Amiloride sensitive sodium channels: physiology and functional diversity
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1999
|
| Schriftenreihe: | Current topics in membranes
47 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 384 S. Ill., graph. Darst. |
| ISBN: | 0121533476 0120890305 |
Internformat
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| 245 | 1 | 0 | |a Amiloride sensitive sodium channels |b physiology and functional diversity |c ed. by Dale J. Benos |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1999 | |
| 300 | |a XXIV, 384 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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| adam_text | Contents
Contributors xv
Preface xix
Previous Volumes in Series xxiii
PART I Structure—Function Relations of Amiloride Sensitive
Sodium Channels
CHAPTER 1 Mapping Structure/Function Relations in abENaC
C. M. Fuller, I. I. hmailov, B. K. Berdiev, V. Gh. Shlyonsky, and
D. J. Benos
I. Introduction 3
II. Cloning and Expression of abENaC 4
III. The C Terminus of abENaC: A Kinetic Switch? 8
IV. A Region in the Extracelular Loop Influences Gating,
Ion Selectivity, and Amiloride Affinity 15
V. Summary 20
References 21
CHAPTER 2 Membrane Topology, Subunit Composition, and
Stoichiometry of the Epithelial Na+ Channel
Peter M. Snyder, Chun Cheng, and Michael J. Welsh
I. Introduction 25
II. Topology of ENaC 26
III. Subunit Composition of hENaC 29
IV. Stoichiometry of hENaC 30
V. Conclusion 34
References 35
CHAPTER 3 Subunit Stoichiometry of Heterooligomeric and
Homooligomeric Epithelial Sodium Channels
Farhad Kosari, Bakhram K. Berdiev, Jinqing Li, Shaohu Sheng,
Iskander hmailov, and Thomas R. Kleyman
I. Introduction 37
vii
viii Contents
II. Stoichiometry of Heterooligomeric at/ly Na+
Channels 39
III. a Subunit Stoichiometry 39
IV. /3 Subunit and y Subunit Stoichiometry 42
V. Stoichiometry of Homooligomeric a Subunit
Na+ Channels 44
References 48
PART II Regulation of Sodium Channels CHAPTER 4 Cell Specific Expression of ENaC and Its Regulation by
Aldosterone and Vasopressin in Kidney and Colon
N. Farman, S. Djelidi, M. Brouard, B. Escoubet,
M. Blot Chabaud, and J. P. Bonvalet
I. Introduction 51
II. Cell Specific Expression 52
III. Regulation of ENaC Expression by Aldosterone
and Vasopressin 55
References 61
CHAPTER 5 Regulation of ENaC by Interacting Proteins and
by Ubiquitination
Olivier Staub, Pamela Plant, Toru Ishikawa, Laurent Schild, and
Daniela Rotin
I. Introduction 65
II. Proline Rich Regions in ENaC and Their
Interacting Proteins 66
III. Nedd4: Its Domains and Mode of Interaction
with ENaC 69
IV. Regulation of ENaC Stability and Function
by Ubiquitination 71
V. Role of the C2 Domain of Nedd4 in Ca2+ Dependent
Membrane Targeting 79
VI. Summary 81
References 82
CHAPTER 6 Role of G Proteins in the Regulation of Apical
Membrane Sodium Permeability by Aldosterone
in Epithelia
Sarah Sariban Sohraby
I. Introduction 87
Contents ix
II. Control of Basal Na+ Transport by G Proteins 88
III. GTP Dependent Methylation of Membrane Proteins 89
IV. Control of Basal Na+ Permeability by Methylation 89
V. Aldosterone Dependent Methylation of
Membrane Proteins 90
VI. Aldosterone Dependent Membrane GTPase Activity 90
VII. The Effect of Pertussis Toxin on Membrane Na+
Transport and GTPase Activity 91
VIII. The Effect of Aldosterone on G Protein Expression 91
IX. Conclusion 92
References 92
CHAPTER 7 The Role of Posttranslational Modifications of Proteins
in the Cellular Mechanism of Action of Aldosterone
/. P. Johnson, J. M. Wang, and R. S. Edinger
References 103
CHAPTER 8 Regulation of Amiloride Sensitive Na+ Channels in the
Renal Collecting Duct
James A. Schafer, Li Li, Duo Sun, Ryan G. Morris, and
Teresa W. Wilborn
I. Introduction 109
II. Vasopressin Can Act as an Antinatriuretic as Well as an
Antidiuretic Hormone 111
III. Autacoids That Limit the Actions of Aldosterone and
Vasopression in the CCD 114
IV. Trafficking and the Regulation of the Amiloride Sensitive
Na+ Channel 122
V. A Challenge for Integrative Physiology—The Link
between Na+ Retention and Hypertension 124
References 126
CHAPTER 9 cAMP Mediated Regulation of Amiloride Sensitive
Sodium Channels: Channel Activation or
Channel Recruitment?
Peter R. Smith
I. Introduction 133
II. Evidence for cAMP Mediated Activation of
Amiloride Sensitive Sodium Channels 135
X Contents
III. Evidence for cAMP Mediated Recruitment of
Amiloride Sensitive Sodium Channels 143
IV. Perspectives 148
References 149
CHAPTER 10 Human Lymphocyte Ionic Conductance
James K. Bubien
I. Introduction 155
II. Lymphocyte Potassium Channels and Cell
Cycle Regulation 156
III. Cell Cycle Dependent Expression of Chloride Channels
by Human Lymphocytes 158
IV. CD20: A B Lymphocyte Specific Unique
Calcium Conductor 161
V. Lymphocyte Amiloride Sensitive
Sodium Conductance 163
References 175
CHAPTER 11 Regulatory Aspects of Apx, a Novel Na+ Channel
with Connections to the Cytoskeleton
Horacio F. Cantiello
I. Sodium Channels of A6 Epithelial Cells 177
II. Apx, an Actin Regulated Sodium Channel 179
III. Sodium Transport in Proximal Tubular Cells 185
IV. Conclusion and Perspective 190
References 192
PART III Sodium Channels in the Lung
CHAPTER 12 Species Specific Variations in ENaC Expression and
Localization in Mammalian Respiratory Epithelium
Colleen R. Talbot
I. Introduction 197
II. Structure/Function of the Respiratory Tract 198
III. Regional ENaC Expression in the
Respiratory Tract 201
IV. Developmental Expression of ENaC in the Lung 210
V. Expression Patterns and ENaC Function 212
References 215
Contents xi
CHAPTER 13 Inhibition of Vectorial Na+ Transport across
Alveolar Epithelial Cells by Nitrogen Oxygen
Reactive Species
Sadis Matalon, Ahmed Lazrak, and Michael D. DuVall
I. Introduction 219
II. Interaction of «NO with Biological Targets: Signal
Transducer and Pathophysiological Mediator 221
III. Modulation of Ion Transport across the Adult Alveolar
Epithelium by Redox States of «NO 224
IV. Inhibition of Na+ Transport across Freshly Isolated ATII
Cells by Redox States of NO 230
V. Does »NO Modulate Alveolar Epithelial Fluid Transport
in Vivo? 233
VI. Conclusions 233
References 234
CHAPTER 14 Induction of Epithelial Sodium Channel (ENaC)
Expression and Sodium Transport in Distal Lung
Epithelia by Oxygen
Bijan Rafii, A. Keith Tanswell, Olli Pitkdnen, and
Hugh O Brodovich
I. Introduction 239
II. Physiologic Increase in Oxygen Augments Na+ Transport
in FDLE 241
III. Oxygen Induction of Na+ Transport Is Mediated by
Reactive Oxygen Species 242
IV. Increase in ENaC mRNA Expression Is Associated with
NF kB Activation 246
V. Possible Sites of ROS Generation for Oxygen Induction
of Na+ Transport in FDLE 248
VI. Conclusion 249
References 250
CHAPTER 15 Catecholamine Regulation of Amiloride Sensitive Na+
Transport in the Fetal Rat Alveolar Epithelium
Yoshinori Marunaka and Naomi Niisato
I. Introduction 256
II. Characteristics of Amiloride Sensitive
Na+ Permeable Channels 257
III. Catecholamine Action 263
xii Contents
IV. Switching Mechanism of FDLE to the Absorptive from
the Secretory Tissue by Catecholamine 273
V. Conclusion 274
References 276
CHAPTER 16 Cyclic Nudeotide Gated Cation Channels Contribute
to Sodium Absorption in Lung: Role of Nonselective
Cation Channels
Sandra Guggino
I. Nonselective Cation Channels in Epithelia 279
II. Analogues of Amiloride Block Multiple Types of
Cation Channels 282
III. The Role of ENaC and Other Channels in
Transepithelial Transport in Lung 284
IV. Nucleotide Gated Nonselective Cation Channels
(aCNCl, aCNC2, aCNC3, jSCNCab) 285
V. Cyclic Nucleotide Gated Channels in the Lung 287
References 290
PART IV Sensory and Mechanical Transduction
CHAPTER 17 C. elegans Members of the DEG/ENaC Channel
Superfamily: Form and Function
Heather A. Thieringer, Sukhvinder Sahota, Itzhak Mano, and
Monica Driscoll
I. Introduction 297
II. C. elegans Proteins Related to ENaC Channels Define
Two Subfamilies 299
III. C. elegans Degenerins Have Been Implicated
in Mechanotransduction 304
IV. Future Directions 311
References 312
CHAPTER 18 Amiloride Sensitive Sodium Channels in Taste
Bernd Lindemann, Timothy A. Gilbertson, and
Sue C. Kinnamon
I. Introduction and Historical Background 315
II. The Frog Sodium Taste Channel 317
Contents xiii
III. Amiloride Sensitive Na+ Channels in
Rodent Tongue 319
IV. ENaC Expression in the Lingual Epithelium (LE) 326
V. ENaC Expression in Taste Buds 327
VI. Development and Plasticity of the Channel 328
VII. Outlook 331
References 332
PART V Clinical Relevance
CHAPTER 19 The Involvement of Amiloride Sensitive Na+
Channels in Human Genetic Hypertension:
Liddle s Syndrome
Dale J. Benos
I. Introduction 339
II. Molecular Mechanism of ENaC Gated Function:
Increased Surface Density or Increased Single Channel
Open Probability, or Both 342
III. Summary 346
References 346
CHAPTER 20 Epithelial Sodium Channels in Cystic Fibrosis
Bakhrom K. Berdiev and hkander I. hmailov
I. Introduction 351
II. Na+ Hyperabsorption in CF 352
III. ENaCs and CFTR 354
IV. CFTR Induced Inhibition of ENaCs and Cell
Regulatory Machinery 359
V. Alpha, Beta, or Gamma? 367
VI. Mutations of CFTR Found in CF and Inhibition
of a#y ENaC 370
VII. Concluding Remarks 372
References 372
Index 381
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| spelling | Amiloride sensitive sodium channels physiology and functional diversity ed. by Dale J. Benos San Diego [u.a.] Acad. Press 1999 XXIV, 384 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 47 Natriumkanal (DE-588)4244067-1 gnd rswk-swf Amilorid (DE-588)4291652-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Natriumkanal (DE-588)4244067-1 s Amilorid (DE-588)4291652-5 s DE-604 Benos, Dale J. Sonstige oth Current topics in membranes 47 (DE-604)BV036839511 47 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008524390&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Amiloride sensitive sodium channels physiology and functional diversity Current topics in membranes Natriumkanal (DE-588)4244067-1 gnd Amilorid (DE-588)4291652-5 gnd |
| subject_GND | (DE-588)4244067-1 (DE-588)4291652-5 (DE-588)4143413-4 |
| title | Amiloride sensitive sodium channels physiology and functional diversity |
| title_auth | Amiloride sensitive sodium channels physiology and functional diversity |
| title_exact_search | Amiloride sensitive sodium channels physiology and functional diversity |
| title_full | Amiloride sensitive sodium channels physiology and functional diversity ed. by Dale J. Benos |
| title_fullStr | Amiloride sensitive sodium channels physiology and functional diversity ed. by Dale J. Benos |
| title_full_unstemmed | Amiloride sensitive sodium channels physiology and functional diversity ed. by Dale J. Benos |
| title_short | Amiloride sensitive sodium channels |
| title_sort | amiloride sensitive sodium channels physiology and functional diversity |
| title_sub | physiology and functional diversity |
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