Handbook of the aging brain:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego, Calif. [u.a.]
Academic Press
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 263 S. Ill., graph. Darst. |
| ISBN: | 0127346104 |
Internformat
MARC
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| 245 | 1 | 0 | |a Handbook of the aging brain |c Eugenia Wang ... |
| 264 | 1 | |a San Diego, Calif. [u.a.] |b Academic Press |c 1998 | |
| 300 | |a XVIII, 263 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Alzheimer, Maladie d' |2 ram | |
| 650 | 7 | |a Cerveau - Vieillissement |2 ram | |
| 650 | 7 | |a Cognitieve processen |2 gtt | |
| 650 | 7 | |a Hersenen |2 gtt | |
| 650 | 4 | |a Sénescence | |
| 650 | 7 | |a Veroudering (biologie, psychologie) |2 gtt | |
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Alzheimer Disease | |
| 650 | 4 | |a Alzheimer's disease |x Physiological aspects | |
| 650 | 4 | |a Brain |x Aging | |
| 650 | 4 | |a Brain |x physiopathology | |
| 650 | 4 | |a Neurodegenerative Diseases |x etiology | |
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| 650 | 0 | 7 | |a Gehirn |0 (DE-588)4019752-9 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Gehirn |0 (DE-588)4019752-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Wang, Eugenia |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008176108 | ||
Datensatz im Suchindex
| _version_ | 1804126678302064640 |
|---|---|
| adam_text | Contents
Contributors xiii
Preface xvii
1
Normal and Abnormal Memory: Aging
and alzheimer s disease
Marilyn S. Albert
Age Related Changes in Memory 1
Age Related Changes in Brain Structure and Function 4
Memory Changes in Early Alzheimer s Disease 7
Changes in Brain Structure in Early Alzheimer s Disease 10
Conclusion 13
References 13
2
Stress, Glucocorticoids, and Hippocampal
Aging in Rat and Human
SONIA J. LUPIEN AND MICHAEL J. MEANEY
HPA Axis 20
Glucocorticoids and Aging 21
Consequences of Elevated Glucocorticoid Levels 23
v
VI Contents
Glucocorticoids and Hippocampal Electrophysiology 23
Glucocorticoids and Synaptic Plasticity Levels 25
Consequences of Elevated Glucocorticoid Levels: Neuronal Survival 26
Individual Differences in HPA Activity and Brain Aging 27
Glucocorticoids and Human Aging 30
Glucocorticoids and Age Related Neuropathology in Humans 31
Glucocorticoids and Human Cognition 32
HPA Function and Hippocampal Aging in Humans 35
Subgroups of Elderly Subjects with Regard to Patterns of Cortisol Secretion
over Years 35
Cognitive Deficits Related to Hippocampal Damage in Relation to
Subgroups 40
References 43
3
Spatial Cognition and Functional Alterations
of aged rat hippocampus
C. A. BARNES
Technical Advances in Single Cell Recording Studies 52
Do Old Rats Have Broader, Less Reliable Place Fields? 52
Effects of Cue and Task Demand Manipulations on Place Cell Firing Properties
of Young and Old Rats 54
Differences between Studies That Remain Unexplained 56
Spatial Selectivity: Interaction with Experience during a Recording
Session 57
Multistability of Place Cell Maps in Old Rats 59
Summary and Conclusions 62
References 63
4
Identification of Molecular and
Cellular Mechanisms of Learning and Memory:
The Impact of gene Targeting
Alcino J. Silva, Karl Peter Giese, and Paul W. Frankland I
LTP as a Cellular Mechanism for L M 68
Short Term Plasticity and Learning 71
Spiking and Learning 73
I
I Contents VII
I Future of Genetic Techniques 76
| Conclusions 78
j References 79
| 5
NORMAL AGING AND ALZHEIMER S DISEASE
BRADLEY T. HYMAN AND TERESA G6MEZ ISLA
Text 83
References 89
_6_
Transgenic Mouse Models with
Neurofilament Induced Pathologies
Jean Pierre Julien
Neurofilament Structure and Function 93
Perturbations of Neurofilament Metabolism in Neurodegenerative Diseases and
in Aging 94
Mouse Models with Neurofilament Pathologies 95
Interference of Axonal Transport by Disorganized Neurofilaments 98
NF H Mutations in Amyotrophic Lateral Sclerosis 100
A Link between Neurofilaments and Oxidative Stress? 100
Future Directions 101
| References 102
7
i Transgenic Models of Amyotrophic Lateral
i Sclerosis and Alzheimer s Disease
Philip C. Wong, David R. Borchelt, Michael K. Lee,
: Gopal Thinakaran, Sangram S. Sisodia, and Donald L. Price
? Transgenic Approaches 108
j Amyotrophic Lateral Sclerosis and Transgenic Mice with SOD 1
I Mutations 108
j Alzheimer s Disease and Transgenic Mice with APP or PS1 Mutations 111
Conclusions 115
References 116
VIII Contents
8
Toward a Genetic Analysis of Unusually
Successful Neural Aging
George m. martin
A Brief Primer of Evolutionary Biological Aspects of Relevant Gene
Action 126
Some Implications of the Evolutionary Biological Theory of Aging for Human
Neurobiology 128
Nature Nurture Interactions 130
Approaches to the Genetic Analysis of Unusually Well Preserved Cognitive
Function 131
Which Phenotypes Deserve Our Initial Attention? 131
Conclusions 133
Further Readings 133
References 134
9
The Role of the Presenilins in
Alzheimer s Disease
RUDOLPH E. TANZI ;
j
Presenilin Metabolism and Function 136 j
Presenilin Mutations and APP Metabolism 136 j
A Role for the Presenilins in Apoptosis 137 ;
Summary 138
References 139
to
Mechanisms of Neuron Death in
Neurodegenerative Diseases of the Elderly:
Role of the Lewy Body
John Q. trojanowski, James e. Galvin, M. luise Schmidt,
pang Hsien Tu, Takeshi iwatsubo, and Virginia m. y. Lee j
Morphological and Immunohistochemical Studies of LBs 144
Generation and Characterization of MAbs to Purified LBs 145
Contents IX
Insight into the Pathobiology of LBs from Transgenic Mice 146
Summary 147
References 148
1 1
mlcrotubule associated protein tau: biochemical
Modifications, Degradation, and Alzheimer s
Disease
1 SHU HUI YEN, PAR1MALA NACHARAJU, Ll WEN KO,
j AGNES KENESSEY, AND WAN KYNG LIU
I Phosphorylation 155
I Degradation of Tau 157
I Gly cation 163
) Summary 165
References 165
A Novel Gene in the armadillo Family
Interacts with Presenilin 1
kenneth s. kosik, carole ho, udaya llyange, cynthia lemere,
Miguel Medina, and Jianhlja Zhou
Discovery of 5 Catenin 175
References 177
13
Putative Links between
Some of the Key pathological Features
of the Alzheimer s Brain
Remi Quirion, Daniel Auld, Uwe Beffert, Judes Poirier,
and satyabrata kar
Cholinergic Deficits and Ap Peptides 182
Cholinergic Deficits and the ApoE4 Gene 190
X Contents
Possible Links between the ApoE4 Genotype and P Amyloid Peptides 194
Concluding Remarks 196
References 196
14
Unraveling the Controversy of Human
Prion Protein Diseases
Andrea leBlanc
Three Manners to Contract Prion Protein Diseases: Inheritance, Iatrogenic
Transmission, and Sporadic Manifestation 202
Clinical Features of Human Prion Protein Diseases 202
Pathological Features of Human Prion Protein Diseases 203
Molecular Biology of Prion Protein Disease 204
Biochemical Hallmarks of Human Prion Protein in Normal and Affected
Brains 206
Molecular Signature of Prion Protein Diseases 207
Functions of the Normal Prion Protein 208
Transmissibility Models for Prion Protein Diseases 210
Conclusions 214
References 214
Translational Control, Apoptosis, and j
THE AGING BRAIN i
Eugenia Wang
Cloning, Sequencing, and Analyzing Full Length Human, Rat, and Mouse EF ;
la and SI cDNA Clones and Rat SI Genomic Clones 223
Characterization of Tissue Specificity and Age Dependent Changes of SI
Expression 224
SI is Found in Neurons Only, Not in Astrocytes or Microglia 225
EF la/Sl Supergene Family 225
Multiple Functional Involvement of EF 1 a 226
General Principles for Translation Regulation 226
Apoptosis, Cell Cycle Traverse, and Cytoskeletal Organization 227
Apoptosis, Cell Cycle Traverse, Protein Translation, and Signal
Transduction 228
i
CONTENTS XI
Reentry to Cell Cycle Traverse, Apoptosis Susceptibility, and Resistance 228
Control of Long Lived Phenotypes and Neuronal Survival 229
Signal Transduction and Chaos Theory 230
Signal Transduction and Neuronal Network Function 232
Signal Transduction, Apoptosis, and Functional Impairment in Neurons 233
Signal Transduction and Translational Control 234
Translational Control and Neuronal Repair 236
Neuronal Functionality, Translational Control, and the Aging Brain s Revisiting
of Embryonic Gene Expression 237
Summary 237
References 238
16
( astrocyte senescence and the pathogenesis
| of Parkinson s Disease
f
i HYMAN M. SCHIPPER
i
I Parkinson s Disease 243
i Oxidative Stress Hypothesis of Parkinson s Disease 245
Iron Deposition in Parkinson s Disease 247
Astrocytes in Health and Disease 248
I Peroxidase Positive Subcortical Glial System 249
Peroxidase Positive Astrocytes in Primary Culture 250
; Subcellular Precursors of Peroxidase Positive Astroglial Inclusions 251
I Astrocyte Granule Biogenesis and the Cellular Stress Response 251
i Iron Sequestration in Aging Astroglia 252
Role of HO 1 in Brain Iron Deposition 253
Protoxin Bioactivation by Aging Astroglia 254
Pathological Neuronal Glial Interaction in Parkinson s Disease 255
Further Readings 257
Index 259
|
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| isbn | 0127346104 |
| language | English |
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| physical | XVIII, 263 S. Ill., graph. Darst. |
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| spelling | Handbook of the aging brain Eugenia Wang ... San Diego, Calif. [u.a.] Academic Press 1998 XVIII, 263 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Alzheimer, Maladie d' ram Cerveau - Vieillissement ram Cognitieve processen gtt Hersenen gtt Sénescence Veroudering (biologie, psychologie) gtt Aging Alzheimer Disease Alzheimer's disease Physiological aspects Brain Aging Brain physiopathology Neurodegenerative Diseases etiology Alter (DE-588)4001446-0 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf Alter (DE-588)4001446-0 s Gehirn (DE-588)4019752-9 s DE-604 Wang, Eugenia Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008176108&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of the aging brain Alzheimer, Maladie d' ram Cerveau - Vieillissement ram Cognitieve processen gtt Hersenen gtt Sénescence Veroudering (biologie, psychologie) gtt Aging Alzheimer Disease Alzheimer's disease Physiological aspects Brain Aging Brain physiopathology Neurodegenerative Diseases etiology Alter (DE-588)4001446-0 gnd Gehirn (DE-588)4019752-9 gnd |
| subject_GND | (DE-588)4001446-0 (DE-588)4019752-9 |
| title | Handbook of the aging brain |
| title_auth | Handbook of the aging brain |
| title_exact_search | Handbook of the aging brain |
| title_full | Handbook of the aging brain Eugenia Wang ... |
| title_fullStr | Handbook of the aging brain Eugenia Wang ... |
| title_full_unstemmed | Handbook of the aging brain Eugenia Wang ... |
| title_short | Handbook of the aging brain |
| title_sort | handbook of the aging brain |
| topic | Alzheimer, Maladie d' ram Cerveau - Vieillissement ram Cognitieve processen gtt Hersenen gtt Sénescence Veroudering (biologie, psychologie) gtt Aging Alzheimer Disease Alzheimer's disease Physiological aspects Brain Aging Brain physiopathology Neurodegenerative Diseases etiology Alter (DE-588)4001446-0 gnd Gehirn (DE-588)4019752-9 gnd |
| topic_facet | Alzheimer, Maladie d' Cerveau - Vieillissement Cognitieve processen Hersenen Sénescence Veroudering (biologie, psychologie) Aging Alzheimer Disease Alzheimer's disease Physiological aspects Brain Aging Brain physiopathology Neurodegenerative Diseases etiology Alter Gehirn |
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