Recombinant cell surface receptors: focal point for therapeutic intervention
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Acad. Press
1997
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 223 S. graph. Darst. |
| ISBN: | 0121377652 |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | I CONTENTS =j|
1. Introduction: Recombinant Cell Surface Receptors—
Focal Point for Therapeutic Intervention 1
MichaelJ. Browne
2. Dopamine Receptors 5
Frederick J. Monsma, Jr. and Olivier Civelli
2.1 Introduction 5
2.2 Molecular Biology of Dopamine Receptor Subtypes 6
2.3 General Structural Features of Dopamine Receptors 6
2.4 The Dl Family of Dopamine Receptors 7
2.5 The D2 Family of Dopamine Receptors 12
2.6 New Dopamine Receptors 17
2.7 Structure Function Analysis of Dopamine Receptors 18
2.8 Knockout of Dopamine Receptors 19
2.9 Therapeutic Implications of Multiple Dopamine
Receptor Subtypes 22
3. Molecular Biology of Opiate Receptors 35
Melanie Tallent, Allan Blake and Terry Reisine
3.1 Introduction 35
3.2 The Opiate Receptors 36
3.3 The Cloning of the Opiate Receptors 37
3.4 Structure Function Analysis of the Cloned Opiate Receptors 41
3.5 G Protein Coupling to Opiate Receptors 45
3.6 Regulation of Opiate Receptors 46
3.7 Conclusions and Future Prospects 49
4. Structure, Function and Regulation
of the Beta Adrenergic Receptors 55
A. D. Strosberg
4.1 Introduction 55
4.2 History 56
4.3 Pharmacology 56
4.4 Structure of the PAR 57
4.5 Expression of the Cloned PAR Receptor Genes 60
4.6 Polymorphism of PAR and Correlation with Disease 6l
4.7 Transgenic Mice Expressing Human PAR Genes 62
4.8 Ligand Binding and Signal Transmission
in Adrenergic Receptors 62
4.9 Regulation of Subtype Expression 65
4.10 Perspectives 68
!
i
I
j
5. Metabotropic Glutamate Receptors: 10 Years of Research 75
Joel Bockaert and Jean Philippe Pin
5.1 Introduction 75
5.2 The mGluR Family and the Unique Structure of mGluR
Protein Compared to Other G Protein Coupled Receptors
(GPCRs) 76
5.3 Pharmacology of mGluRs 81
5.4 Transduction Mechanisms 84
5.5 Physiological Roles of mGluRs in Wild Type
and Mutant Rodents 89
5.6 Role of mGluRs in Neuronal Survival and Death 91
5.7 Conclusion and Prospects 93
6. The 5 HT4, 5 ht5, 5 HT6 and 5 HT7 Receptors:
New Receptors and New Tools to Study Them 103
RonaldS. Oosting, Jose J. Lucas, Regis Grailhe,
MarkJ.S. Heath and Rene Hen
6.1 Introduction 103
6.2 The 5 HT4 Receptor 104
6.3 The 5 ht5A and 5 ht5B Receptors 106
6.4 The 5 HT6 Receptor 108
6.5 The 5 HT7 Receptor 109
6.6 New Ways to Investigate (5 HT) Receptor Function 110
6.7 Concluding Remarks 113
7. Recombinant 5 Hydroxytryptamine3 Receptors 119
John A. Peters, Anthony G. Hope, Lesley Sutherland
and Jeremy J. Lambert
7.1 Introduction 119
7.2 Isolation of Cloned 5 HT3 Receptor Subunits 120
7.3 Alternative Splicing 125
7.4. Organization and Evolution of the 5 HT3R A Gene 127
7.5 Temporal and Spatial Expression of 5 HT3R A 130
7.6 Functional Properties of Recombinant 5 HT3 Receptors 133
7.7 Structure Function Relationships 141
7.8 Conclusion 145
8. Structure and Pharmacology of GABAA Receptors 155
Ruth M. McKernan and Paul J. Whiting
8.1 Introduction 155
8.2 Cloning and Expression of GABAA Receptors 157
8.3 Chromosomal Assignment of GABAA Subunit Genes
and Linkage to Disease States 158
8.4 Transgenic Studies 158
8.5 Expression of Recombinant GABAA Receptors 159
8.6 A Comparison of Native and Recombinant
GABAA Receptors 160
8.7 Future Prospects 165
9. The Common y Chain Among Receptors
for the Cytokines IL 2, IL 4, IL 7, IL 9 and IL 15 175
Masataka Nakamura and Kazuo Sugamura
9.1 Introduction 175
9.2 Cytokines and Cytokine Receptors 176
9.3 IL 2/IL 2 Receptor System 178
9.4 TheyChain 181
9.5 XSCID and y Chain Mutation 185
9.6 Sharing of they Chain in Multiple Receptors 187
9.7 Signals from the IL 2 Receptor 191
9.8 XSCID Model in Mouse 195
9.9 Conclusion 197
10. Complement Receptors and Their Therapeutic
Applications 209
DanutaE. Mossakowska and Richard A.G. Smith
10.1 Introduction 209
10.2 Complement Receptor 1 (CR1/CD35) 212
10.3 Complement Receptor 2 (CR2/CD21) 214
10.4 Complement Receptor 3 (CR3) 215
10.5 CR1 as a Therapeutic Agent 216
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| discipline | Biologie |
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| id | DE-604.BV012232817 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:23:59Z |
| institution | BVB |
| isbn | 0121377652 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008288884 |
| oclc_num | 633166598 |
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| physical | 223 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Acad. Press |
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| spelling | Browne, Michael J. Verfasser aut Recombinant cell surface receptors focal point for therapeutic intervention Michael J. Browne London Acad. Press 1997 223 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Plasmamembran (DE-588)4067550-6 gnd rswk-swf Rekombinantes Protein (DE-588)4277353-2 gnd rswk-swf Arzneimittelrezeptor (DE-588)4305233-2 gnd rswk-swf Arzneimittelrezeptor (DE-588)4305233-2 s Plasmamembran (DE-588)4067550-6 s Rekombinantes Protein (DE-588)4277353-2 s Pharmakotherapie (DE-588)4076066-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008288884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Browne, Michael J. Recombinant cell surface receptors focal point for therapeutic intervention Pharmakotherapie (DE-588)4076066-2 gnd Plasmamembran (DE-588)4067550-6 gnd Rekombinantes Protein (DE-588)4277353-2 gnd Arzneimittelrezeptor (DE-588)4305233-2 gnd |
| subject_GND | (DE-588)4076066-2 (DE-588)4067550-6 (DE-588)4277353-2 (DE-588)4305233-2 |
| title | Recombinant cell surface receptors focal point for therapeutic intervention |
| title_auth | Recombinant cell surface receptors focal point for therapeutic intervention |
| title_exact_search | Recombinant cell surface receptors focal point for therapeutic intervention |
| title_full | Recombinant cell surface receptors focal point for therapeutic intervention Michael J. Browne |
| title_fullStr | Recombinant cell surface receptors focal point for therapeutic intervention Michael J. Browne |
| title_full_unstemmed | Recombinant cell surface receptors focal point for therapeutic intervention Michael J. Browne |
| title_short | Recombinant cell surface receptors |
| title_sort | recombinant cell surface receptors focal point for therapeutic intervention |
| title_sub | focal point for therapeutic intervention |
| topic | Pharmakotherapie (DE-588)4076066-2 gnd Plasmamembran (DE-588)4067550-6 gnd Rekombinantes Protein (DE-588)4277353-2 gnd Arzneimittelrezeptor (DE-588)4305233-2 gnd |
| topic_facet | Pharmakotherapie Plasmamembran Rekombinantes Protein Arzneimittelrezeptor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008288884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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