Eicosanoids, Aspirin, and asthma:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
1998
|
| Schriftenreihe: | Lung biology in health and disease
114 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVII, 605 S. graph. Darst. |
| ISBN: | 0824701461 |
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| 650 | 2 | |a Acide acétylsalicylique - effets indésirables | |
| 650 | 7 | |a Aspirine - Effets secondaires |2 ram | |
| 650 | 7 | |a Aspirine - Immunologie |2 ram | |
| 650 | 2 | |a Asthme - Métabolisme | |
| 650 | 7 | |a Asthme - Physiopathologie |2 ram | |
| 650 | 2 | |a Asthme - induit chimiquement | |
| 650 | 7 | |a Asthme - Étiologie |2 ram | |
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| 650 | 4 | |a Aspirin |x Immunology | |
| 650 | 4 | |a Aspirin |x Side effects | |
| 650 | 4 | |a Aspirin |x adverse effects | |
| 650 | 4 | |a Asthma |x Etiology | |
| 650 | 4 | |a Asthma |x Pathophysiology | |
| 650 | 4 | |a Asthma |x chemically induced | |
| 650 | 4 | |a Asthma |x metabolism | |
| 650 | 4 | |a Cyclooxygenase Inhibitors |x adverse effects | |
| 650 | 4 | |a Eicosanoids |x Pathophysiology | |
| 650 | 4 | |a Eicosanoids |x metabolism | |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
Introduction Claude Lenfant Hi
Preface v
Contributors be
1. Mechanism of Action of Antiinflammatory Drugs 1
John R. Vane and Regina M. Botting
I. Synthesis of Prostaglandins 1
II. Inhibition of Prostaglandin Synthesis 1
III. Two Isoenzymes 3
IV. Physiological and Pathological Functions of COX 1
and COX 2 3
V. COX 2/COX 1 Inhibitory Ratios of NSAIDs 8
VI. Assessment of Selectivity 8
VII. Selective COX 2 Inhibitors 11
VIII. Conclusions 16
References 16
xvii
i
2. Pathways of Arachidonate Metabolism 25
John C. McGiff and Michael Balazy
I. Introduction 25
II. Cyclooxygenases 25
III. Lipoxygenases 26
IV. Eicosanoid Synthesis, Release, and Metabolism 28
V. Hormones and Phospholipases 33
VI. Prostanoids Affect Gene Transcription 35
VII. Prostaglandin Receptors 36
VIII. Endothelial Derived Hyperpolarizing Factor: An
Eicosanoid? 38
References 38
3. Cytochromes P450 and Arachidonic Acid Metabolism 45
Michael Balazy and John C. McGiff
I. Introduction 45
II. Characterization of CYP450 46
III. Metabolism of Eicosanoids by CYP450 51
IV. Metabolism of Arachidonic Acid by CYP450 56
V. Phospholipid Bound CYP450 Eicosanoids and
Potential Role in Signal Transduction 65
VI. Conclusions 68
References 68
4. Mechanisms of Isoprostane Biosynthesis in Humans 77
Paola Patrignani, Roberto Padovano, Maria Gina Sciulli,
Giovanna Santini, Maria Rosaria Panara, Maria Teresa
Rotondo, Giulia Renda, and Carlo Patrono
I. Introduction 77
II. Cyclooxygenase Dependent Formation of
8 epi PGF2a by Human Blood Cells 79
III. Conclusions 86
References 87
5. Intracellular Localization of Eicosanoid Forming Enzymes 91
Thomas G. Brock and Marc Peters Golden
I. Introduction 91
II. Researching Enzyme Localization 92
III. Enzyme Locales: Our Current Understanding 93
IV. The Nuclear Envelope as an Integrated Site of Action 99
V. Consequences of Nuclear Localization 101
VI. Unanswered Questions 103
References 104
6. Cyclooxygenase 2 Expression in Airway Cells 111
Peter J. Barnes, Maria G. Belvisi, Robert Newton,
and Jane A. Mitchell
I. Introduction m
II. Prostanoids in Airways H2
III. Induction of COX 2 in Airway Cells 114
IV. Regulation of COX 2 117
V. Relevance in Asthma 121
References 123
7. Cyclooxygenase Gene Expression and Regulation 129
Kenneth Kun yu Wu
129
I. Introduction rr
II. COX 1 Gene Expression 131
III. Up regulation of COX 1 Expression |32
IV. Induction of COX 2 Gene Expression 133
V. Pathophysiological Implications of COX Induction 137
VI. COX 1 and COX 2 Gene Deletion in Mice 138
VII. COX Overexpression by Gene Transfer 139
„ ., 140
References
8. NSAID InducedApoptosis: A New Therapeutic Activity
of Competitive Cyclooxygenase Inhibitors?
Daniel L. Simmons
. . 145
I. Introduction 148
II. The Role(s) of COXs in Apoptosis j^
References
9. The Three Dimensional Structure of Cydooxygenases 161
Daniel Picot
161
I. Introduction j^2
II. Structure Determination
III. The Structure of PGHS I and PGHS II 164
IV. Catalytic Mechanism 170
V. Structural Basis of the Mechanism of Inhibition
of the Cyclooxygenases 173
VI. Flurbiprofen 174
VII. Iodosuprofen 176
VIII. Indomethacin 178
IX. RS 104897 178
X. Aspirin 178
XL SC 558 180
XII. RS 57067 180
XIII. PGHS II Without Inhibitor 181
XIV. Conclusions 182
References 183
10. The Role of 5 Lipoxygenase Products in a Mouse Model of
Allergic Airway Inflammation 187
Colin D. Funk, Xin Sheng Chen, Charles G, Irvin,
Yuan Po Tu, and James R. Shelter
I. Introduction 187
II. Asthma, Airways Hyperresponsiveness, and
Leukotrienes 187
III. 5LO Products, B Lymphocytes, and the Immune
Response 191
IV. A Murine System of Antigen Driven
Hyperresponsiveness: Model Characterization 192
V. Diminished Airway Responsiveness and Eosinophilia
in 5LO Deficient Mice Using a Mouse Model of
Allergic Airway Inflammation 193
VI. Conclusions 195
References 198
11. Genetic Influences on Asthma 201
William O. C. M. Cookson
I. Introduction 201
II. Finding Genes 202
III. Genes Influencing Asthma 203
IV. HLA 206
V. The T Cell Receptor 208
VI. Whole Genome Screens for Atopy and Asthma 210
if
I
VII. Conclusions 210
References 211
12. Intrinsic Asthma 215
Leonardo M. Fabbri, Gaetano Caramori, Bianca Beghe,
and Cristina Mapp
I. Introduction 215
II. Classification of Asthma 216
III. Epidemiology of Intrinsic Asthma 217
IV. Pathogenesis and Pathology of Intrinsic Asthma 218
V. Conclusions 224
References 224
13. Viral Infection and Asthma: The Modulatory Role of
I Nitric Oxide on Prostaglandin H Synthase 231
1 Gert Folkerts and Frans P. Nijkamp
i
j I. Introduction 231
II. Overview of the Release and Interaction of NO on
j Prostaglandin H Synthase 232
III. Prostaglandin E2 as an Epithelium Derived Relaxing
Factor 235
IV. PGE2 in Animal Models of Airway
Hyperresponsiveness 236
V. NO as an Epithelium Derived Relaxing Factor 236
VI. NO and Virus Induced Airway Hyperresponsiveness 238
VII. Functional Effects of NO Acting on Prostaglandin H
Synthase 240
VIII. Hypothesis on the Interaction of NO on PGHS in
the Respiratory Airways 242
References 245
14. The Pharmacology of Prostaglandin E2: Actions in Human
Diseases Involving the Mast Cell 253
John A. Oates, JohnJ. Murray, David D. Hagaman,
James R. Shelter, Ryszard Dworski, L. Jackson Roberts II,
and Howard R. Knapp
I. Introduction 253
II. Pilot Study 254
III. Misoprostol Trial in Idiopathic Anaphylactoid Attacks 255
IV. Misoprostol Effect on Late Phase Allergic
Bronchoconstriction 255
V. Conclusion 256
References 257
15. Eicosanoids in the Pathogenesis of Exercise and
Allergen Induced Asthma 259
PaulM. O Byrne
I. Introduction 259
II. Exercise Induced Bronchoconstriction 260
III. Exercise Refractoriness 260
IV. Allergen Induced Airway Responses 261
V. Investigating the Role of a Mediator in Asthma 262
VI. Cysteinyl Leukotrienes and Exercise Bronchoconstriction 262
VII. Inhibitory Prostaglandins and Exercise
Refractoriness 264
VIII. Cysteinyl Leukotrienes and Allergen Responses 265
IX. Conclusions 268
References 268
16. Endotoxin Induced Acute Respiratory Distress Syndrome
in Nitric Oxide Deficient Rats 273
Pawel P. Wolkow, Ewa Janowska, Joanna B. Bartus,
Wojciech Uracz, and Ryszard J. GryglewsM
I. Introduction 273
II. Methods 274
III. Results 276
IV. Discussion 279
References 280
17. Eicosanoid Regulation by Glucocorticoids in Asthma 283
Ryszard Dworski
I. Introduction 283
II. Effects of GC on Eicosanoid Metabolism in Cells
Relevant to Asthma In Vitro 284
III. Eicosanoid Involvement in the Inflammatory
Responses in Asthma 286
IV. Regulation of AA Metabolism by GC in Asthmatics
In Vivo 287
J
V. Conclusion 292
References 292
: 18. Mechanisms of Aspirin Induced Asthma 299
Andrzej Szczeklik
I. Introduction 299
II. Clinical Presentation 299
III. Allergic Mechanism 301
IV. Platelet Mechanism 301
V. The Cydooxygenase Theory 301
VI. Involvement of Leukotrienes 302
VII. Release of Mediators at Site of the Reaction 304
VIII. PGE2 and the Switch in Eicosanoid Metabolism 305
IX. Aspirin Desensitization 307
X. Chronic Inflammation of Airways 308
XI. Concluding Remarks 309
References 309
19. Leukotrienes in Aspirin Sensitive Asthma 317
5. M. Shuaib Nasser and Tak H. Lee
I. History of Aspirin Induced Reactions 317
II. Clinical Presentation 318
III. Epidemiology 319
IV. Relevance of Anticyclooxygenase Activity 320
V. Cysteinyl Leukotriene Release in ASA 321
VI. Antileukotriene Drugs 323
VII. Aspirin Desensitization 326
VIII. Cellular Source of Cysteinyl Leukotrienes 328
IX. The Future 331
References 332
20. Mast Cell and Eosinophil Responses After Indomethacin
in Asthmatics Tolerant and Intolerant to Aspirin 337
Esther L. Langmack and Sally E. Wenzel
I. Introduction 337
II. The Eosinophil Response in AIA 338
HI. The Mast Cell Response in AIA 343
IV. The Role of Prostaglandins in AIA 344
V. Conclusions 347
References 348
i
21. Aspects of Mechanisms in Aspirin Intolerant Asthma 351
Barbro DahUn
I. Introduction 351
II. Bronchial Provocations for Diagnosis and Mechanistic
Studies 351
III. Plasma Levels of ASA and SA During Intolerance
Reactions 353
IV. Leukotrienes as Mediators of Aspirin Induced
Bronchoconstriction 355
V. Evidence for Mast Cell Activation During
Aspirin Induced Bronchoconstriction 357
VI. Leukotrienes as Mediators of Persistent Airway
Obstruction in Aspirin Intolerant Asthmatics 360
VII. Concluding Remarks 363
References 364
22. Aspirin Intolerant Asthma: New Insights from Bronchial
Mucosal Biopsies 371
Anthony P. Sampson
I. Introduction 371
II. Profile of Leukocytes in AIA Bronchial Biopsies 372
III. Expression of Cysteinyl LT Synthetic Pathway
Enzymes in AIA Bronchial Biopsies 374
IV. The Cellular Source of Cysteinyl LT Overproduction
in AIA 377
V. LTC4 Synthase Expression Correlates Uniquely with
Bronchial Responsiveness to Inhaled Lysine Aspirin 379
VI. Suppression of Cysteinyl LT Synthesis by Endogenous
PGE2 380
VII. Cytokine Regulation of Cysteinyl LT Production 382
VIII. A New Model of Aspirin Sensitive Asthma 383
References 384
23. Pharmacological Intervention in Generation of Leukotrienes
by Eosinophils 391
Klaus F. Rabe and Gordon Dent
I. Introduction 391
II. Eosinophils as a Source of Leukotrienes 391
III. Physiological Significance of Leukotriene Production
by Eosinophils 395
IV. Modulation of Eosinophil Leukotriene Production 400
V. Concluding Remarks 409
) References 409
24. Airway Ion Transport Mechanisms and Aspirin in Asthma 419
Sebastiano Bianco, Maria Robuschi, Andriano Vaghi,
and Piersante Sestini
I. Introduction 419
II. The Inhalation Challenge Test for Aspirin Induced
Asthma 419
III. Bronchial Obstructive Responses to Pyrazolone
Derivatives 421
IV. Bronchial Hypersensitivity to Hydrocortisone 423
V. Prevention of Aspirin Induced Bronchoconstriction
by Drugs Affecting Ion Transport Mechanisms 424
VI. Furosemide 427
VII. Chromones 429
VIII. Protective Activity of Furosemide and Aspirin like
Drugs 430
IX. Conclusion 432
References 432
! 25. Role of Autoantibodies Against Endothelial Cells in
Severe Asthma 439
Philippe Lassalle, Michel Joseph, and Andre Bernard Tonnel
I. Introduction 439
II. Autoimmune Features in Severe Asthma and More
Particularly AIA 441
III. Involvement of Antiendothelial Antibodies 442
IV. Conclusion 449
References 449
26. Clinical Course of Aspirin Induced Asthma: Results
ofAIANE 451
Ewa Nizankowska, Mariusz Duplaga, Graiyna Bochenek,
andAndrzej SczczekUk
I. The AIANE Project 451
,{ II. Software Tool Development 452
III. The AIANE Database Structure 452
References 470
27. Nasal Polyposis 473
Niels Mygind, Ronald Dahl, PerL. Larsen, Torben Lildholdt,
and Clous Bachert
I. Introduction 473
II. Occurrence and Prevalence 474
III. Etiology 474
IV. Anatomy and Histology 476
V. Pathogenesis: Immune Inflammation 479
VI. Clinical Presentation 484
VII. Diagnosis 485
VIII. Treatment 485
IX. Conclusions 487
References 488
28. The Nose in Aspirin Sensitive Asthma 493
Cesar Picado and Joaquim Mullol
I. Introduction 493
II. Nasal Polyps, Chronic Rinosinusitis, and
Aspirin Sensitive Asthma 493
III. Arachidonic Acid Metabolites in Nasal and Bronchial
Secretions in Aspirin Sensitive Patients 496
IV. Effects of Aspirin on the Release of Mast Cells and
Eosinophil Products in the Nose and Airways 498
V. Clinical Manifestations 499
VI. Diagnosis of Aspirin Sensitivity 499
VII. Treatment of Rhinosinusitis and Nasal Polyposis
in Aspirin Sensitive Patients 500
VIII. Summary 502
References 503
29. The Role of Glucocorticoids in the Modulation of
Eicosanoid Metabolism in Asthma 507
Isabelle Vachier, Pascal Chanez, Claude Chavis,
Jean Bousquet, and Philippe Godard
I. Introduction 507
II. Mechanisms of Glucocorticoid Action 508
•3
^^ i
III. Effects of Glucocorticoids on Arachidonic Acid
Metabolism In Vitro 512
IV. Inhibition of Eicosanoid Biosynthesis In Vivo 514
V. Conclusions 516
References 516
30. Desensitization in Aspirin Induced Asthma 523
Donald D. Stevenson
I. Introduction 523
II. ASA Desensitization Procedures 524
III. ASA Cross Sensitivity and Desensitization 526
IV. Treatment with ASA Desensitization 529
V. Pathogenesis of ASA Desensitization 532
References 535
Author Index 539
Subject Index 597
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV012064684 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:21:01Z |
| institution | BVB |
| isbn | 0824701461 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008166120 |
| oclc_num | 38312001 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XXVII, 605 S. graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Dekker |
| record_format | marc |
| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Eicosanoids, Aspirin, and asthma ed. by Andrzej Szczeklik ... New York [u.a.] Dekker 1998 XXVII, 605 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 114 Acetylsalicylsäure - Bronchialasthma - Aufsatzsammlung Acetylsalicylzuur gtt Acide acétylsalicylique - effets indésirables Aspirine - Effets secondaires ram Aspirine - Immunologie ram Asthme - Métabolisme Asthme - Physiopathologie ram Asthme - induit chimiquement Asthme - Étiologie ram Astma gtt Eicosanoide - Bronchialasthma - Aufsatzsammlung Eicosanoïde - Métabolisme Eicosanoïden gtt Inhibiteurs des cyclooxygénases - effets indésirables Éicosanoïque, Acide - Dérivés - Physiopathologie ram Aspirin Immunology Aspirin Side effects Aspirin adverse effects Asthma Etiology Asthma Pathophysiology Asthma chemically induced Asthma metabolism Cyclooxygenase Inhibitors adverse effects Eicosanoids Pathophysiology Eicosanoids metabolism Bronchialasthma (DE-588)4069674-1 gnd rswk-swf Prostaglandinsynthaseinhibitor (DE-588)4282737-1 gnd rswk-swf Acetylsalicylsäure (DE-588)4000351-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bronchialasthma (DE-588)4069674-1 s Prostaglandinsynthaseinhibitor (DE-588)4282737-1 s DE-604 Acetylsalicylsäure (DE-588)4000351-6 s Szczeklik, Andrzej 1938-2012 Sonstige (DE-588)133676420 oth Lung biology in health and disease 114 (DE-604)BV000008326 114 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008166120&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Eicosanoids, Aspirin, and asthma Lung biology in health and disease Acetylsalicylsäure - Bronchialasthma - Aufsatzsammlung Acetylsalicylzuur gtt Acide acétylsalicylique - effets indésirables Aspirine - Effets secondaires ram Aspirine - Immunologie ram Asthme - Métabolisme Asthme - Physiopathologie ram Asthme - induit chimiquement Asthme - Étiologie ram Astma gtt Eicosanoide - Bronchialasthma - Aufsatzsammlung Eicosanoïde - Métabolisme Eicosanoïden gtt Inhibiteurs des cyclooxygénases - effets indésirables Éicosanoïque, Acide - Dérivés - Physiopathologie ram Aspirin Immunology Aspirin Side effects Aspirin adverse effects Asthma Etiology Asthma Pathophysiology Asthma chemically induced Asthma metabolism Cyclooxygenase Inhibitors adverse effects Eicosanoids Pathophysiology Eicosanoids metabolism Bronchialasthma (DE-588)4069674-1 gnd Prostaglandinsynthaseinhibitor (DE-588)4282737-1 gnd Acetylsalicylsäure (DE-588)4000351-6 gnd |
| subject_GND | (DE-588)4069674-1 (DE-588)4282737-1 (DE-588)4000351-6 (DE-588)4143413-4 |
| title | Eicosanoids, Aspirin, and asthma |
| title_auth | Eicosanoids, Aspirin, and asthma |
| title_exact_search | Eicosanoids, Aspirin, and asthma |
| title_full | Eicosanoids, Aspirin, and asthma ed. by Andrzej Szczeklik ... |
| title_fullStr | Eicosanoids, Aspirin, and asthma ed. by Andrzej Szczeklik ... |
| title_full_unstemmed | Eicosanoids, Aspirin, and asthma ed. by Andrzej Szczeklik ... |
| title_short | Eicosanoids, Aspirin, and asthma |
| title_sort | eicosanoids aspirin and asthma |
| topic | Acetylsalicylsäure - Bronchialasthma - Aufsatzsammlung Acetylsalicylzuur gtt Acide acétylsalicylique - effets indésirables Aspirine - Effets secondaires ram Aspirine - Immunologie ram Asthme - Métabolisme Asthme - Physiopathologie ram Asthme - induit chimiquement Asthme - Étiologie ram Astma gtt Eicosanoide - Bronchialasthma - Aufsatzsammlung Eicosanoïde - Métabolisme Eicosanoïden gtt Inhibiteurs des cyclooxygénases - effets indésirables Éicosanoïque, Acide - Dérivés - Physiopathologie ram Aspirin Immunology Aspirin Side effects Aspirin adverse effects Asthma Etiology Asthma Pathophysiology Asthma chemically induced Asthma metabolism Cyclooxygenase Inhibitors adverse effects Eicosanoids Pathophysiology Eicosanoids metabolism Bronchialasthma (DE-588)4069674-1 gnd Prostaglandinsynthaseinhibitor (DE-588)4282737-1 gnd Acetylsalicylsäure (DE-588)4000351-6 gnd |
| topic_facet | Acetylsalicylsäure - Bronchialasthma - Aufsatzsammlung Acetylsalicylzuur Acide acétylsalicylique - effets indésirables Aspirine - Effets secondaires Aspirine - Immunologie Asthme - Métabolisme Asthme - Physiopathologie Asthme - induit chimiquement Asthme - Étiologie Astma Eicosanoide - Bronchialasthma - Aufsatzsammlung Eicosanoïde - Métabolisme Eicosanoïden Inhibiteurs des cyclooxygénases - effets indésirables Éicosanoïque, Acide - Dérivés - Physiopathologie Aspirin Immunology Aspirin Side effects Aspirin adverse effects Asthma Etiology Asthma Pathophysiology Asthma chemically induced Asthma metabolism Cyclooxygenase Inhibitors adverse effects Eicosanoids Pathophysiology Eicosanoids metabolism Bronchialasthma Prostaglandinsynthaseinhibitor Acetylsalicylsäure Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008166120&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT szczeklikandrzej eicosanoidsaspirinandasthma |