Inorganic polyphosphates biochemistry, biology, biotechnology Heinz C. Schröder ... (eds.) |
| title_fullStr | Inorganic polyphosphates biochemistry, biology, biotechnology Heinz C. Schröder ... (eds.) |
| title_full_unstemmed | Inorganic polyphosphates biochemistry, biology, biotechnology Heinz C. Schröder ... (eds.) |
| title_short | Inorganic polyphosphates |
| title_sort | inorganic polyphosphates biochemistry biology biotechnology |
| title_sub | biochemistry, biology, biotechnology |
| topic | Polyphosphates - Biotechnologie ram Polyphosphates - Effets physiologiques ram Polyphosphates - Métabolisme ram Polyphosphates Physiologie (DE-588)4045981-0 gnd Biotechnologie (DE-588)4069491-4 gnd Polyphosphate (DE-588)4175289-2 gnd Biochemie (DE-588)4006777-4 gnd |
| topic_facet | Polyphosphates - Biotechnologie Polyphosphates - Effets physiologiques Polyphosphates - Métabolisme Polyphosphates Physiologie Biotechnologie Polyphosphate Biochemie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008525523&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002534931 |
| work_keys_str_mv | AT schroderheinzc inorganicpolyphosphatesbiochemistrybiologybiotechnology |