Biotechnology in healthcare: an introduction to biopharmaceuticals
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Pharmaceutical Press
1998
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 228 S Ill., graph. Darst. |
| ISBN: | 0853693722 |
Internformat
MARC
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| 245 | 1 | 0 | |a Biotechnology in healthcare |b an introduction to biopharmaceuticals |c ed. by Gavin Brooks |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London |b Pharmaceutical Press |c 1998 | |
| 300 | |a XVII, 228 S |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Biologie moléculaire | |
| 650 | 2 | |a Biologie moléculaire | |
| 650 | 7 | |a Biologie moléculaire |2 ram | |
| 650 | 4 | |a Biopharmacie | |
| 650 | 2 | |a Biopharmacie | |
| 650 | 7 | |a Biopharmacie |2 ram | |
| 650 | 4 | |a Biotechnologie | |
| 650 | 2 | |a Biotechnologie | |
| 650 | 7 | |a Biotechnologie |2 gtt | |
| 650 | 7 | |a Biotechnologie |2 ram | |
| 650 | 4 | |a Biopharmaceutics | |
| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Pharmaceutical biotechnology | |
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Datensatz im Suchindex
| _version_ | 1804126851744923648 |
|---|---|
| adam_text | Contents
Preface xiii
Acknowledgements xiv
About the editor xv
Contributors xvi
1 An introduction to basic molecular biology 1
DNA and RNA molecules 1
Chromosomes and chromatin 2
Base pairing 3
Transcription 4
Translation 5
Complementary DNA (cDNA) 7
Regulation of gene expression 7
Analysis of DNA 8
Preparation and purification of DNA 8
Detection of specific DNA sequences 9
Analysis of RNA 10
Preparation and purification of mRNA 10
Detection of specific RNA sequences 1 1
Analysis of proteins 12
Preparation and purification of proteins 1 2
Detection of specific proteins 1 3
Conclusions and summary 15
Further reading 15
2 Molecular genetic mapping of disease genes 17
Mendelian inheritance and recombination 1 8
Mapping the human genome 19
Cytogenetic analysis 22
Genetic linkage maps 23
Physical linkage maps 24
Complex disease traits 26
Assessing genetic contribution to complex diseases 26
Mapping complex disease susceptibility genes 27
viii Contents
Future prospects 28
References 30
Further reading 30
3 Gene cloning 31
Plasmids 32
Use of plasmids in cloning 32
How plasmids are used 34
DNA ligases 35
Transformation 35
Selection/screening 36
Purification and further analysis of plasmid DNA 37
Recombinant DNA technology use of DNA chimaeras 38
Uses of gene cloning 39
Recombinant proteins 39
Genetic disease 40
Gene therapy 41
Cancer therapy 41
Vaccines for infectious diseases 42
Recombinant antibodies 42
Antibody targeted cancer therapy 43
Gene therapy for cancer using antibody genes 43
The wider implications of gene cloning 44
Arguments for and against gene cloning 44
Conclusions 47
References 47
4 DNA fingerprinting 49
Basic techniques of DNA fingerprinting 51
Practical applications of DNA fingerprinting 52
Paternity and individual identification by
DNA fingerprinting 53
Forensic applications of DNA fingerprinting 54
Diagnostic applications of DNA fingerprinting 56
Confirmation and evaluation of cell sources by
DNA fingerprinting 57
DNA fingerprinting in transplantation biology 58
References 58
5 The polymerase chain reaction (PCR):
general applications and potential for clinical use 61
Replication of DNA the molecule of life 62
Principles of PCR technology 63
Basic procedure for a successful PCR reaction 64
Contents ix
Advantages and disadvantages of the PCR 67
Advantages of the PCR 67
Disadvantages of the PCR 69
Recent refinements to the PCR amplification procedure 70
Hot start PCR 71
Booster PCR 71
Touchdown PCR 71
Nested PCR 71
Uses of the PCR in research and clinical diagnosis 72
Uses of the PCR in research 72
Uses of the PCR in clinical medicine 73
Future potential 78
Non invasive fetal diagnosis 78
Early detection of cancer 78
Cardiovascular medicine 79
Conclusions and summary 79
References 80
6 Gene therapy for the treatment of disease 83
Gene therapy in search of the perfect disease 84
Gene therapy the real diseases 86
Simple monogenic disorders 86
Complex monogenic disorders 89
Multifactorial genetic disorders 91
Infectious diseases 96
Delivery systems for gene therapy 97
Efficiency of gene transfer 98
Accuracy of gene transfer 98
Stability of gene transfer 99
Safety of gene transfer 100
Delivery systems of the future 100
Gene therapy in the clinic 101
Genetically modified cells as cancer vaccines 102
Direct delivery of foreign HLA and B7 genes to tumour cells 104
Polynucleotide vaccination against cloned tumour antigens 104
Adoptive therapy with genetically modified effector cells 105
Direct delivery of suicide genes into tumour cells 106
Delivery of tumour suppressor genes and/or antioncogenes
into tumour cells 107
Transduction of haemopoietic cells with retroviral vector
containing the MDR 1 drug resistance gene 108
Gene therapy an extension of rational drug design 108
Gene therapy the future 110
References 111
x Contents
7 Potential of antisense oligonucleotides as drugs 117
The science of antisense 117
Requirements of a genetic drug 1 19
Earlier studies 119
Mechanisms of action of antisense molecules 120
Animal models and oligonucleotides 120
Clinical trials 122
Towards the next generation of antisense drugs 122
In vivo behaviour of oligonucleotides 124
And finally 125
Conclusion 126
References 126
8 Potential use of transgenic animals in health and disease 131
Approaches used for the production of transgenic
animals 132
Methods for the introduction of foreign genes into
animals 132
Direct microinjection of DNA into the pronucleus of
fertilised eggs 1 33
Retroviral infection 1 34
Embryonic stem (ES) cells 1 35
Choice of animal species for transgenic technology 135
Gene knockouts (gene targeting) 136
Use of transgenic animals in medicine 137
Research 137
Organ transplantation (xenotransplantation) 1 38
Pharmaceuticals 142
Other uses of transgenic technology 143
Ethical considerations 144
Conclusions and summary 145
References 146
9 The use of peptides in the treatment of neurological disease 147
Proteins, peptides and amino acids 147
Diversity of proteins 147
Composition of proteins 148
Production of synthetic peptides 149
Immune responses to peptides 150
Immune responses in infections 1 50
Immune responses to self antigens 151
Activation of T cells 151
The nervous system 155
Nerves, axons, oligodendrocytes and myelin 1 55
Contents xi
Myelin proteins 156
Neurological diseases 156
Alzheimer s disease 156
Guillain Barre syndrome 157
Myasthenia gravis 157
Multiple sclerosis 158
The use of peptides in the therapy of neurological diseases 160
Therapies in autoimmune neurological diseases 160
Experimental allergic encephalomyelitis 161
Experimental allergic neuritis 163
Experimental allergic myasthenia gravis 164
Alzheimer s disease 164
Problems with peptide therapies 164
Clinical trials 165
Soluble MHC class II—peptide complexes 165
TCR peptides 166
Altered peptide ligands 166
Copolymer 1 1 66
Conclusions 167
Acknowledgements 167
References 167
10 Cytokines in cancer treatment 169
Interferons 170
Hairy cell leukaemia 1 71
Chronic myeloid leukaemia 171
Multiple myeloma 173
Lymphomas 173
Kaposi s sarcoma 1 74
Melanoma 174
Solid tumours 175
Tumour necrosis factor 175
The interleukins 179
Interleukin 1 179
Interleukin 2 179
Interleukin 4 1 84
Interleukin 6 1 85
Interleukin 10 185
Haemopoietic growth factors 186
Erythropoietin 186
Thrombopoietin 187
Interleukin 11 1 88
Myeloid colony stimulating factors 188
Interleukin 3 190
xii Contents
Early acting haemopoietic growth factors 191
Conclusions 191
References 192
11 Monoclonal antibodies as therapeutic agents 201
Introduction to monoclonal antibodies 201
Antibody structure 201
Background to antibody therapy 203
Development of monoclonal antibodies 205
Human anti mouse antibodies 205
Humanised antibodies 205
Xenografting 206
Selected lymphocyte antibodies 206
CD40 binding 206
Allografting 207
Expression of antibody molecules 207
Mammalian cells 207
Bacterial cells 207
Phage antibodies 208
Insect cells 208
Plant antibodies 209
Purification of monoclonal antibodies 209
Clinical uses of monoclonal antibodies 210
Adhesion molecules 210
Cell activation markers 21 1
Immunotoxins 212
Imaging 215
Immunoadhesins 216
Conclusions 217
Acknowledgements 217
References 218
Glossary 219
Index 225
|
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| spelling | Biotechnology in healthcare an introduction to biopharmaceuticals ed. by Gavin Brooks 1. publ. London Pharmaceutical Press 1998 XVII, 228 S Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologie moléculaire Biologie moléculaire ram Biopharmacie Biopharmacie ram Biotechnologie Biotechnologie gtt Biotechnologie ram Biopharmaceutics Biotechnology Molecular Biology Pharmaceutical biotechnology Biopharmazie (DE-588)4006890-0 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Biopharmazie (DE-588)4006890-0 s Biotechnologie (DE-588)4069491-4 s DE-604 Brooks, Gavin Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008290447&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biotechnology in healthcare an introduction to biopharmaceuticals Biologie moléculaire Biologie moléculaire ram Biopharmacie Biopharmacie ram Biotechnologie Biotechnologie gtt Biotechnologie ram Biopharmaceutics Biotechnology Molecular Biology Pharmaceutical biotechnology Biopharmazie (DE-588)4006890-0 gnd Biotechnologie (DE-588)4069491-4 gnd |
| subject_GND | (DE-588)4006890-0 (DE-588)4069491-4 (DE-588)4143413-4 |
| title | Biotechnology in healthcare an introduction to biopharmaceuticals |
| title_auth | Biotechnology in healthcare an introduction to biopharmaceuticals |
| title_exact_search | Biotechnology in healthcare an introduction to biopharmaceuticals |
| title_full | Biotechnology in healthcare an introduction to biopharmaceuticals ed. by Gavin Brooks |
| title_fullStr | Biotechnology in healthcare an introduction to biopharmaceuticals ed. by Gavin Brooks |
| title_full_unstemmed | Biotechnology in healthcare an introduction to biopharmaceuticals ed. by Gavin Brooks |
| title_short | Biotechnology in healthcare |
| title_sort | biotechnology in healthcare an introduction to biopharmaceuticals |
| title_sub | an introduction to biopharmaceuticals |
| topic | Biologie moléculaire Biologie moléculaire ram Biopharmacie Biopharmacie ram Biotechnologie Biotechnologie gtt Biotechnologie ram Biopharmaceutics Biotechnology Molecular Biology Pharmaceutical biotechnology Biopharmazie (DE-588)4006890-0 gnd Biotechnologie (DE-588)4069491-4 gnd |
| topic_facet | Biologie moléculaire Biopharmacie Biotechnologie Biopharmaceutics Biotechnology Molecular Biology Pharmaceutical biotechnology Biopharmazie Aufsatzsammlung |
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