Molecular cardiology for the cardiologist:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boston [u.a.]
Kluwer Academic Publ.
1998
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIII, 301 S. graph. Darst. |
| ISBN: | 0792383230 |
Internformat
MARC
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| 100 | 1 | |a Swynghedauw, Bernard |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Molecular cardiology for the cardiologist |c by Bernard Swynghedauw |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Boston [u.a.] |b Kluwer Academic Publ. |c 1998 | |
| 300 | |a XXIII, 301 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Hart- en vaatziekten |2 gtt | |
| 650 | 7 | |a Moleculaire biologie |2 gtt | |
| 650 | 4 | |a Cardiovascular Diseases |x genetics | |
| 650 | 4 | |a Cardiovascular Physiological Phenomena | |
| 650 | 4 | |a Cardiovascular system |x Diseases |x Molecular aspects | |
| 650 | 4 | |a Cardiovascular system |x Molecular aspects | |
| 650 | 4 | |a Cardiovascular system |x Pathophysiology | |
| 650 | 4 | |a Genetic Techniques | |
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Datensatz im Suchindex
| _version_ | 1804126984166440960 |
|---|---|
| adam_text | CONTENTS
PREFACE TO THE SECOND EDITION
Acknowledgments
1. THE NEW LANGUAGE OF BIOLOGY (1)
FROM CHROMOSOME TO GENE (1)
Chromosome packaging (4)
Cell division (6)
Autosomal cells (6)
Germinal cells (9)
The DNA molecule (11)
Biochemistry (11)
Nomenclature (11)
DNA replication (12)
Genes and the genetic code (14)
Gene structure (14)
Genetic code (15)
Main types of genes(18)
Isogenes (21)
The human genome sequencing program (21)
Gene classification (23)
Transcription (25)
The RNA molecule (26)
Structure (26)
Synthesis (27)
Regulation of gene expression (27)
vi
CURRENT TECHNOLOGIES (31)
Basic tools: probes, stringency and restriction enzymes (31)
Polymerase chain reaction (PCR) (37)
Working with RNA (40)
Quantifying mRNA in cardiology (40)
How to prepare and handle RNA (42)
Quantification of abundant mRNAs (43)
Quantifiaction of rare mRNAs (44)
Working with DNA (45)
cDNA amplification (45)
Making a DNA library (46)
DNA sequencing (48)
GENE TRANSFERS (49)
Gene transfer during viral infection (49)
Transgenic technology (51)
Techniques (51)
Transgenic models of cardiac hypertrophy and failure (59)
Transgenic models of cardiac dysfunction (62)
Gene transfer in autosomal cells (63)
GENOME BASED METHODS (65)
Expressed sequence tags (EST) (66)
Differential gene expression (67)
The serial analysis of gene expression (SAGE) (71)
DNA microarrays (73)
2. THE NORMAL HEART AND VESSELS. MOLECULAR
STRUCTURE IN RELATION TO PHYSIOLOGY (75)
MEMBRANE PROTEINS AND ELECTRICAL ACTIVITY (75)
Inter and intracellular cross talk (75)
Receptors and receptology (79)
Plasma membrane receptors and transduction systems (79)
G proteins (86)
Ion channels and electrical activity (87)
Biological determinants of the action potential (87)
Ion channels and ion currents (93)
Intracellular ion homeostasis (97)
Calcium homeostasis (97)
The sodium/potassium homeostasis (110)
Mechanisms to maintain intracellularpH (111)
Vascular cells membrane protein (112)
SARCOMERE STRUCTURE AND CONTRACTILITY (114)
CYTOSKELETON
Cardiac sarcomere (115)
Thick filament proteins (115)
Thin filament proteins (117)
Contraction movement (120)
Relationships with physiological properties (121)
Smooth muscle sarcomere (123)
Cytoskeleton (126)
EXTRACELLULAR MATRIX AND TISSUE COMPLIANCE
(131)
Extracellular matrix (ECM) (131)
Collagen metabolism (136)
Synthesis and degradation (136)
Collagenases (138)
viii
VASOACTIVE ENDOTHELIAL SUBSTANCES (138)
The renin angiotensin system (RAS) (140)
Structure of RAS components (140)
Angiotensin II receptors (ATR) (142)
The kinin kallicrein system (143)
Endothelium derived vasoactive factors (143)
Endothelium dependent relaxation (144)
Endothelium dependent contraction (148)
Endothelial cells/cardiocytes cross talk (149)
THE HEART AND VESSELS AS ENDOCRINES (150)
Atrial natriuretic peptides (ANP) (150)
Myocardial and vascular RAS (151)
Aldosterone, corticosterone and a few others components (152)
CARDIAC AND VASCULAR GROWTH (152)
Cellular growth (153)
Triggers and pathways for growth (154)
Mechanical factors (154)
Hormones and peptides (157)
Intracellular signaling pathways (158)
Transcription factors (TF) (159)
Genetic control of cardiac development (159)
Nuclear hormone receptors (160)
Early transitory DNA responses (162)
Protooncogenes (162)
Cytokines (163)
Stress or heat shock proteins (HSP) (166)
Permanent responses of the genome (167)
CELL DEATH (168)
3. CARDIAC AND VASCULAR REMODELLING (171)
CARDIAC HYPERTROPHY AND FAILURE (172)
Phenotypic changes in myocytes (172)
The process of adaptation (174)
Cardiac hypertrophy (177)
Energetics (178)
Energy metabolism (179)
Ion currents (180)
Control of intracellular pH (183)
Calcium regulating proteins (183)
Cardiac recptors (185)
Contractile proteins (187)
Cardiac cycle (189)
Excitation contraction coupling (ECC) (190)
Calcium homeostasis (191)
Cardiac autocrine function (192)
Cytoskeleton (193)
Phenotypic changes in ECM (194)
Types offibrosis (194)
Causes offibrosis (194)
Other components of the ECM (197)
Cell death (197)
Ischemia (197)
Cardiac hypertrophy and failure (198)
Transition to cardiac failure (198)
Hypertrophy of the arterial wall (200)
X
THE SENESCENT HEART AND VESSELS (200)
Anatomical and cellular data (201)
Biological determinants of myocardial function at rest (203)
Systolic function (203)
Diastolic function (205)
The cardiovascular response to exercise (206)
Arrhythmias (206)
Cardiac hormones (207)
Protein synthesis (209)
The genetics of aging (210)
The senescent heart, a diseased heart (211)
4. GENETICS FOR NONGENETICIANS (213)
DNA POLYMORPHISM (213)
Definitions (213)
What causes DNA polymorphism ? (216)
What are the consequences of DNA polymorphism ? (219)
INHERITED DISEASES (221)
Strategies for isolating a mutation (221)
Classical genetics (221)
Reverse genetics (221)
Populational approach (candidate gene) (224)
Positional candidate strategy (224)
Main types of hereditary diseases (225)
Genotype and phenotype relationships (228)
Inherited cardiovascular diseases and risk factors (230)
MONOGENIC CARDIOVASCULAR DISEASES (232)
Familial defective Apo B 100 (FDA) (232)
Familial hypercholesterolemia (233)
Mendelian forms of arterial hypertension (235)
Familial cardiomyopathies (235)
Familial hypertrophic cardiomyopathies (FHC) (236)
Familial dilated cardiomyopathies (240)
Familial arrhythmias (241)
MULTIGENIC CARDIOVASCULAR DISEASES AND RISK
FACTORS (242)
Hyperlipidemias (242)
Arterial hypertension (246)
Myocardial infarction (247)
Left ventricular hypertrophy (248)
Diabetes (249)
Obesity (250)
5. GENE THERAPY AND CELL TRANSPLANT (253)
Gene therapy (253)
Vectors for gene transfer (254)
Gene transfer and cell transplant to repair MI (257)
CONCLUSION
GLOSSARY (263)
REFERENCES (273)
INDEX (297)
LIST OF FIGURES.
1.1. From phenotype to genotype (2)
1. 2. From chromosomes to DNA (5)
1. 3. The cell cycle in autosomal cells: mitosis (8)
1. 4. The cell cycle in germinal cells: meiosis (10)
1.5. From DNA to nucleotide (13)
1.6. DNA replication (13)
1. 7. RNA maturation and mRNA structure (16)
1.8. The genetic compass (19)
1. 9. The regulatory part of a gene (29)
1. 10. Cis and trans regulation (29)
1.11. Transcriptional regulation of hormone effect (30)
1. 12. Genetic probes (32)
1.13. Northern blot analysis (32)
1. 14. Restriction enzymes and restriction sites (35)
1. 15. Restriction maps (36)
1. 16. Polymerase chain reaction (PCR) (39)
1.17. Cloning and amplification (47)
1.18. DNA library using X phage (47)
1.19. The retro virus cycle (50)
1. 20. Overexpression of human pM AR in transgenic mice atria (53)
1.21. RNA display (70)
1. 22. Serial analysis of gene expression (SAGE) (73)
2. 1. Inter and intracellular cross talk (78)
2. 2. The transduction system of the (i adrenergic receptors ((J AR) (81)
2. 3. Receptors in the cardiovascular autonomous nervous system (85)
2. 4. The molecular basis of ECG (89)
2. 5. The molecular structure of ion channels (91)
xiv
2. 6. The two components of the calcium transient (99)
2. 7. Main determinants of the intracellular calcium homeostasis (101)
2. 8. Calciproteins (102)
2. 9. Proteins of the sarcoplasmic reticulum (105)
2. 10. Structural basis for the cardiac calcium induced calcium release and the
vascular IP3 induced calcium release in the SR (106)
2.11. Structure of the striated muscle sarcomere (116)
2. 12. Mechano enzymatic relationships during muscle contraction (119)
2. 13. Physiological molecular correspondences of contractility (122)
2. 14. Structure of the smooth muscle sarcomere (124)
2. 15. Cardiocyte cytoskeleton (130)
2. 16. Structure of the collagen network (134)
2. 17. Type I collagen synthesis (135)
2. 18. Zymographic analysis of matrix metalloproteinase activities in rats (137)
2. 19. The renin angiotensin system (139)
2. 20. Endothelial dependent factors causing vasodilatation (145)
2. 21. Metabolism of arachidonic acid and prostaglandins (146)
2. 22. Endothelial dependent factors causing vasoconstriction (146)
2. 23. The biological cascade at the origin of cardiac or vascular hypertrophy
(155)
2. 24. Tyrosine kinase receptors (164)
2. 25. Mechanisms of action of growth factors (GF) (164)
2. 26. Mechanisms of cell death (169)
3. 1. Efficiency as a trigger for adaptation (175)
3. 2. Muscle economy in cardiac hypertrophy (176)
3. 3. Membrane composition of the cardiocyte during compensated CH and
cardiac failure (186)
3. 4. Biological factors responsible for myocardial failure (199)
4. 1. Allelic polymorphism during cell division (215)
4. 2. Restriction polymorphism and haplotype (215)
4. 3. The physical basis for genetic linkage during meiosis (217)
4. 4. Unequal recombination (218)
4. 5. Genetic conversion (220)
4. 6. Strategies for identifying diseased genes (223)
4. 7. Short tandem repeats identification by PCR (223)
4. 8. Monogenic and multigenic hereditary diseases (226)
4. 9. Modes of inheritance (229)
4. 10. Pathways for lipid transport and main mechanisms for hyperlipidemias
(231)
4. 11. Detection of the apoB 3,500 mutation by PCR on blood spots (234)
4. 12. Lipoprotein (LP) receptor (234)
4. 13. Myosin heavy chains mutations in HCM (237)
5. 1. Retroviral vector system (255)
LIST OF TABLES
1. 1. The genetic code (17)
1. 2. Current status of genomic sequences in 1997 (22)
1.3. Cardiovascular specific promoters (54)
1. 4. Transgenic models of cardiac hypertrophy and failure (56)
1. 5. Exploring the myocardial function using transgenic technology (58)
1. 6. Good adresses for Internet cloning: database informations (66)
1. 7. Distribution of genes in the human cardiovascular system (69)
1. 8. Applications of mRNA differential display to cardiovascular research (71)
2. 1. Main families or superfamilies of membrane proteins (76)
2. 2. Main ion channels of the cardiovascular system (92)
2. 3. Vascular cell membrane proteins (113)
2. 4. Smooth muscle sarcomere (123)
2. 5. Cardiocyte cytoskeleton (128)
2. 6. Physiological role of the myocardial and vascular collagen network (132)
2. 7. Major protooncogenes 163)
2. 8. Main families of growth factors (165)
3. 1. Permanent changes in gene expression in compensatory cardiac
hypertrophy in rat (173)
3. 2. Economy of the hypertrophied heart (177)
3. 3. Ion currents and channels in cardiac hypertrophy and cardiac failure (1X2)
3. 4. Senescent heart versus overloaded heart: fibrosis, arrhythmias and
mechanics (202)
3. 5. Senescent heart versus overloaded heart: ANS, RAS and ANF (204)
4. 1. Classification of hyperlipidemias (243)
4. 2. Genetics of hyperlipidemias (244)
|
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| id | DE-604.BV012356788 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:26:08Z |
| institution | BVB |
| isbn | 0792383230 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008378602 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | XXIII, 301 S. graph. Darst. |
| publishDate | 1998 |
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| publishDateSort | 1998 |
| publisher | Kluwer Academic Publ. |
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| spelling | Swynghedauw, Bernard Verfasser aut Molecular cardiology for the cardiologist by Bernard Swynghedauw 2. ed. Boston [u.a.] Kluwer Academic Publ. 1998 XXIII, 301 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hart- en vaatziekten gtt Moleculaire biologie gtt Cardiovascular Diseases genetics Cardiovascular Physiological Phenomena Cardiovascular system Diseases Molecular aspects Cardiovascular system Molecular aspects Cardiovascular system Pathophysiology Genetic Techniques Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd rswk-swf Kardiovaskuläre Krankheit (DE-588)4024666-8 s Molekularpathologie (DE-588)4170396-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008378602&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Swynghedauw, Bernard Molecular cardiology for the cardiologist Hart- en vaatziekten gtt Moleculaire biologie gtt Cardiovascular Diseases genetics Cardiovascular Physiological Phenomena Cardiovascular system Diseases Molecular aspects Cardiovascular system Molecular aspects Cardiovascular system Pathophysiology Genetic Techniques Molekularpathologie (DE-588)4170396-0 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| subject_GND | (DE-588)4170396-0 (DE-588)4024666-8 |
| title | Molecular cardiology for the cardiologist |
| title_auth | Molecular cardiology for the cardiologist |
| title_exact_search | Molecular cardiology for the cardiologist |
| title_full | Molecular cardiology for the cardiologist by Bernard Swynghedauw |
| title_fullStr | Molecular cardiology for the cardiologist by Bernard Swynghedauw |
| title_full_unstemmed | Molecular cardiology for the cardiologist by Bernard Swynghedauw |
| title_short | Molecular cardiology for the cardiologist |
| title_sort | molecular cardiology for the cardiologist |
| topic | Hart- en vaatziekten gtt Moleculaire biologie gtt Cardiovascular Diseases genetics Cardiovascular Physiological Phenomena Cardiovascular system Diseases Molecular aspects Cardiovascular system Molecular aspects Cardiovascular system Pathophysiology Genetic Techniques Molekularpathologie (DE-588)4170396-0 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| topic_facet | Hart- en vaatziekten Moleculaire biologie Cardiovascular Diseases genetics Cardiovascular Physiological Phenomena Cardiovascular system Diseases Molecular aspects Cardiovascular system Molecular aspects Cardiovascular system Pathophysiology Genetic Techniques Molekularpathologie Kardiovaskuläre Krankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008378602&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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