Influence of lecithin on structure and stability of parenteral fat emulsions:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English German |
| Veröffentlicht: |
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 202 S. Ill., graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012253291 | ||
| 003 | DE-604 | ||
| 005 | 20030325 | ||
| 007 | t | ||
| 008 | 981110s1998 ad|| m||| 00||| eng d | ||
| 016 | 7 | |a 954995155 |2 DE-101 | |
| 035 | |a (OCoLC)246115638 | ||
| 035 | |a (DE-599)BVBBV012253291 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng |a ger | |
| 049 | |a DE-29 |a DE-29T |a DE-355 |a DE-12 |a DE-83 |a DE-11 |a DE-188 | ||
| 084 | |a YT 7600 |0 (DE-625)154168:12905 |2 rvk | ||
| 100 | 1 | |a Wabel, Christoph |d 1969- |e Verfasser |0 (DE-588)120607549 |4 aut | |
| 245 | 1 | 0 | |a Influence of lecithin on structure and stability of parenteral fat emulsions |c von Christoph Wabel |
| 264 | 1 | |c 1998 | |
| 300 | |a XII, 202 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Erlangen-Nürnberg, Univ., Diss., 1998 | ||
| 650 | 0 | 7 | |a Fettemulsion |0 (DE-588)4132309-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Parenterale Ernährung |0 (DE-588)4126209-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Stabilisator |0 (DE-588)4182700-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Lecithine |0 (DE-588)4074076-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Parenterale Ernährung |0 (DE-588)4126209-8 |D s |
| 689 | 0 | 1 | |a Fettemulsion |0 (DE-588)4132309-9 |D s |
| 689 | 0 | 2 | |a Stabilisator |0 (DE-588)4182700-4 |D s |
| 689 | 0 | 3 | |a Lecithine |0 (DE-588)4074076-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008302953&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-008302953 | |
Datensatz im Suchindex
| _version_ | 1807323284210974720 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
.
LIST
OF
ABBREVIATIONS
XI
1.
INTRODUCTION
1
1.1
LECITHIN
-
AN
EMULSIFIER
FOR
PARENTERAL
USE
1
1.1.1
PROPERTIES
OF
AMPHIPHILIC
LIPIDS
3
1.1.2
PROPERTIES
OF
PHOSPHOLIPIDS
6
1.2
PARENTERAL
FAT
EMULSIONS
13
1.2.1
PREPARATION
OFPARENTERAL
FAT
EMULSIONS
19
1.2.1.1
PREPARATION
OF
COARSE
EMULSIONS
19
1.2.1.2
HIGH-PRESSURE
HOMOGENISATION
19
1.2.1.3
STERILISATION
BY
AUTOCLAVING
21
1.2.2
STABILITY
OF
PARENTERAL
FAT
EMULSIONS
21
1.2.2.1
STABILITY
AGAINST
RECOALESCENCE
22
1.2.2.2
STABILITY
DURING
AUTOCLAVING
24
1.2.2.3
STABILITY
AGAINST
CHEMICAL
DEGRADATION
24
1.2.2.4
STABILITY
AGAINST
PHYSICAL
DEGRADATION
26
1.2.2.5
STABILITY
AGAINST
MICROBIOLOGICAL
DEGRADATION
29
1.2.2.6
STABILITY
AGAINST
ADMIXING
29
1.2.3
MODEL
THEORIES
OF
PARENTERAL
EMULSION
STRUCTURE
29
1.3
OBJECTIVES
OF
THIS
WORK
31
2.
MATERIALS
AND
METHODS
33
2.1
MATERIALS
33
2.1.1
EMULSIFIERS
33
2.1.2
OILS
AND
WAXES
34
2.1.3
ADDITIVES
34
2.1.4
PARENTERAL
FAT
EMULSIONS
35
2.1.5
REAGENTS
35
2.1.6
SOLVENTS
36
VM
2.2
METHODS
37
2.2.1
INVESTIGATION
OF
EMULSIFYING
PROPERTIES
37
2.2.1.1
MEASUREMENT
OF
DROPLET
COALESCENCE
TIMES
WITH
COALESCENCE
CELL
37
2.2.1.2
DETERMINATION
OF
EMULSIFIER
FILM
COMPRESSIBILITY
WITH
LANGMUIR
FILM
BALANCE
38
2.2.2
PREPARATION
OF
EMULSIONS,
SOLID
LIPID
NANOPARTICLES
(SLN)
AND
LIPOSOMES
39
2.2.2.1
CUSTOMISED
EVACUABLE
ULTRA-TURRAX
MIXER
40
22.2.2
HIGH-PRESSURE
HOMOGENISATION
BY
MICROFLUIDIZER
41
2.2.23
STERILISATION
BY
AUTOCLAVING
43
2.2.3
MEASUREMENT
OF
PARTICLE
SIZE
43
2.2.3.1
PHOTON-CORRELATION
SPECTROSCOPY
(PCS)
43
2.23.2
LASER
DIFFRACTOMETRY
(LD)
45
2.2.33
ASYMMETRICAL
FLOW
FIELD-FLOW
FRACTIONATION
(AFFF)
47
2.2.4
STRUCTURAL
ANALYSIS
48
2.2.4.1
CENTRIFUGATION
48
2.2.4.2
FREEZE-FRACTURE
TRANSMISSION
ELECTRON
MICROSCOPY
(FF-TEM)
49
2.2.43
CRYO-TRANSMISSION
ELECTRON
MICROSCOPY
(CRYO-TEM)
49
2.2.4.4
POLARISED-LIGHT
MICROSCOPY
(PLM)
50
2.2.4.5
X-RAY
DIFFRACTION
ANALYSIS
50
2.2.4.6
31
P-NUCLEAR
MAGNETIC
RESONANCE
SPECTROSCOPY
(
3I
P-NMR)
50
2.2.4.7
FOURIER-TRANSFORM
INFRARED-SPECTROSCOPY
(FT-IR)
51
2.2.4.8
DIFFERENTIAL
SCANNING
CALORIMETRY
(DSC)
54
2.2.4.9
ZETA
POTENTIAL
MEASUREMENT
BY
LASER
DOPPLER
ANEMOMETRY
(LDA)
54
2.2.4.10
MEASUREMENT
OF
CONDUCTIVITY
56
2.2.5
COMPOSITIONAL
ANALYSIS
56
2.2.5.1
LYOPHILISATION
56
2.2.5.2
HIGH-PERFORMANCE
LIQUID
CHROMATOGRAPHY
(HPLC)
56
2.2.53
HIGH-PERFORMANCE
THIN-LAYER
CHROMATOGRAPHY
(HPTLC)
59
2.2.5.4
PH-MEASUREMENT
61
IX
3.
RESULTS
AND
DISCUSSION
(I)
63
PRODUCTION
OF
LECITHIN-STABILISED
EMULSIONS
3.1
CHARACTERISATION
OF
EMULSIFIERS
63
3.1.1
CHARACTERISATION
OF
EMULSIFYING
PROPERTIES
63
3.1.1.1
MEASUREMENT
OF
DROPLET
COALESCENCE
TIMES
63
3.1.1.2
MEASUREMENT
OF
FILM
COMPRESSIBILITY
71
3.1.2
CHARACTERISATION
OF
EMULSIFIER
COMPOSITION
76
3.1.2.1
EMULSIFIER
COMPOSITION
ACCORDING
TO
HPLC
76
3.1.2.2
EMULSIFIER
COMPOSITION
ACCORDING
TO
HPTLC
78
3.1.3
PHYSICAL
CHARACTERISATION
OF
EMULSIFIER
79
3.1.3.1
THERMOANALYTICAL
CHARACTERISATION
79
3.1.3.2
CHARACTERISATION
BY
FT-IR
82
3.1.3.3
CHARACTERISATION
BY
X-RAY
DIFFRACTION
89
3.2
PREPARATION
OF
EMULSIONS,
SOLID
LIPID
NANOPARTICLES
AND
90
LIPOSOMES
3.2.1
LIMITATIONS
ON
DETERMINATION
OF
PARTICLE
SIZE
90
3.2.2
INFLUENCE
OF
EMULSIFIER
CONCENTRATION
92
3.2.3
INFLUENCE
OF
EMULSIFIER
COMPOSITION
96
3.2.4
INFLUENCE
OF
HOMOGENISATION
CONDITIONS
98
3.2.5
INFLUENCE
OF
PH
ADJUSTMENT
AND
AUTOCLAVING
102
3.2.5.1
ZETA
POTENTIAL
103
3.2.5.2
PHYSICAL
STABILITY
107
3.2.5.3
CHEMICAL
COMPOSITION
109
3.2.5.4
EMULSIFIER
DISTRIBUTION
120
3.3
CONCLUSIONS
126
4.
RESULTS
AND
DISCUSSION
(II)
127
STRUCTURES
FORMED
WITHIN
LECITHIN-STABILISED
EMULSIONS
4.1
SEPARATION
OF
EMULSIONS
BY
CENTRIFUGATION
127
4.1.1
ANALYSIS
OF
SEPARATED
OIL
PHASE
128
4.1.2
EMULSIFIED
OIL
DROPLETS
129
4.1.3
LIPOSOMAL
PHOSPHOLIPID
MATERIAL
IN
EMULSIONS
134
X
4.1.4
OTHER
POSSIBLE
STRUCTURES
141
4.2
SEPARATION
OF
EMULSIONS
BY
ASYMMETRICAL
FLOW
FIELD-FLOW
141
FRACTIONATION
4.3
EXAMINATION
OF
UNFRACTIONATED
SAMPLES
144
4.3.1
TEM
ANALYSIS
144
4.3.2
PARTICLE
SIZE
ANALYSIS
USING
LASER
DIFFRACTOMETRY
EQUIPPED
149
WITH
PIDS
4.3.3
DSC
ANALYSIS
154
4.3.4
FT-IR
ANALYSIS
158
4.3.5
31
P-NMR
ANALYSIS
162
4.3.6
INTERMEDIATE
CONCLUSIONS
169
4.4
INFLUENCE
OF
AUTOCLAVING
ON
STRUCTURE
AND
STABILITY
OF
LIPOSOMAL
170
DISPERSIONS
AND
EMULSIONS
4.5
CONCLUSIONS
178
SUMMARY
181
ZUSAMMENFASSUNG
184
CITED
LITERATURE
188 |
| any_adam_object | 1 |
| author | Wabel, Christoph 1969- |
| author_GND | (DE-588)120607549 |
| author_facet | Wabel, Christoph 1969- |
| author_role | aut |
| author_sort | Wabel, Christoph 1969- |
| author_variant | c w cw |
| building | Verbundindex |
| bvnumber | BV012253291 |
| classification_rvk | YT 7600 |
| ctrlnum | (OCoLC)246115638 (DE-599)BVBBV012253291 |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>00000nam a2200000 c 4500</leader><controlfield tag="001">BV012253291</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20030325</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">981110s1998 ad|| m||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">954995155</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)246115638</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012253291</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield><subfield code="a">ger</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-29</subfield><subfield code="a">DE-29T</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-83</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">YT 7600</subfield><subfield code="0">(DE-625)154168:12905</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wabel, Christoph</subfield><subfield code="d">1969-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)120607549</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Influence of lecithin on structure and stability of parenteral fat emulsions</subfield><subfield code="c">von Christoph Wabel</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XII, 202 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Erlangen-Nürnberg, Univ., Diss., 1998</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Fettemulsion</subfield><subfield code="0">(DE-588)4132309-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Parenterale Ernährung</subfield><subfield code="0">(DE-588)4126209-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Stabilisator</subfield><subfield code="0">(DE-588)4182700-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Lecithine</subfield><subfield code="0">(DE-588)4074076-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Parenterale Ernährung</subfield><subfield code="0">(DE-588)4126209-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Fettemulsion</subfield><subfield code="0">(DE-588)4132309-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Stabilisator</subfield><subfield code="0">(DE-588)4182700-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Lecithine</subfield><subfield code="0">(DE-588)4074076-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008302953&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="943" ind1="1" ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008302953</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV012253291 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T01:09:55Z |
| institution | BVB |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008302953 |
| oclc_num | 246115638 |
| open_access_boolean | |
| owner | DE-29 DE-29T DE-355 DE-BY-UBR DE-12 DE-83 DE-11 DE-188 |
| owner_facet | DE-29 DE-29T DE-355 DE-BY-UBR DE-12 DE-83 DE-11 DE-188 |
| physical | XII, 202 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| record_format | marc |
| spelling | Wabel, Christoph 1969- Verfasser (DE-588)120607549 aut Influence of lecithin on structure and stability of parenteral fat emulsions von Christoph Wabel 1998 XII, 202 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 1998 Fettemulsion (DE-588)4132309-9 gnd rswk-swf Parenterale Ernährung (DE-588)4126209-8 gnd rswk-swf Stabilisator (DE-588)4182700-4 gnd rswk-swf Lecithine (DE-588)4074076-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Parenterale Ernährung (DE-588)4126209-8 s Fettemulsion (DE-588)4132309-9 s Stabilisator (DE-588)4182700-4 s Lecithine (DE-588)4074076-6 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008302953&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wabel, Christoph 1969- Influence of lecithin on structure and stability of parenteral fat emulsions Fettemulsion (DE-588)4132309-9 gnd Parenterale Ernährung (DE-588)4126209-8 gnd Stabilisator (DE-588)4182700-4 gnd Lecithine (DE-588)4074076-6 gnd |
| subject_GND | (DE-588)4132309-9 (DE-588)4126209-8 (DE-588)4182700-4 (DE-588)4074076-6 (DE-588)4113937-9 |
| title | Influence of lecithin on structure and stability of parenteral fat emulsions |
| title_auth | Influence of lecithin on structure and stability of parenteral fat emulsions |
| title_exact_search | Influence of lecithin on structure and stability of parenteral fat emulsions |
| title_full | Influence of lecithin on structure and stability of parenteral fat emulsions von Christoph Wabel |
| title_fullStr | Influence of lecithin on structure and stability of parenteral fat emulsions von Christoph Wabel |
| title_full_unstemmed | Influence of lecithin on structure and stability of parenteral fat emulsions von Christoph Wabel |
| title_short | Influence of lecithin on structure and stability of parenteral fat emulsions |
| title_sort | influence of lecithin on structure and stability of parenteral fat emulsions |
| topic | Fettemulsion (DE-588)4132309-9 gnd Parenterale Ernährung (DE-588)4126209-8 gnd Stabilisator (DE-588)4182700-4 gnd Lecithine (DE-588)4074076-6 gnd |
| topic_facet | Fettemulsion Parenterale Ernährung Stabilisator Lecithine Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008302953&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wabelchristoph influenceoflecithinonstructureandstabilityofparenteralfatemulsions |