Isotonic shortening and isometric force frequency relation in human atrial myocardium:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Heidelberg, Univ., Diss., 1998 (Nicht für den Austausch) |
| Beschreibung: | 99 Bl. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Isotonic shortening and isometric force frequency relation in human atrial myocardium |c vorgelegt von Xiaobin Yang |
| 264 | 1 | |c 1998 | |
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Datensatz im Suchindex
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| adam_text |
LIST OF CONTENTS
1. INTRODUCTION
5
1.1 INVESTIGATION ON THE FORCE-FREQUENCY RELATIONSHIP 5
1.2 EFFECT OF CALCIUM ON THE FORCE-FREQUENCY RELATIONSHIP 5
1.3 STUDIES ON THE ISOTONIC SHORTENING 6
1.4 AIM OF THE CURRENT STUDY 8
2. MATERIALS AND METHODS 10
2.1 EXPERIMENTAL PREPARATION 10
2.1.1 MYOCARDIAL TISSUE 10
2.1.2 EXPERIMENTAL SOLUTIONS 12
2.1.3 MUSCLE STRIP PREPARATION 12
2.1.4 LOADING OF TRABECULAE WITH FURA-2 14
2.2 EXPERIMENTAL DESIGN 14
2.2.1 STEREO MICROSCOPE 16
2.2.2 PERFUSION AND SUCTION SYSTEM 17
2.2.3 ELECTRICAL STIMULATION AND FORCE TRANSDUCER 18
2.2.4 LENGTH CONTROL AND SERVOMOTOR 18
2.2.5 CUVETTE AND TWEEZERS 19
2.2.6 FLUORESCENT LIGHT SYSTEM 20
2.2.7 TEMPERATURE CONTROL SYSTEM 20
2.2.8 STORAGE OSCILLOSCOPE 21
2.2.9 COMPUTER SYSTEM 22
2.3 INTRACELLULAR CALCIUM AND MECHANICAL MEASUREMENT 23
2.3.1 MEASUREMENT OF INTRACELLULAR CALCIUM CONCENTRATION 23
2.3.2 CALIBRATION OF FLUORESCENCE SIGNAL 24
2.3.3 MEASUREMENT OF MECHANICAL PERFORMANCE 25
2.4 EXPERIMENTAL PROTOCOL 26
2.5 STATISTICAL ANALYSIS 27
3. RESULTS
28
3.1 RESULTS UNDER ISOMETRIC CONDITIONS 28
3.1.1 TIME COURSE OF TENSION 28
3
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/955008921
3.1.2 ISOMETRIC TENSION DEVELOPMENT 30
3.1.3 PEAK RATES OF INCREASE AND DECREASE OF TENSION 32
3.1.4 INTRACELLULAR CALCIUM TRANSIENTS 37
3.1.5 EFFECT OF STIMULATION FREQUENCY ON ISOMETRIC TENSION
AND INTRACELLULAR CALCIUM 41
3.2 RESULTS UNDER ISOTONIC CONDITIONS 44
3.2.1 TIME COURSE OF SHORTENING 44
3.2.2 ISOTONIC SHORTENING 47
3.2.3 SHORTENING VELOCITY 49
3.2.4 INTRACELLULAR CALCIUM TRANSIENTS 51
3.2.5 EFFECT OF STIMULATION FREQUENCY ON ISOTONIC SHORTENING
AND INTRACELLULAR CALCIUM 54
3.3 COMPARISON OF ISOMETRIC AND ISOTONIC CONDITIONS 57
3.3.1 TIME COURSE OF TENSION AND SHORTENING 57
3.3.2 TENSION AND SHORTENING 62
3.3.3 INTRACELLULAR CALCIUM TRANSIENTS 63
4. DISCUSSION 68
4.1 REASON FOR THE POSITIVE FORCE-FREQUENCY RELATIONSHIP 69
4.2 DIFFERENCE OF ISOMETRIC CONTRACTION AND ISOTONIC SHORTENING 72
4.2.1 INCREASED AMPLITUDE OF TENSION AND SHORTENING 73
4.2.2 TIME COURSE OF TENSION AND SHORTENING 74
4.2.3 TIME COURSE OF PEAK CALCIUM TRANSIENTS 76
4.2.4 TIME COURSE OF CALCIUM DECLINE 77
4.2.5 FREQUENCY EFFECT ON THE CALCIUM TRANSIENT 81
5. SUMMARY
85
6. REFERENCES
87
7. CAREER 98
8. ACKNOWLEDGEMENTS 99
4 |
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| indexdate | 2024-10-09T16:03:32Z |
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| language | English |
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| spelling | Yang, Xiaobin 1958- Verfasser (DE-588)120614952 aut Isotonic shortening and isometric force frequency relation in human atrial myocardium vorgelegt von Xiaobin Yang 1998 99 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Heidelberg, Univ., Diss., 1998 (Nicht für den Austausch) (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008367269&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yang, Xiaobin 1958- Isotonic shortening and isometric force frequency relation in human atrial myocardium |
| subject_GND | (DE-588)4113937-9 |
| title | Isotonic shortening and isometric force frequency relation in human atrial myocardium |
| title_auth | Isotonic shortening and isometric force frequency relation in human atrial myocardium |
| title_exact_search | Isotonic shortening and isometric force frequency relation in human atrial myocardium |
| title_full | Isotonic shortening and isometric force frequency relation in human atrial myocardium vorgelegt von Xiaobin Yang |
| title_fullStr | Isotonic shortening and isometric force frequency relation in human atrial myocardium vorgelegt von Xiaobin Yang |
| title_full_unstemmed | Isotonic shortening and isometric force frequency relation in human atrial myocardium vorgelegt von Xiaobin Yang |
| title_short | Isotonic shortening and isometric force frequency relation in human atrial myocardium |
| title_sort | isotonic shortening and isometric force frequency relation in human atrial myocardium |
| topic_facet | Hochschulschrift |
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