Combinatorial chemistry and molecular diversity in drug discovery:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Wiley-Liss
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 516 S. Ill., graph. Darst. |
| ISBN: | 0471155187 |
Internformat
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Datensatz im Suchindex
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| adam_text | R COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY EN DRUG DISCOVERY
EDITED BY ERIC M. GORDON VERSICOR, INC. FREMONT, CALIFORNIA AND JAMES F.
KERWIN, JR. ABBOTT LABORATORIES ABBOTT PARK, ILLINOIS WILEY-LISS A JOHN
WILEY & SONS, INC., PUBLICATION NEW YORK * CHICHESTER * WEINHEIM *
BRISBANE * SINGAPORE * TORONTO CONTENTS FOREWORD: COMBINATORIAL
CHEMISTRY AT A CROSSROADS IX WALTER H. MOOS, MITOKOR, SAN DIEGO,
CALIFORNIA PREFACE XVII CONTRIBUTORS XXI PART I. COMBINATORIAL CHEMISTRY
AND MOLECULAR DIVERSITY: AN INTRODUCTION 1 1. HISTORICAL OVERVIEW OF THE
DEVELOPING FIELD OF MOLECULAR DIVERSITY . 3 JOHN C. CHABALA,
PHARMACOPEIA INC., PRINCETON, NEW JERSEY 2. STRATEGIES IN THE DESIGN AND
SYNTHESIS OF CHEMICAL LIBRARIES 17 ERIC M. GORDON, VERSICOR, INC.,
FREMONT, CALIFORNIA 3. SOLID-PHASE PEPTIDE SYNTHESIS, LEAD GENERATION,
AND OPTIMIZATION 39 BRUCE SELIGMAN, SIDDCO, TUCSON, ARIZONA, MICHAEL
LEBL, TREGA BIOSCIENCES, SAN DIEGO, CALIFORNIA, KIT S. LAM, ARIZONA
CANCER CENTER, TUCSON, ARIZONA VI CONTENTS 4. LIGHT-DIRECTED CHEMICAL
SYNTHESIS OF POSITIONAL!} ENCODED PEPTIDE ARRAYS 111 JEFFREY W. JACOBS,
DINESH V. PATEL, AND ZHENGYU YUAN, VERSICOR, INC., FREMONT, CALIFORNIA,
CHRISTOPHER P. HOLMES AND JOHN SCHULLEK, AFFYMAX RESEARCH INSTITUTE,
PALO ALTO, CALIFORNIA, VALERY V. ANTONENKO, J. RUSSELL GROVE, NICOLAY
KULIKOV, DEREK MACLEAN, MARC NAVRE, CINDY NGUYEN, LIHONG SHI, ARATHI
SUNDARAM, AND STEVEN A. SUNDBERG, AFFYMAX RESEARCH INSTITUTE, SANTA
CLARA, CALIFORNIA 5. CONFORMATIONALLY RESTRICTED PEPTIDE AND
PEPTIDOMIMETIC LIBRARIES 133 ALEX A. VIRGILIO AND JONATHAN A. ELLMAN,
DEPARTMENT OF CHEMISTRY, UNIVERSITY OF CALIFORNIA AT BERKELEY, BERKELEY,
CALIFORNIA 6. SUBMONOMER APPROACHES FOR THE GENERATION OF MOLECULAR
DIVERSITY: NONNATURAL OLIGOMER AND ORGANIC TEMPLATE LIBRARIES 151 LUTZ
S. RICHTER, DANE A. GOFF, KERRY L. SPEAR, ERIC J. MARTIN, AND RONALD N.
ZUCKERMANN, CHIRON CORPORATION, EMERYVILLE, CALIFORNIA 7.
OLIGONUCLEOTIDE LIBRARIES AS A SOURCE OF MOLECULAR DIVERSITY 165
HOUNG-YAU MEI, PARKE-DAVIS PHARMACEUTICAL RESEARCH, DIVISION OF
WARNER-LAMBERT COMPANY, ANN ARBOR, MICHIGAN AND ANTHONY CZARNIK, IRORI,
LA JOLLA, CALIFORNIA PART II. SMALL MOLECULE LIBRARIES 179 8. SMALL
MOLECULE LIBRARIES: OVERVIEW OF ISSUES AND STRATEGIES IN LIBRARY DESIGN
181 JOHN J. BALDWIN, PHARMACOPEIA, INC., PRINCETON, NEW JERSEY 9.
PROTEASE INHIBITOR LIBRARIES 189 DINESH V. PATEL, VERSICOR, INC.,
FREMONT, CALIFORNIA AND DAVID A. CAMPBELL, AFFYMAX RESEARCH INSTITUTE,
SANTA CLARA, CALIFORNIA 10. HETEROCYCLIC COMBINATORIAL CHEMISTRY: AZINE
AND DIAZEPINE PHARMACOPHORES 201 MIKHAIL F. GORDEEV AND DINESH V. PATEL,
VERSICOR, INC., FREMONT, CALIFORNIA 11. SCAFFOLDS FOR SMALL MOLECULE
LIBRARIES 213 MICHAEL R. PAVIA, MILLENIUM PHARMACEUTICALS INC.,
CAMBRIDGE, MASSACHUSETTS CONTENTS VII 12. APPLICATION OF COMBINATORIAL
CHEMISTRY TO BIOPOLYMERS 227 EDMUND J. MORAN, ONTOGEN CORP., CARLSBAD,
CALIFORNIA 13. OLIGOSACCHARIDE AND GLYCOCONJUGATE SOLID-PHASE SYNTHESIS
TECHNOLOGIES FOR DRUG DISCOVERY 243 MICHAEL J. SOFIA, TRANSCELL
TECHNOLOGIES, INC., CRANBURY, NEW JERSEY 14. ENCODED COMBINATORIAL
CHEMISTRY 271 JEFFREY W. JACOBS AND ZHI-JIE NI, VERSICOR, INC., FREMONT,
CALIFORNIA 15. PARALLEL ORGANIC SYNTHESIS IN ARRAY FORMAT 291 STEVEN E.
HALL, SPHINX PHARMACEUTICALS, A DIVISION OF ELI LILLY & CO., DURHAM,
NORTH CAROLINA 16. SYNTHETIC ORGANIC CHEMISTRY ON SOLID SUPPORT 307
STEPHEN W. KALDOR AND MILES G. SIEGEL, LILLY RESEARCH LABORATORIES, A
DIVISION OF ELI LILLY & COMPANY, INDIANAPOLIS, INDIANA PART III.
AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS 337 17. AUTOMATION OF
COMBINATORIAL CHEMISTRY FOR LARGE LIBRARIES 339 MICHAEL NEEDELS AND
JEFFREY SUGARMAN, AFFYMAX RESEARCH INSTITUTE, PALO ALTO, CALIFORNIA 18.
ANALYTICAL CHEMISTRY ISSUES IN COMBINATORIAL ORGANIC SYNTHESIS 349
WILLIAM L. FITCH, GARY C. LOOK, AND GEORGE DETRE, AFFYMAX RESEARCH
INSTITUTE, SANTA CLARA, CALIFORNIA 19. QUANTIFYING DIVERSITY 369 YVONNE
C. MARTIN, ROBERT D. BROWN, AND MARK G. BURES, PHARMACEUTICAL PRODUCTS
DIVISION, ABBOTT LABORATORIES, ABBOTT PARK, ILLINOIS PART IV. BIOLOGICAL
DIVERSITY 387 20. PROTEIN SCAFFOLDS FOR PEPTIDE LIBRARIES 389 RONALD H.
HOESS, DUPONT-MERCK PHARMACEUTICAL COMPANY, WILMINGTON, DELAWARE 21.
COMBINATORIAL BIOSYNTHESIS OF UNNATURAL NATURAL PRODUCTS 401 CHAITAN
KHOSLA, DEPARTMENTS OF CHEMISTRY AND CHEMICAL ENGINEERING, STANFORD
UNIVERSITY, STANFORD, CALIFORNIA VIII CONTENTS PART V. SCREENING 419 22.
STRATEGIES FOR SCREENING COMBINATORIAL LIBRARIES 421 BRUCE A. BEUTEL,
PHARMACEUTICAL PRODUCTS DIVISION, ABBOTT LABORATORIES, ABBOTT PARK,
ILLINOIS 23. APPROACHES AND TECHNOLOGIES FOR SCREENING LARGE
COMBINATORIAL LIBRARIES 433 NOLAN H. SIGAL AND DANIEL CHELSKY,
PHARMACOPEIA, INC., PRINCETON, NEW JERSEY PART VI. COMBINATORIAL DRUG
SCREENING AND DEVELOPMENT 445 24. COMBINATORIAL DRUG DISCOVERY: CONCEPTS
447 JUDD BERMAN, GLAXO WELLCOME RESEARCH INSTITUTE, RESEARCH TRIANGLE
PARK, NORTH CAROLINA, AND RUSSELL J. HOWARD, AFFYMAX RESEARCH INSTITUTE,
SANTA CLARA, CALIFORNIA 25. ADME/PK ASSAYS IN SCREENING FOR ORALLY
ACTIVE DRUG CANDIDATES 453 JACQUELINE A. GIBBONS, ERIC W. TAYLOR, AND
RENE A. BRAECKMAN, CHIRON CORPORATION, EMERYVILLE, CALIFORNIA 26.
COMBINATORIAL TECHNOLOGIES: PROSPECTS AND FUTURE ISSUES 475 JAMES F.
KERWIN, JR., PHARMACEUTICAL PRODUCTS DIVISION, ABBOTT LABORATORIES,
ABBOTT PARK, ILLINOIS 27. APPENDIX: COMBINATORIAL CHEMISTRY INFORMATION
MANAGEMENT 483 DAVID WEININGER, DAYLIGHT CHEMICAL INFORMATION SYSTEMS,
INC., SANTA FE, NEW MEXICO INDEX 499
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| spelling | Combinatorial chemistry and molecular diversity in drug discovery ed. by Eric M. Gordon ... New York [u.a.] Wiley-Liss 1998 XXIV, 516 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Combinatorische chemie gtt Farmacochemie gtt Geneesmiddelen gtt Quimica farmaceutica larpcal Chemistry, Pharmaceutical Combinatorial chemistry Drug Design Drugs Design Kombinatorische Synthese (DE-588)4513555-1 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Arzneimitteldesign (DE-588)4278218-1 s Kombinatorische Synthese (DE-588)4513555-1 s DE-604 Gordon, Eric M. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008415831&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Combinatorial chemistry and molecular diversity in drug discovery Combinatorische chemie gtt Farmacochemie gtt Geneesmiddelen gtt Quimica farmaceutica larpcal Chemistry, Pharmaceutical Combinatorial chemistry Drug Design Drugs Design Kombinatorische Synthese (DE-588)4513555-1 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| subject_GND | (DE-588)4513555-1 (DE-588)4278218-1 (DE-588)4143413-4 |
| title | Combinatorial chemistry and molecular diversity in drug discovery |
| title_auth | Combinatorial chemistry and molecular diversity in drug discovery |
| title_exact_search | Combinatorial chemistry and molecular diversity in drug discovery |
| title_full | Combinatorial chemistry and molecular diversity in drug discovery ed. by Eric M. Gordon ... |
| title_fullStr | Combinatorial chemistry and molecular diversity in drug discovery ed. by Eric M. Gordon ... |
| title_full_unstemmed | Combinatorial chemistry and molecular diversity in drug discovery ed. by Eric M. Gordon ... |
| title_short | Combinatorial chemistry and molecular diversity in drug discovery |
| title_sort | combinatorial chemistry and molecular diversity in drug discovery |
| topic | Combinatorische chemie gtt Farmacochemie gtt Geneesmiddelen gtt Quimica farmaceutica larpcal Chemistry, Pharmaceutical Combinatorial chemistry Drug Design Drugs Design Kombinatorische Synthese (DE-588)4513555-1 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| topic_facet | Combinatorische chemie Farmacochemie Geneesmiddelen Quimica farmaceutica Chemistry, Pharmaceutical Combinatorial chemistry Drug Design Drugs Design Kombinatorische Synthese Arzneimitteldesign Aufsatzsammlung |
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