McAlpine's multiple sclerosis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Churchill Livingstone
1998
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 592 S. Ill., graph. Darst. |
| ISBN: | 0443050082 |
Internformat
MARC
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| 245 | 1 | 0 | |a McAlpine's multiple sclerosis |c Alastair Compston .. |
| 246 | 1 | 3 | |a Multiple sclerosis |
| 246 | 1 | 3 | |a MacAlpine's multiple sclerosis |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a London [u.a.] |b Churchill Livingstone |c 1998 | |
| 300 | |a XIII, 592 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Multiple sclerose |2 gtt | |
| 650 | 2 | |a Sclérose en plaques | |
| 650 | 7 | |a Sclérose en plaques |2 ram | |
| 650 | 4 | |a Multiple Sclerosis | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 0 | 7 | |a Multiple Sklerose |0 (DE-588)4040693-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Multiple Sklerose |0 (DE-588)4040693-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Compston, Alastair |d 1948- |e Sonstige |0 (DE-588)17280051X |4 oth | |
| 700 | 1 | |a McAlpine, Douglas |d 1890-1981 |e Sonstige |0 (DE-588)1030064946 |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804127003366916096 |
|---|---|
| adam_text | Contents
Preface to the third edition ix
Preface to the first edition xi
Acknowledgements xiii
Section 1: The story of multiple sclerosis
1. The story of multiple sclerosis 3
Alastair Compston
Naming and classifying the disease:
1849 1983 3
Depictions of multiple sclerosis: 1838 1981 6
Case reports and personal accounts of
multiple sclerosis: 1824 1991 9
Pathogenesis of multiple sclerosis:
1849 1972 14
Discovery of glia and remyelination:
1858 1988 23
Reviews of multiple sclerosis: 1871 1955 27
Epidemiology of multiple sclerosis:
1883 1976 32
Attitudes to the treatment of multiple
sclerosis: 1841 1983 39
Section 2: Genetic epidemiology
2. Methods of genetic epidemiology in
multiple sclerosis 45
Alastair Compston
Rationale for epidemiological studies in
multiple sclerosis 45
Definitions and statistics 46
Strategies for epidemiological studies in
multiple sclerosis 50
Methods of genetic analysis 52
3. Distribution of multiple sclerosis 63
Alastair Compston
Geography of multiple sclerosis 63
Multiple sclerosis in migrants 85
Epidemics of multiple sclerosis 89
Exogenous factors and multiple sclerosis 94
4. Genetic susceptibility to multiple
sclerosis 101
Alastair Compston
Racial susceptibility 101
Sex differences in susceptibility 105
Familial multiple sclerosis 106
Twin studies 109
Multiple sclerosis in adoptees and
half siblings 113
Conjugal multiple sclerosis 114
Genetic effects on clinical course of
multiple sclerosis 115
HLA system 116
T cell receptor genes 128
Immunoglobulin heavy chain genes 132
Mitochondrial genes 135
Structural genes of myelin 136
Systematic genome screening 137
Section 3: Clinical neurology
5. Symptoms and signs of multiple
sclerosis 145
Bryan Matthews
Multiple sclerosis as a neurological illness 145
Initial symptoms 147
Symptoms and signs in the course of the
disease 149
Individual symptoms and signs 150
Multiple sclerosis in childhood 186
Conclusion 190
6. Natural history of multiple sclerosis 191
George Ebers
Natural history studies: lessons from
medieval medicine 191
Multiple sclerosis compared with
rheumatoid arthritis 192
Applications of natural history studies 193
The ideal natural history study 194
Temporal course of multiple sclerosis 199
Factors which predict outcome 202
Population based natural history studies 206
Applications of natural history studies to
clinical trials 214
Conclusion 221
7. Differential diagnosis of multiple
sclerosis and related disorders 223
Bryan Matthews
Classification of demyelinating disease 223
Diseases causing multiple lesions 224
Systematized diseases 234
Isolated lesions of the central nervous
system 239
Monosymptomatic presentation 242
Non organic symptoms 249
How successful is diagnosis? 249
8. Diagnostic methods and investigation in
multiple sclerosis 251
Ian McDonald
Selection of investigations 251
Magnetic resonance imaging 252
Evoked potentials 268
Examination of the cerebrospinal fluid 274
Selection of paraclinical tests 277 ;
Strategy for the investigation of
demyelinating disease 277
Section 4: Pathogenesis
9. Neurobiology of multiple sclerosis 283
Alastair Compston
Stem cells in the developing nervous
system 284
Growth factors and cytokines for glia 286
Glial lineages in the rodent nervous system 288
Human oligodendroglial lineages 299
Axon glial interactions in the rodent
and human nervous systems 302
Lessons for glial neurobiology from
experimental demyelination and
remyelination 309
Oligodendrocyte injury 316
10. Pathology of multiple sclerosis 323
Hans Lassmann
Pathological classification of demyelinating
diseases 323
The demyelinated plaque 326
Immunopathology of inflammation 329
Demyelination and oligodendroglia damage 338
Remyelination 346
Axonal pathology 348
Astroglia reaction 350
Distribution of lesions in the nervous
system 351
Virus antigen 354
Dynamic evolution of multiple sclerosis
pathology 354
Association of multiple sclerosis with
other diseases 356
The inflammatory demyelinated plaque:
pathological entity or final stage in multiple
different pathogenetic pathways? 357
Conclusion 357
11. Pathophysiology of multiple sclerosis 359
Ian McDonald
Cardinal pathological features 359
Conduction studies in pathological nerve
fibres 361
Recovery mechanisms 366
Inflammatory and other humoral factors
influencing conduction 368
Gliosis 369
Pathophysiology of the course of multiple
sclerosis 370
Clinical expression and clinical silence 375
Conclusion 377
12. Immunology of multiple sclerosis 379
Hartmut Wekerle with a contribution from
Hans Lassmann
Main classes of lymphocytes 379
Autoimmunity and self tolerance 387
Immune reactivity in the central nervous
system 388
Cytokine defects in multiple sclerosis 397
Lessons for the immunopathogenesis of
multiple sclerosis from studies of
cerebrospinal fluid 398
Conclusion 407
13. Experimental models of multiple
sclerosis 409
Hans Lassmann and Hartmut Wekerle
Experimental allergic encephalomyelitis 409
Content
Virus induced inflammatory demyelinating
diseases 411
Brain specific autoimmune T cells 411
Pathogenesis of demyelination and tissue
damage 425
The ideal animal model for multiple
sclerosis: fact or fiction? 430
Validity of experimental models for
evaluation of new therapeutic strategies 431
Conclusion 433
Section 5: Treatment and management
14. Treatment and management of
multiple sclerosis 437
Alastair Compston
Communicating the diagnosis 438
General aspects of patient management 439
Treatment of the acute relapse with
corticosteroids 440
Treatment of acute optic neuritis with
high dose corticosteroids 446
Treatment of symptoms 449
Modifying the course of multiple sclerosis 456
Other approaches to treatment 487
Future prospects 495
References 499
Index 583
|
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| id | DE-604.BV012373071 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:26:26Z |
| institution | BVB |
| isbn | 0443050082 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008391398 |
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| physical | XIII, 592 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Churchill Livingstone |
| record_format | marc |
| spelling | McAlpine's multiple sclerosis Alastair Compston .. Multiple sclerosis MacAlpine's multiple sclerosis 3. ed. London [u.a.] Churchill Livingstone 1998 XIII, 592 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Multiple sclerose gtt Sclérose en plaques Sclérose en plaques ram Multiple Sclerosis Multiple Sklerose (DE-588)4040693-3 gnd rswk-swf Multiple Sklerose (DE-588)4040693-3 s DE-604 Compston, Alastair 1948- Sonstige (DE-588)17280051X oth McAlpine, Douglas 1890-1981 Sonstige (DE-588)1030064946 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008391398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | McAlpine's multiple sclerosis Multiple sclerose gtt Sclérose en plaques Sclérose en plaques ram Multiple Sclerosis Multiple sclerosis Multiple Sklerose (DE-588)4040693-3 gnd |
| subject_GND | (DE-588)4040693-3 |
| title | McAlpine's multiple sclerosis |
| title_alt | Multiple sclerosis MacAlpine's multiple sclerosis |
| title_auth | McAlpine's multiple sclerosis |
| title_exact_search | McAlpine's multiple sclerosis |
| title_full | McAlpine's multiple sclerosis Alastair Compston .. |
| title_fullStr | McAlpine's multiple sclerosis Alastair Compston .. |
| title_full_unstemmed | McAlpine's multiple sclerosis Alastair Compston .. |
| title_short | McAlpine's multiple sclerosis |
| title_sort | mcalpine s multiple sclerosis |
| topic | Multiple sclerose gtt Sclérose en plaques Sclérose en plaques ram Multiple Sclerosis Multiple sclerosis Multiple Sklerose (DE-588)4040693-3 gnd |
| topic_facet | Multiple sclerose Sclérose en plaques Multiple Sclerosis Multiple sclerosis Multiple Sklerose |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008391398&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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