Mitochondrial DNA mutations in aging, disease and cancer:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 412 S. Ill., graph. Darst. |
| ISBN: | 3540643427 1570594864 |
Internformat
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| 650 | 4 | |a Mitochondrial DNA | |
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| 650 | 4 | |a Mutation | |
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Datensatz im Suchindex
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|---|---|
| adam_text |
I CONTENTS h
1. Introduction 1
Dongchon Kang, Koichiro Takeshige, Mutsuo Sekiguchi
and Keshav K. Singh
Mitochondria Are Essential for Energy Dependent
Function of the Cell 1
Discovery of Mitochondrial DNA
and Mitochondrial Diseases 1
Oxidative Stress: A Common Factor in Aging,
Disease and Cancer 2
Mitochondrial DNA Mutations and Aging 8
Mitochondrial DNA Mutations and Diseases 9
Mitochondria and Cancer 10
Therapy of Mitochondrial Diseases n
Conclusions n
2. Mitochondrial Structure, Function and Biogenesis 17
Alfreds. Lewin
Introduction 17
Mitochondrial Structure 18
Mitochondrial Function 23
Mitochondrial Biogenesis 28
Future Prospects 33
3. The Mitochondrial Genetic System 43
Howard T. Jacobs and Ian J. Holt
Introduction 43
The Mitochondrial Genome 43
Maintenance of Mitochondrial DNA 51
Mitochondrial Assembly and the MGS 67
Signaling and Integration in Mitochondrial Biogenesis 69
Conclusions 71
4. Inheritance of Mitochondrial Mutations 85
C. William Birky, Jr.
Why We Need to Understand the Inheritance
and Population Genetics of Mitochondria 85
Intracellular Population of Mitochondrial Genes 85
Maternal Inheritance 87
Random Drift of Gene Frequencies 87
Evidence for Relaxed Replication and Partitioning 90
A Simple Mathematical Model of the Inheritance
of Neutral Mitochondrial Mutations 91
Non Neutral Mitochondrial Genetics 93
Data and Theory Needed to Improve Our Understanding
of Human Mitochondrial Genetics 96
5. Mitochondrial DNA Replication 101
Kylie F. Keshav and Shorten Yoshida
Introduction 101
H Strand Synthesis 102
L Strand Synthesis 105
Enzymes Involved in Mitochondrial DNA Replication 106
Inhibitors of Mitochondrial DNA Replication 108
Future Trends 109
6. Genetic Integrity of the Mitochondrial Genome 115
Lene Juel Rasmussen and Keshav K. Singh
Introduction 115
Factors Contributing to Mitochondrial
Genome Instability 115
Consequences of Mitochondrial Genome Instability 116
Types of DNA Repair 118
DNA Repair in Mitochondria 121
Conclusions 122
7. Modeling Mitochondrial DNA Mutations 129
T.B.L. Kirkwood and A. Kowald
Why Model Mitochondrial Mutations? 129
Modeling mtDNA Mutations 130
"Defective Organelle" Model 131
"Network Theory" of Aging 134
Mitochondrial DNA Damage and Cancer 139
Mitochondrial Mutations in Plants 140
Conclusion 142
8. Mitochondrial Regulation of Apoptosis H7
Patrice X. Petit and Guido Kroemer
Introduction 147
Alterations of Mitochondrial Functions
as Early Event of Apoptosis 148
Modulation of Mitochondrial Permeability Transition
Decides Cell Fate 153
Bcl 2 as an Endogenous Regulator
of Permeability Transition 156
Bcl XL (Bcl 2) and Hypothetical Pore Regulation 157
Conclusions and Prospects 158
9. Characteristics of Mitochondrial DNA Diseases 167
Carlos T. Moraes
Introduction 167
mtDNA Rearrangements 167
Point Mutations of mtDNA 170
Alterations of mtDNA Associated
with Mendelian Inheritance 175
Clinical Considerations 176
10. Nuclear Defects Affecting Mitochondrial Function 185
Brian H. Robinson
Introduction 185
Principles of Energy Metabolism 185
Protein Composition of the Mitochondrial
Respiratory Chain 186
Symptoms Typical of Defects in Energy Metabolism 186
Defects Located in Mitochondrial DNA 187
Mutations in Protein Coding mtDNA Sequences 188
Mutations in RNA Coding Sequences 189
Defects Encoded in the Nucleus 190
Differential Diagnosis of Energy Metabolism Defects 197
11. Mitochondrial DNA Mutations in Aging 205
Phillip Nagley and Chunfang Zhang
Introduction 205
Mutations in Human mtDNA During Aging 206
Mutations in mtDNA of Other Organisms 225
Possible Functional Consequences of Somatic mtDNA
Mutations in Aging 227
The Vicious Circle Revisited 230
12. Mitochondrial DNA Mutations and Heart Disease 239
Takayuki Ozawa and Mika Hayakawa
Introduction 239
Point Mutational Genotype and Clinical Phenotype 248
Somatic Mutations 253
Conclusion and Perspective 256
13. Mitochondrial Dysfunction and Neurodegenerative
Diseases 265
Michael Lin and M. Flint Beat
Role of Mitochondria in General Mechanisms
of Cell Death 265
Mitochondrial Involvement
in Specific Neurodegenerative Diseases 271
Conclusion 278
14 Toxin Induced Mitochondrial Dysfunction
and Neurodegeneration 297
Mohammad I. Sabri
Introduction 297
Mitochondrial Dysfunction
and Neurodegenerative Disorders 300
Selected Environmental Toxins, Energy Dysfunction
and Neurodegeneration 300
Mitochondrial Dysfunction and Mechanisms
of Neurodegeneration 306
15. Perspectives on Mitochondria in Carcinogenesis 319
Brian Bandy and Allan J. Davison
Introduction 319
Roles of Mitochondria in Neoplastic Transformation 319
Mitochondria are Sensitive to Mutagens
and to Nongenotoxic Carcinogens 322
Mitochondrial Mutations
May Increase Oxidative Stress 323
Mitochondrial DNA Segments
Are Found in Nuclear Genomes 324
Oxidative Stress as a Common Factor in Aging,
Mitochondrial Injury and Carcinogenesis 325
Overview of Mitochondria and Oxidative Stress
in Transformation 325
16. The Mitochondrion as a Target
for Cancer Chemotherapy 337
Josephine S. Modica Napolitano
Historical Perspective 337
Recent Research 339
Directions for Future Research 341
17. Prohibitin: Mitochondrial Tumor Suppressor Protein 345
/. Keith McClung
Introduction 345
Evolutionary Conservation 346
Cell Growth Regulation 351
Tumor Suppression 353
Functional Activity of Prohibitin 3'UTRs 356
Conclusions 360
18. Abnormal Growth and Male Sterility Associated
with Mitochondrial DNA Rearrangements in Plants 365
Kathleen J. Newton and Susan J. Gabay Laughnan
Introduction 365
Abnormal Growth Mutations 367
Cytoplasmic Male Sterility 371
Concluding Remarks 376
19. Mitochondrial Disorder and Migraine 383
K.M.A. Welch and Charles Flippen
Introduction 383
Mechanisms of the Migraine Attack 385
Brain Hyperexcitability Between Migraine Attacks 386
Mitochondrial Disorder in Migraine 386
Conclusion 391
20. Gene Therapy of Mitochondrial DNA Diseases 395
Peter Seibel, Adrian Flierl, Corinna Bachmann
and Martina Seibel
Introduction 395
Somatic Gene Therapy Approaches
for mtDNA Diseases 395
Conclusion 400
Color Figures 403
Index 409 |
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| indexdate | 2024-08-14T00:49:42Z |
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| isbn | 3540643427 1570594864 |
| language | English |
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| spelling | Mitochondrial DNA mutations in aging, disease and cancer Keshav K. Singh (ed.) Berlin [u.a.] Springer 1998 412 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Aging genetics DNA, Mitochondrial Mitochondria genetics Mitochondria pathology Mitochondrial DNA Mitochondrial DNA Abnormalities Mitochondrial pathology Mutation Neoplasms genetics Tumors Genetics Mitochondriopathie (DE-588)4280150-3 gnd rswk-swf Mitochondriale DNS (DE-588)4202301-4 gnd rswk-swf Krankheit (DE-588)4032844-2 gnd rswk-swf Mutation (DE-588)4170883-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mitochondriale DNS (DE-588)4202301-4 s DE-604 Altern (DE-588)4068596-2 s Mutation (DE-588)4170883-0 s Krebs Medizin (DE-588)4073781-0 s Krankheit (DE-588)4032844-2 s Mitochondriopathie (DE-588)4280150-3 s Molekularbiologie (DE-588)4039983-7 s Singh, Keshav K. Sonstige (DE-588)120926415 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008116945&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mitochondrial DNA mutations in aging, disease and cancer Aging genetics DNA, Mitochondrial Mitochondria genetics Mitochondria pathology Mitochondrial DNA Mitochondrial DNA Abnormalities Mitochondrial pathology Mutation Neoplasms genetics Tumors Genetics Mitochondriopathie (DE-588)4280150-3 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Krankheit (DE-588)4032844-2 gnd Mutation (DE-588)4170883-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
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| title | Mitochondrial DNA mutations in aging, disease and cancer |
| title_auth | Mitochondrial DNA mutations in aging, disease and cancer |
| title_exact_search | Mitochondrial DNA mutations in aging, disease and cancer |
| title_full | Mitochondrial DNA mutations in aging, disease and cancer Keshav K. Singh (ed.) |
| title_fullStr | Mitochondrial DNA mutations in aging, disease and cancer Keshav K. Singh (ed.) |
| title_full_unstemmed | Mitochondrial DNA mutations in aging, disease and cancer Keshav K. Singh (ed.) |
| title_short | Mitochondrial DNA mutations in aging, disease and cancer |
| title_sort | mitochondrial dna mutations in aging disease and cancer |
| topic | Aging genetics DNA, Mitochondrial Mitochondria genetics Mitochondria pathology Mitochondrial DNA Mitochondrial DNA Abnormalities Mitochondrial pathology Mutation Neoplasms genetics Tumors Genetics Mitochondriopathie (DE-588)4280150-3 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Krankheit (DE-588)4032844-2 gnd Mutation (DE-588)4170883-0 gnd Krebs Medizin (DE-588)4073781-0 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Aging genetics DNA, Mitochondrial Mitochondria genetics Mitochondria pathology Mitochondrial DNA Mitochondrial DNA Abnormalities Mitochondrial pathology Mutation Neoplasms genetics Tumors Genetics Mitochondriopathie Mitochondriale DNS Krankheit Krebs Medizin Altern Molekularbiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008116945&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT singhkeshavk mitochondrialdnamutationsinagingdiseaseandcancer |