Endothelin receptors and signaling mechanisms:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 224 S. Ill., graph. Darst. |
| ISBN: | 3540645616 |
Internformat
MARC
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| 245 | 1 | 0 | |a Endothelin receptors and signaling mechanisms |c David M. Pollock ... (Eds.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1998 | |
| 300 | |a 224 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Endothelins |x Physiological effect | |
| 650 | 4 | |a Endothelins |x Receptors | |
| 650 | 4 | |a Endothelins |x physiology | |
| 650 | 4 | |a Nitric Oxide |x physiology | |
| 650 | 4 | |a Receptors, Endothelin |x physiology | |
| 650 | 4 | |a Signal Transduction |x physiology | |
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| 700 | 1 | |a Pollock, David M. |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008288035 | ||
Datensatz im Suchindex
| _version_ | 1804126848220659712 |
|---|---|
| adam_text | ¦ CONTENTS i
1. Introduction to the Endothelin System ...................................... 1
David M. Pollock
2. Endothelin Receptors and Receptor Antagonists..................... 3
Andrew S. Tasker and David M. Pollock
ET Receptor Subtypes 3
ET Receptor Antagonists 5
Tissue Distribution of ET Receptors 10
3. Novel Endothelin Receptors ...................................................... 17
Ponnal Nambi
4. Sticky Conundrums in the Endothelin System:
Unique Binding Characteristics of Receptor Agonists
and Antagonists •.•.••••••.••••••••••••••••••••••¦•••••••••¦•••••••••••••••••••••.•••••¦•¦¦ 23
JinshyunR. Wu Wong
Introduction 23
Tenacity of ET Binding 24
Is Antagonist Binding Tenacious? 28
Impact on Antagonist Potency 30
Disparity Between In Vivo and In Vitro Potencies 31
More to Consider: Interaction with Proteins 34
Conclusions 36
5. Functional Coordination and Cooperation
Between Endothelin and Nitric Oxide Systems
in Vascular Regulation............................—............................. 41
Michaels. Goligorsky and Joseph M. Winaver
Introduction 41
Functional Coupling Between ET and NO Systems 42
ET i and NO in Hemodynamic Adaptations 51
Pathophysiology of ET and NO Coordination 57
Conclusions 61
6. Molecular and Structural Biology
of Endothelin Receptors •••••••••••¦••••««•••••••.•.¦••••......¦••..••..........*..•. 67
Maria L. Webb and Stanley R. Krystek Jr.
Introduction 67
Molecular Biology of ETA and ETB Receptors 67
Molecular Structure 75
Conclusion 81
7. Cytokine Regulation of Endothelin Action .............................. 89
Timothy D. Warner
Introduction 89
Kinetics of Endothelin i Release 89
Evidence for a Link Between Cytokines
and ET i Production 90
Conclusion , 95
8. Endothelin Modulation of Renal Sodium
and Water Transport ................................................................ 101
Donald E. Kohan
Introduction 101
Endothelin Regulation of Water
and Electrolyte Transport . 102
Physiologic Significance of ET i Regulation
of Nephron Transport . 108
Conclusion 109
9. Endothelin and Ion Channels ..................4................................ 115
Tracy L. Keith and Robert F. Highsmith
Ca2+Mobilization: A Common Theme in ET Signaling 115
Actions of ET on Vascular Smooth Muscle 116
Actions of ET in Endothelial Cells .. 121
Actions of ET in the Kidney 122
Actions of ET in Cardiac Muscle 123
Actions of ET in Nonvascular Smooth Muscle..,. 124
Actions of ET in Other Cell Types 124
Conclusions . 125
10. Endothelin and Calcium Signaling .....M^~._...UMMN...»........... 131
E. Radford Decker and Tommy A. Brock
Introduction . 131
Signal Transduction Mechanisms ......; 131
Endothelin Receptor G protein Coupling 132
Cytosolic Calcium Signaling Mechanisms .:.. 134
Protein Kinase C Signaling Mechanisms 137
Calcium Sensitization of Contractile Proteins 138
Summary 139
11. Endothelin Regulation of Cardiac Contractility!1
Signal Transduction Pathways ................................................ 147
Meredith Bond ^
Introduction «*..... 147
Inotropic Effects of ET in the Atrium and Ventricle 148
[Cal+]c and the Positive Inotropic Effect of ET? 150
PLC. Dependent PI Turnover in the Positive Inotropic
Response to ET 150
ET dependent Intracellular Alkalinization via Activation
of the Na+ H+ Antiporter 152
ET dependent PKC Phosphorylation
of MyofibfillariProteins 153
Inhibitory Effects of ET Stimulation on the p adrenergic
Pathway in Cardiac Myocytes:
Role ofGj Dependent Pathways 154
ET dependent Activation of PKC and Cross talk
with Other Signaling Pathways 154
12. Endothelin Signaling to the Nucleus:
Regulation of Gene Expression and Phenotype .................... 163
Michael 3. Simonson
Introduction 163
Phenotyp ic Control by ET 164
c Src and Other PTKs in ET i Nuclear Signaling 167
ET i Activates Nonreceptor PTKs Src
and Focal Adhesion Kinase 169
Src in Nuclear Signaling by ET i 170
Src PTKs in ET i Signal Transduction 171
Conclusions 172
13. Mechanisms of Endothelin induced Mitogenesis
and Activation of Stress Response Protein Kinases............ 177
Thomas L. Force
Introduction 177
Endothelin as a Mitogen 178
Signal Transduction Mechanisms of Mitogenesis 181
Tyrosine Kinase Signaling 194
The Stress activated MAP Kinase Signaling Cascades 199
The Biology of SAPK and P38 Activation 202
Conclusions 204
Color Insert ........................................................................................... 217
|
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| dewey-full | 612/.015756 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612/.015756 |
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| discipline | Biologie Medizin |
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| id | DE-604.BV012231818 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:23:58Z |
| institution | BVB |
| isbn | 3540645616 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008288035 |
| oclc_num | 38311513 |
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| physical | 224 S. Ill., graph. Darst. |
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| publisher | Springer |
| record_format | marc |
| spelling | Endothelin receptors and signaling mechanisms David M. Pollock ... (Eds.) Berlin [u.a.] Springer 1998 224 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cellular signal transduction Endothelins Physiological effect Endothelins Receptors Endothelins physiology Nitric Oxide physiology Receptors, Endothelin physiology Signal Transduction physiology Rezeptor (DE-588)4049722-7 gnd rswk-swf Endothelin (DE-588)4255702-1 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Blutgefäß (DE-588)4069549-9 gnd rswk-swf Herzmuskelzelle (DE-588)4127327-8 gnd rswk-swf Zellrezeptor (DE-588)4133853-4 gnd rswk-swf Glatte Muskulatur (DE-588)4157472-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Endothelin (DE-588)4255702-1 s Rezeptor (DE-588)4049722-7 s Signaltransduktion (DE-588)4318717-1 s DE-604 Blutgefäß (DE-588)4069549-9 s Glatte Muskulatur (DE-588)4157472-2 s Zellrezeptor (DE-588)4133853-4 s Herzmuskelzelle (DE-588)4127327-8 s Pollock, David M. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008288035&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Endothelin receptors and signaling mechanisms Cellular signal transduction Endothelins Physiological effect Endothelins Receptors Endothelins physiology Nitric Oxide physiology Receptors, Endothelin physiology Signal Transduction physiology Rezeptor (DE-588)4049722-7 gnd Endothelin (DE-588)4255702-1 gnd Signaltransduktion (DE-588)4318717-1 gnd Blutgefäß (DE-588)4069549-9 gnd Herzmuskelzelle (DE-588)4127327-8 gnd Zellrezeptor (DE-588)4133853-4 gnd Glatte Muskulatur (DE-588)4157472-2 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4255702-1 (DE-588)4318717-1 (DE-588)4069549-9 (DE-588)4127327-8 (DE-588)4133853-4 (DE-588)4157472-2 (DE-588)4143413-4 |
| title | Endothelin receptors and signaling mechanisms |
| title_auth | Endothelin receptors and signaling mechanisms |
| title_exact_search | Endothelin receptors and signaling mechanisms |
| title_full | Endothelin receptors and signaling mechanisms David M. Pollock ... (Eds.) |
| title_fullStr | Endothelin receptors and signaling mechanisms David M. Pollock ... (Eds.) |
| title_full_unstemmed | Endothelin receptors and signaling mechanisms David M. Pollock ... (Eds.) |
| title_short | Endothelin receptors and signaling mechanisms |
| title_sort | endothelin receptors and signaling mechanisms |
| topic | Cellular signal transduction Endothelins Physiological effect Endothelins Receptors Endothelins physiology Nitric Oxide physiology Receptors, Endothelin physiology Signal Transduction physiology Rezeptor (DE-588)4049722-7 gnd Endothelin (DE-588)4255702-1 gnd Signaltransduktion (DE-588)4318717-1 gnd Blutgefäß (DE-588)4069549-9 gnd Herzmuskelzelle (DE-588)4127327-8 gnd Zellrezeptor (DE-588)4133853-4 gnd Glatte Muskulatur (DE-588)4157472-2 gnd |
| topic_facet | Cellular signal transduction Endothelins Physiological effect Endothelins Receptors Endothelins physiology Nitric Oxide physiology Receptors, Endothelin physiology Signal Transduction physiology Rezeptor Endothelin Signaltransduktion Blutgefäß Herzmuskelzelle Zellrezeptor Glatte Muskulatur Aufsatzsammlung |
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