Non-invasive imaging of atherosclerosis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | German |
| Veröffentlicht: |
Boston [u.a.]
Kluwer
1998
|
| Schriftenreihe: | Developments in cardiovascular medicine
199 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 245 S. Ill., graph. Darst. |
| ISBN: | 0792380363 |
Internformat
MARC
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| 245 | 1 | 0 | |a Non-invasive imaging of atherosclerosis |c ed. by Michele Mercuri ... |
| 264 | 1 | |a Boston [u.a.] |b Kluwer |c 1998 | |
| 300 | |a XVI, 245 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Developments in cardiovascular medicine |v 199 | |
| 650 | 2 | |a Artériosclérose - Radiographie | |
| 650 | 7 | |a Atherosclerosis obliterans |2 gtt | |
| 650 | 7 | |a Beeldverwerkende diagnostiek |2 gtt | |
| 650 | 7 | |a Cholesterol |2 gtt | |
| 650 | 2 | |a Ultrasons | |
| 650 | 4 | |a Arteriosclerosis |x diagnosis | |
| 650 | 4 | |a Atherosclerosis |x Imaging | |
| 650 | 4 | |a Ultrasonography | |
| 650 | 0 | 7 | |a Arteriosklerose |0 (DE-588)4068866-5 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
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|---|---|
| adam_text | Table of Contents
Preface xi
List of Contributors xv
Section I. PATHOLOGY OF ATHEROSCLEROSIS 1
Section Editors: Hisham Bassiouny, M.D. and Seymour Glagov, M.D.,
University of Chicago
1. Carotid Atherosclerosis: From Induction to Complication 3
Hisham Bassiouny, M.D., Yasuhiro Sakaguchi, M.D. and Seymour Glagov, M.D.
I. Introduction 5
II. Pathogenesis of Carotid Atherosclerosis 5
III. Mechanical Determinants of Non Atherosclerotic Intimal Thickening 7
IV. Atherosclerotic Intimal Thickening 9
A. Stages of Atherosclerotic Lesions 10
B. Arterial Adaptive Response to Developing Plaque 12
C. Plaque Neoformation 14
V. Features Indicative of Manifest or Imminent Plaque Disruption 15
A. Chemical and Structural Composition of Critical Asymptomatic 16
and Symptomatic Carotid Stenoses
B. Spatial Distribution of Plaque Components in Relation to the Artery 18
Lumen
VI. Conclusion 22
2. The Role of Atherosclerotic Plaque Disruption and Thrombosis in Acute 27
Coronary Heart Disease
Juan Jose Badimon, Ph.D., Richard Gallo, M.D., Lina Badimon, Ph.D.,
James H. Chesebro, M.D. and Valentin Fuster, M.D., Ph.D.
I. Introduction 29
II. Hypothesis on the Origin of Atherosclerosis 29
III. Evolution of Atherosclerotic Lesions 31
A. The Early Lesion (Stary type I, II) 31
B. Mature Plaques (Stary Type III, IV) 32
C. The Vulnerable Plaques (Stary Type IV and V) 32
IV. Atherosclerotic Plaque Progression 33
A. Slow Plaque Progression 33
B. Rapid Plaque Progression 34
V. Plaque Composition and Instability 35
VI. Plaque Composition and Thrombogenicity 35
VII. Arterial Thrombosis: The Clinical Manifestations of Atherosclerosis 37
VIII. Prevention of Plaque Disruption 38
A. Plaque Stabilization 38
B. Trigger Reduction 40
vi
Section II. DETECTION AND MONITORING OF ATHEROSCLEROSIS 47
Section Editor: Michele Mercuri, Ph.D, Wake Forest University
3. Validity and Reproducibility of B Mode Ultrasound in Imaging Carotid 49
Intima Media Thickness
Michele Mercuri, M.D, Ph.D., Rong Tang, M.D., andM. Gene Bond, Ph.D.
I. Introduction 51
II. Rationale for Developing Non Invasive Vascular Imaging 51
HI. Definitions of Vascular Endpoints 52
IV. Validity 53
A. Animal Experimentations 53
B. The NIH Multicenter (US) Validation Study 54
C. The Baylor College of Medicine Study on Atherosclerosis 54
Progression
D. The Pignoli s Experiment 56
V. Quantitative Methods 58
VI. Reproducibility 60
VII. Summary 63
4. Endothelial Function and Non Invasive Detection and Quantification of
Braehial Artery Reactivity
Rong Tang, M.D., Michele Mercuri, M.D., Ph.D. andM. Gene Bond, Ph.D. 65
I. Endothelium dependent Vaso Relaxation, EDRF and NO 67
A. EDRF 67
B. Nitric Oxide and Its Physiology 67
1. NO Release 68
2. Shear Stress Induced Release of NO by the Endothelium 68
3. Cardiovascular Physiology of NO 68
II. Endothelial Dysfunction in Atherosclerosis 69
A. Mechanism underlying Endothelial Dysfunction in Atherosclerosis 69
1. Impaired NO Production 69
2. Shortened NO Half life 70
III. Detection and Quantification of Endothelial Dysfunction 70
A. Systemic Nature of Endothelial Dysfunction 71
B. Non Invasive Assessment of Braehial Artery Vasoreactivity 71
1. Vasodilation Test, Imaging and Data Acquisition 71
2. Reproducibility 74
C. Arterial Reactivity and Atherogenesis 75
1. Aging 75
2. Estrogens 76
3. Cigarette Smoking 76
4. Hypercholesterolemia and Risk Factor Interaction 77
5. Hypertension 78
6. Diabetes Mellitus 79
7. Evaluation of Therapeutic Effects 79
IV. Summary 81
vii
5. Quantitative B Mode Ultrasound Imaging in Observational Studies 87
MichielL. Bots, M.D., Ph.D. and Diederick Grobbee, M.D., Ph.D.
I. Introduction 89
II. Non Invasive Assessment of Atherosclerosis 90
III. Description of Major Observational Studies 91
A. Assessment of Intima Media Thickness 92
B. Near Wall and Far Wall 94
C. Quantifying Carotid Atherosclerosis Using Intima Media Thickness 94
IV. Main Findings of Population Based Studies 96
A. Cross sectional Results 96
B. Longitudinal Results 99
V. Conclusion 101
6. Interventional Clinical Trials on Carotid Atherosclerosis Progression 105
Michele Mercuri, M.D., Ph.D., Rong Tang, M.D. andM. Gene Bond, Ph.D.
I. Rationale for Interventional Clinical Trials 107
II. Endpoints for Controlled Clinical Trials of Atherosclerosis 109
III. Clinical Trials with Antihypertensive Drugs 112
IV. The Multicenter Isradipine/Diuretic Atherosclerosis Study 113
V. Clinical Trials on Patients with Elevated LDL cholesterol. 115
A. The Pravastatin, Lipid and Atherosclerosis in the Carotid Arteries 116
B. The Asymptomatic Carotid Artery Progression Study 117
C. The Kuopio Atherosclerotic Plaque Study 117
D. The Carotid Atherosclerosis Italian Ultrasound Study 118
VI. Other Ongoing Clinical Trials 119
A. The Verapamil Hypertension Atherosclerosis Study 120
B. The Perindopil Regression of Vascular Thickening European 120
Community Trial
C. European Lacidipine Study on Atherosclerosis 121
D. The Plaque Hypertension Lipid Lowering Italian Study 122
VII. Significance and Limitations of Interventional Clinical Trials 123
VIII. Summary 124
Section III. PERSPECTIVES IN ULTRASOUND IMAGING 127
Section Editor: David D. McPherson, M.D., Northwestern University Medical School
7. The Role of Mechanics in Vascular Biology 129
Krishnan Chandran, D.Sc. andMichaelJ. Vonesh, Ph.D.
I. Introduction: The Role of Mechanics in Vascular Biology 131
II. Mechanical Analysis of Vascular Segments 132
A. Anatomy of the Arterial Wall 133
B. Basic Definitions and Assumptions Used in Vascular Mechanics 135
C. Conventional Approaches to Describe the Vascular Mechanical 140
Behavior
1. Static Pressure, Thin Walled Cylinder Approach 140
2. Static Pressure, Thick Walled Cylinder Approach 141
3. Pulse Wave Velocity Approach 143
viii
4. Analytical Determination of Stress Strain (Constitutive) 143
Relationships
5. Parametric Techniques 144
6. Dynamic Analyses 145
7. Finite Element Analyses 146
III. Arterial Wall Properties in Aging and Disease 147
A. Effects of Aging 147
B. Effects of Atherosclerosis 148
C. Effects of Hypertension 150
IV. High Resolution Ultrasound And Potential Applications to Vascular 150
Mechanics
A. Transcutaneous Ultrasound 150
B. Intravascular Ultrasound Imaging 151
C. 3D Reconstruction of Vascular Ultrasound Images 154
D. Finite Element Analysis of 3D Vascular Structures 157
V. Summary 162
8. Quantitative Ultrasonic Tissue Characterization with Intravascular 169
and Transcutaneous Ultrasound
Samuel A. Wickline, M.D., James Miller, Ph.D., and Gregory Lanza, M.D., Ph.D.
I. Introduction: Quantitative Ultrasonic Tissue Characterization with 171
Intravascular Ultrasound
II Quantitative Tissue Characterization 171
A. Physiologic Vascular Structure 172
B. Aortic Aneurysms 176
C. Atherosclerosis 179
III. Tissue Characterization With Intravascular Ultrasound 181
IV. Clinical Use of Quantitative Tissue Characterization With 183
Intravascular Ultrasound
V. Tissue Characterization with Transcutaneous Ultrasound 185
9. The Image Processing Laboratory 189
David D. McPherson, M.D.
I. Introduction 191
II. Basic Concepts of Image Processing 191
A. Image Digitization, Display and Storage 193
B. Processing of Images: Enhancement and Edge Detection 195
C. Variability within Vascular Ultrasound 199
III. Three Dimensional Vascular Reconstruction 201
A. Three Dimensional Reconstruction of Intravascular 202
Ultrasound Data
B. Three Dimensional Reconstruction of Transcutaneous B Mode 207
Ultrasound Data
IV. Use of Acoustic Properties to Characterize Plaque Components 211
ix
V. Novel Uses of Ultrasound 213
A. Liposomes and Other Targetable Agents for Acoustic 213
Plaque Enhancement
B. Forward Viewing Intravascular Ultrasound 214
C. Acoustic Emissions to Characterize Plaque Rupture 217
VI. Summary 218
10. Potential Uses for Ultrasound Imaging in Clinical Trials of Atheroma 221
Progression and Regression
Randal J. Thomas, M.D.
I. Introduction 223
II. Regression Trials: Where Have We Been? 223
HI. Regression Trials: Where Are We Headed? 225
A. Which Patients Will Be Studied? 225
B. Which Treatments Will Be Studied? 227
C. Which Outcomes Will Be Measured? 228
D. Which Vascular Bed(s) Will Be Studied? 229
E. Which Imaging Methods Will Be Used? 229
IV. Potential Role of Non Invasive Ultrasound Imaging in Regression 230
Trials
A. Arterial Wall Thickness 231
B. Plaque Characteristics 231
C. Endothelial Dysfunction 232
D. Blood Flow Characteristics 232
V. Summary 233
Index 237
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:20:36Z |
| institution | BVB |
| isbn | 0792380363 |
| language | German |
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| physical | XVI, 245 S. Ill., graph. Darst. |
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| series | Developments in cardiovascular medicine |
| series2 | Developments in cardiovascular medicine |
| spelling | Non-invasive imaging of atherosclerosis ed. by Michele Mercuri ... Boston [u.a.] Kluwer 1998 XVI, 245 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Developments in cardiovascular medicine 199 Artériosclérose - Radiographie Atherosclerosis obliterans gtt Beeldverwerkende diagnostiek gtt Cholesterol gtt Ultrasons Arteriosclerosis diagnosis Atherosclerosis Imaging Ultrasonography Arteriosklerose (DE-588)4068866-5 gnd rswk-swf Bildgebendes Verfahren (DE-588)4006617-4 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 s Bildgebendes Verfahren (DE-588)4006617-4 s DE-604 Mercuri, Michele Sonstige oth Developments in cardiovascular medicine 199 (DE-604)BV000000660 199 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008148306&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Non-invasive imaging of atherosclerosis Developments in cardiovascular medicine Artériosclérose - Radiographie Atherosclerosis obliterans gtt Beeldverwerkende diagnostiek gtt Cholesterol gtt Ultrasons Arteriosclerosis diagnosis Atherosclerosis Imaging Ultrasonography Arteriosklerose (DE-588)4068866-5 gnd Bildgebendes Verfahren (DE-588)4006617-4 gnd |
| subject_GND | (DE-588)4068866-5 (DE-588)4006617-4 |
| title | Non-invasive imaging of atherosclerosis |
| title_auth | Non-invasive imaging of atherosclerosis |
| title_exact_search | Non-invasive imaging of atherosclerosis |
| title_full | Non-invasive imaging of atherosclerosis ed. by Michele Mercuri ... |
| title_fullStr | Non-invasive imaging of atherosclerosis ed. by Michele Mercuri ... |
| title_full_unstemmed | Non-invasive imaging of atherosclerosis ed. by Michele Mercuri ... |
| title_short | Non-invasive imaging of atherosclerosis |
| title_sort | non invasive imaging of atherosclerosis |
| topic | Artériosclérose - Radiographie Atherosclerosis obliterans gtt Beeldverwerkende diagnostiek gtt Cholesterol gtt Ultrasons Arteriosclerosis diagnosis Atherosclerosis Imaging Ultrasonography Arteriosklerose (DE-588)4068866-5 gnd Bildgebendes Verfahren (DE-588)4006617-4 gnd |
| topic_facet | Artériosclérose - Radiographie Atherosclerosis obliterans Beeldverwerkende diagnostiek Cholesterol Ultrasons Arteriosclerosis diagnosis Atherosclerosis Imaging Ultrasonography Arteriosklerose Bildgebendes Verfahren |
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