Emulsions and nanosuspensions for the formulation of poorly soluble drugs: based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Stuttgart
Medpharm Scientific Publ.
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | 396 S. graph. Darst. |
| ISBN: | 3887630696 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV012121006 | ||
| 003 | DE-604 | ||
| 005 | 20050613 | ||
| 007 | t | ||
| 008 | 980818s1998 gw d||| |||| 10||| ger d | ||
| 020 | |a 3887630696 |9 3-88763-069-6 | ||
| 035 | |a (OCoLC)75896047 | ||
| 035 | |a (DE-599)BVBBV012121006 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a ger | |
| 044 | |a gw |c DE | ||
| 049 | |a DE-12 |a DE-703 |a DE-M49 |a DE-19 | ||
| 084 | |a VX 5650 |0 (DE-625)147802:253 |2 rvk | ||
| 084 | |a MED 960f |2 stub | ||
| 084 | |a CIT 175f |2 stub | ||
| 245 | 1 | 0 | |a Emulsions and nanosuspensions for the formulation of poorly soluble drugs |b based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables |c ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert) |
| 264 | 1 | |a Stuttgart |b Medpharm Scientific Publ. |c 1998 | |
| 300 | |a 396 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Emulsion |0 (DE-588)4014626-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Öl-in-Wasser-Emulsion |0 (DE-588)4285272-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Arzneistoffträger |0 (DE-588)4278196-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nanokapsel |0 (DE-588)4330956-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Arzneimittel |0 (DE-588)4003115-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Schwerlöslicher Stoff |0 (DE-588)4352869-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 1997 |z Berlin |2 gnd-content | |
| 689 | 0 | 0 | |a Emulsion |0 (DE-588)4014626-1 |D s |
| 689 | 0 | 1 | |a Arzneistoffträger |0 (DE-588)4278196-6 |D s |
| 689 | 0 | 2 | |a Schwerlöslicher Stoff |0 (DE-588)4352869-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Nanokapsel |0 (DE-588)4330956-2 |D s |
| 689 | 1 | 1 | |a Schwerlöslicher Stoff |0 (DE-588)4352869-7 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Arzneimittel |0 (DE-588)4003115-9 |D s |
| 689 | 2 | 1 | |a Schwerlöslicher Stoff |0 (DE-588)4352869-7 |D s |
| 689 | 2 | 2 | |a Arzneistoffträger |0 (DE-588)4278196-6 |D s |
| 689 | 2 | 3 | |a Öl-in-Wasser-Emulsion |0 (DE-588)4285272-9 |D s |
| 689 | 2 | |5 DE-604 | |
| 689 | 3 | 0 | |a Arzneimittel |0 (DE-588)4003115-9 |D s |
| 689 | 3 | 1 | |a Schwerlöslicher Stoff |0 (DE-588)4352869-7 |D s |
| 689 | 3 | 2 | |a Arzneistoffträger |0 (DE-588)4278196-6 |D s |
| 689 | 3 | 3 | |a Nanokapsel |0 (DE-588)4330956-2 |D s |
| 689 | 3 | |5 DE-604 | |
| 700 | 1 | |a Müller, Rainer H. |e Sonstige |0 (DE-588)115493573 |4 oth | |
| 711 | 2 | |a CDC |n 3 |d 1997 |c Berlin |j Sonstige |0 (DE-588)2172191-9 |4 oth | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008208538&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-008208538 | ||
Datensatz im Suchindex
| _version_ | 1804126727633371136 |
|---|---|
| adam_text | EMULSIONS AND NANOSUSPENSIONS FOR THE FORMULATION OF POORLY SOLUBLE
DRUGS EDITED BY PROF. DR. RER. NAT. RAINER H. MUUER DEPARTMENT OF
PHARMACEUTICS, BIOPHARMACEUTICS AND BIOTECHNOLOGY FREE UNIVERSITY OF
BERLIN PROF. DR. RER. NAT. SIMON BENITA SCHOOL OF PHARMACY THE HEBREW
UNIVERSITY OF JERUSALEM BERNHARD H. L. BDHM DEPARTMENT OF PHARMACEUTICS,
BIOPHARMACEUTICS AND BIOTECHNOLOGY FREE UNIVERSITY OF BERLIN THE BOOK
CHAPTERS ARE BASED ON THE INVITED LECTURES AND COMMUNICATIONS PRESENTED
AT THE COLLOIDAL DRUG CARRIERS - CDC - 3RD EXPERT MEETING BERLIN
(GERMANY) 29-31 MAY 1997 (MAIN ORGANIZERS: PROF. DR. R. H. MIILLER, DR.
W. MEHNERT) 188 FIGURES AND 34 TABLES SCIENTIFIC PUBLISHERS STUTTGART
1998 TABLE OF CONTENTS PREFACE 1 INTRODUCTION 13 1 POORLY SOLUBLE DRUGS,
A CHALLENGE IN DRUG DELIVERY 15 PROF. DR. P. P. SPEISER, ETH-ZIIRICH 1.1
NOTION 15 1.2 PHARMACEUTICAL CONCEPTS 17 1.2.1 LIQUID COLLOIDAL
SOLUTIONS 17 1.2.2 SOLID DISPERSIONS 17 1.2.3 SOLVENT EVAPORATION 17
1.2.4 SOLVENT DEPOSITION 17 1.2.5 SOLID MATRIX INCORPORATION 17 1.2.6
DRUG INTERACTIONS 17 1.2.7 ADSORPTION AND INCLUSION 17 1.3 STABILIZATION
18 1.4 PHARMACOTECHNIQUES 18 1.4.1 OVERVIEW 18 1.4.1.1 SOLVATATION 18
1.4.1.2 MICRONIZATION 18 1.4.1.3 INSTANT EVAPORATION 18 1.4.1.4 DRUG
DEPOSITION 18 1.4.1.5 SOLID SOLUTIONS 18 1.4.1.6 COMPLEXATION 19 1.4.1.7
SOLID MINICARRIERS 19 1.4.1.8 LIQUID MINICARRIERS 19 1.4.2 SHORT
DESCRIPTION OF SOME PHARMACOTECHNIQUES 20 1.4.2.1 SOLUBILIZATION 20
1.4.2.2 MICRONIZATION 20 1.4.2.3 PRECIPITATION 21 1.4.2.4 MELTING AND
INSTANT COOLING 21 TABLE OF CONTENTS 1.4.2.5 INJECTION MOULDING 21
1.4.2.6 SPRAYING 21 1.4.2.7 LYOPHILIZATION 22 1.4.2.8 COMPLEXES 22
1.4.2.9 SOLID MINICARRIERS 23 1.4.2.10 VESICULAR MINICARRIERS 24 1.5
SUMMARY 26 1.6 REFERENCES 27 EMULSIONS 29 2 EMULSIONS AS DRUG CARRIERS -
POSSIBILITIES, LIMITATIONS AND FUTURE PERSPECTIVES 31 SHMUEL H. KLANG,
MARINA PARNAS AND SIMON BENITA, DEPARTMENT OF PHARMACEUTICS, SCHOOL OF
PHARMACY, THE HEBREW UNIVERSITY OF JERUSALEM 2.1 INTRODUCTION 31 2.2
POSSIBILITIES 33 2.2.1 EMULSIONS INTENDED FOR PARENTERAL ADMINISTRATION
33 2.2.1.1 CURRENT STATUS OF MARKETED EMULSIONS 33 2.2.1.2 EMULSIONS
UNDER CURRENT CLINICAL EVALUATION 37 2.2.1.3 MEDICATED EMULSIONS UNDER
PRECLINICAL EVALUATION 45 2.2.2 NON-PARENTERAL EMULSION FORMULATIONS 47
2.2.2.1 TOPICAL DELIVERY 48 2.2.2.2 ORAL DELIVERY 48 2.2.2.3 OCULAR
DELIVERY 49 2.3 LIMITATIONS 51 2.4 PERSPECTIVES 54 2.4.1
LONG-CIRCULATING EMULSIONS 54 2.4.2 POSITIVELY-CHARGED SUBMICRON
EMULSIONS 55 2.5 REFERENCES 60 3 MULTIPLE EMULSIONS IN COSMETICS 67 J.
NIELSEN, S.H. GOHLA, BEIERSDORF AG, HAMBURG 3.1 INTRODUCTION 67 3.2
HISTORY 67 3.3 MANUFACTURING METHODS AND CURRENT TECHNOLOGIES 69 TABLE
OF CONTENTS 3.3.1 TWO STEP TECHNOLOGY 69 3.3.2 ONE STEP TECHNOLOGY 71
3.3.2.1 GEL NETWORK DERIVED DROPLET FORMATION 71 3.3.2.2 DIRECT
EMULSIFICATION (,,OLEOSOME FORMATION) 71 3.3.2.3 FORMATION OF
INTERMEDIATE MULTIPLE DROPLETS DURING PHASE-INVERSION . 72 3.3.2.4
PARTIAL-PHASE SOLU-INVERSION TECHNOLOGY (PPS1T): 73 3.4 STABILITY
CONTROL AND CHARACTERIZATION OF MULTIPLE EMULSIONS 75 3.5 COSMETIC
APPLICATIONS 77 3.6 SUMMARY 77 3.7 LITERATURE 78 4 EMULSIONS IN FOOD
PRODUCTS: PREPARATION, STABILIZATION AND APPLICATIONS 79 WILLEM VAN
NIEUWENHUYZEN, ERIDANIA BEGHIN-SAY RESEARCH & DEVELOPMENT CENTRE,
CENTRAL SOYA/STERN LECITHIN, VILVOORDE, BELGIUM 4.1 INTRODUCTION 79 4.2
BASICS OF FOOD PRODUCTION 80 4.3 FOOD EMULSIFIERS 82 4.3.1 LECITHIN 83
4.3.1.1 PRODUCTION OF LECITHINS 84 AA PREPARATION AND FORMULATION OF
FOOD EMULSIONS 88 4.5 PRINCIPLES OF FOOD EMULSION STABILITY 90 4.5.1
EFFECT OF PHOSPHOLIPIDS 91 4.5.2 PHOSPHOLIPIDS IN NANOEMULSIONS 92 4.6
APPLICATIONS 93 4.6.1 MARGARINE / LOW FAT SPREADS 94 4.6.2 MAYONNAISE /
DRESSINGS 95 4.6.3 DAIRY INSTANT PRODUCTS 97 4.6.4 CHOCOLATE 97 4.6.5
FLAVOR / ANTIOXIDANT ENCAPSULATION 99 4.7 CONCLUSION 99 4.8 LITERATURE
99 5 DRUG RELEASE AND INTERFACIAL STRUCTURE IN EMULSIONS 101 C.
WASHINGTON, DEPARTMENT OF PHARMACEUTICAL SCIENCES, UNIVERSITY OF
NOTTINGHAM 5.1 INTRODUCTION 101 5.2 MEASUREMENT OF DRUG RELEASE 103
TABLE OF CONTENTS 5.3 SMALL-ANGLE NEUTRON SCATTERING FROM EMULSIONS 108
5.3.1 DATA ANALYSIS 110 5.3.2 EFFECT OF ELECTROLYTES 113 5.3.3 EFFECT OF
TEMPERATURE 115 5.4 CONCLUSIONS 116 5.5 ACKNOWLEDGEMENTS 116 5.6
REFERENCES 117 6 DISTRIBUTION AND METABOLISM OF EMULSIONS IN VIVO 119 M.
ADOLPH, KRANKENHAUSZWECKVERBAND, INSTITUT FUR ANASTHESIOLOGIE UND
OPERATIVE SPORTMEDIZIN, AUGSBURG, GERMANY 6.1 METABOLISM OF
TRIGLYCERIDE-RICH PARTICLES 119 6.2 METABOLISM OF PHOSPHOLIPID-RICH
PARTICLES 121 6.3 LIPID EMULSIONS AND RETICULOENDOTHELIAL SYSTEM
FUNCTION 122 6.4 HEPATIC COMPLICATIONS DURING LONG-TERM PARENTERAL
NUTRITION 123 6.5 LIPID EMULSIONS AND CELLULAR IMMUNITY 124 6.6
PEROXIDATION IN PARENTERAL NUTRITION 125 6.7 LIPID EMULSIONS AND DRUG
DELIVERY 126 6.8 CONCLUSION 128 6.9 REFERENCES 128 7 SAFETY AND
TOLERABILITY OF INTRAVENOUSLY ADMINISTERED PHOSPHOLIPIDS AND EMULSIONS
131 MICHAEL J. PARNHAM, PHARMACOLOGICAL INSTITUTE FOR THE NATURAL
SCIENCES, FRANKFURT 7.1 -INTRODUCTION 131 7.2 SAFETY OF PARENTERAL
PHOSPHOLIPIDS 133 7.3 INTERACTIONS OF PHOSPHOLIPIDS WITH TRANSPORTED
DRUG 134 7.4 SAFETY OF EMULSIONS 135 7.5 TOLERABILITY OF MIXED MICELLES
136 7.6 REDUCTION OFDRUGTOXICITY BY FORMULATION IN LIPID EMULSIONS 136
7.7 SPECIAL PATIENT CONSIDERATION 137 7.8 CONCLUSIONS 137 7.9 REFERENCES
138 TABLE OF CONTENTS NANOSUSPENSIONS 141 8 DISSOLUTION PROPERTIES OF
POORLY SOLUBLE DRUGS: THEORETICAL BACKGROUND AND POSSIBILITIES TO
IMPROVE THE DISSOLUTION BEHAVIOUR 143 CHRISTER NYSTROM, DEPARTMENT OF
PHARMACEUTICS, UPPSALA UNIVERSITY, SWEDEN 8.1 INTRODUCTION 143 8.2
DISSOLUTION THEORY AND ENHANCEMENT OF DISSOLUTION RATE 144 8.2.1
INCREASE IN SOLUBILITY 144 8.2.2 DECREASE IN EFFECTIVE DIFFUSIONAL
DISTANCE 144 8.2.3 INCREASE IN EFFECTIVE DISSOLUTION SURFACE AREA 145
8.3 FORMULATIONS FOR INSTANT DISSOLUTION OF PRACTICALLY INSOLUBLE DRUGS
145 8.3.1 ORDERED MIXTURES 145 8.3.2 SOLID DISPERSIONS 146 8.4
CONCLUSIONS 147 8.5 REFERENCES 147 9 NANOSUSPENSIONS 149 RAINER H.
MIILLER, BERNHARD H.L. BOHM, INSTITUTE OF PHARMACEUTICAL TECHNOLOGY,
FREE UNIVERSITY OF BERLIN 9.1 INTRODUCTION 149 9.2 PRODUCTION OF
NANOSUSPENSIONS 151 9.3 PROPERTIES OF NANOSUSPENSIONS 153 9.3.1 SIZE AND
WIDTH OF SIZE DISTRIBUTION OF BULK POPULATION 153 9.3.2 CONTENT OF
MICROPARTICLES IN NANOSUSPENSIONS 155 9.3.3 SATURATION SOLUBILITY 156
9.3.4 DISSOLUTION VELOCITY 158 9.3.5 ELECTRON MICROSCOPY OF
NANOSUSPENSIONS 160 9.3.6 STRUCTURE OF NANOSUSPENSIONS 161 9.3.7
PHYSICAL STABILITY OF AQUEOUS NANOSUSPENSIONS 162 9.3.8 LYOPHILIZATION
164 9.3.9 SPRAY DRYING OF NANOSUSPENSIONS . 166 9.4 LARGE SCALE
PRODUCTION OF NANOSUSPENSIONS 166 9.5 REGULATORY ASPECTS 170 K 9.6
NANOSUSPENSIONS VERSUS OTHER HIGHLY DISPERSED SYSTEMS 171 TABLE OF
CONTENTS 9.7 PERSPECTIVES 172 9.8 REFERENCES . 173 DISPERSION
TECHNIQUES 175 10 THE THEORY OF HIGH-PRESSURE HOMOGENIZATION 177
DIPL.-ING. S. JAHNKE, APV HOMOGENISER GMBH, LIIBECK 10.1 THE PRINCIPLE
OF HIGH-PRESSURE HOMOGENIZATION 177 10.2 THE HOW CONDITIONS IN THE
HOMOGENIZING VALVE 178 10.2.1 PRESSURE REDUCTION THROUGH FRICTION IN THE
HOMOGENIZING VALVE GAP 179 10.2.2 FRICTIONAL PRESSURE LOSS 181 10.2.3
TOTAL PRESSURE LOSS IN THE HOMOGENIZING VALVE 182 10.2.4 DESCRIPTION OF
THE PRESSURE COURSE IN THE HOMOGENIZING VALVE GAP 182 10.3 SPECIFIC
AMOUNT OF ENERGY AND TEMPERATURE LOAD 184 10.4 MECHANISMS CAUSING THE
COMMINUTION IN THE HOMOGENIZING VALVE .... 186 10.4.1 COMMINUTION IN THE
LAMINAR SHEAR FIELD 187 10.4.2 COMMINUTION IN THE TURBULENT SHEAR FIELD
188 10.4.3 CAVITATION 191 10.5 INFLUENCE OF IMPORTANT PRODUCT AND
PROCESS PARAMETERS 193 10.5.1 VISCOSITY OF THE DISPERSE PHASE 193 10.5.2
CONCENTRATION OF EMULSIFIER AGENT 194 10.5.3 EMULSIFIER SURFACE
OCCUPATION KINETICS AND OIL CONCENTRATION 195 10.5.4 PARTICLE SIZE OF
PREMIX 195 10.5.5 HOMOGENIZING PRESSURE AND NUMBER OF PASSES 196 10.5.6
INFLUENCE OF THE HOMOGENIZING TEMPERATURE 196 10.6 HOMOGENIZERS IN
PRACTICAL USE 197 10.6.1 DIVISION, CAPACITY RANGES 197 10.6.2
REQUIREMENTS FOR HIGH-PRESSURE HOMOGENIZERS FOR THE PRACTICAL USE IN
PHARMACEUTICAL PLANTS 198 10.6.3 FACTORS INFLUENCING THE SELECTION OF
HOMOGENIZING VALVES 199 10.7 SUMMARY , 199 10.8 LITERATURE 200 TABLE OF
CONTENTS 11 MANUFACTURE OF EMULSIONS BY MEANS OF HIGH-PRESSURE
HOMOGENIZATION: INFLUENCE OF HOMOGENIZATION PARAMETERS, OILS AND
SURFACTANTS 201 THOMAS BOCK, PETER KLEINEBUDDE AND BERND W. MIILLER,
BOEHRINGER INGELHEIM PHARMA KG, BIBERACH, GERMANY CHRISTIAN ALBRECHTS
UNIVERSITAT, KIEL, GERMANY 11.1 STUDY DESIGN 203 11.2 EMULSIONS
CONTAINING 20% SOYA OIL AND 1.5% LIPOID S75 205 11.2.1 EFFECT OF
HOMOGENIZATION PARAMETERS ON D50 VALUES 205 11.2.2 EFFECT OF
HOMOGENIZATION PARAMETERS ON D99 VALUES 209 11.2.3 EFFECT OF
HOMOGENIZATION PARAMETERS ON PCS RADII 213 11.2.4 SUMMARY OF RESULTS 215
11.3 EMULSIONS CONTAINING 10% SOYA OIL AND 1.5% LIPOID S75 218 11.4
EMULSIONS CONTAINING 10% SOYA OIL AND 0.75% LIPOID S75 220 11.5
COMPARISON OF RESULTS OBTAINED WITH EMULSIONS 222 11.5.1 SELECTION OF
HOMOGENIZATION CONDITIONS 222 11.5.2 HOMOGENIZATION AT 400 BAR / 26C
222 11.5.3 HOMOGENIZATION AT 800 BAR / 26C 224 11.5.4 HOMOGENIZATION AT
400 BAR / 46C 226 11.5.5 HOMOGENIZATION AT 800 BAR/46C 227 11.5.6
COMPARISON OF EMULSIONS MANUFACTURED AT OPTIMAL TEMPERATURES AND
PRESSURES 229 11.5.7 SUMMARY OF RESULTS 230 11.6 ROW DIAGRAM FOR
OPTIMISING THE MANUFACTURE OF EMULSIONS 232 11.7 REFERENCES 236 12
OPTICAL REFLECTANCE MEASUREMENT (ORM) - A NOVEL APPROACH FOR PARTICLE
SIZE MEASUREMENT ON HIGHLY CONCENTRATED DISPERSIONS 237 RUDOLF DANIELS,
ROLAND KARWOTH, DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, TU
BRAUNSCHWEIG, GERMANY MEBTECHNIK SCHWARTZ GMBH, DIISSELDORF, GERMANY
12.1 INTRODUCTION : 237 12.2 PRINCIPLE OF OPERATION 239 12.3 DATA
PROCESSING 242 12.4 RANGE OF PARTICLE SIZES AND RESOLUTION 246 12.5
EXPERIMENTAL ASPECTS 246 10 TABLE OF CONTENTS 12.5.1 SAMPLING
CONSIDERATIONS 246 12.5.2 CALIBRATION 247 12.5.3 REPRODUCIBILITY 247
12.5.4 INFLUENCE OF MEASURING TIME AND STIRRING SPEED 248 12.6
APPLICATIONS 249 12.6.1 PARTICLE SIZE MEASUREMENT ON HIGHLY CONCENTRATED
O/W EMULSIONS 249 12.6.2 INFLUENCE OF FORMULATION VARIABLES ON THE SIZE
DISTRIBUTION OF O/W EMULSIONS 253 12.7 CONCLUSIONS 255 12.8 REFERENCES
255 13 LARGE-SCALE PRODUCTION OF LIPOSOMES BY CONTINUOUS HIGH PRESSURE
EXTRUSION 257 A. SACHSE, SCHERING AG, BERLIN 13.1 INTRODUCTION 257 13.2
EXTRUSION OF LIPOSOME SUSPENSIONS 258 13.3 CONTINUOUS HIGH PRESSURE
EXTRUSION 261 13.4 CONCLUSIONS 264 13.5 REFERENCES 265 14 HIGH-PRESSURE
HOMOGENIZATION TECHNIQUES FOR THE PRODUCTION OF LIPOSOME DISPERSIONS:
POTENTIAL AND LIMITATIONS 267 MARTIN BRANDL, PHARMACEUTICAL TECHNOLOGY,
INSTITUTE OF PHARMACY OF THE ALBERT-LUDWIGS- UNIVERSITY FREIBURG,
GERMANY 14.T INTRODUCTION 267 14.1.1 LIPOSOME CHARACTERISTICS AND
POTENTIAL APPLICATIONS 267 14.1.1.1 SURVEY ON LIPOSOME PREPARATION
TECHNIQUES 269 14.2 LIPOSOME PREPARATION BY HIGH-PRESSURE HOMOGENIZATION
270 14.2.1 HOMOGENIZERS 270 14.2.2 WAYS OF USING HOMOGENIZERS FOR
LIPOSOME PREPARATION 271 14.2.3 CONTROLLING LIPOSOME SIZE AND
LAMELLARITY 272 14.2.3.1 REASONS FOR CONTROLLING LIPOSOME SIZE AND
LAMELLARITY 272 14.2.3.2 WHAT IS THE REAL SIZE OF HOMOGENIZED LIPOSOMES
273 14.2.3.3 INFLUENCE OF PROCESS VARIABLES PRETREATMENT, HOMOGENIZATION
PRESSURE, NUMBER OF CYCLES, I VALVE GEOMETRY AND TEMPERATURE 275 TABLE
OF CONTENTS 11 14.2.3.4 INFLUENCE OF PRODUCT VARIABLES LIPID COMPOSITION
AND CONCENTRATION 280 14.2.3.5 SECONDARY PARTICLE GROWTH 281 14.2.4
LOADING OF LIPOSOMES 282 14.2.4.1 ENCAPSULATION OF HYDROPHILIC MATERIALS
283 14.2.4.2 INCORPORATION OF AMPHIPHILIC AND LIPOPHILIC MATERIALS 285
14.2.4.3 CALORIMETRIC (DSC) METHOD FOR MONITORING HOMOGENEOUS
INTEGRATION OF SUBSTANCES INTO THE BILAYER 285 14.2.5 UNWANTED EFFECTS
286 14.2.5.1 DEGRADATION OF MATERIALS 286 14.2.5.2 EROSION OF THE
HOMOGENIZERS 286 14.2.5.3 PROBLEMS WITH HIGH LIPID CONCENTRATIONS, DEAD
SPACE AND LIPID LOSS 287 14.2.6 SHELF STABILITY 287 14.3 CONCLUSIONS AND
PROSPECTS 288 14.3.1 SUMMARY OF PRODUCT CHARACTERISTICS AND PROCESS
VARIABLES 288 14.3.2 PROS AND CONS USING HIGH-PRESSURE HOMOGENIZERS FOR
LIPOSOME PRODUCTION 288 14.3.3 POTENTIAL AND LIMITATIONS 289 14.3.4
OUTLOOKS 289 14.4 ACKNOWLEDGEMENTS 290 14.5 REFERENCES 291 14.6
ABBREVIATIONS 294 SHORT COMMUNICATIONS ON DELIVERY SYSTEMS 295 15
EMULSIONS 297 IN VIVO EVALUATION OF SUBMICRON EMULSIONS FORMULATED WITH
PILOCARPINE 298 CORRELATION OF STATISTICAL OPTIMIZATION 301 PRODUCTION
AND STABILITY OF LIPID PARENTERAL EMULSIONS 304
THIN-FILM-FT-IR-SPECTROSCOPY OF LECITHIN-STABILIZED O/W-EMULSIONS 307
CHARACTERIZATION OF A SOYA-OIL-EMULSION WITH AFFF 311 16 LIPID DELIVERY
SYSTEMS 315 PREPARATION AND CHARACTERIZATION OF COLLOIDAL 316 AN X-RAY
STUDY ON COLLOIDAL MONOGLYCERIDE-WATER DISPERSIONS 318 MULTIPLE MELTING
BEHAVIOR OF LIPID NANOPARTICLES 320 EFFECT OF THE PHYSICAL STATE OF
LIPID NANOPARTICLES ON INCORPORATED DRUGS 322 MECHANISM OF THE GEL
FORMATION 324 12 TABLE OF CONTENTS COLLOIDAL DRUG DISPERSIONS AS AN
ALTERNATIVE DELIVERY SYSTEM 326 SOLID LIPID NANOPARTICLES (SLN) IN
AQUEOUS DISPERSIONS 328 PRODUCTION OF SOLID LIPID NANOPARTICLES 330 IN
VITRO DEGRADATION ASSAY FOR SOLID LIPID NANOPARTICLES 334 STRUCTURE
INVESTIGATIONS OF ACICLOVIR SOLID LIPID NANOPARTICLES 338 DRUG
LOCALIZATION IN SOLID LIPID NANOPARTICLES 341 17 LIPOSOMAL FORMULATIONS
345 HIGHLY CONCENTRATED SEMISOLID PHOSPHOLIPID DISPERSIONS 346 BINDING
OF POSITIVELY CHARGED LIPOSOMES TO BACTERIA 350 INTERACTION BETWEEN DNA,
NUCLEIC ACID STAINS AND DIFFERENTLY CHARGED LIPIDS 353 CONDITIONING
EFFECT OF LECITHIN DISPERSIONS VERSUS LIPOSOMES ON HAIR 356 18
NANOSUSPENSIONS 359 HIGH PRESSURE HOMOGENIZATION AS A NOVEL TECHNIQUE
FOR THE PRODUCTION 360 19 VARIOUS DELIVERY SYSTEMS INCLUDING PRODUCTION
TECHNIQUES 363 EVALUATION OFPH-SENSITIVE NANOPARTICLES FOR ORAL DELIVERY
364 INCORPORATION OF OLIGONUCLEOTIDES IN POLY(D, L-LACTIC ACID)
NANOPARTICLES 367 STUDIES ON PHENIRAMINEMALEATE MICROPELLETS 370 HIGH
PRESSURE EQUIPMENT FOR PREPARATION OF NANOPARTICLES 373 20 INTERACTION
BETWEEN PARTICULATE SYSTEMS AND BODY PROTEINS 377 TWO-DIMENSIONAL
ELECTROPHORESIS AND N-TERMINAL MICROSEQUENCING 378 EX VIVO
INVESTIGATIONS INTO THE OPSONIZATION OF IRON OXIDE 382 ANALYSIS OF
PLASMA PROTEIN ADSORPTION ON COMMERCIAL EMULSIONS 385 INDEX 391
|
| any_adam_object | 1 |
| author_GND | (DE-588)115493573 |
| building | Verbundindex |
| bvnumber | BV012121006 |
| classification_rvk | VX 5650 |
| classification_tum | MED 960f CIT 175f |
| ctrlnum | (OCoLC)75896047 (DE-599)BVBBV012121006 |
| discipline | Chemie / Pharmazie Chemie-Ingenieurwesen Medizin |
| format | Conference Proceeding Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02796nam a2200625 c 4500</leader><controlfield tag="001">BV012121006</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20050613 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">980818s1998 gw d||| |||| 10||| ger d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3887630696</subfield><subfield code="9">3-88763-069-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)75896047</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV012121006</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-M49</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VX 5650</subfield><subfield code="0">(DE-625)147802:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">MED 960f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">CIT 175f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Emulsions and nanosuspensions for the formulation of poorly soluble drugs</subfield><subfield code="b">based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables</subfield><subfield code="c">ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Stuttgart</subfield><subfield code="b">Medpharm Scientific Publ.</subfield><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">396 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturangaben</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Emulsion</subfield><subfield code="0">(DE-588)4014626-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Öl-in-Wasser-Emulsion</subfield><subfield code="0">(DE-588)4285272-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Arzneistoffträger</subfield><subfield code="0">(DE-588)4278196-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Nanokapsel</subfield><subfield code="0">(DE-588)4330956-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Arzneimittel</subfield><subfield code="0">(DE-588)4003115-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Schwerlöslicher Stoff</subfield><subfield code="0">(DE-588)4352869-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)1071861417</subfield><subfield code="a">Konferenzschrift</subfield><subfield code="y">1997</subfield><subfield code="z">Berlin</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Emulsion</subfield><subfield code="0">(DE-588)4014626-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Arzneistoffträger</subfield><subfield code="0">(DE-588)4278196-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Schwerlöslicher Stoff</subfield><subfield code="0">(DE-588)4352869-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Nanokapsel</subfield><subfield code="0">(DE-588)4330956-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Schwerlöslicher Stoff</subfield><subfield code="0">(DE-588)4352869-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Arzneimittel</subfield><subfield code="0">(DE-588)4003115-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="1"><subfield code="a">Schwerlöslicher Stoff</subfield><subfield code="0">(DE-588)4352869-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="2"><subfield code="a">Arzneistoffträger</subfield><subfield code="0">(DE-588)4278196-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="3"><subfield code="a">Öl-in-Wasser-Emulsion</subfield><subfield code="0">(DE-588)4285272-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="3" ind2="0"><subfield code="a">Arzneimittel</subfield><subfield code="0">(DE-588)4003115-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2="1"><subfield code="a">Schwerlöslicher Stoff</subfield><subfield code="0">(DE-588)4352869-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2="2"><subfield code="a">Arzneistoffträger</subfield><subfield code="0">(DE-588)4278196-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2="3"><subfield code="a">Nanokapsel</subfield><subfield code="0">(DE-588)4330956-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="3" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Müller, Rainer H.</subfield><subfield code="e">Sonstige</subfield><subfield code="0">(DE-588)115493573</subfield><subfield code="4">oth</subfield></datafield><datafield tag="711" ind1="2" ind2=" "><subfield code="a">CDC</subfield><subfield code="n">3</subfield><subfield code="d">1997</subfield><subfield code="c">Berlin</subfield><subfield code="j">Sonstige</subfield><subfield code="0">(DE-588)2172191-9</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">GBV Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008208538&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-008208538</subfield></datafield></record></collection> |
| genre | (DE-588)1071861417 Konferenzschrift 1997 Berlin gnd-content |
| genre_facet | Konferenzschrift 1997 Berlin |
| id | DE-604.BV012121006 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:22:03Z |
| institution | BVB |
| institution_GND | (DE-588)2172191-9 |
| isbn | 3887630696 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008208538 |
| oclc_num | 75896047 |
| open_access_boolean | |
| owner | DE-12 DE-703 DE-M49 DE-BY-TUM DE-19 DE-BY-UBM |
| owner_facet | DE-12 DE-703 DE-M49 DE-BY-TUM DE-19 DE-BY-UBM |
| physical | 396 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Medpharm Scientific Publ. |
| record_format | marc |
| spelling | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert) Stuttgart Medpharm Scientific Publ. 1998 396 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Emulsion (DE-588)4014626-1 gnd rswk-swf Öl-in-Wasser-Emulsion (DE-588)4285272-9 gnd rswk-swf Arzneistoffträger (DE-588)4278196-6 gnd rswk-swf Nanokapsel (DE-588)4330956-2 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Schwerlöslicher Stoff (DE-588)4352869-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1997 Berlin gnd-content Emulsion (DE-588)4014626-1 s Arzneistoffträger (DE-588)4278196-6 s Schwerlöslicher Stoff (DE-588)4352869-7 s DE-604 Nanokapsel (DE-588)4330956-2 s Arzneimittel (DE-588)4003115-9 s Öl-in-Wasser-Emulsion (DE-588)4285272-9 s Müller, Rainer H. Sonstige (DE-588)115493573 oth CDC 3 1997 Berlin Sonstige (DE-588)2172191-9 oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008208538&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables Emulsion (DE-588)4014626-1 gnd Öl-in-Wasser-Emulsion (DE-588)4285272-9 gnd Arzneistoffträger (DE-588)4278196-6 gnd Nanokapsel (DE-588)4330956-2 gnd Arzneimittel (DE-588)4003115-9 gnd Schwerlöslicher Stoff (DE-588)4352869-7 gnd |
| subject_GND | (DE-588)4014626-1 (DE-588)4285272-9 (DE-588)4278196-6 (DE-588)4330956-2 (DE-588)4003115-9 (DE-588)4352869-7 (DE-588)1071861417 |
| title | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables |
| title_auth | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables |
| title_exact_search | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables |
| title_full | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert) |
| title_fullStr | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert) |
| title_full_unstemmed | Emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables ed. by Rainer H. Müller ... (Main organizers: R. H. Müller ; W. Mehnert) |
| title_short | Emulsions and nanosuspensions for the formulation of poorly soluble drugs |
| title_sort | emulsions and nanosuspensions for the formulation of poorly soluble drugs based on the invited lectures and communications presented at the colloidal drug carriers cdc 3rd expert meeting berlin germany 29 31 may 1997 34 tables |
| title_sub | based on the invited lectures and communications presented at the colloidal drug carriers - CDC - 3rd expert meeting, Berlin (Germany), 29 - 31 May 1997 ; 34 tables |
| topic | Emulsion (DE-588)4014626-1 gnd Öl-in-Wasser-Emulsion (DE-588)4285272-9 gnd Arzneistoffträger (DE-588)4278196-6 gnd Nanokapsel (DE-588)4330956-2 gnd Arzneimittel (DE-588)4003115-9 gnd Schwerlöslicher Stoff (DE-588)4352869-7 gnd |
| topic_facet | Emulsion Öl-in-Wasser-Emulsion Arzneistoffträger Nanokapsel Arzneimittel Schwerlöslicher Stoff Konferenzschrift 1997 Berlin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008208538&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mullerrainerh emulsionsandnanosuspensionsfortheformulationofpoorlysolubledrugsbasedontheinvitedlecturesandcommunicationspresentedatthecolloidaldrugcarrierscdc3rdexpertmeetingberlingermany2931may199734tables AT cdcberlin emulsionsandnanosuspensionsfortheformulationofpoorlysolubledrugsbasedontheinvitedlecturesandcommunicationspresentedatthecolloidaldrugcarrierscdc3rdexpertmeetingberlingermany2931may199734tables |