Cancer and the search for selective biochemical inhibitors:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton [u.a.]
CRC Press
1999
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 560 S. |
| ISBN: | 0849391180 |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012510048 | ||
| 003 | DE-604 | ||
| 005 | 19990608 | ||
| 007 | t | ||
| 008 | 990415s1999 |||| 00||| eng d | ||
| 020 | |a 0849391180 |9 0-8493-9118-0 | ||
| 035 | |a (OCoLC)40249793 | ||
| 035 | |a (DE-599)BVBBV012510048 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 050 | 0 | |a RC268.5 | |
| 082 | 0 | |a 616.99/4 |2 21 | |
| 084 | |a XI 7000 |0 (DE-625)153024:12905 |2 rvk | ||
| 100 | 1 | |a Hoffman, Edward J. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Cancer and the search for selective biochemical inhibitors |c E. J. Hoffman |
| 264 | 1 | |a Boca Raton [u.a.] |b CRC Press |c 1999 | |
| 300 | |a 560 S. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Antineoplastic Agents, Phytogenic |x therapeutic use | |
| 650 | 4 | |a Antineoplastic agents | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Enzyme Inhibitors |x therapeutic use | |
| 650 | 4 | |a Enzyme inhibitors |x Therapeutic use | |
| 650 | 4 | |a Materia medica, Vegetable | |
| 650 | 4 | |a Neoplasms |x drug therapy | |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Enzyminhibitor |0 (DE-588)4152479-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |D s |
| 689 | 0 | 1 | |a Enzyminhibitor |0 (DE-588)4152479-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008490812&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008490812 | ||
Record in the Search Index
| _version_ | 1804127152867639296 |
|---|---|
| adam_text | Contents
The Biochemistry of Cancer and Its Treatment 1
Chapter 1 The Biochemistry of Cancer and Its Treatment 3
1.1 Introductory Remarks 3
1.2 A Detailing of Enzyme Catalyzed Biochemical Reactions Involved in
Cell Metabolism 5
1.3 Cancer Cells vs. Normal Cells 20
1.4 Enzyme Inhibitors for Glycolysis, Lactate Formation, and Glutaminolyis
in T imor Cells 25
1.5 Tricarboxylic Acid Cycle: Enzyme Inhibitors to be Avoided 26
1.6 Cofactors, Coenzymes, Vitamins, and Hormones 27
1.7 Chemotherapy Drugs 29
1.8 The DNA/RNA Connection 32
1.9 Gene Therapy and Escherichia Coli 32
1.10 FolicAcid 33
1.11 Enzyme Changes 35
1.12 DNA, RNA, and the Synthesis of Proteins 36
1.13 The Genetic Code 40
1.14 Digestion 41
1.15 Proteases and Protease Inhibitors 43
1.16 Protein Degradation 44
1.17 Antibiotics 45
1.18 DNA Replication 46
1.19 DNA Alterations 46
1.20 Viruses and Subviruses 47
1.21 Chemoprevention 49
1.22 Comments 51
Plant Biochemistry and Cancer 55
Chapter 2 Plant Biochemistry and Cancer 57
2.1 Introduction 57
2.2 Cancer and Anticancer Agents 59
2.3 Antibacterial and Antiviral Agents 66
2.4 Antifungal and Miscellaneous Agents 69
2.5 Plant Enzymes 70
2.6 Bioactive/Toxic Plant Substances 72
2.7 Glycosides 76
2.8 Phenolics 80
2.9 Flavonoids 81
2.10 Proteins and Amino Acids 84
2.11 Alkaloids 86
2.12 Plant Carcinogens 90
2.13 Screening Plants for Anticancer Activity 95
2.14 Some Conclusions 96
Chemical Taxonomy 101
Chapter 3 Chemical Taxonomy 103
3.1 A Review of Medicinal Plant Literature Sources 103
3.2 Some Anticancer Plants Noted in the United States 106
3.3 Investigations in Other Countries 112
3.4 Plant Chemistry and Taxonomy 115
3.5 Toxic/Medicinal Substances and Cancer 121
3.6 A Chinese Protocol 124
3.7 Other Information about Chinese Anticancer Agents 126
3.8 Synthetic vs. Natural Compounds 130
3.9 Some Common Possibilities for Anticancer Agents 134
Alkaloids as Medicines 141
Chapter 4 Alkaloids as Medicines 143
4.1 Introduction 143
4.2 Classification of Alkaloids 144
4.3 Alkaloids as Anticancer Agents 147
4.4 Alkaloids as Antibacterial Agents 147
4.5 Alkaloids as Antiviral Agents 149
4.6 Alkaloids as Antifungal Agents 149
4.7 Other Medicinal Uses for Alkaloids 149
4.8 Toxicity versus Medical Benefits 152
4.9 Screening Plants for Alkaloids 153
4.10 Common Garden Vegetables and Alkaloids 154
4.11 Plants and Plant Families Containing Potential Anticancer Agents,
Notably Alkaloids 160
4.12 A Review of Bioactive Plants and Plant Families 167
Medicinal Uses of Fungi 171
Chapter 5 Medicinal Uses of Fungi 173
5.1 The Mycota or Fungi 173
5.2 Mycetismus 175
5.3 Mycotoxicosis 175
5.4 Medicinal Fungi and Cancer 177
5.5 Antibiotics 179
5.6 Antifungal vis a vis Anticancer Agents 183
5.7 Microbial Toxins 183
Biogenesis of Cancer 185
Chapter 6 Biogenesis of Cancer 187
6.1 Introductory Remarks 187
6.2 Cancer Initiation, Enzymes, and Enzyme Inhibitors 188
6.3 Stress Proteins or Heat Shock Proteins and Molecular Chaperones 195
6.4 Metastasis and Glycoproteins 202
6.5 Intestinal Flora and Cancer 205
6.6 Digestive Metabolism 219
6.7 Lignans and Phyto oestrogens 225
6.8 Intense Sweeteners 226
6.9 Hydrolysis and Other Interactions Between Intestinal Flora and
Chemicals 227
6.10 All Meat and All Vegetarian Diets 232
Viruses and Cancer 237
Chapter 7 Viruses and Cancer 239
7.1 More about Viruses and Other Pathogens 239
7.2 Lysogeny, Viruses, and Cancer 256
7.3 Retroviruses and Oncogenes 261
7.4 Viruses and Degenerative Diseases 265
7.5 Plant and Insect Viruses 274
7.6 Fungal Viruses 280
7.7 Bacterial and Protozoan Viruses 284
7.8 Viruses in Animal Products 289
7.9 The Tropical Connection 299
7.10 Immunity 307
Anticancer Agents as Enzyme Inhibitors and Other Issues 323
Chapter 8 Anticancer Agents as Enzyme Inhibitors and Other Issues... .325
8.1 Bioactive Plants as Enzyme Inhibitors 325
8.2 A Review of Anaerobic Glycolysis 327
8.3 Enzymes and Inhibitors for Anaerobic Glycolysis 331
8.4 Enzyme Inhibitors for Melanoma 349
8.5 Phytochemicals that May Act Against Cancer 349
8.6 Testing Procedures 363
8.7 Anticancer Agents and Angiogenesis 365
8.8 Plant or Herbal Remedies Challenged 368
8.9 An Update on Plant or Other Substances as Enzyme Inhibitors 371
8.10 Lactate Dehydrogenase Inhibitors 386
8.11 Update on Glutaminolysis 397
8.12 Objectives, Mileposts, and Roadblocks 405
Appendices 415
Appendix A Enzymes and Inhibitors for Glycolyis, Lactate Formation,
and Glutaminolysis 417
Appendix B Enzymes and Inhibitors for the Carboxylic Acid Cycle
and as Affecting Respiration 419
Appendix C Enzymes and Inhibitors Pertaining to Chemotherapy 420
Appendix D Enzymes and Inhibitors for Enzymatic Changes 421
Appendix E DNA Enzymes and Inhibitors 422
Appendix F RNA Enzymes and Inhibitors 426
Appendix G Proteases and Protease Inhibitors 430
Appendix H A Worldwide Selection of Anticancer Plants 432
Appendix I Antibacterial Plant Agents 440
Appendix J Antiviral Plant Agents 444
Appendix K Antifungal Plant Agents 446
Appendix L Miscellaneous Plant Agents 448
Appendix M Some Bioactive Plants Found in the United States 454
Appendix N Anticancer Plants of the Neo Tropics 458
Appendix O Anticancer Plants of Africa 461
Appendix P Bioactive/Poisonous Plants Found in Australia 463
Appendix Q Anticancer Plants of India and Pakistan 465
Appendix R Anticancer Plants of East and Southeast Asia 467
Appendix S Anticancer Plants from China 470
Appendix T Chemical Taxa of Medicinal Plants 483
Appendix U Plant Families Listed in Hartwell and Cordell 504
Appendix V Bioactive/Toxic Plants Found in the United States 513
Appendix W Antitumor Phytochemicals 518
Appendix X Agents that Affect Angiogenesis 528
Appendix Y Update on Enzymes and Inhibitors Involved in Anaerobic
Glycolysis 531
Appendix Z Vitamins and Hormones as Enzyme Inhibitors 532
Index 537
|
| any_adam_object | 1 |
| author | Hoffman, Edward J. |
| author_facet | Hoffman, Edward J. |
| author_role | aut |
| author_sort | Hoffman, Edward J. |
| author_variant | e j h ej ejh |
| building | Verbundindex |
| bvnumber | BV012510048 |
| callnumber-first | R - Medicine |
| callnumber-label | RC268 |
| callnumber-raw | RC268.5 |
| callnumber-search | RC268.5 |
| callnumber-sort | RC 3268.5 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | XI 7000 |
| ctrlnum | (OCoLC)40249793 (DE-599)BVBBV012510048 |
| dewey-full | 616.99/4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4 |
| dewey-search | 616.99/4 |
| dewey-sort | 3616.99 14 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01644nam a2200445 c 4500</leader><controlfield tag="001">BV012510048</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">19990608 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">990415s1999 |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0849391180</subfield><subfield code="9">0-8493-9118-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)40249793</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012510048</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC268.5</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.99/4</subfield><subfield code="2">21</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">XI 7000</subfield><subfield code="0">(DE-625)153024:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hoffman, Edward J.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cancer and the search for selective biochemical inhibitors</subfield><subfield code="c">E. J. Hoffman</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton [u.a.]</subfield><subfield code="b">CRC Press</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">560 S.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic Agents, Phytogenic</subfield><subfield code="x">therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antineoplastic agents</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carcinogenesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzyme Inhibitors</subfield><subfield code="x">therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzyme inhibitors</subfield><subfield code="x">Therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Materia medica, Vegetable</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplasms</subfield><subfield code="x">drug therapy</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Krebs</subfield><subfield code="g">Medizin</subfield><subfield code="0">(DE-588)4073781-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Enzyminhibitor</subfield><subfield code="0">(DE-588)4152479-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Krebs</subfield><subfield code="g">Medizin</subfield><subfield code="0">(DE-588)4073781-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Enzyminhibitor</subfield><subfield code="0">(DE-588)4152479-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008490812&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008490812</subfield></datafield></record></collection> |
| id | DE-604.BV012510048 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T18:28:49Z |
| institution | BVB |
| isbn | 0849391180 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008490812 |
| oclc_num | 40249793 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 560 S. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Hoffman, Edward J. Verfasser aut Cancer and the search for selective biochemical inhibitors E. J. Hoffman Boca Raton [u.a.] CRC Press 1999 560 S. txt rdacontent n rdamedia nc rdacarrier Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Carcinogenesis Enzyme Inhibitors therapeutic use Enzyme inhibitors Therapeutic use Materia medica, Vegetable Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Enzyminhibitor (DE-588)4152479-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Enzyminhibitor (DE-588)4152479-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008490812&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hoffman, Edward J. Cancer and the search for selective biochemical inhibitors Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Carcinogenesis Enzyme Inhibitors therapeutic use Enzyme inhibitors Therapeutic use Materia medica, Vegetable Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd Enzyminhibitor (DE-588)4152479-2 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4152479-2 |
| title | Cancer and the search for selective biochemical inhibitors |
| title_auth | Cancer and the search for selective biochemical inhibitors |
| title_exact_search | Cancer and the search for selective biochemical inhibitors |
| title_full | Cancer and the search for selective biochemical inhibitors E. J. Hoffman |
| title_fullStr | Cancer and the search for selective biochemical inhibitors E. J. Hoffman |
| title_full_unstemmed | Cancer and the search for selective biochemical inhibitors E. J. Hoffman |
| title_short | Cancer and the search for selective biochemical inhibitors |
| title_sort | cancer and the search for selective biochemical inhibitors |
| topic | Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Carcinogenesis Enzyme Inhibitors therapeutic use Enzyme inhibitors Therapeutic use Materia medica, Vegetable Neoplasms drug therapy Krebs Medizin (DE-588)4073781-0 gnd Enzyminhibitor (DE-588)4152479-2 gnd |
| topic_facet | Antineoplastic Agents, Phytogenic therapeutic use Antineoplastic agents Carcinogenesis Enzyme Inhibitors therapeutic use Enzyme inhibitors Therapeutic use Materia medica, Vegetable Neoplasms drug therapy Krebs Medizin Enzyminhibitor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008490812&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hoffmanedwardj cancerandthesearchforselectivebiochemicalinhibitors |