Malignant tumors of the skin:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Arnold
1999
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 446 S. Ill., graph. Darst. |
| ISBN: | 0340740868 |
Internformat
MARC
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| 245 | 1 | 0 | |a Malignant tumors of the skin |c ed. by A. C. Chu ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Arnold |c 1999 | |
| 300 | |a XVI, 446 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008440510 | ||
Datensatz im Suchindex
| _version_ | 1804127076565909504 |
|---|---|
| adam_text | Contributors xiii
Preface xvii
1 Basal cell carcinomas 1
Stephanie Munn, Tamara Basarab and Tony Chu
1.1 Introduction 1
1.2 Definition 1
1.3 Epidemiology 1
1.4 Etiology 2
1.5 Molecular aspects 5
1.6 Cytokines 6
1.7 CD44 6
1.8 Adhesion molecules 7
1.9 Proteoglycans 7
1.10 Basement membrane changes 7
1.11 Clinical features 7
1.12 Differential diagnosis 9
1.13 Histology 9
1.14 Treatment 10
1.15 Prognosis 14
1.16 Prevention 14
References 15
2 Squamous cell carcinoma and its precursors: clinical
biology and molecular basis 19
Douglas Grossman and David ]. Leffell
2.1 Introduction 19
2.2 History and epidemiology 20
vi Contents
2.3 Precursors to SCC 22
2.4 SCC 24
2.5 Photomutagenesis and DNA repair 28
2.6 Genetic lesions and carcinogenesis 33
2.7 UVR and cutaneous immunosuppression 36
References 40
3 The biology of melanoma 49
Maria Concetta Fargnoli and Jean L. Bolognia
3.1 Introduction 49
3.2 Ultraviolet radiation and melanoma 49
3.3 Genetics and melanoma 50
3.4 Tumor progression 55
3.5 Immunology and immunotherapy of melanoma 58
References 61
4 Melanoma clinical 66
Axel Hauschild, Petra Kiene and Enno Christophers
4.1 Incidence and mortality rates 66
4.2 Melanoma risk factors 67
4.3 Clinical features of malignant melanoma 69
4.4 Staging 71
4.5 Prognosis 72
4.6 Histopathology 73
References 76
5 The treatment of melanoma 78
Julia A. Newton Bishop
5.1 Staging of melanoma 78
5.2 Prognosis 79
5.3 Surveillance 80
5.4 Surgery in melanoma 80
5.5 The palliation of multiple limb metastases 84
5.6 Radiotherapy 84
5.7 Chemotherapy of melanoma 85
5.8 Hormones and melanoma: use of tamoxifen 86
5.9 Biological and immunotherapies 87
5.10 Gene therapy: the future 91
5.11 Immunotherapy: the future 92
5.12 Adjuvant therapy for poor prognosis melanoma 92
References 92
6 Keratoacanthoma 96
Robert A. Schwartz
6.1 Definition 96
6.2 History 96
63 Incidence 97
6.4 Etiology/pathogenesis 97
Contents vii
6.5 Etiology 97
6.6 Clinical manifestations 99
6.1 Pathology 103
6.8 Complications 106
6.9 Laboratory findings 106
6.10 Diagnosis 106
6.11 Treatment 108
6.12 Course/prognosis 109
6.13 Prevention 109
References 110
7 Xeroderma pigmentosum 119
W. Clark Lambert, Hon Reen Kuo and Muriel W. Lambert
7.1 Introduction 119
7.2 Historical aspects 120
7.3 Etiopathogenesis 122
7.4 Genetics 128
7.5 Complementation groups 129
7.6 Clinical features 130
7.7 Diagnosis 131
7.8 Xeroderma pigmentosum as a model for
cutaneous carcinogenesis 132
7.9 Management 133
7.10 Current and future developments 133
7.11 Other diseases with DNA and chromosomal
instability with cutaneous manifestations 135
References 135
8 Cutaneous T cell lymphoma 138
Peter W. Heald and Richard L. Edelson
8.1 The origins of CTCL 138
8.2 Clinical presentations of CTCL 140
8.3 Diagnosis 141
8.4 Staging 142
8.5 Prognosis 143
8.6 Management 143
References 145
9 HTLV related lymphomas 146
Tetsuo Nagatani, Megumi Miyazawa, Toshiko Matsuzaki,
Naoko Baba and Hiroshi Nakajima
9.1 Introduction 146
9.2 Epidemiology 147
9.3 Clinical features of ATL 149
9.4 Criteria for classification of ATL 150
9.5 Prognosis of ATL 152
9.6 Diagnosis 153
I
viii Contents
9.7 Cytology, histopathology and
immunohistochemistry 155
9.8 Treatment 159
9.9 Chromosomal abnormality 160
9.10 HTLV I associated organopathy 161
9.11 HTLV I 162
9.12 Transmission of HTLV I 163
9.13 Leukemogenesis 164
References 165
10 Cutaneous B cell lymphomas 169
Rein Willemze
10.1 Introduction 169
10.2 Classification of cutaneous B cell lymphomas 170
10.3 Cutaneous B cell lymphomas with an indolent
clinical behavior 171
10.4 Cutaneous B cell lymphomas with an
intermediate clinical behavior 176
10.5 Provisional types of CBCL 177
10.6 Differentiation between CBCL and
pseudo B cell lymphoma 178
10.7 Spectrum of cutaneous B cell
lymphoproliferative disorders 179
10.8 Pathogenesis of cutaneous B cell
lymphoproliferative disorders 179
10.9 Conclusion 181
References 181
11 Malignant adnexal tumors 184
5. Mohsen Khorshid and Rino Cerio
11.1 Introduction 184
11.2 Diagnosis and management 185
11.3 Malignant tumors of the hair follicle 186
11.4 Malignant sweat gland neoplasms 187
11.5 Malignant sebaceous gland tumors 195
References 196
12 Sarcomas of the skin 198
Bert J. Vermeer, Jan N. Bouwes Bavinck and Jan
Anthonie Bruijn
12.1 Introduction 198
12.2 Fibrosarcoma 203
12.3 Malignant fibrous histiocytoma 204
12.4 Dermatofibrosarcoma protuberans 205
12.5 Liposarcoma 206
12.6 Synovial sarcoma 208
12.7 Leiomyosarcoma 209
i
Contents ix
12.8 Rhabdomyosarcoma 209
12.9 Malignant nerve sheath tumor 211
12.10 Angiosarcoma 212
12.11 Lymphangiosarcoma 213
12.12 Malignant hemangiopericytoma 214
12.13 Kaposi s sarcoma 215
12.14 Alveolar soft part sarcoma 218
12.15 Epithelioid (cell) sarcoma of Enzinger 218
12.16 Clear cell sarcoma 219
12.17 Extraskeletal osteosarcoma 220
12.18 Extraskeletal chondrosarcoma 220
12.19 Important benign tumors that can be confused
with malignancy atypical fibroxanthoma 221
12.20 Important benign tumors that can be confused
with malignancy nodular fasciitis 222
References 223
13 Kaposi s sarcoma 227
Joselyn Gonzalez, Joseph Schwartz and Emil Bisaccia
13.1 Kaposi s sarcoma 227
13.2 Epidemiology 227
13.3 Etiological factors 229
13.4 Pathology 229
13.5 Electron microscopy 230
13.6 Histogenesis 231
13.7 Pathogenesis 232
13.8 Clinical manifestations 232
13.9 Staging 235
13.10 Treatment 235
References 239
14 Mast cell tumors 245
B. Jack Longley
14.1 Incidence 245
14.2 Etiology 245
14.3 Anatomy 246
14.4 Metastasis and natural history 247
14.5 General considerations 247
14.6 Clinical morphology 249
14.7 Urticaria pigmentosa 250
14.8 Mastocytoma 250
14.9 Diffuse cutaneous mastocytosis 250
14.10 Telangiectasia macularis eruptiva perstans 251
14.11 Extracutaneous mastocytosis 251
14.12 Pathology 255
14.13 Diagnosis 255
14.14 Management 257
x Contents
14.15 Future trends 258
References 258
15 Histiocytic tumors 263
Etnilio Berti, Dario Tomasini and Marco Santucci
15.1 Introduction and historical perspectives 263
15.2 Acute monocytic leukemia (AML M5A, B) 265
15.3 True histiocytic lymphoma 267
15.4 Malignant histiocytosis 268
15.5 Follicular dendritic cell sarcoma 269
15.6 Interdigitating dendritic cell sarcoma 270
15.7 Indeterminate cell tumor (precursor Langerhans
cell histiocytosis) 271
15.8 Plasmacytoid monocytic lymphoma 272
References 274
16 Langerhans cell histiocytosis 277
Tony Chu
16.1 Incidence 277
16.2 Etiology 278
16.3 The origin of the LCH cell 278
16.4 Clonality and LCH 279
16.5 Function of LCH cells 280
16.6 Cytokines in LCH 280
16.7 Clinical features 281
16.8 Histopathology 285
16.9 Diagnosis 286
16.10 Investigations 286
16.11 Treatment 287
16.12 Treatment for the future 290
References 291
17 Paget s disease, mammary and extramammary 294
Robert W. Goltz
17.1 Introduction 294
17.2 Mammary Paget s disease 294
17.3 Extramammary Paget s disease 297
17.4 Summary 300
References 300
18 Skin tumors associated with immunosuppression 302
Stefania Jablonska, Slawomir Majewski and
Slawomir Obalek
18.1 Incidence 302
18.2 Epidemiology 302
18.3 Association of tumors with HPVs 303
18.4 Epidermodysplasia verruciformis 304
18.5 Etiology 305
Contents xi
18.6 Anatomy 307
18.7 Natural history 308
18.8 Pathology 308
18.9 Diagnosis 309
18.10 Management and prophylaxis 309
18.11 Future trends 309
References 310
19 Skin tumors in children 314
Ramon Ruiz Maldonado and Ma. de la Luz Orozco
Covarrubias
19.1 Introduction 314
19.2 Malignant melanoma 314
19.3 Basal cell carcinoma 321
19.4 Squamous cell carcinoma 323
19.5 Soft tissue sarcomas 325
19.6 Rhabdomyosarcoma 325
19.7 Kaposi s sarcoma 326
19.8 Other rare soft tissue sarcomas 327
19.9 Neuroblastoma 328
19.10 Leukemia 329
19.11 Lymphomas 331
19.12 Other tumors 334
References 335
20 Metastatic tumors 343
Ketty Peris, Iris Schmitt and Sergio Chimenti
20.1 Biological events of metastasis 343
20.2 Incidence 344
20.3 Clinical features 345
20.4 Histological and immunohistochemical features 348
20.5 Prognosis 352
20.6 Therapy 352
References 352
21 Laser treatment and photodynamic therapy in skin cancer 355
Arielle N. B. Kauvar and Roy G. Geronemus
21.1 Introduction 355
21.2 Laser physics and laser tissue interaction 355
21.3 Laser therapy for skin cancer 357
21.4 Photodynamic therapy 361
21.5 Summary 364
References 364
22 Radiotherapy 367
Conrad Lewanski and Simon Stewart
22.1 Introduction 367
22.2 Fractionation 368
xii Contents
22.3 Physics 369
22.4 Radiation effect on normal tissue 370
22.5 Treatment of skin cancer 371 j
References 378 j
23 Mohs micrographic surgery 381
Antonello Tulli
23.1 Introduction 381
23.2 The micrographic approach to skin tumor
eradication 382 j
23.3 Chemosurgery 386
23.4 Contributions of Mohs surgery in the field of
dermatological oncology 388 i
23.5 Use of the chemosurgery technique 392
23.6 Limitations of Mohs surgery 393
23.7 Conclusions 393
References 394
24 Extracorporeal photochemotherapy 396
Richard L. Edelson and Carole Berger
24.1 Introduction 396
24.2 The pharmacological system 398
24.3 Clinical trials 399
24.4 Experimental tumor model 403
24.5 Class I peptides 405
24.6 Unifying hypothesis and conclusion 406
References 408
25 Spontaneous regression 411
Gary M. Halliday and Ross St C. Barnetson
25.1 Introduction 411
25.2 Clinical and histological features of regression 412
25.3 Role of the immune system in spontaneous
regression 415
25.4 Cytokine/growth factor production during
tumor regression 418
25.5 Evidence for regression caused by changes
in tumor cell differentiation 419
25.6 Evidence for regression caused by tumor
suppressor gene activation 419
25.7 Why does a skin tumor begin to regress? 419
25.8 Conclusions 421
References 422
Index 425
f
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| indexdate | 2024-07-09T18:27:36Z |
| institution | BVB |
| isbn | 0340740868 |
| language | English |
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| spelling | Malignant tumors of the skin ed. by A. C. Chu ... 1. publ. London [u.a.] Arnold 1999 XVI, 446 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Peau - Cancer ram Peau - Tumeurs ram Melanom (DE-588)4074707-4 gnd rswk-swf Hautkrebs (DE-588)4140169-4 gnd rswk-swf Melanom (DE-588)4074707-4 s DE-604 Hautkrebs (DE-588)4140169-4 s Chu, A. C. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008440510&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Malignant tumors of the skin Peau - Cancer ram Peau - Tumeurs ram Melanom (DE-588)4074707-4 gnd Hautkrebs (DE-588)4140169-4 gnd |
| subject_GND | (DE-588)4074707-4 (DE-588)4140169-4 |
| title | Malignant tumors of the skin |
| title_auth | Malignant tumors of the skin |
| title_exact_search | Malignant tumors of the skin |
| title_full | Malignant tumors of the skin ed. by A. C. Chu ... |
| title_fullStr | Malignant tumors of the skin ed. by A. C. Chu ... |
| title_full_unstemmed | Malignant tumors of the skin ed. by A. C. Chu ... |
| title_short | Malignant tumors of the skin |
| title_sort | malignant tumors of the skin |
| topic | Peau - Cancer ram Peau - Tumeurs ram Melanom (DE-588)4074707-4 gnd Hautkrebs (DE-588)4140169-4 gnd |
| topic_facet | Peau - Cancer Peau - Tumeurs Melanom Hautkrebs |
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