Diazinon:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Geneva
World Health Organization
1998
|
| Ausgabe: | 1. draft |
| Schriftenreihe: | Environmental health criteria
198 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 140 S. |
| ISBN: | 9241571985 |
Internformat
MARC
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| 100 | 1 | |a Barabás, K. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Diazinon |c prepared by K. Barabás |
| 250 | |a 1. draft | ||
| 264 | 1 | |a Geneva |b World Health Organization |c 1998 | |
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| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 1 | |a Environmental health criteria |v 198 | |
| 650 | 7 | |a Arbeidshygiëne |2 gtt | |
| 650 | 7 | |a Blootstelling |2 gtt | |
| 650 | 4 | |a Diazinon - Aspect de l'environnement | |
| 650 | 4 | |a Diazinon - Effets physiologiques | |
| 650 | 4 | |a Diazinon - Sécurité - Mesures | |
| 650 | 4 | |a Diazinon - Toxicologie | |
| 650 | 7 | |a Diazinon |2 gtt | |
| 650 | 7 | |a Gezondheidseffecten |2 gtt | |
| 650 | 7 | |a Toxiciteit |2 gtt | |
| 650 | 4 | |a Diazinon | |
| 650 | 4 | |a Environmental Exposure | |
| 650 | 4 | |a Environmental health | |
| 650 | 4 | |a Insecticides |x Toxicology | |
| 650 | 4 | |a Insecticides |x adverse effects | |
| 650 | 4 | |a Organophosphorus compounds |x Toxicology | |
| 650 | 4 | |a Organothiophosphorus Compounds | |
| 650 | 0 | 7 | |a Umweltbelastung |0 (DE-588)4061619-8 |2 gnd |9 rswk-swf |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008214127 | ||
Datensatz im Suchindex
| _version_ | 1804126736206528512 |
|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
DIAZINON
PREAMBLE x
ABBREVIATIONS xx
1. SUMMARY 1
1.1 Identity, physical and chemical properties,
analytical methods 1
1.2 Production, uses and sources of human
and environmental exposure 1
1.3 Environmental transport, distribution
and transformation 1
1.4 Environmental levels and human exposure 2
1.5 Kinetics and metabolism 3
1.6 Effects on experimental animals and
in vitro test systems 4
1.7 Effects on humans 4
1.8 Effects on other organisms in the
laboratory and field 5
2. IDENTITY. PHYSICAL AND CHEMICAL
PROPERTIES. ANALYTICAL METHODS 6
2.1 Identity 6
2.1.1 Primary constituent 6
2.1.2 Technical product 6
2.2 Physical and chemical properties 7
2.3 Analytical methods 8
Hi
EHC 198: Diazinon
3. SOURCES OF HUMAN AND ENVIRONMENTAL
EXPOSURE 11
3.1 Natural occurrence 11
3.2 Man made sources 11
3.2.1 Production levels and processes 11
3.2.1.1 Manufacturing process 11
3.2.2 Uses 11
3.2.3 Formulations 12
4. ENVIRONMENTAL TRANSPORT, DISTRIBUTION
AND TRANSFORMATION 13
4.1 Transport and distribution between media 13
4.1.1 Volatilization 13
4.1.2 Movement in soil 13
4.2 Degradation 14
4.2.1 Degradation in soil 14
4.2.2 Degradation in water 17
4.2.3 Bioconcentration 17
4.2.3.1 Fish and aquatic invertebrates 17
5. ENVIRONMENTAL LEVELS AND HUMAN
EXPOSURE 20
5.1 Environmental levels 20
5.1.1 Air 20
5.1.2 Water 21
5.1.3 Soil 22
5.1.4 Fruit, vegetables and food 22
5.1.5 Milk 24
5.1.6 Meat and fat 24
5.2 General population exposure 25
5.3 Occupational exposure 26
6. KINETICS AND METABOLISM 29
6.1 Absorption, distribution and excretion 29
6.1.1 Oral administration 29
6.1.1.1 Rats 29
6.1.1.2 Guinea pigs 30
6.1.1.3 Dogs 30
iv ¦¦
6.1.1.4 Goats 31
6.1.1.5 Cow 31
6.1.1.6 Hens 31
6.1.2 Dermal application 32
6.1.2.1 Rats 32
6.1.2.2 Sheep 33
6.1.2.3 Humans 33
6.1.3 Other routes 33
6.1.3.1 Intrapentoncal administration 33
6.1.3.2 Subcutaneous administration 34
6.1.3.3 Intravenous administration 34
6.2 Metabolism 35
6.2.1 n vivo metabolic transformations 37
6.2.1.1 Mice 37
6.2.1.2 Rats 38
6.2.1.3 Dogs 38
6.2.1.4 Sheep 38
6.2.1.5 Goats 39
6.2.1.6 Hens 39
6.2.2 In vitro metabolic transformations 40
6.3 Metabolic aspects of diazinon toxicity 41
7. EFFECTS ON LABORATORY MAMMALS AND
IN VITRO TEST SYSTEMS 43
7.1 Single exposure 43
7.1.1 Oral 43
7.1.2 Dermal 47
7.1.3 Inhalation 48
7.1.4 Intrapentoneal 48
7.2 Short term exposure 49
7.2.1 Oral 49
7.2.1.1 Rats 49
7.2.1.2 Dogs 52
7.2.1.3 Pigs 52
7.2.2 Inhalation 52
7.2.3 Dermal 53
7.2.3.1 Rabbits 53
7.3 Long term exposure 54
7.3.1 Rats 54
7.3.2 Dogs 55
i 7.3.3 Rhesus monkeys 56
:
I
I V
EHC 198: Diazinon
7.4 Skin and eye irritation; sensitization 56
7.4.1 Primary skin irritation 56
7.4.2 Primary eye irritation 57
7.4.3 Skin sensitization 57
7.5 Reproduction, embryotoxicity and teratogenicity 57
7.5.1 Reproduction 57
7.5.1.1 Rat 57
7.5.1.2 Cattle 58
7.5.2 Embryotoxicity and teratogenicity 58
7.5.2.1 Mice 58
7.5.2.2 Rats 59
7.5.2.3 Hamsters 60
7.5.2.4 Rabbits 61
7.5.2.5 Chicken 61
7.6 Mutagenicity and related end points 61
7.7 Carcinogenicity 64
7.7.1 Mice 64
7.7.2 Rats 65
7.8 Special studies 66
7.8.1 Neurotoxicity 66
7.8.2 Effects on enzymes and transmitters 68
7.8.3 Effects on the immune system 69
7.8.4 Effect on pancreas 69
7.9 Factors that modify toxicity; toxicity of metabolites 70
7.9.1 Metabolic enzymes 70
7.9.2 Antidotes 70
7.9.3 Potentiation 71
8. EFFECTS ON HUMANS 72
8.1 Exposure of the general population 72
8.1.1 Acute toxicity, poisoning incidents 72
8.1.1.1 Acute pancreatitis 72
8.1.1.2 Intermediate syndrome 73
8.1.1.3 Unusual case reports 73
8.1.2 Controlled human studies 74
8.2 Occupational exposure 75
8.2.1 Acute poisoning 75
8.2.2 Effect of short term and long term
exposure 76
vi
9. EFFECTS ON OTHER ORGANISMS IN THE
LABORATORY AND FIELD 78
9.1 Microorganisms 78
9.2 Aquatic invertebrates 79
9.3 Fish 81
9.4 Effects in mesocosms and the field 85
9.5 Terrestrial invertebrates 86
9.6 Birds 87
9.6.1 Field studies 90
10. EVALUATION OF HUMAN HEALTH RISK AND
EFFECTS ON THE ENVIRONMENT 92
10.1 Evaluation of human health risk 92
10.2 Evaluation for effects on the environment 92
10.2.1 Aquatic organisms 93
10.2.1.1 Acute risk 93
10.2.1.2 Chronic risk 95
10.2.2 Terrestrial organisms 95
10.2.2.1 Birds 95
10.2.2.2 Mammals 98
10.2.2.3 Bees 100
10.2.2.4 Earthworms 101
11. CONCLUSIONS AND RECOMMENDATIONS FOR
PROTECTION OF HUMAN HEALTH AND THE
ENVIRONMENT 102
11.1 Conclusions 102
11.2 Recommendations for protection of human health
and the environment 102
11.2.1 Recommendation on regulation of
compound 102
11.2.1.1 Transport and storage 103
11.2.1.2 Handling 103
11.2.1.3 Disposal 103
11.2.1.4 Selection, training and medical
supervision of workers 103
11.2.1.5 Labelling 104
11.2.1.6 Residues in food 104
EHC 198: Dlazinon
11.2.2 Prevention of poisoning in man and
emergency aid 104
11.2.2.1 Manufacture and formulation 104
11.2.2.2 Mixers and applicators 104
11.2.2.3 Other associated workers 104
11.2.2.4 Other populations likely to
be affected 105
11.2.3 Entry into treated areas 105
11.2.4 Emergency aid 105
11.2.5 Surveillance test 105
12. FURTHER RESEARCH 106
13. PREVIOUS EVALUATIONS BY INTERNATIONAL
BODIES 107
REFERENCES 108
RESUME ET EVALUATIONS 129
RESUMEN Y EVALUACIONES 135
viii
|
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| dewey-full | 615.9 |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| discipline | Medizin |
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| indexdate | 2024-07-09T18:22:11Z |
| institution | BVB |
| isbn | 9241571985 |
| language | English |
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| physical | XX, 140 S. |
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| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spelling | Barabás, K. Verfasser aut Diazinon prepared by K. Barabás 1. draft Geneva World Health Organization 1998 XX, 140 S. txt rdacontent n rdamedia nc rdacarrier Environmental health criteria 198 Arbeidshygiëne gtt Blootstelling gtt Diazinon - Aspect de l'environnement Diazinon - Effets physiologiques Diazinon - Sécurité - Mesures Diazinon - Toxicologie Diazinon gtt Gezondheidseffecten gtt Toxiciteit gtt Diazinon Environmental Exposure Environmental health Insecticides Toxicology Insecticides adverse effects Organophosphorus compounds Toxicology Organothiophosphorus Compounds Umweltbelastung (DE-588)4061619-8 gnd rswk-swf Diazinon (DE-588)4313461-0 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Diazinon (DE-588)4313461-0 s Toxikologie (DE-588)4060538-3 s DE-604 Umweltbelastung (DE-588)4061619-8 s Environmental health criteria 198 (DE-604)BV000011459 198 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008214127&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Barabás, K. Diazinon Environmental health criteria Arbeidshygiëne gtt Blootstelling gtt Diazinon - Aspect de l'environnement Diazinon - Effets physiologiques Diazinon - Sécurité - Mesures Diazinon - Toxicologie Diazinon gtt Gezondheidseffecten gtt Toxiciteit gtt Diazinon Environmental Exposure Environmental health Insecticides Toxicology Insecticides adverse effects Organophosphorus compounds Toxicology Organothiophosphorus Compounds Umweltbelastung (DE-588)4061619-8 gnd Diazinon (DE-588)4313461-0 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4061619-8 (DE-588)4313461-0 (DE-588)4060538-3 |
| title | Diazinon |
| title_auth | Diazinon |
| title_exact_search | Diazinon |
| title_full | Diazinon prepared by K. Barabás |
| title_fullStr | Diazinon prepared by K. Barabás |
| title_full_unstemmed | Diazinon prepared by K. Barabás |
| title_short | Diazinon |
| title_sort | diazinon |
| topic | Arbeidshygiëne gtt Blootstelling gtt Diazinon - Aspect de l'environnement Diazinon - Effets physiologiques Diazinon - Sécurité - Mesures Diazinon - Toxicologie Diazinon gtt Gezondheidseffecten gtt Toxiciteit gtt Diazinon Environmental Exposure Environmental health Insecticides Toxicology Insecticides adverse effects Organophosphorus compounds Toxicology Organothiophosphorus Compounds Umweltbelastung (DE-588)4061619-8 gnd Diazinon (DE-588)4313461-0 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Arbeidshygiëne Blootstelling Diazinon - Aspect de l'environnement Diazinon - Effets physiologiques Diazinon - Sécurité - Mesures Diazinon - Toxicologie Diazinon Gezondheidseffecten Toxiciteit Environmental Exposure Environmental health Insecticides Toxicology Insecticides adverse effects Organophosphorus compounds Toxicology Organothiophosphorus Compounds Umweltbelastung Toxikologie |
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