Gene therapy for HIV infection:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1998
|
| Schriftenreihe: | Biotechnology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 178 S. graph. Darst. |
| ISBN: | 3540647139 1570595402 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804127017484943360 |
|---|---|
| adam_text | [ CONTENTS i
1. Replicative Cycle of HIV 1
Magnus Gottfredsson
Introduction 1
HIV Replication and Genome Structure 2
Viral Binding and Entry 2
Reverse Transcription 2
Nuclear Import and Integration 4
Transcription and Splicing 5
Translation 7
Viral Assembly 8
2. Gene Therapy Strategies for Inhibition of HIV ...................... 13
Magnus Gottfredsson
Introduction 13
Inhibition Strategies 13
Viral Targets for Gene Therapy 15
Reverse Transcriptase 15
Integrase 15
Tat and TAR 16
Rev and RRE 17
Nef Function 19
5 Leader Sequence (U5) 23
gag Function 23
Nucleocapsid Protein 24
gpi2O and gp4i 24
Protease 25
The Vpr, Vif and Vpu Accessory Proteins 26
Packaging Sequence |) 26
HIV Induced Suicide Genes 26
Cellular Targets for Gene Therapy 27
Chemokine Receptors Ccr 5 and Cxcr 4 28
NF kB 28
Eukaryotic Initiation Factor 5A 29
Interferons and RBP9 27 29
Other Cellular Cofactors 30
Combinations of Antiviral Strategies 31
Ribozyme RNA Decoy Combinations 31
Transdominant Mutant Combinations 31
Antisense Combinations 32
Intracellular Antibodies with RNA Decoys 32
Multitarget Ribozymes 32
Other Approaches 33
Site Specific Recombination 33
Clinical Protocols 34
Conclusions and Future Prospects 35
3. Trans Splicing Ribozymes
as Potential HIV Gene Inhibitors. .. .. . . 49
Seong Wook Lee and Bruce A. Sullenger
Introduction 49
Ribozymes as Potential Anti HIV Agents 49
Limitations of Trans Cleaving Ribozymes
as HIV Inhibitors 50
Advantages of Trans Splicing Ribozymes 51
Targeted Trans Splicing by the Tetrahymena Ribozyme 52
Conclusions 56
4. Viral Vectors for HIV Gene Therapy........................................ 59
Kenneth L. Phillips
Introduction 59
Retrovirus Gene Transfer Systems 60
Lentiviral Vectors 66
Adeno Associated Virus Gene Delivery Systems 69
Conclusions 72
5. T Lymphocyte Based HIV Gene Therapy Strategies............... 77
Tracy Gentry
Introduction 77
Vectors for Gene Transfer into T Lymphocytes 77
Improving Retroviral Vector Gene Transfer Efficiency
in T Lymphocytes 81
Clinical Trials Involving Gene Transfer
into T Lymphocytes 87
Summary 90
6. Stem Cell Based Gene Therapies in the Treatment
of AIDS . 95
Robert Storms
Introduction 95
The HIV Life Cycle and Antiviral Therapies 96
HIV as a Target for Gene Therapy 97
Candidate Cell Types for HIV Gene Therapy 99
Hematopoietic Stem Cells as Targets for Gene Therapy 100
Gene Therapy Using Hematopoietic Stem Cells 105
Gene Delivery into Human Hematopoietic Stem Cells 109
Conclusions 111
7. Animal Models of Gene Therapy for AIDS............................. 119
Linda M. Kofeldt and David Camerini
Introduction 119
SCID Mice 120
The hu PBL SCID Mouse 120
The SCID hu Mouse 121
The SCID hu Bone Model 126
Bone Marrow SCID hu Mice 127
Strengths and Weaknesses of the SCID Mouse Models 128
Gene Transfer into Primate Hemopoietic
Precursor Cells 130
Strengths and Weaknesses of Primate Models 134
Summary 135
8. Hematopoietic Stern Cell Transplantation
and HIV Gene Therapy .............................................................. 141
Clay Smith and Cristina Gasparetto
Introduction 141
Principles of Hematopoietic Stern Cell Transplantation 141
Autologous Bone Marrow and Peripheral Blood Stern
Cell Transplantation 142
Allogeneic Bone Marrow and Peripheral Blood Stem
Cell Transplantation 147
Umbilical Cord Blood Transplantation 152
Clinical Experience with Stem Cell Transplantation
in HIV Infected Persons 155
Potential Methods for Decreasing
the Morbidity and Mortality of Stem Cell
Transplantation in Persons with HIV Infection 157
Prospects for Stem Cell Based Gene Therapy Approaches
to Treating HIV Infection 160
Index •••••••••••••••••••••••••••••••••• 177
|
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| dewey-search | 616.97/92042 |
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| id | DE-604.BV012384474 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:26:40Z |
| institution | BVB |
| isbn | 3540647139 1570595402 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008400762 |
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| physical | 178 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Springer |
| record_format | marc |
| series2 | Biotechnology intelligence unit |
| spelling | Gene therapy for HIV infection Clay Smith Berlin [u.a.] Springer 1998 178 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnology intelligence unit HIV, infection - Thérapeutique Immunogénétique ram Traitement génique Virus de l'immunodéficience humaine - Thérapie génique ram AIDS (Disease) Gene therapy Immunogenetics Gentherapie (DE-588)4296957-8 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 gnd rswk-swf Aids (DE-588)4112470-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content HIV-Infektion (DE-588)4203852-2 s Gentherapie (DE-588)4296957-8 s DE-604 Aids (DE-588)4112470-4 s Smith, Clay 1957- Sonstige (DE-588)12072944X oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008400762&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gene therapy for HIV infection HIV, infection - Thérapeutique Immunogénétique ram Traitement génique Virus de l'immunodéficience humaine - Thérapie génique ram AIDS (Disease) Gene therapy Immunogenetics Gentherapie (DE-588)4296957-8 gnd HIV-Infektion (DE-588)4203852-2 gnd Aids (DE-588)4112470-4 gnd |
| subject_GND | (DE-588)4296957-8 (DE-588)4203852-2 (DE-588)4112470-4 (DE-588)4143413-4 |
| title | Gene therapy for HIV infection |
| title_auth | Gene therapy for HIV infection |
| title_exact_search | Gene therapy for HIV infection |
| title_full | Gene therapy for HIV infection Clay Smith |
| title_fullStr | Gene therapy for HIV infection Clay Smith |
| title_full_unstemmed | Gene therapy for HIV infection Clay Smith |
| title_short | Gene therapy for HIV infection |
| title_sort | gene therapy for hiv infection |
| topic | HIV, infection - Thérapeutique Immunogénétique ram Traitement génique Virus de l'immunodéficience humaine - Thérapie génique ram AIDS (Disease) Gene therapy Immunogenetics Gentherapie (DE-588)4296957-8 gnd HIV-Infektion (DE-588)4203852-2 gnd Aids (DE-588)4112470-4 gnd |
| topic_facet | HIV, infection - Thérapeutique Immunogénétique Traitement génique Virus de l'immunodéficience humaine - Thérapie génique AIDS (Disease) Gene therapy Immunogenetics Gentherapie HIV-Infektion Aids Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008400762&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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