Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
1997
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Text engl.. - Berlin, Freie Univ., Diss., 1997 |
| Beschreibung: | 107 Bl. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster |c vorgelegt von Urte Gayko |
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Datensatz im Suchindex
| _version_ | 1812453079381966848 |
|---|---|
| adam_text |
"DISSECTION OF TORSO RECEPTOR TYROSINE KINASE SIGNALING IN
DROSOPHILA MELANOGASTER "
PAGE
1. INTRODUCTION
1
DISCOVERING THE PATHWAY 3
BUILDING THE PATHWAY 4
THE ROLE OF RECEPTOR TYROSINE KINASES IN
DROSOPHILA 7
RTK STRUCTURE AND THEIR ROLE IN SIGNAL TRANSDUCTION 8
DER -
DROSOPHILA EPIDERMAL GROWTH FACTOR RECEPTOR 10
BREATHLESS 13
SEVENLESS 14
DROSOPHILA
INSULIN RECEPTOR 15
DERAILED 16
THE ELEMENTS IN THE SIGNAL TRANSDUCTION PATHWAYS OF RTKS IN
DROSOPHILA 16
OOGENESIS AND EMBRYOGENESIS IN DROSOPHILA 19
THE COORDINATES IN THE
DROSOPHILA EMBRYO 20
THE TORSO PATHWAY 22
THE TORSO LOSS OF FUNCTION (LOF) PHENOTYPE 22
THE TORSO GAIN OF FUNCTION (GOF) PHENOTYPE 24
EPISTASIS 25
TORSO-THE CENTRAL ELEMENT 26
UPSTREAM OF TORSO 28
1. TORSOLIKE 28
2. TRUNK, NASRAT, POLEHOLE 29
DOWNSTREAM OF TORSO: FROM THE MEMBRANE TO THE NUCLEUS 29
1. CORKSCREW (CSW) 31
2. DOS-DAUGHTER OF SEVENLESS 32
3. DOWNSTREAM OF RECEPTOR KINASES DRK/GRB2 33
4. SOS- SON OF SEVENLESS 34
5. RASL ' 34
6. RASGAP 35
7. GAPL 36
8. DRAF 36
9. KSR- KINASE SUPPRESSORS OF RAS 37
10.14-3-3 38
11. MEK/DSORL 40
12. MAPK/ROLLED 40
13. GRH- GRAINYHEAD 40
14. TAILLESS AND HUCKEBEIN 41
2. SUMMARY
43
3. RESULTS
48
FUNCTION OF AUTOPHOSPHORYLATION SITES ON TORSO
IN VIVO 48
IN VIVO
FUNCTION OF Y630 50
IN VIVO
FUNCTION OF TYROSINE Y644 50
IN VIVO
FUNCTION OF TYROSINE Y656 52
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/953504344
IN VIVO
FUNCTION OF TYROSINE
Y697 52
IN VIVO
FUNCTION OF TYROSINE
Y918 52
IDENTIFICATION OF TORSO AUTOPHOSPHORYLATION SITES
54
IDENTIFICATION OF PHOSPHOTYROSINE
Y630
AND
Y918 55
IDENTIFICATION OF PHOSPHOTYROSINE
Y767
AND
Y772 57
IDENTIFICATION OF PHOSPHOTYROSINE
Y698 59
IDENTIFICATION OF PHOSPHOTYROSINE
Y644 61
MAJOR VERSUS MINOR SITES OF AUTOPHOSPHORYLATION
62
IN VIVO
FUNCTION OF THE KINASE INSERT DOMAIN
63
IN VIVO
FUNCTION OF
Y767
AND
Y772 65
ACTIVATED TORSO RECEPTORS CONTAIN BINDING SITES FOR CORKSCREW AND
OTHER SH2 DOMAIN-CONTAINING PROTEINS 66
CORKSCREW IS A SUBSTRATE OF THE TOR RTK 68
TYROSINE PHOSPHORYLATION OF CORKSCREW IN
DROSOPHILA EMBRYOS
70
COMPENSATION OF POSITIVE AND NEGATIVE SIGNALING SITES IN
TORYY630+918FF 72
4. DISCUSSION
73
CSW ASSOCIATES WITH Y630 TO POSITIVELY TRANSDUCE THE TOR SIGNAL 73
THE ROLE OF Y918 AS A NEGATIVE EFFECTOR OF THE TOR SIGNAL 77
THE CONTRIBUTION OF Y644, Y657 AND Y698 TO FACILITATE POSITIVE SIGNALING
AT THE TOR RECEPTOR 79
TYROSINES Y767 AND Y772 ARE NECESSARY FOR PROPER PHOSPHORYLATION OF THE
TOR RECEPTOR 81
PLASTICITY IN SIGNALING 82
CONCLUDING REMARKS 82
FUTURE OUTLOOK 83
5. MATERIALS AND METHODS
85
ANTIBODIES 85
CONSTRUCTION OF VECTORS ENCODING MUTANT TOR PROTEINS 85
EXPRESSION OF RECOMBINANT TOR PROTEINS, PREPARATION OF CELLULAR
LYSATES AND IMMUNOPRECIPITATION ASSAYS. 85
IN VITRO
KINASE ASSAYS AND PHOSPHOAMINO ACID ANALYSIS 86
REVERSE-PHASE HPLC 87
EDMAN DEGRADATION 87
IN VITRO
ASSOCIATION ASSAYS 88
GENERATION OF TRANSGENIC FLIES 88
EXAMINATION OF EMBRYOS 89
6. ACKNOWLEDGMENTS
89
7. REFERENCE
90
8. LEBENSLAUF (CV)
102
9. ZUSAMMENFASSUNG (GERMAN SUMMARY)
103 |
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| id | DE-604.BV011997568 |
| illustrated | Illustrated |
| indexdate | 2024-10-09T16:05:50Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008119313 |
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| owner | DE-29T DE-12 DE-11 DE-188 |
| owner_facet | DE-29T DE-12 DE-11 DE-188 |
| physical | 107 Bl. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
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| spelling | Gayko, Urte 1971- Verfasser (DE-588)120121441 aut Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster vorgelegt von Urte Gayko 1997 107 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Text engl.. - Berlin, Freie Univ., Diss., 1997 Berlin, Freie Univ., Diss., 1997 Taufliege (DE-588)4078168-9 gnd rswk-swf Rezeptor-Tyrosinkinasen (DE-588)4342440-5 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Embryonalentwicklung (DE-588)4070792-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Taufliege (DE-588)4078168-9 s Embryonalentwicklung (DE-588)4070792-1 s Signaltransduktion (DE-588)4318717-1 s Rezeptor-Tyrosinkinasen (DE-588)4342440-5 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008119313&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gayko, Urte 1971- Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster Taufliege (DE-588)4078168-9 gnd Rezeptor-Tyrosinkinasen (DE-588)4342440-5 gnd Signaltransduktion (DE-588)4318717-1 gnd Embryonalentwicklung (DE-588)4070792-1 gnd |
| subject_GND | (DE-588)4078168-9 (DE-588)4342440-5 (DE-588)4318717-1 (DE-588)4070792-1 (DE-588)4113937-9 |
| title | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster |
| title_auth | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster |
| title_exact_search | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster |
| title_full | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster vorgelegt von Urte Gayko |
| title_fullStr | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster vorgelegt von Urte Gayko |
| title_full_unstemmed | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster vorgelegt von Urte Gayko |
| title_short | Untersuchungen des Signaltransduktionsweges an der Rezeptor-Tyrosin-Kinase Torso in Drosophila melanogaster |
| title_sort | untersuchungen des signaltransduktionsweges an der rezeptor tyrosin kinase torso in drosophila melanogaster |
| topic | Taufliege (DE-588)4078168-9 gnd Rezeptor-Tyrosinkinasen (DE-588)4342440-5 gnd Signaltransduktion (DE-588)4318717-1 gnd Embryonalentwicklung (DE-588)4070792-1 gnd |
| topic_facet | Taufliege Rezeptor-Tyrosinkinasen Signaltransduktion Embryonalentwicklung Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008119313&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gaykourte untersuchungendessignaltransduktionswegesanderrezeptortyrosinkinasetorsoindrosophilamelanogaster |