Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | German |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Jena, Univ., Diss., 1998 |
| Beschreibung: | 55 Bl. graph. Darst. |
Internformat
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Datensatz im Suchindex
| _version_ | 1812452927666651136 |
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| adam_text |
1. INTRODUCTION. 2
1.1. GLUTAMATE RECEPTOR ACTIVATION AND DEVELOPMENT OF CENTRAL NERVOUS
SYSTEM. 2
1.2. GLUTAMATE RECEPTORS. 3
1.2.1. CLASSIFICATION AND GENERAL FUNCTION OF GLUTAMATE RECEPTORS. 3
1.2.2. STRUCTURE AND FUNCTION RELATION OF AMPA RECEPTORS. 4
1.3. THE PURPOSE OF THIS STUDY. 6
2. MATERIAL AND METHODS. 7
2.1. PREPARATION METHOD. 7
2.2. SOLUTION, ELECTRODES AND DRUGS. 7
2.3. RECORDING SET-UP AND FAST APPLICATION TECHNIQUE. 9
\
2.4. DATA ANALYSIS. 10
3. RESULTS. 13
3.1. IDENTIFICATION OF CA1 PYRAMIDAL NEURONS. 13
3.1.1. MORPHOLOGICAL CHARACTERISTICS OF DISPERSED CA1 PYRAMIDAL NEURON.
13
3.1.2. DEVELOPMENTAL REGULATION OF VOLTAGE-GATED CHANNELS. 13
3.2. IDENTIFICATION OF GLUR SUBTYPE EXPRESSED IN CA1 PYRAMIDAL NEURONS.
16
3.3. DEVELOPMENTAL CHANGES IN AMPA RECEPTOR AGONIST CURRENT
DENSITIES. 20
3.4. DEVELOPMENTAL CHANGE IN KAINATE AFFINITIES. 22
3.5. EFFECTS OF AMPA-R ANTAGONISTS ON KAINATE-INDUCED CURRENTS. 24
3.5.1. COMPETITIVE ANTAGONISM OF KAINATE RESPONSE BY NBQX. 24
*
3.5.2. NONCOMPETITIVE ANTAGONISM OF KAINATE RESPONSE BY GYKIS^. 27
3.6. DEVELOPMENTAL REGULATION OF CA
2+-PERMEABILITY OF AMPA RECEPTOR CHANNELS. 29
3.7. AGE-DEPENDENT MODULATION OF AMPA RECEPTORS BY CTZ. 33
4. DISCUSSION. 38
4.1. LACK OF EXPRESSION OF FUNCTIONAL HIGH-AFFINITY KAINATE RECEPTORS IN
CA1 PYRAMIDAL
NEURONS. 38
4.2. FUNCTIONAL EVIDENCE OF THE EXPRESSION OF MULTIPLE AMPA RECEPTOR
COMPLEXES. 39
4.3. VARIATION OF AMPA RECEPTOR COMPLEXES DURING DEVELOPMENT. 39
4.4. DIVERSE CA
2+-PERMEABILITY OF AMPA RECEPTORS IN THE OLDER CA1 PYRAMIDAL NEURONS. 40
4.5. SWITCH IN SPLICE VARIANTS EXPRESSION DURING MATURATION. 41
5.6. FUNCTIONAL IMPLICATIONS. 41
5. SUMMARY. 43
ZUSAMMENFASSUNG. 44
6. LITERATURE. 46
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/954706501 |
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| spelling | Zhou, Min 1961- Verfasser (DE-588)120504219 aut Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte von Min Zhou 1998 55 Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Jena, Univ., Diss., 1998 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008295257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Zhou, Min 1961- Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte |
| subject_GND | (DE-588)4113937-9 |
| title | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte |
| title_auth | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte |
| title_exact_search | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte |
| title_full | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte von Min Zhou |
| title_fullStr | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte von Min Zhou |
| title_full_unstemmed | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte von Min Zhou |
| title_short | Entwicklungsabhängige Regulierung von AMPA-Rezeptoreigenschaften in CA1-Pyramidenneuronen des Hippokampus der Ratte |
| title_sort | entwicklungsabhangige regulierung von ampa rezeptoreigenschaften in ca1 pyramidenneuronen des hippokampus der ratte |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008295257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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