Stress proteins:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1999
|
| Schriftenreihe: | Handbook of experimental pharmacology
136 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 422 S. Ill., graph. Darst. |
| ISBN: | 3540650172 |
Internformat
MARC
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| 245 | 1 | 0 | |a Stress proteins |c contributors H. Abe ... Ed. David S. Latchman |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1999 | |
| 300 | |a XXII, 422 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 136 | |
| 650 | 7 | |a Stress |2 cabt | |
| 650 | 7 | |a Heat Shock Proteins |2 cabt | |
| 650 | 7 | |a Heat-shock-proteïnen |2 gtt | |
| 650 | 4 | |a Chaperonin 60 |x physiology | |
| 650 | 4 | |a Heat shock proteins | |
| 650 | 4 | |a Heat-Shock Proteins | |
| 650 | 4 | |a Heat-Shock Proteins 70 |x physiology | |
| 650 | 4 | |a Heat-Shock Proteins 90 |x physiology | |
| 650 | 4 | |a Heat-Shock Response | |
| 650 | 4 | |a Stress (Physiology) | |
| 650 | 0 | 7 | |a Physiologische Chemie |0 (DE-588)4076124-1 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
| _version_ | 1813162448230809600 |
|---|---|
| adam_text |
STRESS PROTEINS
CONTRIBUTORS
H. ABE
, D.M
. ALTMANN
, A.-P. ARRIGO
, M. BACHELET. L. BATTISTINI,
R. BOMPREZZI, G. BORSELLINO, I.R. BROWN. C. BUTTINELLI. R. CARROLL.
R.S. GUPTA
, J.B
. HARRUB
, K. HIMENO
, A.D
. JOHNSON
, D.E
. KOVACS.
D.S. LATCHMAN
. G.C. LI, C. MATTEI
, E. MIMNAUGH. N.F. MIVECHI.
C. MONTESPERELLI
, M. MORANGE, R.I. MORIMOTO
. G. MULTHOFF.
K. NAGATA
, L. NECKERS, S.G. NEWTON, J. NISHIZAWA. T.S. NOWAK. JR.
CM
. PICKART, B.S. POLLA, C. POZZILLI, X. PREVILLE. G. RISTORI.
M. SALVETTI, T.W. SCHULTE, F.R. SHARPE
. Y. SHI. B.J. SOLTYS.
P.K. SRIVASTAVA, A
. STEPHANOU
, W.J. VALENTINE
. W. VAN EDEN
.
M. VIGNOLA, D.M. YELLON. Q. ZHO
U
EDITOR
DAVID S. LATCHMAN
SPRINGER
CONTENTS
CHAPTER 1
STRESS PROTEINS: AN OVERVIEW
D.S.
LATCHMAN.
WITH 1 FIGURE 1
A. INTRODUCTION 1
B. THE STRESS PROTEINS 1
C. FUNCTIONS OF STRESS PROTEINS 3
D. HSP EXPRESSION AND REGULATION 4
E. STRESS PROTEINS AND PROTECTION 5
F. STRESS PROTEINS AND HUMAN DISEASE 6
CI. CONCLUSION 7
CHAPTE
R 2
THE HSP90 CHAPERONE FAMILY
L.
NECKERS,
E.
MIMNAUGII
AND T.W.
SCHULTE.
WITH 2 FIGURES 9
A. GENERA
L ASPECTS 9
B. THE EARLY PROTEIN FOLDING COMPLEX 11
C. HSP9()-CONTAINING MULTIMOLECULAR COMPLEXES 11
I. TH
E STEROID RECEPTOR-ASSOCIATED HSP90-CONTAINING
INTERMEDIAT
E FOLDING COMPLEX 11
II. THE STEROID RECEPTOR-ASSOCIATED HSP90-CONTAINING
MATURE FOLDING COMPLEX 12
D. INDIVIDUAL CHAPERON
E AND CO-CHAPERONE PROTEINS FOUND IN
HSP9() COMPLEXES 13
I. HSP7() 13
II. P48"'
P
13
III.
P6()""
P
13
IV. P23 14
V. IMMUNOPHILINS 14
VI. OTHE
R TPR-CONTAINING PROTEINS 15
VII.
P
5()
(J
^
."" IS
E. REFOLDING OF DENATURE
D PROTEINS 16
F. BENZOQUINONE ANSAMYCINS AND NUCLEOTIDE BINDING
TO HSP90 IS
YY
^J
J
('(INTENTS
2
G. HSP90 CLIENT PROTEINS 22
I. TRANSCRIPTION FACTORS 22
1. STEROID RECEPTORS 22
2. ARYL HYDROCARBON RECEPTOR 23
3. MUTATED P53
2
4
4. HEAT SHOCK FACTOR 24
II. PROTEIN KINASES 25
1. TYROSINE KINASES 25
A) THE SRC FAMILY KINASES 25
B) WEE
L KINASE 26
C) SEVENLESS TYROSINE KINASE 26
D) RECEPTOR TYROSINE KINASES - PL85
ERILHZ
27
2. SERINE/THREONINE KINASES 27
A) RAF-1 KINASE 27
B) CASEIN KINASE II 28
C) HEME-REGULATED EIF-2A KINASE
(HRI)
28
D) CDK4/CDK6 29
III.
OTHER PROTEINS 29
1. CYTOSKELETAL PROTEINS 29
2. CALMODULIN 29
3. PV-SUBUNITS OF TRIMERIC GTP-BINDING PROTEINS 30
4. PROTEASOME 30
5. HEPADNAVIRUS REVERSE TRANSCRIPTASE 30
6. TUMOR NECROSIS FACTOR RECEPTOR AND
RETINOBLASTOMA PROTEIN 31
H. HSP9() AND DRUG DEVELOPMENT 31
I. CONCLUSION 32
REFERENCES
YY
CHAPTER 3
HEAT SHOCK PROTEIN 70
G.C. LI AND N.F.
MIVECHI.
WITH 7 FIGURES
4
3
A. INTRODUCTION
4
-
B. EXPRESSION AND FUNCTION OF HSP70
4
-
I. HSP7(). TRANSIENT THERMOTOLERANCE AND
PERMANENT HEAT RESISTANCE 43
II. HSP7() AND APOPTOSIS 47
III. HSP70 PROTECTS CELLS FROM OXIDATIVE STRESS 49
IV. HSP7( PROTECTS CELLS FROM X-RAY DAMAGE 49
V. HSP70 AS MOLECULAR CHAPERONE 50
C. REGULATION OF HSP70 52
I. HEAT SHOCK TRANSCRIPTION FACTOR (HSF)
, THE
TRANSCRIPTIONAI REGULATOR OF HSP7() 52
CONTENTS XIII
II. SIGNAL TRANSDUCTION LEADING TO MODULATION
OF HSP70 LEVELS 53
III. NEGATIVE REGULATORY EFFECT OF ERK1 ON HSP70
GEN
E EXPRESSION 54
IV. MUTATIONA
L ANALYSIS OF HSF-1 PHOSPHORYLATION
BY ERK
1 PROTEIN KINASE 55
V. MODULATION OF HSF-I BY OTHE
R PROTEIN KINASES 58
VI. IMPLICATION OF HSF-1 REGULATION BY FUNCTIONALLY
OPPOSING SIGNALING CASCADES 58
VII
. REGULATION OF HEAT SHOCK RESPONSE:
POSSIBLE INVOLVEMENT OF KU AUTOANTIGE
N 59
REFERENCES 61
CHAPTE
R 4
MITOCHONDRIAL MOLECULAR CHAPERONES HSP60 AND
MHSP70: ARE THEIR ROLES RESTRICTED TO MITOCHONDRIA?
B.J.
SOLTYS
AND R.S.
GUPTA.
WITH 4 FIGURES 69
A. INTRODUCTION 69
B. STRUCTURE AND FUNCTION 70
I. STUDIES WITH PURIFIED PROTEINS 70
1. HSP7()/DNAK 70
2. HSP6()/GROEL 71
II. IN VIVO AND MITOCHONDRIAL SYSTEMS 73
C. AR
E HSP60 AND MHSP70 RESTRICTED TO MITOCHONDRIA? 75
I. SUBCELLULAR LOCALIZATION: THE UNEXPLAINED FINDINGS 75
II. CONSIDERATION OF POSSIBLE ARTIFACTS 81
III. POSSIBLE EXTRAMITOCHONDRIAL FUNCTIONS 84
IV. PROPOSED TRANSPORT MECHANISMS 85
D. HSP60 IN DRUG RESISTANCE AND DISEASE 90
E. FUTUR
E PROSPECTS 92
REFERENCES 93
CHAPTE
R 5
ROLE OF HSP27 AND RELATED PROTEINS
A.-P
.
ARRICJO
AND X.
PREVILI.E.
WITH 4 FIGURES 101
A
. INTRODUCTIO
N 101
B. SHS
P GENE
S AND CONTRO
L OF THEI
R EXPRESSION 102
I. TH
E FAMILY OF SHS
P AND TH
E STRUCTUR
E OF THE
GENE
S ENCODIN
G THES
E PROTEIN
S 102
II. REGULATIO
N OF TH
E EXPRESSION OF SHS
P GENE
S
BY HEA
T SHOCK 103
III
. REGULATIO
N OF TH
E CONSTITUTIV
E AND HORMONE-DEPENDEN
T
EXPRESSIO
N OF SHS
P GENE
S 104
CONTENTS
XIV
IV. TISSUE-SPECIFIC SHSP EXPRESSION DURING
DEVELOPMENT AND IN ADULT ORGANISMS
1()
4
V. SPECIFIC SHSP EXPRESSION DURING EARLY
DIFFERENTIATION
1()
-
VI. PATHOLOGICAL SHSP EXPRESSION AND
ASSOCIATED DISEASES
1(
'
6
C. BIOCHEMICAL PROPERTIES OF SHSP '
8
I. STRUCTURAL ORGANIZATION OF SHSP '"
^
II. QUATERNARY STRUCTURE OF SHSP
1()
8
III. PHOSPHORYLATION OF SHSP
1(
9
IV. CELLULAR LOCALIZATION OF SHSP 11
()
D. FUNCTIONS OF SHSP ' "
I. SHSP EXPRESSION INDUCES THERMOTOLERANCE AND
PROTECTS CYTOSKELETAL ARCHITECTURE IL
L
II. SHSP ACT AS PROTEIN CHAPERONES H
2
III. SHSP PROTECTION AGAINST TN
F AND
OXIDATIVE STRESS INDUCERS 112
IV. SHSP EXPRESSION PROTECTS AGAINST APOPTOSIS 116
1. SHSP INTERFERE WITH IN VITRO-MEDIATED APOPTOSIS 116
2. SHSP AS ESSENTIAL ANTI-APOPTOTIC PROTEINS
DURING EARLY CELL DIFFERENTIATION 117
3. MOLECULAR MECHANISMS UNDERLYING THE
ANTI-APOPTOTIC FUNCTION OF SHSP 117
E. CONCLUSIONS 118
REFERENCES 120
CHAPTER 6
UHIQUITIN AND THE STRESS RESPONSE
CM
.
PICKART.
WITH 3 FIGURES 133
A. INTRODUCTION 133
B. TH
E UBIQUITIN-PROTEASOME PATHWAY 134
C. THE UBIQUITIN PATHWAY AND THE STRESS RESPONSE 136
I. STRESS PROTEINS IN THE UBIQUITIN PATHWAY 137
1. UBIQUITIN 137
2. UBIQUITIN-CONJUGATING ENZYMES 138
3. OTHER PATHWAY COMPONENTS 139
II. UBIQUITIN CONJUGATION IN STRESSED CELLS 140
HI. UBIQUITIN-MEDIATED DEGRADATION IN STRESSED CELLS 142
IV. DIE UBIQUITIN PATHWAY AND INDUCTION OF
THE STRESS RESPONSE [44
V. INVOLVEMENT OF MOLECULAR CHAPERONES IN
I BIQUITM-DEPENDENT DEGRADATION 145
D. OUTSTANDING QUESTIONS , .10
,
, , YYYY
14
REFERENCES . . ,,,
\4V
CONTENTS XV
CHAPTER 7
REGULATION OF HEAT SHOCK GENE
S BY CYTOKINES
A
.
STEPHANOU
AN
D D.S
.
LATCHMAN.
WIT
H 6 FIGURE
S 153
A
. INTRODUCTIO
N 153
B
. CYTOKINE
S 154
C. TRANSCRIPTIO
N FACTOR
S ACTIVATE
D BY TH
E
IL-
6 RECEPTO
R FAMIL
Y 155
I. C/EBP
S 155
II
. STAT
S 156
D
. ROL
E OF INTERLEUKIN-
6 FAMILY OF CYTOKINE
S IN REGULATIN
G
HSPS 157
E. ROL
E OF IFN-
Y IN REGULATIN
G HS
P EXPRESSIO
N 161
F. ELEVATIO
N OF C/EBP
S AND STAT
S AN
D HSP
S EXPRESSIO
N DURIN
G
INFLAMMATOR
Y PATHOLOGICA
L STATE
S 163
G. ROL
E OF IL-6 AND HSP
S IN SL
E 164
H
. CONCLUSIO
N 167
REFERENCE
S 167
CHAPTE
R 8
REGULATION OF HEAT SHOCK
GENE
S BY
ISCHEMIA
T.S.
NOWAK. JR.
,
Q.
ZHOU
,
W.J.
VALENTINE.
J.B.
HARRUB
AND
H.
ABE
.
WITH 6 FIGURES 173
A. INTRODUCTIO
N 173
B. PATTERN
S OF HEAT SHOCK GENE EXPRESSION AFTER
GLOBAL AND FOCAL ISCHEMIA 174
I. GEN
E EXPRESSION AND NEURONAL VULNERABILITY
AFTER GLOBAL ISCHEMIA 174
II. GEN
E EXPRESSION AFTER FOCAL ISCHEMIA 178
III. CRYPTIC HSP72 EXPRESSION AFTER ISCHEMIA 180
C. REGULATION OF THE POSTISCHEMIC HEAT SHOCK RESPONSE 183
I. INJURY THRESHOLDS AND THE STRESS RESPONSE 183
1. THRESHOLDS FOR EXPRESSION OF HSP72 AND
OTHE
R ISCHEMIA-INDUCIBLE GENES 183
2. TEMPERATUR
E EFFECTS ON HSP72 EXPRESSION AFTER
GLOBAL ISCHEMIA 184
II. HEAT SHOCK FACTOR ACTIVATION AFTER
GLOBAL ISCHEMIA 185
III. HEAT SHOCK REGULATION AFTER ANOXIA/AGLYCEMIA IN
HIPPOCAMPAL SLICES 187
1. HSP72 INDUCTION AFTER IN VITRO ANOXIA AGLVCEMIA 187
2. PHARMACOLOGICAL MANIPULATION OF HSP72 FXPRESSION 189
D. SUMMARY AND CONCLUSIONS 190
REFERENCES 191
CONTENTS
IV. TISSUE-SPECIFIC SHSP EXPRESSION DURIN
G
DEVELOPMEN
T AND IN ADUL
T ORGANISMS 104
V. SPECIFIC SHSP EXPRESSION DURIN
G EARLY
DIFFERENTIATION
1()
5
VI
. PATHOLOGICAL SHS
P EXPRESSION AND
ASSOCIATED DISEASES 106
C. BIOCHEMICAL PROPERTIE
S OF SHSP 108
I. STRUCTURAL ORGANIZATION OF SHSP 108
II. QUATERNAR
Y STRUCTUR
E OF SHSP 108
III.
PHOSPHORYLATION OF SHSP 109
IV. CELLULAR LOCALIZATION OF SHSP 110
D
. FUNCTIONS OF SHSP 111
I. SHSP EXPRESSION INDUCES THERMOTOLERANC
E AN
D
PROTECT
S CYTOSKELETAL ARCHITECTUR
E II
1
II. SHSP ACT AS PROTEI
N CHAPERONE
S 112
III. SHSP PROTECTION AGAINST TN
F AND
OXIDATIVE STRESS INDUCERS 112
IV. SHSP EXPRESSION PROTECT
S AGAINST APOPTOSI
S 116
1. SHSP INTERFERE WITH IN VITRO-MEDIATE
D APOPTOSI
S 116
2. SHSP AS ESSENTIAL ANTI-APOPTOTI
C PROTEINS
DURIN
G EARLY CELL DIFFERENTIATION 117
3. MOLECULAR MECHANISMS UNDERLYING THE
ANTI-APOPTOTI
C FUNCTION OF SHSP 117
E. CONCLUSIONS 118
REFERENCES 120
CHAPTE
R 6
UBIQUITIN AND THE STRESS RESPONSE
CM
.
PICKART.
WITH 3 FIGURES 133
A. INTRODUCTION 133
B. THE UBIQUITIN-PROTEASOM
E PATHWAY 134
C. THE UBIQUITIN PATHWAY AND TH
E STRESS RESPONS
E 136
I. STRESS PROTEINS IN THE UBIQUITIN PATHWAY 137
1. UBIQUITIN 137
2. UBIQUITIN-CONJUGATING ENZYMES 138
3. OTHE
R PATHWAY COMPONENT
S 139
II. UBIQUITIN CONJUGATION IN STRESSED CELLS 140
III. UBIQUITIN-MEDIATED DEGRADATIO
N IN STRESSED CELLS 142
IV. THE UBIQUITIN PATHWAY AND INDUCTION OF
THE STRESS RESPONSE 144
V. INVOLVEMENT OF MOLECULAR CHAPERONE
S IN
UBIQUITIN-DEPENDEN
T DEGRADATIO
N 145
D. OUTSTANDING QUESTIONS 148
REFERENCES [49
CONTENTS XV
CHAPTER 7
REGULATION OF HEAT SHOCK GENES BY CYTOKINES
A
.
STEPHANOU
AN
D D.S
.
LATCHMAN.
WITH 6 FIGURE
S 153
A
. INTRODUCTIO
N 153
B. CYTOKINE
S 154
C. TRANSCRIPTIO
N FACTOR
S ACTIVATE
D BY TH
E
IL-6 RECEPTO
R FAMILY 155
I. C/EBP
S 155
II
. STAT
S 156
D
. ROL
E OF INTERLEUKIN-
6 FAMILY OF CYTOKINE
S IN REGULATIN
G
HSP
S ! 157
E
. ROL
E OF IFN-
Y IN REGULATIN
G HS
P EXPRESSIO
N 161
F
. ELEVATIO
N OF C/EBP
S AN
D STAT
S AND HSP
S EXPRESSIO
N DURIN
G
INFLAMMATOR
Y PATHOLOGICA
L STATE
S 163
G. ROL
E OF IL-6 AND HSPS IN SL
E 164
H. CONCLUSIO
N 167
REFERENCE
S 167
CHAPTE
R 8
REGULATION OF HEAT SHOCK
GENE
S BY
ISCHEMIA
T.S.
NOWAK, JR.
,
Q.
ZHOU
,
W.J.
VALENTINE.
J.B.
HARRUB
AND
H.
ABE
.
WITH 6 FIGURES 173
A. INTRODUCTIO
N ] 73
B. PATTERN
S OF HEAT SHOCK GEN
E EXPRESSION AFTER
GLOBAL AND FOCAL ISCHEMIA 174
I. GEN
E EXPRESSION AND NEURONAL VULNERABILITY
AFTER GLOBAL ISCHEMIA 174
II. GEN
E EXPRESSION AFTER FOCAL ISCHEMIA 178
III. CRYPTIC HSP72 EXPRESSION AFTER ISCHEMIA 180
C. REGULATION OF THE POSTISCHEMIC HEAT SHOCK RESPONSE 183
I. INJURY THRESHOLDS AND THE STRESS RESPONSE 183
1. THRESHOLDS FOR EXPRESSION OF HSP72 AND
OTHE
R ISCHEMIA-INDUCIBLE GENES 183
2. TEMPERATUR
E EFFECTS ON HSP72 EXPRESSION AFTER
GLOBAL ISCHEMIA 184
II. HEA
T SHOCK FACTOR ACTIVATION AFTER
GLOBAL ISCHEMIA 185
III. HEAT SHOCK REGULATION AFTER ANOXIA/AGLYCEMIA IN
HIPPOCAMPAL SLICES 1 S7
1
. HSP72 INDUCTION AFTER IN VITRO ANOXIA/AGLYCEMIA 187
2. PHARMACOLOGICAL MANIPULATION OF HSP72 EXPRESSION 189
D. SUMMARY AND CONCLUSIONS 190
REFERENCES 191
CONTENTS
CHAPTER 9
REGULATION OF HEAT SHOCK TRANSCRIPTION FACTORS BY HYPOXIA OR
ISCHEMIA/REPERFUSION IN THE HEART AND BRAIN
J.
NISHIZAWA
AND K.
NAGATA.
WITH 4 FIGURES 201
A
. INTRODUCTIO
N 201
B
. REGULATIO
N OF HEA
T SHOCK GEN
E TRANSCRIPTIO
N 202
I. FAMILY OF HEAT SHOCK FACTORS 202
II
. REGULATION OF DNA-BINDIN
G ACTIVITY OF HSF1 203
C. DAMAG
E BY ISCHEMIA AND REPERFUSION 203
I. ISCHEMIA 203
II
. REPERFUSION 205
D
. REGULATION OF HSPS BY ISCHEMIA/REPERFUSION
IN THE BRAIN AND HEAR
T 205
I. INDUCTION OF HSPS BY ISCHEMIA/REPERFUSION
IN TH
E BRAIN 205
II
. INDUCTIO
N OF HSPS BY ISCHEMIA/REPERFUSION
IN TH
E HEAR
T 208
E
. REGULATION OF HSF ACTIVATION BY FLYPOXIA OR
ISCHEMIA/REPERFUSION 208
I. HS
F ACTIVATION BY HYPOXIA 208
II. HS
F ACTIVATION BY ISCHEMIA IN THE BRAIN 209
III
. HS
F ACTIVATION BY ISCHEMIA/REPERFUSION
IN TH
E HEAR
T 209
IV. HS
F ACTIVATION BY ISCHEMIA/REPERFUSION
IN OTHE
R TISSUES 212
F
. ISCHEMIC TOLERANCE BY HSPS IN TH
E BRAIN AN
D HEAR
T 213
I. ISCHEMIC TOLERANCE BY HSPS IN THE BRAIN 213
II. MYOCARDIAL PROTECTION AGAINST ISCHEMIA BY HSPS 213
G. MECHANISMS OF HSF ACTIVATION BY HYPOXIA OR
ISCHEMIA/REPERFUSION 214
I. SPECIFIC ACTIVATION OF HSF1 BY HYPOXIA OR
ISCHEMIA/REPERFUSION 214
II
. SIGNALS FOR THE ACTIVATION OF HSF1 BY
HYPOXIA O
R ISCHEMIA/REPERFUSION 214
1. AT
P DEPLETIO
N 215
2. REACTIVE OXYGEN SPECIES 215
3. ARACHIDONIC ACID AND ITS METABOLITE
S 217
4. DECREASED INTRACELLULAR P
H 217
H. CLINICAL APPLICATION AND FUTUR
E PERSPECTIVE 217
REFERENCES 218
CHAPTE
R 10
AUTOREGULATION OF THE HEAT SHOCK RESPONSE
Y.
SH
I
AND
R.I.
MORIMOTO.
WITH 3 FIGURES 225
CONTENTS XVII
A. INTRODUCTIO
N 225
B. REGULATION OF THE HEAT SHOCK RESPONSE IN EUKARYOTE
S 226
I. OVERVIEW 226
II
. BIOCHEMICAL STUDY OF AUTOREGULATIO
N IN
HIGHER EUKARYOTE
S 228
III. GENETI
C EVIDENCE FOR AUTOREGULATIO
N OF THE HEA
T SHOCK
RESPONS
E IN YEAST AND
DROSOPHILA
230
C. REGULATION OF THE HEAT SHOCK RESPONSE IN PROKARYOTES 231
I. OVERVIEW 231
II. GENETI
C EVIDENCE FOR AUTOREGULATIO
N OF THE
E. COLI
HEA
T SHOCK RESPONSE 232
III. BIOCHEMICAL STUDIES ON AUTOREGULATIO
N OF THE
E. COLI
HEA
T SHOCK RESPONSE 233
D. COMMON FEATURE
S OF THE PROKARYOTIC AND
EUKARYOTI
C HEA
T SHOCK RESPONSE 234
REFERENCES 235
CHAPTE
R 11
THE CELLULAR STRESS GENE RESPONSE IN BRAIN
I.R.
BROWN
AND F.R.
SHARP.
WITH 2 FIGURES 243
A. INTRODUCTIO
N 243
B. RESPONSE OF THE BRAIN TO PHYSIOLOGICALLY RELEVANT
TEMPERATUR
E INCREASE 243
I. DIFFERENTIAL INDUCTION OF HEA
T SHOCK MRN
A IN
DIFFERENT CELL TYPES OF THE HYPERTHERMI
C BRAIN 243
II. INTRACELLULAR TARGETING OF NEURAL HEAT SHOCK MRNA
S 245
III. CELL TYPE DIFFERENCES IN NEURA
L HEA
T SHOCK PROTEINS 245
IV. EXPRESSION OF HEA
T SHOCK PROTEINS IN THE
DEVELOPING BRAIN 247
V. ACTIVATION OF NEURAL HEA
T SHOCK TRANSCRIPTION
FACTOR HSF1 247
VI. IN VIVO TRANSCRIPTION RATE OF HEAT SHOCK GENES
IN THE BRAIN 248
VII
. NEUROPROTECTIV
E EFFECT OF HEAT SHOCK PROTEIN
IN THE RETINA 249
VIII
. CONCLUSIONS 249
C. CELLULAR STRESS GEN
E RESPONSE TO FOCAL
CEREBRA
L ISCHEMIA 249
I. HSP70 AND DELINEATION OF THE PENUMBRA 249
II. HSP32 (HO-1
) SPREADING DEPRESSION MEDIATED
INDUCTION IN MICROGLIA 251
III. HSP27 SPREADING DEPRESSION MEDIATED INDUCTION IN
ASTROCYTES 252
XVIII CONTENTS
IV. GLUCOSE TRANSPORTERS/GRP75/GRP78: HI
F MEDIATE
D
INDUCTION 253
V. CONCLUSIONS 253
D
. CELLULAR STRESS GEN
E RESPONS
E T
O
SUBARACHNOID HEMORRHAG
E 254
I. CLINICAL SYNDROME OF SUBARACHNOID HEMORRHAG
E
AND TH
E ROLE OF H
O 254
II
. INDUCTION OF HO-
1 FOLLOWING EXPERIMENTA
L SUBARACHNOI
D
HEMORRHAG
E 255
III
. INDUCTION OF HO-
1 FOLLOWING SUBARACHNOID INJECTIONS OF
HEMOGLOBIN AND PROTOPORPHYRIN
S 256
IV. MODEL FOR METABOLISM OF HEM
E BY MICROGLIA, NEURON
S
AND MENINGEAL CELLS FOLLOWING SUBARACHNOID
HEMORRHAG
E 258
REFERENCES 258
CHAPTE
R 12
HEAT STRESS PROTEINS AND THEIR RELATIONSHIP TO MYOCARDIAL PROTECTION
R.
CARROLL
AND D.M.
YELLON
265
A. INTRODUCTIO
N 265
B. HEA
T STRESS AND THE STRESS RESPONS
E 265
C. AR
E STRESS PROTEINS PROTECTIVE? 266
D
. EVIDENCE FOR TH
E ABILITY OF STRESS PROTEINS
T
O PROTECT THE CELL 266
I. THERMOTOLERANC
E 266
II. CROSS-TOLERANCE 267
III. STRESS PROTEINS AND TH
E HEAR
T 268
IV. HEA
T STRESS AND MYOCARDIAL PROTECTION 268
V. HEAT STRESS PROTEINS AND ISCHAEMIC PRECONDITIONING 271
VI. HEA
T STRESS AND PROTECTION AGAINST NON-ISCHAEMIC
INJURY 272
VII
. MECHANISMS OF CARDIAC PROTECTION BY
ELEVATE
D TEMPERATUR
E 273
E. CONCLUSIONS 274
REFERENCES 275
CHAPTE
R 13
HEAT SHOCK PROTEINS IN INFLAMMATION AND IMMUNITY
M.
BACHELET,
G.
MULTHOFF,
M.
VIGNOLA,
K.
HIMENO
AND B.S.
POLLA
WITH 4 FIGURES 281
A. INTRODUCTION: MULTIPLE ROLES OF HEA
T SHOCK PROTEIN
S IN
INFLAMMATION AND IMMUNITY 281
B. ROLE OF HSP LOCALIZATION IN THE INDUCTION OF AN
IMMUNE RESPONSE 282
CONTENTS XIX
C. HSP AN
D CELL ADHESION IN THE INITIATION OF INFLAMMATION 284
D
. NON-SPECIFIC IMMUNITY: CELLS AND MEDIATORS INVOLVED IN
TH
E INDUCTION OF A HEA
T SHOCK/STRESS RESPONSE 286
I. MONOCYTES-MACROPHAGES 286
1. REACTIVE OXYGEN SPECIES 286
2. LIPID MEDIATORS OF INFLAMMATION 287
3. CYTOKINES 288
4. NUCLEAR FACTOR
KB (NF-KB
)
289
II. GRANULOCYTIC PHAGOCYTES 289
1. POLYMORPHONUCLEAR LEUKOCYTES (PMN) 289
2. EOSINOPHILS 290
E. CELLULAR IMMUNITY 290
I. T CELLS 291
II.
YD
T CELLS 292
III. HSP, NK CELLS AND CANCER IMMUNITY 294
F. THE PARADIGM OF ASTHM
A 295
G. CONCLUSIONS AN
D PERSPECTIVES 298
REFERENCES 298
CHAPTE
R 14
HEAT SHOCK PROTEINS IN EMBRYONIC DEVELOPMENT
M.
MORANGE
305
A. INTRODUCTIO
N 305
B. SPECIFIC EXPRESSION OF HSPS DURING
DROSOPHILA
DEVELOPMEN
T 307
C. ESSENTIAL ROLES OF HSPS DURING DEVELOPMENT 309
I. MAMMALIAN SMALL HSP: A "CHECKPOINT
" BETWEEN
PROLIFERATION, DIFFERENTIATION AND CELL DEAT
H 309
II. HSP90 AND THE CONTROL OF MUSCLE CELL DIFFERENTIATION
THROUG
H THE REGULATION OF MYOGENIC
TRANSCRIPTION FACTORS 312
III. HSP70-2
: A SPECIALIZED CHAPERON
E ESSENTIAL FOR
MEIOSIS 313
D. MECHANISMS REGULATING THE EXPRESSION OF HSPS DURING
DIFFERENTIATION AND DEVELOPMENT 314
E. IN SEARCH OF ADDITIONAL DEVELOPMENTAL CHAPERONE
S 316
F. THE PLACE OF HSPS IN AGING 317
G. CONCLUSION 319
REFERENCES 319
CHAPTE
R 15
HEAT SHOCK PROTEINS IN RHEUMATOID ARTHRITIS
W.
VAN EDE
N
329
X
X CONTENTS
A
. INTRODUCTIO
N 329
B. AUTOIMMUN
E ARTHRITI
S AND IMMUNITY T
O BACTERIAL ANTIGENS 330
C. HSP60 IS THE CRITICAL ANTIGE
N IN RA
T ADJUVANT ARTHRITI
S 333
D
. NASAL TOLERANC
E T
O HSP PEPTIDE
S SUPPRESSES ANTIGEN AND
NON-ANTIGEN INDUCED ARTHRITI
S 335
E
. CONSERVED HSP60 EPITOPE
S INDUCE ARTHRITI
S SUPPRESSIVE
T CELLS 335
F
. SUPPRESSION IN ARTHRITI
S MODELS IS SPECIFIC FOR
HEAT SHOCK PROTEINS 336
G. IMMUNE MEDIATED DISEASES 337
H
. RHEUMATOI
D ARTHRITI
S AS A MODEL AUTOIMMUN
E DISEASE 337
I. HSPS IN AUTOIMMUN
E AND OTHE
R INFLAMMATORY DISEASES 338
J. HSPS IN HUMA
N ARTHRITIC DISEASES 339
K. HSP60 T CELL RESPONSES IN R
A AND JR
A AR
E ASSOCIATED WITH
SUPPRESSIVE CYTOKINE PRODUCTION 340
L. MECHANISMS BY WHICH HSPS PRODUCE PROTECTIO
N IN
AUTOIMMUN
E ARTHRITI
S 341
M. LESSONS FOR THE DEVELOPMEN
T OF SPECIFIC IMMUNOTHERAP
Y IN
AUTOIMMUNITY 342
N
. CONCLUSION 343
REFERENCES 344
CHAPTE
R 16
HEAT SHOCK PROTEIN 60 AND TYPE I DIABETES
S.G.
NEWTON
AND D.M.
ALTMANN
347
A. INTRODUCTION 347
B. HSP60 AND AUTOIMMUN
E DISEASES 348
C. HSP60 REACTIVITY AND THE NO
D MOUSE MODEL OF
TYPE I DIABETE
S 349
D. CELL TYPES REQUIRE
D FOR DIABETOGENESIS IN PATIENTS 351
E. ISLET CELL ANTIBODY RESPONSE
S 352
F. AUTOREACTIVE T CELL RESPONSES 353
G. T CELL CLONES OF UNKNOWN ANTIGEN SPECIFICITY 355
H. EVIDENCE FROM SUPPRESSION OF SPECIFIC T CELL RESPONSES IN
NO
D MICE 355
I. CONCLUDING REMARK
S 357
REFERENCES 358
CHAPTE
R 17
HEAT SHOCK PROTEINS AND MULTIPLE SCLEROSIS
G
. RLSTORL. C
. MONTESPERELLI, D
. KOVACS, G
. BORSELLINO,
L.
BAITISTINI,
C.
BUTHNELU
,
C.
POZZILLI,
C.
MATIE
I
AND
M.
SALVETTI.
WITH 3 FIGURES 363
CONTENTS XXI
A. INTRODUCTIO
N 363
B. HSP EXPRESSION IN INFLAMMATORY, DEMYELINATING DISEASES
OF THE BRAIN 365
I. HS
P EXPRESSION IN GLIAL CELLS 365
II. EXPERIMENTA
L ALLERGIC ENCEPHALOMYELITIS 366
III. MULTIPLE SCLEROSIS 367
C. IMMUN
E RESPONSE T
O HSPS 368
I. EXPERIMENTA
L ALLERGIC ENCEPHALOMYELITIS 371
II. MULTIPLE SCLEROSIS 372
D. OTHE
R ROLE
S OF HSPS IN MS 374
E. CONCLUSIONS AND FUTUR
E WORK 376
REFERENCES 377
CHAPTE
R 18
HEAT SHOCK PROTEINS IN ATHEROSCLEROSIS
A.D
.
JOHNSON
381
A. INTRODUCTIO
N 381
B. PATHOGENESIS OF PRIMARY ATHEROSCLEROTIC LESIONS 381
C. ARTERIA
L HSP EXPRESSION AFTER VASCULAR INJURY AND DURING
DEVELOPMEN
T OF ATHEROSCLEROTI
C LESIONS 382
D. ASSOCIATION OF HSPS WITH SPECIFIC STAGES OF
ATHEROSCLEROTI
C LESION DEVELOPMENT 383
I. HSPS IN HYPERTENSION, A RISK FACTOR FOR
ATHEROSCLEROSIS 383
II
. IMMUNOLOGICAL RESPONSES T
O HSPS IN PRIMARY PLAQUE
DEVELOPMEN
T 385
1. T-LYMPHOCYTE ACTIVATION BY HSP60 IN ATHEROSCLEROTIC
VESSELS 386
2. D
O ANTI-HSP60 ANTIBODIES CONTRIBUT
E TO NECROTIC
CORE FORMATION
? 388
3. BIPHASIC EFFECTS OF HSP EXPRESSION IN ORGAN
TRANSPLANTATION
: TISSUE PRESERVATION VERSUS GRAFT
ARTERIOSCLEROSIS 389
III. HSPS IN THE MATURE ATHEROSCLEROTI
C PLAQUE 390
1. INDUCTION OF HSP EXPRESSION BY OXLDL 390
2. THE STRESS RESPONSE AND PLAQUE CELL SURVIVAL VERSUS
NECROSIS 392
E. FUTUR
E DIRECTIONS 395
REFERENCES 396
CHAPTE
R 19
HEAT SHOCK PROTEIN-PEPTIDE INTERACTION: BASIS FOR A NEW GENERATION
OF VACCINES AGAINST CANCERS AND INTRACELLULAR INFECTIONS
P.K.
SRIVASTAVA
403
XXII CONTENTS
A. INTRODUCTIO
N 403
B. HSPS CHAPERON
E ANTIGENIC PEPTIDES 405
C. UNIQUE ADVANTAGES OF HSP-PEPTID
E VACCINES 406
D. USE OF HSP-PEPTIDE COMPLEXES AS CANCER VACCINES 407
E. PROTECTIVE HUMA
N CANCER ANTIGENS
: UNIQU
E T
O EACH INDIVIDUAL
CANCER OR SHARED BETWEE
N CANCERS? 409
F
. HSP-PEPTIDE COMPLEXES AS VACCINES AGAINST INTRACELLULAR
INFECTIOUS AGENT
S 411
REFERENCES 412
SUBJECT INDEX 415 |
| any_adam_object | 1 |
| author_GND | (DE-588)120416859 |
| building | Verbundindex |
| bvnumber | BV012189823 |
| callnumber-first | Q - Science |
| callnumber-label | QP905 |
| callnumber-raw | QP905 |
| callnumber-search | QP905 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 2700 WD 5100 XI 1701 |
| ctrlnum | (OCoLC)39747470 (DE-599)BVBBV012189823 |
| dewey-full | 615/.1 572/.6 |
| dewey-hundreds | 600 - Technology (Applied sciences) 500 - Natural sciences and mathematics |
| dewey-ones | 615 - Pharmacology and therapeutics 572 - Biochemistry |
| dewey-raw | 615/.1 572/.6 |
| dewey-search | 615/.1 572/.6 |
| dewey-sort | 3615 11 |
| dewey-tens | 610 - Medicine and health 570 - Biology |
| discipline | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012189823 |
| illustrated | Illustrated |
| indexdate | 2024-10-17T12:00:58Z |
| institution | BVB |
| isbn | 3540650172 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008261324 |
| oclc_num | 39747470 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-12 DE-703 DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-12 DE-703 DE-11 DE-188 DE-578 |
| physical | XXII, 422 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Stress proteins contributors H. Abe ... Ed. David S. Latchman Berlin [u.a.] Springer 1999 XXII, 422 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 136 Stress cabt Heat Shock Proteins cabt Heat-shock-proteïnen gtt Chaperonin 60 physiology Heat shock proteins Heat-Shock Proteins Heat-Shock Proteins 70 physiology Heat-Shock Proteins 90 physiology Heat-Shock Response Stress (Physiology) Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Hitzeschock-Proteine (DE-588)4255487-1 gnd rswk-swf Stressproteine (DE-588)4426248-6 gnd rswk-swf Pathobiochemie (DE-588)4044888-5 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Stressproteine (DE-588)4426248-6 s DE-604 Hitzeschock-Proteine (DE-588)4255487-1 s Pathophysiologie (DE-588)4044898-8 s Physiologische Chemie (DE-588)4076124-1 s Pathobiochemie (DE-588)4044888-5 s Latchman, David S. 1956- Sonstige (DE-588)120416859 oth Abe, Hiroshi Sonstige oth Handbook of experimental pharmacology 136 (DE-604)BV002390716 136 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008261324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stress proteins Handbook of experimental pharmacology Stress cabt Heat Shock Proteins cabt Heat-shock-proteïnen gtt Chaperonin 60 physiology Heat shock proteins Heat-Shock Proteins Heat-Shock Proteins 70 physiology Heat-Shock Proteins 90 physiology Heat-Shock Response Stress (Physiology) Physiologische Chemie (DE-588)4076124-1 gnd Hitzeschock-Proteine (DE-588)4255487-1 gnd Stressproteine (DE-588)4426248-6 gnd Pathobiochemie (DE-588)4044888-5 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4076124-1 (DE-588)4255487-1 (DE-588)4426248-6 (DE-588)4044888-5 (DE-588)4044898-8 (DE-588)4143413-4 |
| title | Stress proteins |
| title_auth | Stress proteins |
| title_exact_search | Stress proteins |
| title_full | Stress proteins contributors H. Abe ... Ed. David S. Latchman |
| title_fullStr | Stress proteins contributors H. Abe ... Ed. David S. Latchman |
| title_full_unstemmed | Stress proteins contributors H. Abe ... Ed. David S. Latchman |
| title_short | Stress proteins |
| title_sort | stress proteins |
| topic | Stress cabt Heat Shock Proteins cabt Heat-shock-proteïnen gtt Chaperonin 60 physiology Heat shock proteins Heat-Shock Proteins Heat-Shock Proteins 70 physiology Heat-Shock Proteins 90 physiology Heat-Shock Response Stress (Physiology) Physiologische Chemie (DE-588)4076124-1 gnd Hitzeschock-Proteine (DE-588)4255487-1 gnd Stressproteine (DE-588)4426248-6 gnd Pathobiochemie (DE-588)4044888-5 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Stress Heat Shock Proteins Heat-shock-proteïnen Chaperonin 60 physiology Heat shock proteins Heat-Shock Proteins Heat-Shock Proteins 70 physiology Heat-Shock Proteins 90 physiology Heat-Shock Response Stress (Physiology) Physiologische Chemie Hitzeschock-Proteine Stressproteine Pathobiochemie Pathophysiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008261324&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT latchmandavids stressproteins AT abehiroshi stressproteins |