Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
1999
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Dresden, Techn. Univ., Diss., 1999 |
| Beschreibung: | II, 178 S. graph. Darst. |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1807500919481303040 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
GENERAL
PART
1.
INTRODUCTION
AND
OBJECTIVE
1
2.
STEROIDS
AND
STEROID
HORMONE
RECEPTORS
5
3.
OVERVIEW
OF
METAL-LABELED
RECEPTOR
BINDING
STEROIDS
8
MAIN
PART
4.
DESIGN,
SYNTHESIS
AND
BIOLOGICAL
EVALUATION
OF
RHENIUM
AND
TECHNETIUM-ESTROGENS
AS
LIGANDS
FOR
THE
ESTROGEN
RECEPTOR
(ER)
4.1.
INTRODUCTION
14
4.2.
SYNTHESIS
OF
2
SUBSTITUTED
3,
170-ESTRADIOLS
17
4.3.
SYNTHESIS
OF
17A-SUBSTITUTED
3,
17P-ESTRADIOLS
22
4.4.
SYNTHESIS
OF
7A-SUBSTITUTED
3,
170-ESTRADIOLS
35
4.5.
"3+L"-MIXED
LIGAND
COMPLEXES
ACCORDING
TO
THE
INTEGRATED
DESIGN
48
4.6.
RECEPTOR
BINDING
AFFINITY
AND
LIPOPHILICITY
54
4.7.
SYNTHESIS,
STABILITY
AND
IN
VIVO
DISTRIBUTION
OF
TC-99M
"3+1"
MIXED
58
LIGAND
COMPLEX
OF
7A-SUBSTITUTED
3,17P-ESTRADIOL
5.
DESIGN,
SYNTHESIS
AND
BIOLOGICAL
EVALUATION
OF
RHENIUM-PROGESTINS
AS
LIGANDS
FOR
THE
PROGESTERONE
RECEPTOR
(PGR)
5.1.
INTRODUCTION
68
5.2.
SYNTHESIS
OF
2
1-SUBSTITUTED
PROGESTERONES
71
5.3.
RECEPTOR
BINDING
AFFINITY
AND
LIPOPHILICITY
79
6.
DESIGN,
SYNTHESIS
AND
BIOLOGICAL
EVALUATION
OF
RHENIUM-ANDROGENS
AS
LIGANDS
FOR
THE
ANDROGEN
RECEPTOR
(AR)
6.1.
INTRODUCTION
81
6.2.
SYNTHESIS
OF
7A-SUBSTITUTED
TESTOSTERONES
84
6.3.
RECEPTOR
BINDING
AFFINITY
AND
LIPOPHILICITY
90
TABLE
OF
CONTENTS
SUMMARY
7.
SUMMARY
92
EXPERIMENTAL
PART
8.
CHEMICAL
SYNTHESES
8.1.
GENERAL
97
8.2.
2-SUBSTITUTED
ESTRADIOLS
99
8.3.
17A-SUBSTITUTED
ESTRADIOLS
103
8.4.
7A-SUBSTITUTED
ESTRADIOLS
120
8.5.
"3+L"-MIXED
LIGAND
COMPLEXES
ACCORDING
TO
THE
INTEGRATED
DESIGN
132
8.6.
21-SUBSTITUTED
PROGESTERONES
135
8.7.
7A-SUBSTITUTED
TESTOSTERONES
141
8.8.
[3-(A-METHYL)AZAPENTANE-L,5-DITHIOLATO][7A(6-MERCAPTOHEX-L-YL)
ESTRA-L,3,5(10)-TRIENE-3,17P-DIOL]OXO-[
!
'
'
M
TC]TECHNETIUIN(V)
77
148
9.
BIOCHEMICAL
MATERIALS
AND
METHODS
9.1.
ESTROGEN
RECEPTOR
BINDING
AFFINITY
149
9.2.
PROGESTERONE
RECEPTOR
BINDING
AFFINITY
149
9.3.
ANDROGEN
RECEPTOR
BINDING
AFFINITY
149
9.4.
LIPOPHILICITY
150
9.5.
IN
VITRO
STABILITY
STUDIES
150
9.6.
IN
VIVO
BIODISTRIBUTION
STUDIES
151
APPENDIX
10.
REFERENCES
152
11.
TABLES
OF
CRYSTAL
STRUCTURE
ANALYSES
162
12.
TABLE
OF
ABBREVIATIONS
174
13.
VITA
177
14.
PUBLICATIONS
178 |
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| author | Wüst, Frank Rudolf 1969- |
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| bvnumber | BV012547582 |
| ctrlnum | (OCoLC)245828212 (DE-599)BVBBV012547582 |
| format | Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV012547582 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T00:13:21Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008520384 |
| oclc_num | 245828212 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-355 DE-BY-UBR |
| owner_facet | DE-91 DE-BY-TUM DE-355 DE-BY-UBR |
| physical | II, 178 S. graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| record_format | marc |
| spelling | Wüst, Frank Rudolf 1969- Verfasser (DE-588)120960788 aut Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor von Frank Rudolf Wüst 1999 II, 178 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dresden, Techn. Univ., Diss., 1999 Rheniumorganische Verbindungen (DE-588)4178006-1 gnd rswk-swf Technetiumverbindungen (DE-588)4184561-4 gnd rswk-swf Ligand Biochemie (DE-588)4606532-5 gnd rswk-swf Steroide (DE-588)4057379-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Steroide (DE-588)4057379-5 s Technetiumverbindungen (DE-588)4184561-4 s Ligand Biochemie (DE-588)4606532-5 s DE-604 Rheniumorganische Verbindungen (DE-588)4178006-1 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008520384&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wüst, Frank Rudolf 1969- Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor Rheniumorganische Verbindungen (DE-588)4178006-1 gnd Technetiumverbindungen (DE-588)4184561-4 gnd Ligand Biochemie (DE-588)4606532-5 gnd Steroide (DE-588)4057379-5 gnd |
| subject_GND | (DE-588)4178006-1 (DE-588)4184561-4 (DE-588)4606532-5 (DE-588)4057379-5 (DE-588)4113937-9 |
| title | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor |
| title_auth | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor |
| title_exact_search | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor |
| title_full | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor von Frank Rudolf Wüst |
| title_fullStr | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor von Frank Rudolf Wüst |
| title_full_unstemmed | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor von Frank Rudolf Wüst |
| title_short | Rhenium- and technetium-containing steroids as ligands for the estrogen receptor, progesterone receptor and androgen receptor |
| title_sort | rhenium and technetium containing steroids as ligands for the estrogen receptor progesterone receptor and androgen receptor |
| topic | Rheniumorganische Verbindungen (DE-588)4178006-1 gnd Technetiumverbindungen (DE-588)4184561-4 gnd Ligand Biochemie (DE-588)4606532-5 gnd Steroide (DE-588)4057379-5 gnd |
| topic_facet | Rheniumorganische Verbindungen Technetiumverbindungen Ligand Biochemie Steroide Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008520384&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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