Neurotrophic factors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1999
|
| Schriftenreihe: | Handbook of experimental pharmacology
134 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 325 S. Ill., graph. Darst. |
| ISBN: | 3540646140 |
Internformat
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| 245 | 1 | 0 | |a Neurotrophic factors |c contributors P. Aebischer ... Ed. Franz Hefti |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1999 | |
| 300 | |a XVIII, 325 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of experimental pharmacology |v 134 | |
| 650 | 4 | |a Nerve growth factor | |
| 650 | 4 | |a Nervous system |x Diseases | |
| 650 | 4 | |a Nervous system |x Diseases |x Chemotherapy | |
| 650 | 4 | |a Neurotrophic functions | |
| 650 | 0 | 7 | |a Neuropharmakologie |0 (DE-588)4041896-0 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
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| adam_text |
CONTENTS
CHAPTER
1
BIOLOGICAL
ROLES
OF
NEUROTROPHINS
Y.-A.
B
ARDE
.
1
A.
INTRODUCTION
.
1
B.
NEUROTROPHINS
IN
DIFFERENT
SPECIES
.
2
C.
TROPHIC
ROLES
OF
NEUROTROPHINS
IN
THE
PERIPHERAL
NERVOUS
SYSTEM
.
3
I.
SENSORY
NEURONS
.
4
1.
NERVE
GROWTH
FACTOR
.
4
2.
BRAIN-DERIVED
NEUROTROPHIC
FACTOR
.
5
3.
NEUROTROPHIN-3
.
6
4.
NEUROTROPHIN-4/5
.
9
II.
SYMPATHETIC
NEURONS
.
10
D.
TROPHIC
ROLES
OF
NEUROTROPHINS
IN
THE
CENTRAL
NERVOUS
SYSTEM
.
11
I.
PREVENTION
OF
CELL
DEATH
.
11
II.
OTHER
TROPHIC
ACTIONS
.
13
1.
REGULATION
OF
GENE
EXPRESSION
.
13
2.
FUNCTIONAL
AND
MORPHOLOGICAL
EFFECTS
ON
THE
DEVELOPING
CORTEX
AND
MOTONEURONS
.
14
E.
SYNAPTIC
TRANSMISSION
.
15
F.
MODULATION
OF
TRANSCRIPTION
OF
NEUROTROPHIN
GENES
.
16
G.
REGRESSIVE
EVENTS
AND
NEUROTROPHINS
.
18
H.
CONCLUSIONS
AND
PERSPECTIVES
.
20
REFERENCES
.
21
CHAPTER
2
MOLECULAR
ANATOMY
OF
NEUROTROPHIC
FACTORS
C.F.
I
BANEZ
.
WITH
7
FIGURES
.
33
A.
MULTI-COMPONENT
RECEPTORS,
SPECIFICITY
AND
CROSS-TALK
.
33
B.
INSIGHTS
INTO
NEUROTROPHIC-FACTOR
FUNCTION
FROM
STRUCTURAL
ANALYSES
.
36
C.
ELECTROSTATIC
FORCES
AND
THE
INTERACTION
OF
NEUROTROPHIC
FACTORS
WITH
THEIR
RECEPTORS
.
38
X
CONTENTS
D.
SITE-DIRECTED
MUTAGENESIS
AND
STRUCTURE
ACTIVITY
RELATIONSHIPS
.
42
E.
LIGANDS
WITH
ALTERED
RECEPTOR-BINDING
SPECIFICITY
OFFER
NEW
INSIGHTS
INTO
NEUROTROPHIC
FACTOR
FUNCTION
.
46
F.
CONCLUSIONS
.
48
REFERENCES
.
48
CHAPTER
3
NEUROTROPHIN
TREATMENT
OF
PERIPHERAL
SENSORY
NEUROPATHIES
C.A.
R
ASK
AND
E.
E
SCANDON
.
WITH
1
FIGURE
.
53
ABBREVIATIONS
.
53
A.
INTRODUCTION
.
54
B.
ORGANIZATION
OF
THE
PERIPHERAL
NERVOUS
SYSTEM
.
54
I.
SENSORY
NEURONS
.
54
II.
SYMPATHETIC
NEURONS
.
55
III.
PARASYMPATHETIC
NEURONS
.
56
C.
ROLE
OF
NGF
IN
PNS
DEVELOPMENT
.
56
D.
ROLE
OF
NGF
IN
THE
ADULT
PNS
.
57
E.
NGF
RECEPTORS
.
58
I.
EXPRESSION
IN
NORMAL
NERVES
.
59
II.
EXPRESSION
IN
INJURED
NERVES
.
59
III.
ALTERATIONS
IN
NGF
AND
NGF-RECEPTOR
EXPRESSION
IN
HUMAN
DIABETIC
NEUROPATHY
.
59
F.
THE
ROLE
OF
NEUROTROPHINS
IN
THE
PATHOGENESIS
OF
PERIPHERAL
SENSORY
NEUROPATHIES
.
60
I.
PHARMACOLOGY
OF
NEUROTROPHINS
IN
CHEMOTHERAPEUTIC
INDUCED
(TOXIC)
PERIPHERAL
SENSORY
NEUROPATHIES
.
60
II.
PHARMACOLOGY
OF
NGF
IN
EXPERIMENTAL
DIABETIC
NEUROPATHY
.
60
1.
THERAPEUTIC
EFFECTS
OF
NGF
IN
EXPERIMENTAL
DIABETIC
NEUROPATHY
.
61
III.
SUMMARY
.
61
G.
CLINICAL
PERIPHERAL
SENSORY
NEUROPATHIES:
DIABETIC
POLYNEUROPATHY
.
62
I.
EPIDEMIOLOGY
OF
DIABETIC
NEUROPATHY
.
62
II.
CURRENT
TREATMENT
OF
PERIPHERAL
SENSORY
NEUROPATHIES
.
63
H.
TRIAL
DESIGN
CONSIDERATIONS
FOR
THE
STUDY
OF
PERIPHERAL
SENSORY
NEUROPATHIES
.
64
I.
SELECTION
OF
STUDY
ENDPOINTS
.
64
II.
STUDY
ENDPOINTS
FOR
EVALUATION
OF
EFFICACY
OF
RHNGF
.
66
I.
CLINICAL
STUDIES
OF
NERVE
GROWTH
FACTOR
.
67
I.
SAFETY,
PHARMACOKINETICS
AND
PHARMACODYNAMIC
EFFECTS
OF
RHNGF
.
67
CONTENTS
XI
II.
PRELIMINARY
EVIDENCE
OF
EFFICACY
OF
RHNGF
IN
THE
TREATMENT
OF
PERIPHERAL
SENSORY
NEUROPATHIES
.
68
J.
INTERPRETATION
OF
CLINICAL-TRIAL
RESULTS
.
71
K.
CONCLUSIONS
.
71
REFERENCES
.
72
CHAPTER
4
NEUROTROPHIC
FACTORS
AND
AMYOTROPHIC
LATERAL
SCLEROSIS
M.
S
ENDTNER
.
WITH
2
FIGURES
.
81
A.
INTRODUCTION
.
81
I.
DEVELOPMENTAL
CELL
DEATH
OF
MOTONEURONS
.
81
II.
PATHOLOGICAL
CELL
DEATH
OF
MOTONEURONS
AND
HUMAN
MOTONEURON
DISEASE
.
82
III.
WHY
SHOULD
NEUROTROPHIC
FACTORS
INTERFERE
WITH
THE
PATHOGENIC
MECHANISMS
IN
SPORADIC
ALS?
.
84
IV.
CILIARY
NEUROTROPHIC
FACTOR
(CNTF)
AND
RELATED
MOLECULES
.
86
1.
THE
CNTF
RECEPTOR
COMPLEX:
ACTIONS
OF
LEUKEMIA
INHIBITORY
FACTOR,
ONCOSTATIN
M
AND
CARDIOTROPHIN-1
ARE
MEDIATED
THROUGH
SHARED
RECEPTOR
SUBUNITS
.
87
2.
THE
FUNCTION
OF
ENDOGENOUS
CNTF
AND
RELATED
FACTORS
FOR
MOTONEURONS
.
87
3.
PHARMACOLOGICAL
EFFECTS
OF
CNTF
ON
LESIONED
MOTONEURONS
.
88
4.
EFFECTS
OF
CNTF
AND
OTHER
NEUROTROPHIC
FACTORS
IN
MURINE
ANIMAL
MODELS
FOR
MOTONEURON
DISEASE
.
89
5.
PHARMACOLOGICAL
EFFECTS
OF
SYSTEMICALLY
APPLIED
CNTF
.
92
V.
THE
EFFECTS
OF
NEUROTROPHINS
ON
MOTONEURONS
.
94
1.
NERVE
GROWTH
FACTOR
.
94
2.
THE
EFFECTS
OF
BRAIN-DERIVED
NEUROTROPHIC
FACTOR
(BDNF),
NEUROTROPHIN-3
(NT-3)
AND
NEUROTROPHIN-4/5
(NT-4/5)
ON
MOTONEURONS
.
94
3.
PHYSIOLOGICAL
FUNCTIONS
OF
NEUROTROPHINS
FOR
MOTONEURONS,
AS
REVEALED
BY
GENE
TARGETING
.
96
4.
PHARMACOLOGICAL
POTENTIAL
OF
NEUROTROPHINS
FOR
TREATMENT
OF
AMYOTROPHIC
LATERAL
SCLEROSIS
.
96
VI.
GLIAL-DERIVED
NEUROTROPHIC
FACTOR
.
100
1.
SPECIFICITY
OF
GDNF
FOR
MOTONEURONS
AND
NEURONAL
POPULATIONS
IN
THE
PERIPHERAL
NERVOUS
SYSTEM
.
100
2.
PHYSIOLOGICAL
FUNCTION
OF
GDNF:
EVIDENCE
FROM
GENE
KNOCKOUT
STUDIES
.
101
3.
THE
PHARMACOLOGICAL
POTENTIAL
OF
GDNF
FOR
TREATMENT
OF
HUMAN
MOTONEURON
DISEASE
.
102
XII
CONTENTS
VIL
INSULIN-LIKE
GROWTH
FACTORS
(IGF)
.
103
1.
SPECIFIC
FUNCTION
OF
IGF-I
ON
DEVELOPING
AND
POSTNATAL
MOTONEURONS
.
103
2.
PHARMACOKINETICS
OF
IGF-I
.
104
3.
EFFECTS
OF
IGF-I
IN
ANIMAL
MODELS
OF
MOTONEURON
DEGENERATION
.
104
VIII.
FUTURE
PERSPECTIVES:
ARE
NEWEST
CLINICAL
TRIALS
IN
ALS
PATIENTS
WITH
NEUROTROPHIC
FACTORS
MEANINGFUL?
.
105
1.
STRATEGIES
TO
INCREASE
THE
AVAILABILITY
OF
PHARMACOLOGICALLY
APPLIED
NEUROTROPHIC
FACTORS
TO
DEGENERATING
MOTONEURONS
.
107
2.
DEVELOPMENT
OF MODIFIED
FACTORS
WITH
INCREASED
SPECIFICITY
AND
IMPROVED
PHARMACOKINETIC
PROPERTIES
.
107
3.
COMBINATIONS
OF
NEUROTROPHIC
FACTORS:
THE
BETTER
STRATEGY?
.
108
REFERENCES
.
108
CHAPTER
5
NEUROPHARMACOLOGY
OF
INSULIN-LIKE
GROWTH
FACTORS
D.N.
I
SHII
AND
S.-F.
PU
.
119
ABBREVIATIONS
.
119
A.
INTRODUCTION
.
119
B.
BACKGROUND
.
120
I.
IGF
GENES
AND
TRANSCRIPTS
.
120
1.
IGF-I
.
120
2.
IGF-II
.
121
II.
IGF
RECEPTORS
.
121
1.
TYPE-I
RECEPTORS
.
121
2.
TYPE-II
RECEPTORS
.
122
III.
IGF
BINDING
PROTEINS
.
122
C.
NEUROTROPHIC
RELATIONSHIPS
.
122
I.
PERIPHERAL
NERVOUS
SYSTEM
.
123
II.
CENTRAL
NERVOUS
SYSTEM
.
123
D.
NEUROLOGICAL
DISORDERS
TARGETED
FOR
IGF
THERAPY
.
124
I.
DIABETIC
NEUROPATHY
.
124
1.
PATHOPHYSIOLOGY
.
124
2.
EXPERIMENTAL
OBSERVATIONS
IN
NON-PRIMATES
.
126
A)
IGF
ACTIVITY
IN
EXPERIMENTAL
IDDM
.
126
B)
IGF
ACTIVITY
IN
EXPERIMENTAL
NIDDM
.
127
C)
IGF
TREATMENT
PREVENTS
NEUROPATHY
.
128
D)
RELATIONSHIP
OF
DISTURBANCES
IN
IGF
AXIS
TO
HYPERGLYCEMIA,
HYPERINSULINEMIA
AND
WEIGHT
LOSS
.
128
CONTENTS
XIII
3.
IGF
ACTIVITY
IN
PRIMATES
.
129
A)
DIABETIC
MONKEYS
.
129
B)
CLINICAL
DIABETES
.
129
II.
CHEMOTHERAPY-INDUCED
NEUROPATHY
.
129
III.
AMYOTROPHIC
LATERAL
SCLEROSIS
(ALS)
.
129
IV.
STROKE
.
130
V.
ALZHEIMER
'
S
DISEASE
.
131
VI.
MYOTONIC
DYSTROPHY
.
132
E.
PHARMACOLOGICAL
CONSIDERATIONS
.
132
I.
ROUTES
OF
ADMINISTRATION
.
132
II.
VOLUME
OF
DISTRIBUTION
AND
DAILY
PRODUCTION
.
133
III.
BOUND
AND
FREE
IGF
POOLS
.
134
IV.
ELIMINATION
HALF-TIME
.
134
V.
CLINICAL
EFFECTS
OF
RECOMBINANT
HUMAN
IGF-I
.
135
1.
NORMAL
SUBJECTS
.
135
2.
PATIENT
POPULATIONS
.
136
VI.
EFFECTS
OF
RECOMBINANT
HUMAN
IGF-II
.
137
F.
CONCLUDING
COMMENTS
.
137
REFERENCES
.
138
CHAPTER
6
NEUROTROPHIC
FACTORS
IN
PERIPHERAL
NERVE
INJURY
AND
REGENERATION
N.M.J.
R
UPNIAK
,
J.M.A.
L
AIRD
,
S.
B
OYCE
,
AND
R.G.
H
ILL
.
WITH
4
FIGURES
.
147
A.
INTRODUCTION
.
147
B.
CAUSES
OF
PERIPHERAL
NERVE
DAMAGE
.
148
C.
SYMPTOMS
AND
PATHOPHYSIOLOGY
OF
PERIPHERAL-NERVE
DAMAGE
.
149
I.
SENSORY
NEUROPATHIES
.
150
II.
MOTOR
NEURONOPATHIES
.
151
D.
CURRENT
APPROACHES
TO
THERAPY
.
152
I.
SENSORY
NEUROPATHIES
.
152
1.
SURGERY
.
152
2.
ANALGESIC
DRUGS
.
153
II.
MOTOR
NEURONOPATHIES
.
153
E.
METHODS
FOR
THE
STUDY
OF
PERIPHERAL
NERVE
DAMAGE
IN
LABORATORY
ANIMALS
.
154
I.
MECHANICAL
INJURY
.
154
II.
NEUROTOXINS
.
155
III.
DIABETES
.
156
IV.
HEREDITARY
MOTOR
NEURONOPATHIES
IN
MICE
.
156
F.
ENDPOINTS
USED
TO
ASSESS
PERIPHERAL
NERVE
REGENERATION
IN
VIVO
.
157
XIV
CONTENTS
I.
QUANTITATIVE
MORPHOMETRIC
ANALYSIS
.
157
II.
FUNCTIONAL
ASSAYS
OF
NERVE
REGENERATION
DISTANCE
.
159
III.
ASSESSING
THE
FUNCTIONAL
INNERVATION
OF
TARGET
TISSUES
.
160
G.
BENEFICIAL
EFFECTS
OF
NEUROTROPHIC
AGENTS
IN
ANIMAL
MODELS
OF
NEUROPATHY
.
162
I.
MECHANICAL
NERVE
INJURY
.
162
II.
NEUROTOXINS
.
163
III.
DIABETES
.
164
IV.
MOTOR
NEURONOPATHY
IN
MICE
.
164
H.
DRUG-DEVELOPMENT
ISSUES
.
165
I.
CLINICAL
EXPERIENCE
WITH
NEUROTROPHIC
FACTORS
.
165
J.
CONCLUSIONS
AND
FUTURE
DIRECTIONS
.
166
REFERENCES
.
169
CHAPTER
7
NERVE
GROWTH
FACTOR
TREATMENT
FOR
ALZHEIMER
'
S
DISEASE:
THE
EXPERIENCE
OF
THE
FIRST
ATTEMPT
AT
INTRACEREBRAL
NEUROTROPHIC
FACTOR
THERAPY
F.
H
EFTI
.
175
A.
INTRODUCTION
.
175
B.
NERVE
GROWTH
FACTOR
AS
A
THERAPEUTIC
AGENT
TO
COUNTERACT
CHOLINERGIC
NEURON
DEGENERATION
.
176
I.
CHOLINERGIC
NEURON
ATROPHY
IN
ALZHEIMER
'
S
DISEASE
(AD)
.
176
II.
ROLE
OF
NGF
IN
CHOLINERGIC
NEURON
DEVELOPMENT
AND
ADULT
FUNCTION
.
177
III.
PHARMACOLOGICAL
EFFECTS
OF
NGF
IN
ANIMALS
WITH
EXPERIMENTAL
CHOLINERGIC
DEFICITS
.
177
IV.
HUMAN
STUDIES
WITH
NGF:
EFFICACY
AND
POSSIBLE
ADVERSE
EFFECTS
.
178
V.
ALTERNATIVE
ADMINISTRATION
STRATEGIES
AND
SMALL-MOLECULE
MIMETICS
.
180
C.
NEUROTROPHIC
FACTORS
FOR
NON-CHOLINERGIC
NEURONS
AFFECTED
BY
THE
DISEASE
.
180
D.
RELATIONSHIP
TO
ALZHEIMER
'
S
DISEASE
PATHOLOGY
.
181
E.
CONCLUSIONS
.
182
REFERENCES
.
183
CHAPTER
8
NEUROTROPHIC
ROLES
OF
GDNF
AND
RELATED
FACTORS
K.
U
NSICKER
,
C.
S
UTER
-C
RAZZOLARA
,
AND
K.
K
RIEGLSTEIN
.
WITH
6
FIGURES
.
189
CONTENTS
XV
A.
INTRODUCTION
.
189
B.
MOLECULAR
STRUCTURE
OF
GDNF
AND
RELATED
MOLECULES
.
191
I.
GLIAL
CELL
LINE-DERIVED
NEUROTROPHIC
FACTOR
.
191
II.
NEURTURIN
.
192
1.
PERSEPHIN
.
192
C.
RECEPTORS
AND
SIGNAL
TRANSDUCTION
OF
GDNF
AND
NEURTURIN
.
192
I.
RET
.
193
1.
MOLECULAR
STRUCTURE
AND
SIGNALING
PATHWAYS
.
193
2.
RET
AS
A
FUNCTIONAL
RECEPTOR
FOR
GDNF
AND
NEURTURIN
.
194
II.
ADDITIONAL
COMPONENTS
OF
THE
RET-RECEPTOR
COMPLEX:
AL
AND
A2-RECEPTORS
.
195
1.
THE
GFR-AL
RECEPTOR
.
195
2.
THE
NEURTURIN-/TRNR2-/RTL2/GFR-A2-RECEPTOR
.
195
D.
DISTRIBUTION
OF
GDNF,
NEURTURIN
AND
THEIR
RECEPTORS
.
196
I.
GDNF
AND
NEURTURIN
IN
THE
NERVOUS
SYSTEM
.
196
II.
GDNF
AND
NEURTURIN
IN
NON-NEURAL
TISSUES
.
198
III.
EXPRESSION
OF
RET,
GFR-AL
AND
GFR-A2
IN
THE
DEVELOPING
AND
ADULT
NERVOUS
SYSTEM
.
199
IV.
EXPRESSION
OF
GDNF
AND
ITS
RECEPTORS
IN
THE
LESIONED
NERVOUS
SYSTEM
.
200
V.
EXPRESSION
OF
RET,
GFR-AL
AND
GFR-A2
OUTSIDE
THE
NERVOUS
SYSTEM:
INVOLVEMENT
OF
RET
IN
NEUROENDOCRINE
AND
GASTROINTESTINAL
DISORDERS
.
201
E.
FUNCTIONS
OF
GNDF
AND
NEURTURIN
IN
THE
NERVOUS
SYSTEM
AS
REVEALED
IN
VITRO
AND
IN
VIVO
.
202
I.
GLIAL
CELL
LINE-DERIVED
NEUROTROPHIC
FACTOR
.
202
1.
GDNF
AND
THE
NIGROSTRIATAL
DOPAMINERGIC
SYSTEM
.
202
A)
CULTURED
MESENCEPHALIC
CELLS
.
202
B)
ANIMAL
MODELS
OF
PARKINSONISM
.
203
C)
EFFECTS
IN
UNLESIONED
ANIMALS
.
206
2.
OTHER
CNSAMINERGIC
NEURONS
.
207
3.
GDNF
AND
INTRINSIC
STRIATAL
NEURONS
.
208
4.
SPINAL
CORD
AND
BRAINSTEM
MOTONEURONS
.
208
5.
CEREBELLAR
NEURONS
.
210
6.
SENSORY
NEURONS
.
210
7.
AUTONOMIC
NEURONS
.
210
8.
NEURAL
CREST
.
211
9.
GDNF
IN
CNS
LESION
MODELS
OTHER
THAN
PARKINSONISM
.
211
II.
NEURTURIN
.
212
F.
DEVELOPMENTAL
ROLES
OF
GDNF,
NEURTURIN
AND
THEIR
RECEPTORS
AS
REVEALED
BY
GENE
TARGETING
.
212
I.
GLIAL
CELL
LINE-DERIVED
NEUROTROPHIC
FACTOR
.
212
II.
RET
.
213
XVI
CONTENTS
III.
NEURTURIN
.
213
G.
PERSPECTIVES
.
214
I.
CLINICAL
RELEVANCE
.
214
IL
NEUROBIOLOGICAL
RELEVANCE
.
214
REFERENCES
.
215
CHAPTER
9
ROLE
OF
NEUROTROPHIC
FACTORS
IN
CEREBRAL
ISCHEMIA
K.
N
IKOLICS
.
225
A.
NEUROTROPHIC
FACTORS,
THEIR
RECEPTORS
AND
THEIR
EXPRESSION
IN
THE
CENTRAL
NERVOUS
SYSTEM
(CNS)
.
225
I.
NEUROTROPHIC
FACTORS
SUPPORT
SURVIVAL
AND
FUNCTIONALITY
OF
NEURONS
.
225
II.
NEUROTROPHIC-FACTOR
FAMILIES
.
226
1.
NEUROTROPHINS
.
226
2.
GLIAL-DERIVED
NEUROTROPHIC
FACTOR
(GDNF)
AND
TRANSFORMING
GROWTH
FACTORS
(TGFS)
.
226
3.
CILIARY
NEUROTROPHIC
FACTOR
(CNTF),
FIBROBLAST
GROWTH
FACTORS
(FGFS),
INSULIN-LIKE
GROWTH
FACTORS
(IGFS)
AND
OTHER
FACTORS
.
227
III.
AFFERENT
ACTIVITY
REGULATES
NEUROTROPHIC
FACTOR
EXPRESSION
.
228
B.
HYPOXIC-ISCHEMIC
INJURY
REGULATES
THE
EXPRESSION
OF
NEUROTROPHIC
FACTORS
AND
THEIR
RECEPTORS
IN
THE
CENTRAL
NERVOUS
SYSTEM
.
229
I.
GLOBAL
HYPOXIC-ISCHEMIC
INJURY
.
229
1.
NEUROTROPHINS
.
230
2.
BASIC
FIBROBLAST
GROWTH
FACTOR
.
231
3.
IGFS,
TGF-B
AND
OTHER
FACTORS
.
232
II.
FOCAL
HYPOXIC-ISCHEMIC
INJURY
.
233
1.
NEUROTROPHINS
.
233
2.
BASIC
FIBROBLAST
GROWTH
FACTOR
.
234
3.
OTHER
FACTORS
.
235
C.
SPECIFIC
GROWTH
FACTORS
CAN
ATTENUATE
MORPHOLOGICAL
AND
FUNCTIONAL
DAMAGE
CAUSED
BY
HYPOXIC-ISCHEMIC
BRAIN
INJURY
.
235
I.
GLOBAL
ISCHEMIC
INJURY
.
236
1.
NEUROTROPHINS
.
236
2.
BASIC
FIBROBLAST
GROWTH
FACTOR
.
237
3.
TGF-B,
IGF-I
AND
OTHER
FACTORS
.
237
II.
FOCAL
ISCHEMIC
INJURY
.
239
1.
NEUROPROTECTIVE
EFFECTS
OF
NEUROTROPHINS
.
239
2.
NEUROPROTECTIVE
EFFECTS
OF
BFGF
.
240
3.
NEUROPROTECTIVE
EFFECTS
OF
IGF-I,
TGF-/5
AND
OTHER
GROWTH
FACTORS
.
241
CONTENTS
XVII
4.
PROTECTION
VIA
NEUROTROPHIC-FACTOR
INDUCTION
.
242
D.
THERAPEUTIC
POTENTIAL
OF
NEUROTROPHIC
FACTORS
IN
HYPOXIC-ISCHEMIC
BRAIN
INJURY
.
243
REFERENCES
.
244
CHAPTER
10
STRATEGIES
FOR
ADMINISTERING
NEUROTROPHIC
FACTORS
TO
THE
CENTRAL
NERVOUS
SYSTEM
A.F.
H
OTTINGER
,
P.
A
EBISCHER
.
WITH
2
FIGURES
.
255
ABBREVIATIONS
.
255
A.
INTRODUCTION
.
255
I.
CHARACTERISTICS
OF
NEUROTROPHIC
FACTORS
(NFS)
.
255
II.
RATIONALE
FOR
USING
NFS
IN
CLINICAL
PARADIGMS
.
256
B.
ADMINISTRATION
OF
NFS
TO
THE
CENTRAL
NERVOUS
SYSTEM
.
256
I.
DELIVERY
ISSUES
.
256
C.
DELIVERY
METHODS
.
257
I.
DELIVERY
OF
NFS
USING
MECHANICAL-RELEASE
DEVICES
.
257
1.
SYSTEMIC
DELIVERY
.
257
2.
PUMPS
.
261
3.
SLOW
POLYMER-RELEASE
SYSTEM
.
262
II.
DELIVERY
OF
NFS
USING
GENE
THERAPY
APPROACHES
.
262
1.
IN
VIVO
GENE
THERAPY
.
263
A)
VIRAL
VECTORS
.
263
B)
ADENOVIRAL
VECTORS
.
263
C)
ADENO-ASSOCIATED
VIRAL
VECTORS
.
265
D)
RETROVIRAL
VECTORS
.
267
2.
EX
VIVO
GENE
THERAPY
.
268
A)
CELL
GRAFTING
.
268
B)
ENCAPSULATION
OF
ENGINEERED
CELL
LINES
.
270
D.
CONCLUSION
.
273
REFERENCES
.
275
CHAPTER
11
NEUROTROPHIC
FACTOR
MIMETICS
C.
S
WAIN
,
S.
H
ARPER
,
S.
P
OLLACK
,
R.
S
MITH
,
AND
F.
H
EFTI
.
WITH
6
FIGURES
.
281
A.
INTRODUCTION
.
281
B.
DIRECT
AND
INDIRECT
RECEPTOR
LIGANDS
.
282
I.
PEPTIDE
MIMETICS
.
282
II.
K-252A
AND
RELATED
COMPOUNDS
THAT
MODULATE
TRK
RECEPTOR
SIGNALLING
.
283
III.
IMMUNOPHILIN
LIGANDS
.
287
IV.
OTHERS
.
291
C.
REGULATORS
OF
NEUROTROPHIC
FACTOR
SYNTHESIS
OR
RELEASE
.
293
XVIII
CONTENTS
I.
HORMONAL
REGULATION
OF
NEUROTROPHIN
OR
NEUROTROPHIN
RECEPTOR
EXPRESSION
.
294
II.
COMPOUNDS
REGULATING
NEUROTROPHIN
SYNTHESIS
.
295
D.
EXAMPLES
OF
GROWTH
HORMONE
SECRETAGOGUES
.
295
I.
DISCOVERY
OF
L-692,
429
AND
MK-0677
.
297
II.
THE
MK-0677
RECEPTOR
.
299
III.
CLINICAL
USE
.
299
E.
CONCLUSIONS
.
300
REFERENCES
.
300
SUBJECT
INDEX
.
311 |
| any_adam_object | 1 |
| author_GND | (DE-588)1073762580 |
| building | Verbundindex |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615/.1 |
| dewey-sort | 3615 11 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012162808 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T01:20:09Z |
| institution | BVB |
| isbn | 3540646140 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008239267 |
| oclc_num | 277465921 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XVIII, 325 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Neurotrophic factors contributors P. Aebischer ... Ed. Franz Hefti Berlin [u.a.] Springer 1999 XVIII, 325 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 134 Nerve growth factor Nervous system Diseases Nervous system Diseases Chemotherapy Neurotrophic functions Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Neurotropher Faktor (DE-588)4317638-0 gnd rswk-swf Nervenwachstumsfaktor (DE-588)4171485-4 gnd rswk-swf Brain-derived neurotrophic factor (DE-588)4291642-2 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervenwachstumsfaktor (DE-588)4171485-4 s Pharmakologie (DE-588)4045687-0 s DE-604 Neurotropher Faktor (DE-588)4317638-0 s Neuropharmakologie (DE-588)4041896-0 s Brain-derived neurotrophic factor (DE-588)4291642-2 s Hefti, Franz Sonstige oth Aebischer, Patrick 1954- Sonstige (DE-588)1073762580 oth Handbook of experimental pharmacology 134 (DE-604)BV002390716 134 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008239267&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurotrophic factors Handbook of experimental pharmacology Nerve growth factor Nervous system Diseases Nervous system Diseases Chemotherapy Neurotrophic functions Neuropharmakologie (DE-588)4041896-0 gnd Neurotropher Faktor (DE-588)4317638-0 gnd Nervenwachstumsfaktor (DE-588)4171485-4 gnd Brain-derived neurotrophic factor (DE-588)4291642-2 gnd Pharmakologie (DE-588)4045687-0 gnd |
| subject_GND | (DE-588)4041896-0 (DE-588)4317638-0 (DE-588)4171485-4 (DE-588)4291642-2 (DE-588)4045687-0 (DE-588)4143413-4 |
| title | Neurotrophic factors |
| title_auth | Neurotrophic factors |
| title_exact_search | Neurotrophic factors |
| title_full | Neurotrophic factors contributors P. Aebischer ... Ed. Franz Hefti |
| title_fullStr | Neurotrophic factors contributors P. Aebischer ... Ed. Franz Hefti |
| title_full_unstemmed | Neurotrophic factors contributors P. Aebischer ... Ed. Franz Hefti |
| title_short | Neurotrophic factors |
| title_sort | neurotrophic factors |
| topic | Nerve growth factor Nervous system Diseases Nervous system Diseases Chemotherapy Neurotrophic functions Neuropharmakologie (DE-588)4041896-0 gnd Neurotropher Faktor (DE-588)4317638-0 gnd Nervenwachstumsfaktor (DE-588)4171485-4 gnd Brain-derived neurotrophic factor (DE-588)4291642-2 gnd Pharmakologie (DE-588)4045687-0 gnd |
| topic_facet | Nerve growth factor Nervous system Diseases Nervous system Diseases Chemotherapy Neurotrophic functions Neuropharmakologie Neurotropher Faktor Nervenwachstumsfaktor Brain-derived neurotrophic factor Pharmakologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008239267&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT heftifranz neurotrophicfactors AT aebischerpatrick neurotrophicfactors |