Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Heidelberg, Univ., Diss., 1998 (Nicht für den Austausch) |
| Beschreibung: | 87 Bl. graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |c vorgelegt von Jianguo Chen |
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Datensatz im Suchindex
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3
CONTENTS
ABBREVIATIONS.6
1. INTRODUCTION.7
1.1 NEUROTRANSMISSION AND NOCICEPTION IN SPINAL DORSAL HORN.7
1.2 ACTIVITY-DEPENDENT CHANGES IN SYNAPTIC STRENGTH.8
1.3 THE CLASSIFICATION AND DISTRIBUTION OF METABOTROPIC GLUTAMATE
RECEPTORS. 10
1.4 PUTATIVE ROLES OF METABOTROPIC GLUTAMATE RECEPTORS IN SPINAL CORD.
13
1.5 ROLES OF METABOTROPIC GLUTAMATE RECEPTORS IN SYNAPTIC PLASTICITY. 14
1.6 THE AIMS OF THIS STUDY.15
2. MATERIALS AND METHODS.I 7
2.1 PREPARATION OF SPINAL CORD SLICE. 17
2.2 RECORDING AND STIMULATION TECHNIQUES. 17
2.3 EXPERIMENTAL PROTOCOL.20
2.4 DATA ANALYSIS.20
2.5 APPLICATION OF DRUGS.21
3
. RESULTS.22
3.1 AFFERENT FIBER VOLLEYS IN DORSAL ROOT EVOKED BY ELECTRICAL
STIMULATION.22
3.2 PRIMARY AFFERENT-EVOKED EXCITATORY POSTSYNAPTIC POTENTIALS IN
SUPERFICIAL
SPINAL DORSAL HORN.24
3.2.1 A8- AND C-FIBER-EVOKED EPSPS. 24
3.2.2 IDENTIFICATION OF MONO- AND POLYSYNAPTIC EPSPS. 24
3.2.3 PAIRED-PULSE STIMULATION. 25
3.2.4 CONTRIBUTION OF NMD A AND NON-NMDA RECEPTORS TO EPSPS.27
3.2.5 SCULPTURE OF EPSPS BY
GABAA AND GLYCINE RECEPTORS. 29
3.3 INDUCTION OF LONG-TERM DEPRESSION IN SPINAL DORSAL HORN.29
3.3.1 LOW-FREQUENCY STIMULATION OF A8-FIBERS INDUCES LONG-TERM
DEPRESSION
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/955008883
4
OF PRIMARY AFFERENT NEURONTRANSMISSION. 29
3.3.2 LFS INDUCES HOMOSYNAPTIC LTD IN SPINAL CORD. 29
3.4 LFS-INDUCED LTD IS NMDA RECEPTOR DEPENDENT.33
3.5 THE MGIUR ANTAGONIST (S)-MCPG REVERSIBLY AND STEREO-SELECTIVELY
BLOCKS
LFS-INDUCED LTD.35
3.5.1 (S)-MCPG REVERSIBLY BLOCKS THE INDUCTION OF LFS-INDUCED LTD. 35
3.5.2 THE BLOCKADE EFFECT OF (S)-MCPG ON LFS-INDUCED LTD IS
STEREO-SELECTIVE.35
3.6 ACTIVATION OF GROUP I MGLURS IS REQUIRED FOR INDUCTION OF LTD.37
3.7 ACTIVATION OF GROUP II MGLURS IS REQUIRED FOR INDUCTION OF LTD. 37
3.8 GROUP III MGLURS ARE NOT INVOLVED IN THE INDUCTION OF LFS-INDUCED
LTD.38
3.9 AN INCREASE IN POSTSYNAPTIC FREE CA
2+ IS INVOLVED IN THE INDUCTION OF LFS
-INDUCED LTD.42
3.10 APPLICATION OF (IS, 3R)-ACPD ALONE IS NOT SUFFICIENT TO INDUCE LTD
IN SPINAL DORSAL HORN.44
3.11 THE BLOCKADE OF INHIBTORY RECEPTORS UNMASKS LTD INDUCTION BY
(IS, 3R)-ACPD.46
3.12 (IS, 3R)-ACPD-INDUCED LTD IS NMDA RECEPTOR INDEPENDENT.47
3.13 PTX-SENSITIVE G-PROTEINS ARE NOT INVOLVED IN THE GENERATION OF
(IS, 3R)-ACPD INDUCED LTD.50
4. DISCUSSION.52
4.1 CURRENT STIMULATION OF PRIMARY AFFERENTS IN DORSAL ROOTS. 52
4.2 THE ANALYSIS OF THE COMPONENTS IN A5-FIBER INDUCED EPSPS.52
4.3 THE CONDITIONS FOR LFS-INDUCED HOMOSYNAPTIC LTD INDUCTION.53
4.4 ACTIVATION MGLURS IS INVOLVED IN THE GENERATION OF LONG-LASTING
ALTERATION OF SYNAPTIC EFFICACY. 54
4.4.1 MGLURS MODULATE SYNAPTIC NEUROTRANSMISSION. 54
4.4.2 ACTIVATION OF MGLURS IS REQUIRED FOR LTD INDUCTION IN THE CENTRAL
NERVOUS SYSTEM. 55
4.4.3 ACTIVATION OF GROUP I AND GROUP II, BUT NOT GROUP III MGLURS IS
REQUIRED
5
FOR THE INDUCTION OF LTD IN SPINAL DORSAL HORN. 56
4.5 AN INCREASE IN POSTSYNAPTIC CA
2+ IS INVOLVED IN HOMOSYNAPTIC LTD INDUCTION. 59
4.6 DISINHIBITION IS NECESSARY FOR THE GENERATION OF (IS,
3R)-ACPD-INDUCED LTD. 60
4.7 (IS, 3R)-ACPD-INDUCED LTD IS MEDIATED BY PTX-INSENSITIVE
G-PROTEINS.62
4.8 POSSIBLE BIOLOGICAL FUNCTIONS OF MGLURS IN NOCICEPTION AND
ANTINOCICEPTION
IN SPINAL CORD.62
4.9 CONCLUSIONS.63
5. SUMMARY.
64
6. REFERENCES.
68
7. PUBLICATIONS.
85
8. CURRICULUM VITAE.
86
9. ACKNOWLEDGEMENTS
87 |
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| spelling | Chen, Jianguo 1963- Verfasser (DE-588)120614936 aut Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn vorgelegt von Jianguo Chen 1998 87 Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Heidelberg, Univ., Diss., 1998 (Nicht für den Austausch) (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008367268&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chen, Jianguo 1963- Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| subject_GND | (DE-588)4113937-9 |
| title | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| title_auth | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| title_exact_search | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| title_full | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn vorgelegt von Jianguo Chen |
| title_fullStr | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn vorgelegt von Jianguo Chen |
| title_full_unstemmed | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn vorgelegt von Jianguo Chen |
| title_short | Role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| title_sort | role of metabotropic glutamate receptors for induction of homosynaptic long term depression in rat spinal dorsal horn |
| topic_facet | Hochschulschrift |
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