Towards prolongation of the healthy life span: practical approaches to intervention
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
New York Acad. of Sciences
1998
|
| Schriftenreihe: | New York Academy of Sciences: Annals of the New York Academy of Sciences
854 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 524 S. Ill., graph. Darst. |
| ISBN: | 1573311081 |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 854
November 20, 1998
TOWARDS PROLONGATION OF THE
HEALTHY LIFE SPAN
Practical Approaches to Intervention**
Editors
Denham Harman, Robin Holliday, and Mohsen Meydani
Conference Organizers
Joseph Cannon, Denham Harman, Robin Holliday, Donald K. Ingram,
Mohsen Meydani, and Sang Chul Park
Advisory Board
Kenichi Kitani, Imre Zs. Nagy, Edwardo Porta, and Byung P. Yu
CONTENTS Preface. By Denham Harman xiii
Aging: Phenomena and Theories. By Denham Harman 1
Part I. Molecular and Cellular Changes with Age
Genes Involved in the Control of Cellular Proliferative Potential.
By Roger R. Reddel 8
Somatic Mutation and Aging. By Alec Morley 20
Chromosomal Damage Rate, Aging, and Diet. By Michael Fenech 23
Pluripotent Protective Effects of Carnosine, a Naturally Occurring Dipeptide.
By A.R. Hipkiss, J.E. Preston, D.T.M. Himsworth, V.C. Worthington,
M. Keown, J. Michaelis, J. Lawrence, A. Mateen, L. Allende,
P.A.M. Eagles, and N. Joan Abbott 37
The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated
Heat Shock on Human Fibroblasts. By Suresh I. S. Rattan 54
Causes of Aging. By Robin Holliday 61
Part II. Exercise and Aging
Intrinsic and Extrinsic Factors in Muscle Aging. By Joseph G. Cannon 72
Age associated Changes in the Response of Skeletal Muscle Cells to
Exercise and Regeneration. By Miranda D. Grounds 78
Age associated Changes in the Innervation of Muscle Fibers and Changes in the
Mechanical Properties of Motor Units. By Anthony R. Luff 92
Oxidative Stress and Aging: Role of Exercise and Its Influences on Antioxidant
Systems. By Li Li Ji, Chris Leeuwenburgh, Steve Leichtweis, Mitch Gore,
Russel Fiebig, John Hollander, and Jeffery Bejma 102
Part III. Role of Mitochondria in Aging
Mitochondrial Aging: Open Questions. By Kenneth B. Beckman and
Bruce N. Ames 118
Mitochondrial DNA Mutations and Age. By Takayuki Ozawa 128
Oxidative Damage and Mutation to Mitochondrial DNA and Age dependent
Decline of Mitochondrial Respiratory Function. By Yau Huei Wei,
Ching You Lu, Hsin Chen Lee, Cheng Yoong Pang, and Yi Shing Ma 155
Tissue specific Distribution of Multiple Mitochondrial DNA Rearrangements
during Human Aging. By Sergey A. Kovalenko, George Kopsidas,
Joanne Kelso, Franklin Rosenfeldt, and Anthony W. Linnane 171
Influences of Caloric Restriction on Age associated Skeletal Muscle Fiber
Characteristics and Mitochondrial Changes in Rats and Mice.
By Connie M. Lee, Lauren E. Aspnes, Susan S. Chung,
Richard Weindruch, and Judd M. Aiken 182
The Effects of Dietary Restriction on Mitochondrial Dysfunction in Aging.
By Ritchie J. Feuers 192
The Universality of Bioenergetic Disease: Age associated Cellular Bioenergetic
Degradation and Amelioration Therapy. By Anthony W. Linnane,
S. Kovalenko, and E.B. Gingold 202
Mitochondrial Decay in Aging: Reversal through Supplementation of
Acetyl L Carnitine and Af ferf Butyl oc phenyl nitrone. By Tory M. Hagen,
Carol M. Wehr, and Bruce N. Ames 214
Mitochondrial Free Radical Production and Aging in Mammals and Birds.
By Gustavo Barja 224
Oxidative Damage in the Senescence accelerated Mouse. By Akitane Mori,
Kozo Utsumi, Jiankang Liu, and Masanori Hosokawa 239
Roundtable Discussion: How Best to Ameliorate the Normal Increase in
Mitochondrial Superoxide Formation with Advancing Age 251
Part IV. Pharmacological Intervention in Aging Processes:
Focus on Oxyradicals and Molecular Mechanisms
Membrane and Receptor Modifications of Oxidative Stress Vulnerability in
Aging: Nutritional Considerations. By J.A. Joseph, N. Denisova,
D. Fisher, B. Shukitt Hale, P. Bickford, R. Prior, and G. Cao 268
Immunohistochemical and ELISA Assays for Biomarkers of Oxidative
Stress in Aging and Disease. By Joelle M. Onorato, Suzanne R. Thorpe, and
John W. Baynes 277
Assessing the Effects of Deprenyl on Longevity and Antioxidant Defenses
in Different Animal Models. By Kenichi Kitani, Setsuko Kanai,
Gwen O. Ivy, and Maria Cristina Carrillo 291
Age associated Memory Impairment: Assessing the Role of Nitric
Oxide. By Robert C. Meyer, Edward L. Spangler, Hideki Kametani, and
Donald K. Ingram 307
Telomeres: Influencing the Rate of Aging. By Thomas von Zglinicki 318
Redox Regulation of the Caspases during Apoptosis. By Mark B. Hampton,
Bengt Fadeel, and Sten Orrenius 328
Part V. Nutritional Intervention in Aging
Nutrition, Osteoporosis, and Aging. By B.E. Christopher Nordin,
Allan G. Need, Tracy Steurer, Howard A. Morris,
Barry E. Chatterton, and Michael Horowitz 336
The Effect of Long term Dietary Supplementation with Antioxidants.
By M. Meydani, R. D. Lipman, S.N. Han, D. Wo, A. Beharka,
K.R. Martin, R. Bronson, G. Cao, D. Smith, and S.N. Meydani 352
B Vitamins and Homocysteine in Cardiovascular Disease and Aging.
By David E.L. Wilcken and Bridget Wilcken 361
Nutrition, Cancer, and Aging. By Ivor E. Dreosti 371
Combined Exercise and Dietary Intervention to Optimize Body
Composition in Aging. By Maria A. Fiatarone Singh 378
Part VI. Antioxidants and Aging
The Biochemical, Pathophysiological, and Medical Aspects of Ubiquinone
Function. By Hans Nohl, Lars Gille, and KaTrin Staniek 394
Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to
Melatonin. By Russel J. Reiter, Juan M. Guerrero,
Joaquin J. Garcia, and Dario Acuna Castroviejo 410
Recycling and Redox Cycling of Phenolic Antioxidants. By V.E. Kagan and
Y.Y. Tyurina 425
The Chemistry and Biological Effects of Flavonoids and Phenolic Acids.
By Kevin D. Croft 435
The Antioxidant and Biological Properties of the Carotenoids.
By Norman I. Krinsky 443
Structural and Functional Changes in Proteins Induced by Free Radical mediated
Oxidative Stress and Protective Action of the Antioxidants A/ ter? Butyl a
phenylnitrone and Vitamin E. By D. Allan Butterfield, Tanuia Koppal,
Beverly Howard, Ram Subramaniam, Nathan Hall, Kenneth Hensley,
Servet Yatin, Kerry Allen, Michael Aksenov, Marina Aksenova, and
John Carney 448
Roundtable Discussion: How Best to Ensure Daily Intake of Antioxidants
(from the Diet and Supplements) That is Optimal for Life Span, Disease,
and General Health 463
Part VII. Poster Papers
Synergistic Multitherapy as a Rational Strategy in Aging: Multifactorial Process.
By Sorin Riga and Dan Riga 477
Cell Signaling as a Major Factor of Intervention into the Aging Process.
By Hans Niedermuller, Alois Strasser, and Gerhard Hofecker 478
Are Free Radicals a Cause of Aging? By Jose Remacle 479
A New Genetic Conception of Aging and the Possible Mechanisms of Aging
Pathologies. By Teimuraz Lezhava 480
The Pineal Peptide Preparation, Epithalamin, Slows Aging in Drosophila
melanogaster, Mice, and Rats. By V.N Anisimov, S.V. Mylnikov, and
V.Kh. Khavinson 481
Similar Gene Expression Patterns in Senescent and Hyperoxically Blocked
Fibroblasts. By Gabriele Saretzki, Thomas von Zglinicki, and
Bryant Villeponteau 482
Altered Gene Expression in the Brain of the Senescence accelerated Mouse.
By Ryoya Takahashi, Yuki Makabe, and Sataro Goto 483
Prolongation of the Healthy Life Span with Early Diagnosis of T(14;18)
Translocation. By I. Semsei, Gy. Szegedi, M. Zeher, I. Takacs, and
P. Sebok 484
Genetic Dissection of Senile Hypoactivity in Drosophila melanogaster.
By Christopher Driver 485
Structural Changes of Chromosomes Induced by Heavy Metal Salts during
in Vivo and in Vitro Aging. By Tina Jokhadze 486
Total Extent and Cellular Distribution of Mitochondrial DNA Mutations in
Aging. By S.A. Kovalenko, J. Kelso, G. Kopsidas, and A.W. Linnane 487
Coenzyme Qlo Treatment Improves the Tolerance of the Senescent
Myocardium to Pacing Stress in the Rat. By Franklin L. Rosenfeldt,
Michael A. Rowland, Philip Nagley, and Anthony W. Linnane 488
Response of the Human Myocardium to Hypoxia and Ischemia Declines
with Age: Correlation with Increased Mitochondrial DNA Deletions.
By Franklin L. Rosenfeldt, Justin A. Mariani, Rouchong Ou,
Salvatore Pepe, Philip Nagley, and Anthony W. Linnane 489
Impairment of Mitochondrial Function in the Aging Heart: Molecular and
Pharmacological Aspects. By G. Paradies, G. Petrosillo, and
F.M. Ruggiero 491
Aluminosilicate Paniculate and Beta Amyloid in Vitro Interactions: A Model of
Alzheimer Plaque Formation. By Peter Evans and Charles Harrington 492
Does Extracellular Ascorbate Promote Oxidative Damage to the Aging
Brain? By Maria M. Romanas, Mitchell R. Emerson,
Stanley R. Nelson, Fred E. Samson, and Thomas L. Pazdernik 493
Low Levels of 4977 BP deleted Molecules of Mitochondrial DNA in the
Presence of High OH8DG Contents in Healthy Subjects and Alzheimer s
Disease Patients. By A.M.S. Lezza, P. Mecocci, A. Cormio, A. Cherubim,
M. Flint Beal, P. Cantatore, U. Senin, and M.N. Gadaleta 494
Correlations between Lipofuscin Accumulation and Aging Neuropathology.
By Dan Riga and Sorin Riga 495
Proteasome but Not Lysosomal Protease Activities Decline with Age in the Liver
of Male F344 Rats. By T. Hayashi, Y. Nakano, R. Takahashi, and S. Goto .. 496
Macrophage Membrane Proteins That Recognize Carbohydrate Chains of
Oxidized Erythrocytes. By Masatoshi Beppu, Shigetoshi Eda, and
Kiyomi Kikugawa 497
Aging and Dietary Protein: Effects of Collagen and Muscle Fiber Distribution
in the Rat Diaphragm. By Emilio A. Jeckel Neto, Tatiana Ribeiro da Silva,
Alessandra L. Rosa, Yoshitake Ito, Tsuneko Sato, and Hisashi Tauchi .... 498
Characterization of Age dependent Multiple Yellow Fluorescent Components in
Rat Kidney. By Kiyomi Kikugawa, Masatoshi Beppu, Akihide Sato,
and Hiroyoshi Kasai 499
Heart and Brain OXO8dG in the Genomic DNA of Rats and Pigeons and Maximum
Longevity. By A. Herrero and G. Barja 518
Cell Proliferation Restriction: Is It the Primary Cause of Aging? By Alexander N.
Khokhlov 519
Study of Stationary Phase Aging of Cultured Cells under Various Types of
Proliferation Restriction. By Serge S. Akimov and Alexander N. Khokhlov. . 520
Index of Contributors 521
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| genre | (DE-588)1071861417 Konferenzschrift 1997 Adelaide gnd-content |
| genre_facet | Konferenzschrift 1997 Adelaide |
| id | DE-604.BV012466192 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:28:04Z |
| institution | BVB |
| isbn | 1573311081 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008460092 |
| oclc_num | 39922084 |
| open_access_boolean | |
| owner | DE-12 DE-20 |
| owner_facet | DE-12 DE-20 |
| physical | XIV, 524 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| series2 | New York Academy of Sciences: Annals of the New York Academy of Sciences |
| spelling | Towards prolongation of the healthy life span practical approaches to intervention ed. by Denham Harman ... New York, NY New York Acad. of Sciences 1998 XIV, 524 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New York Academy of Sciences: Annals of the New York Academy of Sciences 854 Adelaïde - 1997 Fysiologische aspecten gtt Levensduur gtt Longévité - Congrès Longévité - Congrès comme sujet Longévité - Congrès ram Veroudering (biologie, psychologie) gtt Vieillissement - Aspect moléculaire - Congrès Vieillissement - Aspect moléculaire - Congrès ram Vieillissement - Aspect physiologique - Congrès Vieillissement - Aspect physiologique - Congrès ram Vieillissement - Congrès comme sujet Aging congresses Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Longevity Congresses Longevity congresses Longevity physiology Congresses Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Langlebigkeit (DE-588)4166707-4 gnd rswk-swf Prävention (DE-588)4076308-0 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Alterskrankheit (DE-588)4132293-9 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 Adelaide gnd-content Alterskrankheit (DE-588)4132293-9 s Prävention (DE-588)4076308-0 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Molekularpathologie (DE-588)4170396-0 s Langlebigkeit (DE-588)4166707-4 s Physiologische Chemie (DE-588)4076124-1 s Harman, Denham Sonstige oth New York Academy of Sciences: Annals of the New York Academy of Sciences 854 (DE-604)BV002532608 854 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008460092&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Towards prolongation of the healthy life span practical approaches to intervention New York Academy of Sciences: Annals of the New York Academy of Sciences Adelaïde - 1997 Fysiologische aspecten gtt Levensduur gtt Longévité - Congrès Longévité - Congrès comme sujet Longévité - Congrès ram Veroudering (biologie, psychologie) gtt Vieillissement - Aspect moléculaire - Congrès Vieillissement - Aspect moléculaire - Congrès ram Vieillissement - Aspect physiologique - Congrès Vieillissement - Aspect physiologique - Congrès ram Vieillissement - Congrès comme sujet Aging congresses Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Longevity Congresses Longevity congresses Longevity physiology Congresses Molekularpathologie (DE-588)4170396-0 gnd Physiologische Chemie (DE-588)4076124-1 gnd Langlebigkeit (DE-588)4166707-4 gnd Prävention (DE-588)4076308-0 gnd Pharmakotherapie (DE-588)4076066-2 gnd Alterskrankheit (DE-588)4132293-9 gnd |
| subject_GND | (DE-588)4170396-0 (DE-588)4076124-1 (DE-588)4166707-4 (DE-588)4076308-0 (DE-588)4076066-2 (DE-588)4132293-9 (DE-588)1071861417 |
| title | Towards prolongation of the healthy life span practical approaches to intervention |
| title_auth | Towards prolongation of the healthy life span practical approaches to intervention |
| title_exact_search | Towards prolongation of the healthy life span practical approaches to intervention |
| title_full | Towards prolongation of the healthy life span practical approaches to intervention ed. by Denham Harman ... |
| title_fullStr | Towards prolongation of the healthy life span practical approaches to intervention ed. by Denham Harman ... |
| title_full_unstemmed | Towards prolongation of the healthy life span practical approaches to intervention ed. by Denham Harman ... |
| title_short | Towards prolongation of the healthy life span |
| title_sort | towards prolongation of the healthy life span practical approaches to intervention |
| title_sub | practical approaches to intervention |
| topic | Adelaïde - 1997 Fysiologische aspecten gtt Levensduur gtt Longévité - Congrès Longévité - Congrès comme sujet Longévité - Congrès ram Veroudering (biologie, psychologie) gtt Vieillissement - Aspect moléculaire - Congrès Vieillissement - Aspect moléculaire - Congrès ram Vieillissement - Aspect physiologique - Congrès Vieillissement - Aspect physiologique - Congrès ram Vieillissement - Congrès comme sujet Aging congresses Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Longevity Congresses Longevity congresses Longevity physiology Congresses Molekularpathologie (DE-588)4170396-0 gnd Physiologische Chemie (DE-588)4076124-1 gnd Langlebigkeit (DE-588)4166707-4 gnd Prävention (DE-588)4076308-0 gnd Pharmakotherapie (DE-588)4076066-2 gnd Alterskrankheit (DE-588)4132293-9 gnd |
| topic_facet | Adelaïde - 1997 Fysiologische aspecten Levensduur Longévité - Congrès Longévité - Congrès comme sujet Veroudering (biologie, psychologie) Vieillissement - Aspect moléculaire - Congrès Vieillissement - Aspect physiologique - Congrès Vieillissement - Congrès comme sujet Aging congresses Aging Molecular aspects Congresses Aging Physiological aspects Congresses Aging physiology Congresses Longevity Congresses Longevity congresses Longevity physiology Congresses Molekularpathologie Physiologische Chemie Langlebigkeit Prävention Pharmakotherapie Alterskrankheit Konferenzschrift 1997 Adelaide |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008460092&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT harmandenham towardsprolongationofthehealthylifespanpracticalapproachestointervention |