Conditional ablation of MHC class II expression in the mouse:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | German |
| Veröffentlicht: |
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 88 S. Ill., graph. Darst. |
Internformat
MARC
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| 100 | 1 | |a Clausen, Björn E. |d 1966- |e Verfasser |0 (DE-588)120483378 |4 aut | |
| 245 | 1 | 0 | |a Conditional ablation of MHC class II expression in the mouse |c vorgelegt von Björn E. Clausen |
| 264 | 1 | |c 1998 | |
| 300 | |a 88 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Köln, Univ., Diss., 1998 | ||
| 650 | 4 | |a Kunst | |
| 650 | 4 | |a Art | |
| 650 | 4 | |a Artists | |
| 650 | 0 | 7 | |a MHC Klasse II |0 (DE-588)4328366-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Maus |0 (DE-588)4169148-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Antigenpräsentation |0 (DE-588)4211468-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Deletionsmutante |0 (DE-588)4360244-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Genexpression |0 (DE-588)4020136-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Maus |0 (DE-588)4169148-9 |D s |
| 689 | 0 | 1 | |a Deletionsmutante |0 (DE-588)4360244-7 |D s |
| 689 | 0 | 2 | |a MHC Klasse II |0 (DE-588)4328366-4 |D s |
| 689 | 0 | 3 | |a Genexpression |0 (DE-588)4020136-3 |D s |
| 689 | 0 | 4 | |a Antigenpräsentation |0 (DE-588)4211468-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008262654&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-008262654 | |
Datensatz im Suchindex
| _version_ | 1807773205719416832 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
A
INTRODUCTION
1
AL
T
CELLS
AND
ANTIGEN
RECOGNITION
1
A2
MAJOR
HISTOCOMPATIBILITY
COMPLEX
CLASS
II
GENES
-
GENOMIC
1
ORGANIZATION
AND
REGULATION
OF
EXPRESSION
A3
PROFESSIONAL
ANTIGEN
PRESENTING
CELLS
AND
T
CELL
COSTIMULATION
5
A4
ROLE
OF
PROFESSIONAL
APC
IN
THE
INDUCTION
OF
TOLERANCE/
6
AUTOIMMUNITY
A5
CELL
TYPE-SPECIFIC
ABLATION
OF
MHC-II
ON
PROFESSIONAL
APC
8
A6
TARGETED
AND
CONDITIONAL
MUTAGENESIS
IN
MICE
9
A7
CELL
TYPE-SPECIFIC
EXPRESSION
OF
CRE
RECOMBINASE
IN
MACROPHAGES
12
A8
OBJECTIVES
OF
THIS
STUDY
13
B
EXPERIMENTAL
PROCEDURES
14
BL
MOLECULAR
BIOLOGICAL
METHODS
14
BL
.1
ISOLATION
OF
THE
MURINE
RFX5
GENE
AND
PREPARATION
OF
THE
RFX5
14
TARGETING
VECTOR
BL
.2
MOLECULAR
CLONING
OF
THE
LYSMCRE
TARGETING
CONSTRUCT
14
B1.3
DNA
SEQUENCING
16
BL.
4
POLYMERASE
CHAIN
REACTION
16
B1.5
SYNTHESIS
OF
OLIGONUCLEOTIDES
17
B1.6
GENOMIC
SOUTHERN
BLOT
ANALYSIS
17
B1.7
RNASE
PROTECTION
ANALYSIS
20
B2
CELL
BIOLOGY
METHODS
20
B2.1
ES
CELL
CULTURE
20
B2.2
CELL
PREPARATION
AND
CULTURE
20
B2.3
T-CELL
PROLIFERATION
ASSAY
21
B2.4
CYTOFLUOROMETRIC
ANALYSIS
22
B3
GENERATION
OF
MUTANT
MICE
22
B4
IMMUNOHISTOCHEMISTRY
23
B5
IMMUNIZATIONS
AND
ELISA
ANALYSIS
24
B6
MICE
24
C
RESULTS
CL
RFX5-/
MICE
CL.L
GENERATION
OF
RFX5"/'
MICE
C1.2
CD4
T-CELL
DEVELOPMENT
IS
SEVERELY
IMPAIRED
IN
RFX5'/"
MICE
C1.3
FUNCTIONAL
IMMUNODEFICIENCY
IN
RFX5'/'
MICE
C1.4
ANALYSIS
OF
CONSTITUTIVE
MHC-II
EXPRESSION
ON
DC,
B
CELLS,
AND
MACROPHAGES
OF
RFX5"/'
MICE
C1.5
RFX5
INDEPENDENT
EXPRESSION
OF
MHC-II
IN
MATURE
DC
C1.6
REDUCED
ANTIGEN
PRESENTING
CAPABILITY
OF
RFX5-DEFICIENT
DC
C1.7
IFNY
INDUCED
MHC-II
EXPRESSION
IS
ABOLISHED
IN
PERITONEAL
MACROPHAGES
C1.8
INDUCTION
OF
MHC-II
EXPRESSION
ON
ACTIVATED
B
CELLS
IN
VITRO
C1.9
REDUCED
EXPRESSION
OF
MHC-I
ON
B
AND
T
CELLS
C1.10
EFFECT
OF
THE
RFX5
MUTATION
ON
MHC-II,
LI
AND
H-2M
MRNA
LEVELS
C2
GENERATION
OF
RFX5FL
OX
^FL
X
MICE
C3
LYSMCRE
EXPRESSING
MICE
C3.1
CONSTRUCTION
OF
THE
LYSMCRE
TARGETING
VECTOR
C3.2
GENERATION
OF
LYSMCRE
MICE
C3.3
EFFICIENT
AND
CELL
TYPE
SPECIFIC
CRE-MEDIATED
DELETION
OF
A
LOXP-FLANKED
POLYMERASE
P
GENE
C4
LYSMCRE/RFX5FL
OX
^FL
X
DOUBLE
TRANSGENIC
MICE
C4.1
DELETION
EFFICIENCY
OF
THE
/OXP-FLANKED
RFX5
TARGET
GENE
IN
MACROPHAGES
C4.2
RESIDUAL
SURFACE
EXPRESSION
OF
MHC-II
ON
MACROPHAGES
D
DISCUSSION
DI
RFX5-/
MICE
DL.L
IMPAIRED
CD4
+
T
CELL
DEVELOPMENT
AND
IMMUNODEFICIENCY
IN
RFX5'/'
MICE
D1.2
COMPARTMENTALIZATION
OF
MHC-II
EXPRESSION
IN
THE
ABSENCE
OF
RFX5
D1.3
DYS-COORDINATE
EFFECT
OF
THE
RFX5
MUTATION
ON
THE
EXPRESSION
OF
DIFFERENT
MURINE
MHC-II
GENES
DI
.4
IMPACT
OF
THE
RFX5
MUTATION
ON
MHC-I
EXPRESSION
D1.5
DIFFERENTIAL
REQUIREMENTS
FOR
RFX5
AND
CUTA
IN
THE
TRANSCRIPTIONAL
CONTROL
OF
MHC-II
GENES
26
26
26
A
8
2
8
8
8
$
8
8
3
8
8
S
8
D2
D2.1
LYSMCRE
MICE
66
DISCREPANCY
BETWEEN
EFFICIENT
GENOMIC
DELETION
OF
RFX5
AND
67
RESIDUAL
SURFACE
EXPRESSION
OF
MHC-II
ON
MACROPHAGES
D2.2
PERSPECTIVES
FOR
A
FUNCTIONAL
ANALYSIS
OF
LYSMCRE/RFX5FL
X
/^
OX
MICE
69
E
EL
SUMMARY
71
ZUSAMMENFASSUNG
73
F
REFERENCES
75 |
| any_adam_object | 1 |
| author | Clausen, Björn E. 1966- |
| author_GND | (DE-588)120483378 |
| author_facet | Clausen, Björn E. 1966- |
| author_role | aut |
| author_sort | Clausen, Björn E. 1966- |
| author_variant | b e c be bec |
| building | Verbundindex |
| bvnumber | BV012192663 |
| callnumber-first | N - Fine Arts |
| callnumber-label | N7445 |
| callnumber-raw | N7445 |
| callnumber-search | N7445 |
| callnumber-sort | N 47445 |
| callnumber-subject | N - Visual Arts |
| ctrlnum | (OCoLC)50026684 (DE-599)BVBBV012192663 |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV012192663 |
| illustrated | Illustrated |
| indexdate | 2024-08-19T00:21:15Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008262654 |
| oclc_num | 50026684 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-83 DE-11 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-83 DE-11 DE-188 |
| physical | 88 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| record_format | marc |
| spelling | Clausen, Björn E. 1966- Verfasser (DE-588)120483378 aut Conditional ablation of MHC class II expression in the mouse vorgelegt von Björn E. Clausen 1998 88 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 1998 Kunst Art Artists MHC Klasse II (DE-588)4328366-4 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Antigenpräsentation (DE-588)4211468-8 gnd rswk-swf Deletionsmutante (DE-588)4360244-7 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Maus (DE-588)4169148-9 s Deletionsmutante (DE-588)4360244-7 s MHC Klasse II (DE-588)4328366-4 s Genexpression (DE-588)4020136-3 s Antigenpräsentation (DE-588)4211468-8 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008262654&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Clausen, Björn E. 1966- Conditional ablation of MHC class II expression in the mouse Kunst Art Artists MHC Klasse II (DE-588)4328366-4 gnd Maus (DE-588)4169148-9 gnd Antigenpräsentation (DE-588)4211468-8 gnd Deletionsmutante (DE-588)4360244-7 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4328366-4 (DE-588)4169148-9 (DE-588)4211468-8 (DE-588)4360244-7 (DE-588)4020136-3 (DE-588)4113937-9 |
| title | Conditional ablation of MHC class II expression in the mouse |
| title_auth | Conditional ablation of MHC class II expression in the mouse |
| title_exact_search | Conditional ablation of MHC class II expression in the mouse |
| title_full | Conditional ablation of MHC class II expression in the mouse vorgelegt von Björn E. Clausen |
| title_fullStr | Conditional ablation of MHC class II expression in the mouse vorgelegt von Björn E. Clausen |
| title_full_unstemmed | Conditional ablation of MHC class II expression in the mouse vorgelegt von Björn E. Clausen |
| title_short | Conditional ablation of MHC class II expression in the mouse |
| title_sort | conditional ablation of mhc class ii expression in the mouse |
| topic | Kunst Art Artists MHC Klasse II (DE-588)4328366-4 gnd Maus (DE-588)4169148-9 gnd Antigenpräsentation (DE-588)4211468-8 gnd Deletionsmutante (DE-588)4360244-7 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | Kunst Art Artists MHC Klasse II Maus Antigenpräsentation Deletionsmutante Genexpression Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008262654&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT clausenbjorne conditionalablationofmhcclassiiexpressioninthemouse |