An introduction to radiobiology:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
1998
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 384 S. Ill., graph. Darst. |
| ISBN: | 0471975893 0471975907 |
Internformat
MARC
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| 100 | 1 | |a Nias, A. H. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a An introduction to radiobiology |c A. H. W. Nias |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 1998 | |
| 300 | |a XII, 384 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Radiobiology | |
| 650 | 4 | |a Nuclear Medicine | |
| 650 | 4 | |a Radiation Effects | |
| 650 | 4 | |a Radiobiology | |
| 650 | 4 | |a Radiology, Medical | |
| 650 | 0 | 7 | |a Strahlenbiologie |0 (DE-588)4057819-7 |2 gnd |9 rswk-swf |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008377146 | ||
Datensatz im Suchindex
| _version_ | 1804126981969674240 |
|---|---|
| adam_text | Contents
Preface xiii
Acknowledgements xv
1 History and Definitions 1
Synopsis 2
History 2
Radiation 5
Time scale 8
Radiation units 9
Summary of conclusions 11
References 11
2 Cells and Tissues 12
Cytoplasmic organelles 13
Types of mammalian cell 14
Proliferation of cell populations 16
The cell cycle 18
Synchrony and synchronization 21
Physical methods of synchronization 22
Chemical methods of synchronization 23
Circadian rhythm 27
Patterns of synthesis 28
Summary of conclusions 28
References 28
3 Proliferation Kinetics 30
Increase in tissue volume 30
Increase in total cell number 32
Mitotic rate and mitotic index 32
Time lapse observations 34
DNA labelling methods 34
Flow cytometry 37
Growth fraction and cell loss 42
Potential doubling time fpo, 43
Summary of conclusions 46
References 46
viii CONTENTS
4 Ionizing Radiations 47
X rays and y rays 48
Electrons and ß rays 50
Radioactive isotopes 51
Radiation dosimetry 53
Ionization and radical formation 55
The oxygen effect 59
Protection and sensitization 60
Summary of conclusions 61
References 62
5 Subcellular Radiobiology 63
Radiation biochemistry 63
Effect of radiation on macromolecular synthesis 64
Radiosensitivity of the nucleus 67
Molecular radiobiology 68
Chromosome damage 72
Size of radiation target 78
Summary of conclusions 79
References 79
6 Radiation Cell Damage 80
Giant cells 81
Interphase death and apoptosis 84
Radiation cell death and reproductive capacity 86
Loss of reproductive integrity 89
Pedigree analysis 90
Clone size analysis 93
Summary of conclusions 97
References 98
7 Reparable Damage 99
Division delay 99
Position of G2 block 101
Recovery from sublethal damage 103
Repair mechanism 107
Recovery from potentially lethal damage 111
Half time of recovery 112
Summary of conclusions 114
References 115
8 Intrinsic Radiosensitivity 116
Target theory 118
The initial slope of survival curves 121
Spheroid cultures 125
CONTENTS ix
Phase sensitivity to radiation 127
Time course of phase sensitivity 130
Dose response curves in vivo 133
The significance of survival curves 135
Summary of conclusions 137
References 138
9 Densely Ionizing Radiation 140
Linear energy transfer 140
Types of radiation 143
Neutron dosimetry and weighting factor 148
Relative biological effectiveness 148
Phase sensitivity 151
Summary of conclusions 154
References 155
10 The Oxygen Effect 156
Oxygen diffusion distance 157
Oxygen enhancement ratio (OER) 161
The oxygen effect at low doses 163
Hypoxic fraction 165
K value 166
Hyperbaric oxygen (HPO) 168
Carbogen 171
Recovery in hypoxic cells 171
Summary of conclusions 174
References 174
11 Radiosensitizers and Radioprotectors 176
Biochemical sensitizers 177
Drug radiation combinations 178
Recovery 183
Phase specific drugs 185
Recall 187
Protection and sensitization 187
Hypoxic cell sensitizers 188
Protection 192
Summary of conclusions 195
References 195
12 Normal and Malignant Cells 197
Radiosensitivity of tumour cell populations 199
Kinetics of normal and malignant cell populations 204
Radiation response of tumours 206
Clonogenic assays 209
x CONTENTS
Summary of conclusions 214
References 215
13 Radiation Pathology 217
Skin 218
Gastrointestinal tract 221
Bone marrow 223
The immune system 225
Late effects on normal tissues 228
Vascular tissue 229
Kidney 231
Thoracic organs 232
Lung 233
Central nervous system 234
Thyroid gland 236
Lens and cataract formation 236
Summary of conclusions 238
References 239
14 Whole body Radiation 241
The cellular basis of the total body syndromes 241
Cell renewal systems 243
Mean lethal dose LDso 246
Human syndromes 251
Partial body irradiation 255
Clinical TBI 255
Doses and times 256
Summary of conclusions 256
References 257
15 Proliferation Kinetics after Radiation 258
Tumour models 259
Cell loss 262
Growth delay 263
Tumour bed effect 266
In vivo/in vitro assay 267
Fractionation studies 267
Pattern of response 269
Prognosis 271
Summary of conclusions 272
References 273
16 Fractionated Radiotherapy 274
Biological factors 274
Recovery from sublethal damage 275
CONTENTS xi
Potentially lethal damage 276
Repopulation 277
Reoxygenation 279
Redistribution of cells in the cycle 282
Division delay 283
Physical factors 283
Radiation quality 283
Chronobiological effects 288
Iso effect curves and fractionation formulae 289
Summary of conclusions 294
References 295
17 Protracted Radiation 297
In vitro studies 298
Continuous irradiation in vivo 310
Whole body radiation 311
Summary of conclusions 312
References 313
18 Diagnostic Radiology 314
Radiation dose per examination 314
Effective dose of radiological examinations 317
Genetic effects of radiation 320
Effects on the embryo and foetus 324
Avoidance of irradiation of embryo 326
Benefit and detriment 327
Summary of conclusions 328
References 328
19 Environmental Radiation 330
Radon 332
Ultraviolet radiation 334
Radiation and food 335
Nuclear power industry 337
Occupational doses 338
Radiation carcinogenesis and leukaemogenesis 339
Mechanisms of carcinogenesis 343
Atomic bomb explosions 345
The latent period 345
Summary of conclusions 348
References 349
20 Radiation Protection 351
Risk comparisons 351
Dose limits 353
xii CONTENTS
Dose monitoring 354
Rad equivalence 356
General guidelines 358
Summary of conclusions 359
References 359
Further Reading 361
Glossary 363
Index 365
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:26:06Z |
| institution | BVB |
| isbn | 0471975893 0471975907 |
| language | English |
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| spelling | Nias, A. H. Verfasser aut An introduction to radiobiology A. H. W. Nias 2. ed. Chichester [u.a.] Wiley 1998 XII, 384 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Radiobiology Nuclear Medicine Radiation Effects Radiology, Medical Strahlenbiologie (DE-588)4057819-7 gnd rswk-swf Strahlenbiologie (DE-588)4057819-7 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008377146&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nias, A. H. An introduction to radiobiology Radiobiology Nuclear Medicine Radiation Effects Radiology, Medical Strahlenbiologie (DE-588)4057819-7 gnd |
| subject_GND | (DE-588)4057819-7 |
| title | An introduction to radiobiology |
| title_auth | An introduction to radiobiology |
| title_exact_search | An introduction to radiobiology |
| title_full | An introduction to radiobiology A. H. W. Nias |
| title_fullStr | An introduction to radiobiology A. H. W. Nias |
| title_full_unstemmed | An introduction to radiobiology A. H. W. Nias |
| title_short | An introduction to radiobiology |
| title_sort | an introduction to radiobiology |
| topic | Radiobiology Nuclear Medicine Radiation Effects Radiology, Medical Strahlenbiologie (DE-588)4057819-7 gnd |
| topic_facet | Radiobiology Nuclear Medicine Radiation Effects Radiology, Medical Strahlenbiologie |
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