Failure of apoptosis and cancer metastasis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 178 S. graph. Darst. |
| ISBN: | 3540645608 1570594783 |
Internformat
MARC
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|---|---|---|---|
| 001 | BV012174977 | ||
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| 005 | 19990326 | ||
| 007 | t | ||
| 008 | 980930s1998 d||| |||| 00||| eng d | ||
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| 100 | 1 | |a Glinsky, Gennadi V. |d 1952- |e Verfasser |0 (DE-588)120730774 |4 aut | |
| 245 | 1 | 0 | |a Failure of apoptosis and cancer metastasis |c Gennadi V. Glinsky |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1998 | |
| 300 | |a 178 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Adhérence cellulaire - Physiologie | |
| 650 | 2 | |a Apoptose | |
| 650 | 2 | |a Métastase tumorale - prévention et contrôle | |
| 650 | 2 | |a Métastase tumorale | |
| 650 | 2 | |a Survie cellulaire - Physiologie | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Apoptosis |x physiology | |
| 650 | 4 | |a Cell Adhesion |x physiology | |
| 650 | 4 | |a Cell Survival |x physiology | |
| 650 | 4 | |a Cell adhesion | |
| 650 | 4 | |a Metastasis | |
| 650 | 4 | |a Neoplasm Metastasis |x physiopathology | |
| 650 | 4 | |a Neoplasm Metastasis |x prevention & control | |
| 650 | 0 | 7 | |a Zelladhäsion |0 (DE-588)4314136-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Metastase |0 (DE-588)4125915-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Apoptosis |0 (DE-588)4291096-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Krebszelle |0 (DE-588)4128704-6 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 0 | 1 | |a Metastase |0 (DE-588)4125915-4 |D s |
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| 689 | 1 | 0 | |a Metastase |0 (DE-588)4125915-4 |D s |
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| 689 | 1 | 3 | |a Apoptosis |0 (DE-588)4291096-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008249252&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008249252 | ||
Datensatz im Suchindex
| _version_ | 1804126789466849280 |
|---|---|
| adam_text | ¦= CONTENTS = =t
l Cell Adhesion Cascade as a Multicomponent and Multistep
Process with Multiple Decision Forks for Death and life....... 1
1.1. Introduction x
u. Cell Adhesion as a Cascade Process with Cooperative and
Combinatorial Adhesive Specificity 4
1.3. The Role of Carbohydrate Determinants in the
Adhesion of Circulating Cells 22
1.4. The Role of Carbohydrate Determinants in Cellular
Adhesion During Embryo and Organogenesis 29
1.5. The Cancer Associated Glycoepitopes and Sugar Binding
Proteins as Key Molecular Determinants in
Cancer Adhesion and Metastasis 32
1.6. Conclusion: A Prospect of Anti Cell Adhesion Therapy for
Cancer Metastasis 39
1 Apoptosis and Metastasis:
Failure of Apoptosis in Metastatic Cancer Cells as a Key Factor
of Metastatic Disease.......... ............................................... 69
2.1. Introduction 69
2.2. Adhesion Dependent Regulation
of Apoptosis 71
2.3. Superior Resistance of Metastatic Cancer Cells to
Programmed Cell Death 72
2.4 Cellular and Molecular Mechanisms of Higher
Resistance to Apoptosis by Metastatic Cancer Cells 74
2.5. Role of Apoptosis in Tumor Progression 81
2.6. Conclusion 84
3. Apoptosis Resistance of Metastatic Cancer Cells Is Associated
with Deficiency of Apoptosis Execution Mechanisms........... 97
3.1. Summary 97
3.2. Introduction 98
3.3. Association of High Metastatic Potential with Increased
Resistance toward Apoptosis 99
3.4. Activation of ICE like Protease(s) is Required for
Execution of Serum Deprivation Induced Apoptosis 100
3.5. Low Level of Apoptosis in Highly Metastatic
Cancer Cells Is Correlated with Reduced Activity
of the CPP32/Yama Death Protease 101
3.6. Increased Resistance toward Apoptosis in
Highly Metastatic Cancer Cells Is Associated with Low
ActivityofNudearCa2+ DependentEndonucleases 103
3.7. Conclusion: Deficiency of the Two Major Apoptosis
Execution Mechanisms as a Potential Molecular Cause of
Increased Apoptosis Resistance
in Metastatic Cancer Cells 104
4* A Hypothesis for Telomere Dependent
Control of Apoptosis* ••••••••••••••»•••••••••••••••••.•••••¦•••..••••••..•...••...... ui
4.1. Summary 111
4.2. Introduction 113
4.3. Identification of the Telomeric Repeat Degradation
Products (TRDP) Using a Polymerase Chain Reaction *
(PCR) Based Assay of Telomere Fragmentation in Murine
and Human Cancer Cells 115
4.4. Enhanced Degradation of Telomeric DNA is Correlated
with the Increased Apoptosis Levels in Metastatic Cancer
Cells 118
4.5. Enhanced Degradation of Telomeric DNA is Associated
with Activation of Nuclear
Ca2+ Dependent Endonucleases 119
4.6. Caspase Activation is not Necessary for Degradation of
Telomeric DNA 119
4.7. CPP32/Yama Death Protease Activation does not
Lead to Apoptosis In the Cells Treated with Short
Telomere Specific Oligonudeotides TTAGGG 125
4.8. The Cells with Experimentally Elongated Telomeres
Manifest Higher Resistance Toward Apoptosis 137 i
4.9. Two Major Apoptosis Execution Mechanisms Are |
Deficient in the Cells with Experimentally Elongated §
Telomeres 128
4.10. Role of Telomerase, Telomeres, and Telomere Binding
Proteins in Regulation of Apoptosis Execution:
A Hypothesis 130
4.11. Conclusion: The Possible Molecular Mechanisms and
Consequences of Telomere Dependent Control
of Apoptosis Execution 131
5. Inhibition of Homotypic Cancer Cell Aggregation and Colony
Formation in Agarose of Metastatic Human Cancer Cells by
Synthetic Glycoamine Analogs................................................ 143
5.1. Summary 143
5.2. Introduction 144
5.3. Structural Analysis of Synthetic Glycoamine Analogs.. 146
5.4. Inhibition of Colony Formation in Agarose
by Synthetic Glycoamines 146
5.5. Inhibition of B16 Melanoma Cell Aggregation
by Synthetic Glycoamines 150
5.6. Galactoside Specific Lectins as Potential Molecular
Targets for Synthetic Glycoamines 151
5.7. Conclusion: A Carbohydrate Lectin Recognition as a
Common Molecular Determinant of Cell Aggregation,
Clonogenic Growth and Apoptosis 153
6. Inhibition of Human Breast Cancer Metastasis in Nude
Mice by Synthetic Glycoamines............................................... 163
6.1. Summary 163
6.2. Introduction 164
6.3. Selection of Inhibitors of Colony Formation
by MDA MB 435 Cells in Dense Agarose 166
6.4. Nude Mouse—Human Breast Cancer Xenograft
Experiments 166
6.5. Inhibition of Homotypic Aggregation and Induction of
Apoptosis in MDA MB 435 Human Breast Carcinoma
Cells by Synthetic Glycoamines 170
6.6. Conclusion: Synthetic Glycoamines as Prototype
Compounds for a Novel Class of Antimetastatic Drugs.. 170
|
| any_adam_object | 1 |
| author | Glinsky, Gennadi V. 1952- |
| author_GND | (DE-588)120730774 |
| author_facet | Glinsky, Gennadi V. 1952- |
| author_role | aut |
| author_sort | Glinsky, Gennadi V. 1952- |
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| dewey-full | 616.99/407 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/407 |
| dewey-search | 616.99/407 |
| dewey-sort | 3616.99 3407 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV012174977 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:23:02Z |
| institution | BVB |
| isbn | 3540645608 1570594783 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008249252 |
| oclc_num | 38312375 |
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| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | 178 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Springer |
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| spelling | Glinsky, Gennadi V. 1952- Verfasser (DE-588)120730774 aut Failure of apoptosis and cancer metastasis Gennadi V. Glinsky Berlin [u.a.] Springer 1998 178 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Adhérence cellulaire - Physiologie Apoptose Métastase tumorale - prévention et contrôle Métastase tumorale Survie cellulaire - Physiologie Apoptosis Apoptosis physiology Cell Adhesion physiology Cell Survival physiology Cell adhesion Metastasis Neoplasm Metastasis physiopathology Neoplasm Metastasis prevention & control Zelladhäsion (DE-588)4314136-5 gnd rswk-swf Metastase (DE-588)4125915-4 gnd rswk-swf Apoptosis (DE-588)4291096-1 gnd rswk-swf Krebszelle (DE-588)4128704-6 gnd rswk-swf Apoptosis (DE-588)4291096-1 s Metastase (DE-588)4125915-4 s DE-604 Krebszelle (DE-588)4128704-6 s Zelladhäsion (DE-588)4314136-5 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008249252&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Glinsky, Gennadi V. 1952- Failure of apoptosis and cancer metastasis Adhérence cellulaire - Physiologie Apoptose Métastase tumorale - prévention et contrôle Métastase tumorale Survie cellulaire - Physiologie Apoptosis Apoptosis physiology Cell Adhesion physiology Cell Survival physiology Cell adhesion Metastasis Neoplasm Metastasis physiopathology Neoplasm Metastasis prevention & control Zelladhäsion (DE-588)4314136-5 gnd Metastase (DE-588)4125915-4 gnd Apoptosis (DE-588)4291096-1 gnd Krebszelle (DE-588)4128704-6 gnd |
| subject_GND | (DE-588)4314136-5 (DE-588)4125915-4 (DE-588)4291096-1 (DE-588)4128704-6 |
| title | Failure of apoptosis and cancer metastasis |
| title_auth | Failure of apoptosis and cancer metastasis |
| title_exact_search | Failure of apoptosis and cancer metastasis |
| title_full | Failure of apoptosis and cancer metastasis Gennadi V. Glinsky |
| title_fullStr | Failure of apoptosis and cancer metastasis Gennadi V. Glinsky |
| title_full_unstemmed | Failure of apoptosis and cancer metastasis Gennadi V. Glinsky |
| title_short | Failure of apoptosis and cancer metastasis |
| title_sort | failure of apoptosis and cancer metastasis |
| topic | Adhérence cellulaire - Physiologie Apoptose Métastase tumorale - prévention et contrôle Métastase tumorale Survie cellulaire - Physiologie Apoptosis Apoptosis physiology Cell Adhesion physiology Cell Survival physiology Cell adhesion Metastasis Neoplasm Metastasis physiopathology Neoplasm Metastasis prevention & control Zelladhäsion (DE-588)4314136-5 gnd Metastase (DE-588)4125915-4 gnd Apoptosis (DE-588)4291096-1 gnd Krebszelle (DE-588)4128704-6 gnd |
| topic_facet | Adhérence cellulaire - Physiologie Apoptose Métastase tumorale - prévention et contrôle Métastase tumorale Survie cellulaire - Physiologie Apoptosis Apoptosis physiology Cell Adhesion physiology Cell Survival physiology Cell adhesion Metastasis Neoplasm Metastasis physiopathology Neoplasm Metastasis prevention & control Zelladhäsion Metastase Krebszelle |
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