Heart development:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1999
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 530 S. Ill., graph. Darst. |
| ISBN: | 0123298601 |
Internformat
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| 245 | 1 | 0 | |a Heart development |c ed. by Richard P. Harvey ... |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1999 | |
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| 650 | 4 | |a Heart - Development | |
| 650 | 4 | |a Coronary Vessels | |
| 650 | 4 | |a Embryonic Induction | |
| 650 | 4 | |a Heart Defects, Congenital |x embryology | |
| 650 | 4 | |a Heart |x Growth | |
| 650 | 4 | |a Heart |x Growth |x Molecular aspects | |
| 650 | 4 | |a Heart |x embryology | |
| 650 | 4 | |a Heart |x growth & development | |
| 650 | 4 | |a Morphogenesis |x genetics | |
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Datensatz im Suchindex
| _version_ | 1804127099182645248 |
|---|---|
| adam_text | Com
Contributors xiii
Preface xvii
Introduction xix
I Origins and Early
Morphogenesis
1 Cardiac Fate Maps: Lineage
Allocation, Morphogenetic Movement,
and Cell Commitment
Patrick P. L. Tarn and Gary C. Schoenwolf
I. Prelude to Germ Layer Formation 3
II. Experimental Strategy of Fate Mapping 5
III. Fate Maps of Cardiac Tissues 7
IV. Patterning and Cell Commitment to a
Heart Fate 1 3
V. Summary 16
References 16
2 Cardiac Lineages
Takashi Mikawa
I. Introduction 19
II. Origin of Endocardial and Myocardial
Cell Lineages 19
III. Origin or Coronary Vascular
Cell Lineages 23
IV. Origin of the Cardiac
Conduction System 26
V. Concluding Remarks 30
References 31
vii
ents
II Cardiac Induction
3 Heart Formation and the Heart Field
in Amphibian Embryos
Timothy J. Mohun and Li Ming Leong
I. Introduction 37
II. The Heart Field 37
III. Specification of the Amphibian
Heart Field 40
IV. Regulative Properties of the
Heart Field 43
V. Cardiac Differentiation and the
Heart Field 44
VI. Restriction of the Heart Field
during Development 46
VII. Conclusions 46
References 47
4 Vertebrate Heart Induction
Thomas M. Schultheiss and Andrew B. Lassar
I. Fate Mapping 52
II. Acquisition of a Cardiac Fate: The Timing of
Specification and Commitment 53
III. Timing of Differentiation:
Molecular Markers 55
IV. Induction of Cardiogenesis 56
V. Inhibition of Cardiogenesis 59
VI. Molecular Mediators of
Cardiac Induction 59
VII. Summary 61
References 61
VIM III Genetic Dissection of
Heart Development
5 Genetic Determination of DrosophWa
Heart Development
Rolf Bodmer and Manfred Frasch
I. Introduction 65
II. Morphology and Morphogenesis of the
Drosophila Heart 65
III. Genetic Control of the Formation and Dorsal
Expansion of the Mesoderm 68
IV. Expression and Function of tinman
in Mesoderm Patterning and
Heart Development 70
V. A Combination of Inductive Signals Is
Necessary for Cardiac Specification 74
VI. Specification of Cardiac Cell Types 82
References 86
6 Mutations Affecting Cardiac
Development in Zebrafish
Jonathan Alexander and Didier Y. R. Stainier
I. Introduction 91
II. The Zebrafish as a Genetic
Model System 94
III. Zebrafish Embryonic Development 95
IV. Development of the Zebrafish Heart 95
V. Conclusions 107
References 107
7 Transcriptional Control and Pattern
Formation in the Developing Vertebrate
Heart: Studies on NK 2 Class
Homeodomain Factors
Richard P. Harvey, Christine Biben, and David A. Elliott
I. Introduction 111
II. Overview of Cardiac Development
in Mammals 112
III. Genetic Regulation of Myocardial
Development: A General Concept 11 2
IV. Homeobox Genes and
Embryonic Patterning 11 3
V. Pattern Formation in the Heart 11 3
VI. The Drosophila Heart and the
tinman Gene 11 5
VII. Vertebrate Relatives of tinman and
Evolution of the NK 2 Gene Family 116
Contents
VIM. Expression of Nkx2 5 118
IX. Expression of Nkx2 Genes and the Heart
Morphogenetic Field 119
X. Known Target Genes 119
XI. Are tinman and Vertebrate Nkx2 Genes
Functionally Homologous? 120
XII. Nkx2 5 Knockout Phenotype 121
XIII. Marker Analysis 122
XIV. Hand Gene Expression in Normal and
Nkx2 5~/~ Hearts 123
XV. Nkx2 5 and Human
Cardiac Defects 125
References 125
8 Control of Cardiac Development by
the MEF2 Family of Transcription Factors
Brian L. Black and Eric N. Olson
I. Heart Formation during
Vertebrate Embryogenesis 131
II. Cardiogenesis at the Cellular Level 1 32
III. Transcriptional Control by MEF2 1 32
IV. Combinatorial Control of Muscle
Development by MEF2 1 36
V. Regulation of MEF2 Expression 1 38
VI. An Evolutionary Conserved Pathway for
Cardiogenesis 139
VII. Future Questions 140
References 140
9 Segmental Regulation of Cardiac
Development by the Basic Helix Loop
Helix Transcription Factors dHAND
and eHAND
Deepak Srivastava
I. Introduction 1 43
II. Cardiac Morphogenesis 144
III. Molecular Segmentation of
the Heart 145
IV. Basic Helix Loop Helix Factors
in Development 145
V. Basic Helix Loop Helix Factors in
Heart Development 146
VI. Targeted Gene Deletion in Mice 148
VII. Relevance to Human Disease 1 53
VIII. Summary 153
References 154
Contents
IV Normal and Abnormal
Morphogenesis
10 Mechanisms of Segmentation,
Septation, and Remodeling of the
Tubular Heart: Endocardial Cushion
Fate and Cardiac Looping
Corey H. Mjaatvedt, Hideshi Yamamura, Andy Wessels,
Anne Ramsdell, Debi Turner, and Roger R. Markwald
I. Development of Heart Segments 1 59
II. Progenitors of the Cardiac Epithelia 160
III. Molecular Interactions of JB3+ Endothelial
Cells in the Heart Cushions 163
IV. Developmental Fates of theJB3+ Endocardial
Cushion Cells 168
V. The Cardiac Inner Curvature: Remodeling
by Myocardialization 1 70
VI. Conclusion 1 73
References 174
11 Contribution of Neural Crest to
Heart and Vessel Morphology
Margaret L. Kirby
I. Introduction 1 79
II. The Neural Crest Ablation Model in
Chick Embryos 180
III. Phenocopies of Neural Crest Ablation
in Mammals 183
IV. DORV and Red Herrings 187
V. Conclusions and Future Perspectives 189
References 189
12 Development of the Conduction
System of the Vertebrate Heart
Antoon F. M. Moorman and Wouter H. Lamers
I. Introduction 195
II. Cardiac Polarity and Development of the
Sinus Node 196
III. Chamber Formation and Development of the
Atrioventricular Node 197
IV. Primary Myocardium and the
Nodal Phenotype 1 99
V. The Trabecular Ventricular Component and
Development of the Ventricular Part of the
Conduction System 200
VI. Perspectives 204
References 204
ix
13 Retinoids in Heart Development
Steven W. Kubalak and Henry M. Sucov
I. Introduction 209
II. Vitamin A Metabolism 210
III. Vitamin A Receptors 210
IV. Retinoids in Precardiac Fields 211
V. Retinoids and Axial Specification 212
VI. Retinoids in Endocardial
Cushion Development 212
VII. Retinoids in Looping and Wedging 214
VIII. Retinoids in Ventricular Maturation 214
IX. Retinoids in Neural Crest and
Aorticopulmonary Septation 215
X. Concluding Remarks 216
References 216
14 Molecular Mechanisms of
Vascular Development
Ondine Cleaver and Paul A. Krieg
I. Introduction 221
II. Origin of Endothelial Cells 222
III. Molecules Involved in Early Mesodermal
Differentiation of Endothelial Cells 225
IV. The Blood Islands 225
V. The Hemangioblast 226
VI. Endothelial Proliferation 227
VII. Assembly of Blood Vessels 227
VIII. Vascular Pruning and Remodeling 237
IX. Remodeling, Patterning,
and Maturation 237
X. Conclusion 244
References 244
V Genetic Control of Muscle
Gene Expression
1 5 The MLC 2 Paradigm for Ventricular
Heart Chamber Specification,
Maturation, and Morphogenesis
Van Thi Bich Nguyen Trim, Ju Chen, Pilar Ruiz Lozano,
and Kenneth Randall Chien
I. Background 255
II. Temporal and Regional Expression
of MLC 2v and MLC 2a during
Cardiac Morphogenesis 256
III. MLC 2v as a Paradigm for
Gene Regulation 258
IV. The Role of MLC 2v in Embryonic
Heart Function 264
X V. MLC 2a as a Negatively Regulated
Ventricular Muscle Gene 266
VI. Induction of MLC 2v and MLC 2a
during Hypertrophy 267
VII. MLC 2v as a Tool for Lineage Tracing
and Cardiac Restricted Gene Targeting
via Cre/LoxP Strategies 268
VIII. Conclusions and
Future Prospectives 270
References 270
16 Serum Response Factor A/K
Homeodomain Factor Interactions,
Role in Cardiac Development
James M. Reecy, Narasimhaswamy S. Belaguli,
and Robert J. Schwartz
I. Introduction 273
II. NK Homeodomain Factors 273
III. Serum Response Factor 280
References 287
17 GATA Transcription Factors and
Cardiac Development
Michael S. Parmacek and Jeffrey M. Leiden
I. Introduction 291
II. The GATA Family of Zinc Finger
Transcription Factors 293
III. The GATA 4/5/6 Subfamily of Zinc Finger
Transcription Factors 294
IV. Multiple Cardiac Specific Transcriptional
Regulatory Elements Contain Functionally
Important GATA Binding Sites 296
V. GATA 4 Activates Transcription via Two
Novel Domains That Are Conserved within
the GATA 4/5/6 Subfamily 297
VI. GATA 4 Is Required for Ventral
Morphogenesis and Heart Tube
Formation 298
VII. Potential Functional Redundancy and Cross
Talk between GATA 4 and GATA 6 301
VIM. Summary and Future Directions 303
References 303
18 Multiple Layers of Control in
Transcriptional Regulation by MCAT
Elements and the TEF 1 Protein Family
Sarah B. Larkin and Charles P. Ordahl
I. Introduction 307
II. The TEF 1 Family of MCAT
Binding Factors 311
contents
III. TEF 1 Structure Function 318
IV. Regulation of TEF 1 Expression 321
V. Potential Modalities of MCAT Dependent
Gene Regulation 323
VI. Summary and Conclusions 325
References 326
VI Heart Patterning: The
Anterior Posterior Axis
19 Regionalization of Transcriptional
Potential in the Myocardium
Robert C. Kelly, Diego Franco, Antoon F. M. Moorman,
and Margaret Buckingham
I. Introduction 333
II. The Development of the Heart and the
Onset of Atrial and Ventricular
Transcriptional Regionalization 334
III. Left and Right Cardiac Compartments:
Regionalized Transgene Expression 337
IV. Myocardial Regionalization: Anterior Posterior
and Left Right Patterning 344
V. The Molecular Basis
of Regionalization 347
VI. Morphogenetic Implications of Regionalized
Transcriptional Potential in the Heart 349
References 352
20 Chamber Specific Gene Expression
and Regulation during
Heart Development
Gang Feng Wang and Frank E. Stockdale
I. Heart Formation and Early Atrial and
Ventricular Regionalization 357
II. Developmental Expression Patterns
of Atrial and Ventricular
Chamber Specific Genes 358
III. Mechanisms of Atrial Chamber Specific
Gene Expression 360
References 367
VII Heart Patterning:
Left Right Asymmetry
21 Establishing Cardiac
Left Right Asymmetry
H. Joseph Yost
I. Overview of Cardiac Development
Preceding Looping 373
Contents II. Left Right Nomenclature 375
III. Discovery of Molecular Signals That Precede
Cardiac L R Specification 376
IV. Initiation of the L R Axis before
Node Formation 378
V. Role of the Midline 380
VI. Looping Morphogenesis 384
VII. Conclusions and
Future Perspectives 386
References 387
22 Left Right Asymmetry and
Cardiac Looping
Kumud Majumder and Paul A. Overbeek
I. Introduction 391
II. Early Cardiac Morphogenesis 391
III. Asymmetric Gene Expression Prior to
Cardiac Looping 392
IV. Gene Expression within the
Embryonic Heart 395
V. Mutations in Genes That Affect
L R Asymmetry 396
VI. Embryonic Alterations of Cardiac Looping
in Vertebrates 397
VII. Signal Transduction 398
VIM. Initiation of L R Asymmetry: An Axis
Conversion Model 398
IX. Concluding Remarks 400
References 400
VIII Cell Proliferation
in Cardiovascular
Development and Disease
23 The Cardiac Cell Cycle
W. Robb MacLellan and Michael D. Schneider
I. Introduction 405
II. Cardiac Myocyte Proliferation in Utero
and in Ovo 407
III. Growth Factors, Cytokines,
and Receptors 407
IV. Signal Transducers 409
V. Transcription Factors 409
VI. d Cyclins and Cyclin Dependent
Kinases 410
VII. Cdk Inhibitors 412
VIII. Pocket Proteins 413
xi
IX. Viral Oncoproteins as a Probe for
Cell Cycle Regulators in Cardiac
Muscle: Pocket Protein and
p300 Dependent Pathways 414
X. E2F Transcription Factors 41 7
XI. The C2/M Boundary 417
XII. Reactivation of the Cell Cycle in Adult
Ventricular Myocytes 418
XIII. Conclusions and Perspectives 420
References 421
24 Regulation of Vascular Smooth
Muscle Differentiation and Cell Cycle
Kenneth Walsh, Harris R. Perlman, and Roy C. Smith
I. Developmental Origins of Vascular
Smooth Muscle 429
II. VSMC Phenotypic Modulation 430
III. Mitogen Regulated Transcription
Factors 431
IV. The CATA 6 Transcription Factor 434
V. Cell Cycle Regulation in VSMCs 435
VI. Regulation of VSMC Apoptosis 436
VII. Smooth Muscle in Human Atherosclerotic
and Restenotic Lesions 438
VIM. Perspective 440
References 440
IX Human Cardiac
Development Defects
25 Symmetry and Laterality
in the Human Heart:
Developmental Implications
Nigel A. Brown and Robert H. Anderson
I. Introduction 447
II. Morphology of the Atriums
and Ventricles 448
III. Morphology of Transpositions 450
IV. Morphology of Hearts with Isomeric
Atrial Appendages 453
V. Implications of Morphology 455
VI. The Development of Heart Laterality 456
References 461
26 The Genetic Basis of Conotruncal
Cardiac Defects: The Chromosome
22qll.2 Deletion
Beverly S. Emanuel, Marcia L. Budarf,
and Peter J. Scambler
I. History 463
xii
II. Incidence and Clinical Details 465
III. Development of Structures Affected in
DGS/VCFS 467
IV. Mapping the 22ql 1.2 Deletions 469
V. Gene Identification in the 22ql 1
Deleted Region 471
VI. Identification of the Etiologic Gene(s) 473
References 473
27 Genetics of Human Left Right
Axis Malformations
Brett Casey and Kenjiro Kosaki
I. Introduction 479
II. Review of Relevant Embryology
and Anatomy 479
III. Terminology of Abnormal
Left Right Asymmetry 481
IV. Syndromic Left Right
Axis Malformations 481
V. Spectrum of Malformations in
Situs Ambiguus 481
VI. Familial Heterotaxy: Inheritance Patterns
and Phenotypic Variability 483
VII. Epidemiology of Heterotaxy 484
Contents
VIII. Molecular Genetics of Heterotaxy 484
IX. Considerations for the Future 488
References 488
X Lessons from
Skeletal Muscle
28 Molecular Genetics of Skeletal
Muscle Development
Michael J. McCrew, Jose Xavier Neto, Olivier Pourquie
and Nadia Rosenthal
I. Introduction 493
II. Gene Regulation in Skeletal Muscle 494
III. Skeletal Muscle Development 498
IV. Positional Information in Striated Muscle 507
V. Skeletal Muscle Cell Diversity and Fiber
Type Specification 509
VI. Future Prospects 512
References 512
Index 519
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| indexdate | 2024-07-09T18:27:57Z |
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| language | English |
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| publisher | Acad. Press |
| record_format | marc |
| spelling | Heart development ed. by Richard P. Harvey ... San Diego [u.a.] Acad. Press 1999 XX, 530 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Heart - Development Coronary Vessels Embryonic Induction Heart Defects, Congenital embryology Heart Growth Heart Growth Molecular aspects Heart embryology Heart growth & development Morphogenesis genetics Herz (DE-588)4024632-2 gnd rswk-swf Organogenese (DE-588)4266352-0 gnd rswk-swf Ontogenie (DE-588)4043565-9 gnd rswk-swf Herz (DE-588)4024632-2 s Organogenese (DE-588)4266352-0 s DE-604 Ontogenie (DE-588)4043565-9 s Harvey, Richard P. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008455442&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heart development Heart - Development Coronary Vessels Embryonic Induction Heart Defects, Congenital embryology Heart Growth Heart Growth Molecular aspects Heart embryology Heart growth & development Morphogenesis genetics Herz (DE-588)4024632-2 gnd Organogenese (DE-588)4266352-0 gnd Ontogenie (DE-588)4043565-9 gnd |
| subject_GND | (DE-588)4024632-2 (DE-588)4266352-0 (DE-588)4043565-9 |
| title | Heart development |
| title_auth | Heart development |
| title_exact_search | Heart development |
| title_full | Heart development ed. by Richard P. Harvey ... |
| title_fullStr | Heart development ed. by Richard P. Harvey ... |
| title_full_unstemmed | Heart development ed. by Richard P. Harvey ... |
| title_short | Heart development |
| title_sort | heart development |
| topic | Heart - Development Coronary Vessels Embryonic Induction Heart Defects, Congenital embryology Heart Growth Heart Growth Molecular aspects Heart embryology Heart growth & development Morphogenesis genetics Herz (DE-588)4024632-2 gnd Organogenese (DE-588)4266352-0 gnd Ontogenie (DE-588)4043565-9 gnd |
| topic_facet | Heart - Development Coronary Vessels Embryonic Induction Heart Defects, Congenital embryology Heart Growth Heart Growth Molecular aspects Heart embryology Heart growth & development Morphogenesis genetics Herz Organogenese Ontogenie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008455442&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT harveyrichardp heartdevelopment |