Pediatric critical care:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
St. Louis [u.a.]
Mosby
1998
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XXXII, 1438 S. Ill., graph. Darst. |
| ISBN: | 0815125364 |
Staff View
MARC
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| 245 | 1 | 0 | |a Pediatric critical care |c Bradley P. Fuhrman ; Jerry J. Zimmerman |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a St. Louis [u.a.] |b Mosby |c 1998 | |
| 300 | |a XXXII, 1438 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Intensive care |2 gtt | |
| 650 | 7 | |a Kinderen |2 gtt | |
| 650 | 4 | |a Kind | |
| 650 | 4 | |a Child | |
| 650 | 4 | |a Critical Care | |
| 650 | 4 | |a Infant | |
| 650 | 4 | |a Pediatric intensive care | |
| 700 | 1 | |a Fuhrman, Bradley P. |e Sonstige |4 oth | |
| 700 | 1 | |a Zimmerman, Jerry J. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008082093&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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| adam_text | CONTENTS
PART I The Patient and the Discipline
1 THE PEDIATRIC CRITICAL CARE PATIENT, 1
Jerry J. Zimmerman
2 WHAT IS A PEDIATRIC INTENSIVIST? 6
Bradley P. Fuhrman
The Pediatric Intensivist and the PICU, 6
The Pediatric Intensivist as the Answer, 7
3 ETHICS IN PEDIATRIC INTENSIVE CARE, 8
Joel E. Frader
Moral Theory, 8
Surrogate Decision Making: Parental Rights and Obligations, 12
The Pediatric ICU and Experimentation, 15
4 MALPRACTICE AND OTHER SORROWS, 18
Ellen Wright Clayton
Malpractice, 18
Confidentiality, 21
Organizational Concerns within the Hospital, 23
Efforts by the Courts to Reduce their Involvement in the
Intensive Care Unit, 23
5 SOCIOECONOMICS OF PEDIATRIC CRITICAL
CARE, 25
Thomas A. Massaro
Socioeconomic Status and Health Risk, 25
US Health Care System, 26
Physician Resources, 29
PICU Resources, 30
Summary, 30
6 ETHICAL ISSUES IN DEATH AND DYING, 32
Norman Post
Withholding and Withdrawing Life Support, 32
Definition of Death and Organ Retrieval, 36
7 THE FAMILY IS THE PATIENT, 38
Stephen M. Schexnayder, Patricia H.I. Bryant,
Debra H. Fiser
Coping, 38
Interventions, 38
Hostility, 39
The Dying Child, 40
Long Term Impact of Crisis on the Family, 41
Impact of Stress on the PICU Staff, 41
8 NONACCIDENTAL INJURY, 43
David L. Chadwick, Bradley M. Peterson
Overview and Approach to the Problem, 43
Reports and Testimony, 47
9 HISTORY OF PEDIATRIC INTENSIVE CARE
IN THE UNITED STATES, 49
Lucian K. DeNicola, I. David Todres
Summary, 52
10 ISSUES IN UNIT MANAGEMENT AND DESIGN, 54
Timothy S. Yeh
Characteristics of PICU Capabilities—System Development, 54
The Pediatric Intensive Care Unit, 56
PICU Organization, 57
Summary, 60
11 PEDIATRIC TRANSPORT, 62
Richard A. Orr, Karin A. McCloskey,
Shekhar T. Venkataraman
Interhospital Transport, 62
Intrahospital Transport, 67
Conclusion, 68
12 INVASIVE MEASUREMENTS EM THE PICU, 70
William H. Perloff
Role of Invasive Measurements, 70
Hemodynamic Monitoring, 70
Invasive Hemodynamic Monitoring Techniques, 81
Monitoring Respiratory Mechanics, 86
Intracranial Dynamics Monitoring, 89
Comment, 91
13 NONINVASIVE VITAL MONITORING
IN CHILDREN, 95
Michael F. Sweeney, Melanie S. Madsen, Kumar G. Belani,
David B. Swedlow
Pulse Oximetry, 95
Capnometry and Capnography, 98
Temperature Monitoring and Routine Temperature
Management, 101
Noninvasive Blood Pressure Measurement (NIBP), 103
Conclusion, 104
14 PEDIATRIC AIRWAY MANAGEMENT, 106
Ann E. Thompson
Anatomical Considerations, 106
Basic Airway Management, 106
Endotracheal Intubation, 109
Special Circumstances, 117
Alternative Airways, 121
15 PEDIATRIC VASCULAR ACCESS, 126
Richard H. Strauss
Epidemiology, 126
Physics of Flow Through a Tube, 126
Types of Vascular Access Devices, 126
Routes of Vascular Access, 129
16 DIAGNOSTIC AND THERAPEUTIC CENTESES, 140
Thomas B. Rice, Stephen P. Pontus, Jr.
Pericardiocentesis, 140
Thoracentesis, 143
Abdominal Paracentesis, 147
17 PREDICTION OF OUTCOME, 152
Murray M. Pollack
Development and Validation of Clinical Scores, 152
Intensive Care Uses of Scoring Systems, 154
18 RESEARCH IN PEDIATRIC CRITICAL CARE, 162
Randall C. Wetzel
Research Areas, 162
The Wellsprings of Research, 163
Doing Research, 166
Medical Research, 169
Statistics: A Word, 172
Research Funding, 175
Ethics in Research, 182
19 THE NURSE IN PEDIATRIC CRITICAL CARE, 187
Mary Fran Hazinski
Nurse Recruitment, 187
Staff Nurse Orientation, 187
Staff Nurse Retention, 193
Interdisciplinary Collaboration, Staff Development, and Quality
of Care, 194
Nursing Leadership, 196
Summary, 197
PART II Organ System Function
and Failure
Section A Circulation
20 STRUCTURE AND FUNCTION OF THE HEART, 200
Julien I.E. Hoffman
Contents xxiii
Anatomical Development and Structure, 200
Physiological Development and Function, 202
21 STRUCTURE AND FUNCTION OF THE REGIONAL
VASCULATURE, 222
Bradley P. Fuhrrnan
Collective Characteristics of the Peripheral Vasculature, 222
Common Characteristics of the Peripheral Vasculature, 225
Local Regulation of the Circulation, 225
Pulmonary Circulation, 226
Cerebral Circulation, 228
Coronary Circulation, 230
Intestinal Circulation, 231
Conflicting Needs of Regional Circulations, 232
22 OXYGEN DEMAND, DELIVERY,
AND CONSUMPTION, 235
John T. Fahey, George Lister
Determinants of O2 Supply, 235
Determinants of O2 Demands, 236
Response to Inadequate Do2, 238
Estimating Adequacy of O2 Delivery, 240
Current Controversies, 244
Therapeutic Implications and Clinical Usefulness, 246
Summary, 247
23 CARDIOPULMONARY INTERACTIONS, 250
Adelaida M. Miro, Michael R. Pinsky
Effects of Respiration on Cardiovascular Function, 250
Effects of Cardiovascular Function on Respiration, 253
Clinical Applications, 254
Summary, 259
24 DISORDERS OF THE CIRCULATION:
MYOCARDIAL DYSFUNCTION, 261
Thomas P. Graham, Jr.
Basic Concepts of Ventricular Function, 261
Basic Concepts of Diastolic Ventricular Function, 263
Assessment of Ventricular Function, 265
Treatment of Myocardial Dysfunction, 268
Summary, 270
25 DISORDERS OF CARDIAC RHYTHM, 272
Frank A. Fish, D. Woodrow Benson, Jr.
Classification of Dysrhythmias, 272
Approach to Diagnosis, 276
Treatment of Rhythm Disturbances, 279
Specific Dysrhythmias, 286
26 SHOCK STATES, 293
Mark S. McConnell, Ronald M. Perkin
Definition and Physiology, 293
Recognition and Assessment of the Shock State, 294
Treatment of Shock, 294
xxiv Contents
Multisystem Effects of Shock, 295
Functional Classification and Common Underlying Etiologies,
296
Hypovolemic Shock, 296
Cardiogenic Shock or Congestive Heart Failure, 298
Obstructive Shock, 301
Distributive Shock, 302
Septic Shock, 302
27 INFECTION OF THE HEART AND PERICARDIUM,
307
Michael D. Green, Edward L. Kaplan
Endocarditis, 307
Bacterial Infection of the Pericardium, 311
Bacterial Infection of the Myocardium, 312
Viral Myocarditis, 312
28 HYPERTENSION IN THE PICU, 314
Denise M. Goodman, Thomas P. Green
Definition of Terms, 314
Pathophysiology, 314
Measurement of Blood Pressure, 317
Evaluation, 317
Management, 318
Summary, 321
29 ASSESSMENT AND MONITORING
OF CARDIOVASCULAR FUNCTION, 323
Jon N. Meliones, Jennifer Li
Determinants of Ventricular Function, 323
Methods of Assessing and Monitoring Cardiovascular Function,
324
30 PHARMACOLOGY OF THE CARDIOVASCULAR
SYSTEM, 329
Daniel A. Notterman
Mechanisms of Response, 329
Sympathomimetic Amines, 331
Bipyradines, 342
Digitalis Glycosides, 343
Conclusion, 345
31 CARDIOPULMONARY BYPASS FOR REPAIR
OF CONGENITAL HEART DISEASE IN INFANTS
AND CHILDREN, 347
John E. Mayer, Jr.
Principles and Mechanics of Cardiopulmonary Bypass, 347
Myocardial Protection, 351
32 CRITICAL CARE AFTER SURGERY
FOR CONGENITAL CARDIAC DISEASE, 354
Michele C. Papo, Eliot R. Rosenkranz, Lynn J. Hernan,
Bradley P. Fuhrman
Surgical Treatment of Congenital Heart Defects, 354
Common Complications of Operations for CHD, 360
Issues in Critical Care After Pediatric Cardiac Operations, 362
33 ECHOCARDIOGRAPHY, 371
Joseph D. One, Daniel R. Pieroni, Jean Michel A. Roland,
Robert L. Gingell
Principles of Echocardiography, 371
Echocardiography in the ICU Setting, 372
Conclusions, 375
Section B Respiration
34 STRUCTURE OF THE RESPIRATORY SYSTEM, 377
Jacqueline J. Coalson
Upper Respiratory System, 377
Lower Respiratory System, 379
Pulmonary Circulation, 383
Pulmonary Lymphatics, 384
Diaphragm, 385
35 FUNCTION AND PHYSIOLOGY OF THE
RESPIRATORY SYSTEM, 386
Robert Katz
Upper Airway, 386
Lung, 387
Pulmonary Circulation, 393
Mechanics of Breathing, 393
Dynamic Properties of the Lung, 394
Distribution of Ventilation, 395
Control of Breathing, 395
Immune Function in the Lung, 397
Metabolic Function of the Vascular Endothelium, 398
36 VENTILATION PERFUSION INEQUALITY, 400
Howard Eigen, Jeffrey Macke
General Principles of V: Q Inequality, 400
Clinical Measures of V: Q Inequality, 402
Pulmonary Pathology and V:Q Inequality, 403
Therapeutic Considerations, 407
37 MECHANICAL DYSFUNCTION OF THE
RESPIRATORY SYSTEM, 409
J. Julio Perez Fontdn
Energy Expenditure in the Respiratory System, 409
Determinants of Respiratory Work, 409
Determinants of Respiratory Efficiency, 417
Conclusion, 420
38 ASSESSMENT AND MONITORING
OF RESPIRATORY FUNCTION, 422
Harris P. Baden, P. Pearl O Rourke
Physical Examination, 422
Radiography, 422
Evaluation of Gas Exchange, 423
Shunt, 424
Dead Space Ventilation: Estimation of Dead Space, 425
Pulmonary Function Tests, 426
Endoscopy, 427
Summary, 427
39 SPECIFIC DISEASES OF THE RESPIRATORY
SYSTEM: UPPER AIRWAY, 429
David Jardine
Initial Management, 429
Congenital Malformations, 430
Infectious Processes, 432
Trauma, 436
Angioedema, 438
Tracheostomy, 439
40 SPECIFIC DISEASES OF THE RESPIRATORY
SYSTEM: NEONATAL RESPIRATORY DISEASE, 442
James J. Cummings
Acute or Early Onset Respiratory Disorders, 442
Congenital Malformations of the Lung, 445
New Treatment Modalities for Acute Respiratory Failure, 449
Chronic Pulmonary Disease, 450
Nonpulmonary Conditions that Result in Respiratory Disease,
452
41 PULMONARY EDEMA AND ARDS, 457
James A. Royall
Fluid Flux in the Lung, 457
Permeability (Noncardiogenic) Pulmonary Edema and ARDS,
459
Special Causes of Pulmonary Edema, 468
42 LOWER AIRWAY DISEASE, 472
Veda L. Ackerman, Howard Eigen
Malformations of the Lower Airway, 472
Bronchospastic Disorders, 473
43 PHARMACOLOGY OF THE RESPIRATORY
SYSTEM, 477
Veda L. Ackerman, Dennis Gardner
Apnea, 477
Respiratory Muscle Pharmacotherapy, 478
Laryngotracheobronchitis, 478
Acute Asthma, 479
Bronchiolitis, 481
Bronchopulmonary Dysplasia, 482
Acute Lung Injury, 482
44 PNEUMONITIS AND INTERSTITIAL DISEASE, 485
Thomas B. Rice, Stephen P. Pontus, Jr.
Pathogenesis, 485
Pathophysiology, 485
Diagnosis, 486
Laboratory Diagnosis, 486
Bacterial Pneumonitis, 486
Viral Pneumonitis, 489
Fungal Pneumonitis, 494
Primary Pulmonary Fungi, 494
Opportunistic Pulmonary Mycoses, 497
Pneumocystis Carinii Pneumonia, 498
Chemical Pneumonitis, 500
Contents xxv
Idiopathic Interstitial Lung Disease, 503
Pediatric Pulmonary Hemorrhage, 503
Summary, 507
45 DISEASES OF PULMONARY CIRCULATION, 512
Sandra Suchomski, Frederick C. Morin, HI
Pulmonary Vasculature Development: Anatomical, 512
Pulmonary Vasculature Development: Functional, 514
Transition at Birth, 515
Etiologies of Persistent Pulmonary Hypertension in the
Newborn, 517
Diagnosis of PPHN, 519
Management of PPHN, 519
Pulmonary Vascular Disease After the Immediate Newborn
Period, 521
Pulmonary Vasodilation After the Immediate Newborn Period,
523
Pulmonary Hypertension in Association with Congenital Heart
Disease, 524
Summary, 525
46 CONTROL OF BREATHING AND ACUTE
RESPIRATORY FAILURE, 529
Robert K. Kanter
Normal Regulation of Breathing, 529
Factors Impairing Respiratory Controls, 530
Controls of Breathing in Advanced Respiratory Failure, 534
Implications for Patient Management, 535
47 MECHANICAL VENTILATION AND RESPIRATORY
CARE, 538
Shekhar T. Venkataraman, Richard A. Orr
Applied Respiratory Physiology, 538
Indications for Mechanical Ventilation, 539
Design and Functional Characteristics of Mechanical
Positive Pressure Ventilators, 540
Modes of Ventilation, 542
CPAP/PEEP, 544
Selection of Parameters During Mechanical Ventilation, 545
Approach to Mechanical Ventilation Based on Underlying
Pathophysiology, 546
Special Techniques of Respiratory Support, 548
Noninvasive Mechanical Ventilation, 548
Airway Pressure Release Ventilation, 549
High Frequency Ventilation, 549
Adverse Effects of Mechanical Ventilation, 552
Effects on Circulatory System, 553
Respiratory Care During Mechanical Ventilation, 553
Weaning from Mechanical Ventilation. 555
Discontinuing Mechanical Ventilation, 557
Home Respiratory Care, 557
Summary, 558
48 EXTRACORPOREAL MEMBRANE
OXYGENATION, 562
Heidi J. Dalton, Ann E. Thompson
ECMO Circuit, 562
xxvi Contents
Membrane Oxygenator, 564
Oxygen Delivery with ECMO, 565
Modes of Extracorporeal Support, 566
Disease States Treated with ECMO, 566
Patient Selection Criteria, 568
Patient Management, 569
Complications and Concerns, 571
Outcome, 571
ECMO Use in Myocardial Dysfunction, 572
Summary, 573
49 PERFLUOROCARBON LIQUID VENTILATION, 576
Bradley P. Fuhrman, Lynn J. Hernan, Michele C. Papo,
David M. Steinhorn
Liquid Breathing, 576
Tidal Liquid Ventilation (TLV), 576
Partial Liquid Ventilation and Perfluorocarbon Associated Gas
Exchange, 577
Partial Liquid Ventilation in Models of Lung Disease, 578
Antiinflammatory Effects of Perflubron, 579
Surfactant Production, 580
Management of Secretions, 580
Partial Liquid Ventilation as a Means of Drug Delivery, 580
Combining New Therapies, 580
Clinical Trials of PLV with LiquiVent (Perflubron), 581
Section C CNS and Neuromuscular
50 DEVELOPMENT, STRUCTURE, AND FUNCTION
OF THE BRAIN AND NEUROMUSCULAR
SYSTEMS, 583
Michael V. Johnston
Cellular Development, 583
Anatomical Development, 588
Clinical Correlates of Postnatal Neuromuscular Development,
590
Anatomical Localization: Physiology and Function, 591
51 PEDIATRIC NEUROLOGICAL ASSESSMENT
AND MONITORING, 595
Giilay Pinar Alper, Ira Bergman
Observation, 595
Level of Consciousness and Mental Status, 596
General Neurological Examination, 597
Psychogenic Coma, 600
Sedation and Paralysis, 600
Laboratory Adjuncts, 600
CSF, 601
Brain Death, 605
52 INTRACRANIAL HYPERTENSION, 607
W. Bradley Poss, S. David Moss, J. Michael Dean
Physiology of the Intracranial Vault, 607
Purposes of Monitoring Intracranial Pressure, 608
Intracranial Pressure Monitoring Devices, 608
Intracranial Pressure Waveform Analysis, 612
Complications of Intracranial Pressure Monitoring, 614
Treatments of Intracranial Hypertension, 615
Reduction of Intracranial Volume, 615
Does Intracranial Pressure Monitoring Affect Outcome?, 616
Summary, 616
53 COMA IN THE PEDIATRIC PATIENT, 618
Curt M. Steinhart, Anthony L. Pearson Shaver
Levels of Coma, 618
Anatomical Causes of Coma and Their Physiological
Consequences, 618
Mass Lesions, 619
Causes of Coma and Their Manifestations, 620
Diagnostic Evaluation, 621
Imaging Modalities, 623
Therapeutic Strategies, 623
Outcome, 623
54 DIAGNOSIS AND TREATMENT OF STATUS
EPILEPTICUS, 625
James P. Orlowski, A. David Rothner
Generalized Tonic Clonic or Major Motor Status Epilepticus,
625
Physiological Changes During Convulsive Status Epilepticus,
625
Pathophysiology of Status Epilepticus, 628
Neonatal Status Epilepticus, 628
Management, 628
Recommended Protocol for Status Epilepticus, 631
Newer Agents for Status Epilepticus, 631
Induced Electrocerebral Silence for Refractory Status
Epilepticus, 632
Diagnosing the Cause of Status Epilepticus, 632
Metabolic Causes of Status Epilepticus and Their Treatment,
634
Febrile Status Epilepticus, 634
Conclusion, 634
55 ACUTE NEUROMUSCULAR DISEASES AND
DISORDERS IN PEDIATRIC CRITICAL CARE, 636
Robert L. Sufit
Disorders Located Primarily Within the Motor Neuron, 636
Diseases and Disorders that Affect the Peripheral Nerves, 637
Diseases of the Neuromuscular Junction, 639
Diseases of Muscle, 641
Muscle Disorders in Other Contexts, 642
Summary, 643
56 ACUTE PEDIATRIC CENTRAL NERVOUS SYSTEM
INFECTIONS, 645
Jeffrey S. Rubenstein
Bacterial Meningitis, 645
Viral Meningoencephalitis or Encephalitis, 650
Viral Meningitis, 652
57 NEUROSURGICAL INTENSIVE CARE: SELECTED
ASPECTS, 654
Stephen R. Guertin
Cerebral Vascular Disease, 654
Brain Tumors: Selected Aspects, 661
CSF Shunts, 665
58 HYPOXIC ISCHEMIC ENCEPHALOPATHY:
PATHOBIOLOGY AND THERAPY OF THE
POSTRESUSCITATION SYNDROME IN CHILDREN,
671
Patrick M. Kochanek, Mark W. Uhl, Rebecca J. Schoettle,
Laurence Katz, Robert S.B. Clark, Peter Safar
Mechanisms of Hypoxic Ischemic Brain Injury, 672
Cellular and Molecular Pathobiology, 672
Clinical Pathophysiology, 678
Treatment of Cardiopulmonary Arrest, 683
Summary, 687
Section D Renal
59 AN OVERVIEW OF RENAL STRUCTURE
AND FUNCTION, 692
Andrew S. Brem
Overview of Structure, 692
Physiological Principles, 695
Tubular Function, 697
Hormone Effects, 699
60 FLUID AND ELECTROLYTE BALANCE, 703
Ellen G. Wood, Robert E. Lynch
Water Spaces, 703
Water Balance, 703
Sodium, 703
Potassium, 709
Magnesium, 714
Phosphorus, 716
61 ACID BASE BALANCE AND DISORDERS, 723
Larry S. Jefferson, J. Timothy Bricker
Acid Base Homeostasis, 723
Acid Base Disorders, 724
Therapy, 728
62 FUNCTIONAL TESTS OF THE KIDNEY IN HEALTH
AND DISEASE, 732
Michael C. Chobanian
Measurement of Glomerular Filtration Rate and the Glomerular
Barrier, 732
Measurements of Salt and Water Homeostasis, 733
Measurement of Acid Base Parameters, 734
Measurement of Other Tubular Functions, 736
Assessment of the Diseased Kidney, 737
Developmental and Maturational Differences in Assessment of
Renal Function, 738
63 GLOMERULOTUBULAR DYSFUNCTION
AND ACUTE RENAL FAILURE, 741
Deborah P. Jones, Russell W. Chesney, Aaron L. Friedman
Pathophysiology of Acute Renal Failure, 741
Classification of Acute Glomerulotubular Dysfunction, 746
Contents xxvii
Specific Renal Diseases that May Lead to Acute Renal
Failure, 750
64 PEDIATRIC RENAL REPLACEMENT THERAPY,
767
William E. Smoyer, Norma J. Maxvold,
Robert T. Remenapp, Timothy E. Bunchman
Indications for Therapy, 767
Peritoneal Dialysis, 767
Continuous Hemofiltration, 771
Continuous Hemofiltration on Extracorporeal Membrane
Oxygenation, 775
Outcome, 776
Summary, 777
65 RENAL PHARMACOLOGY, 779
Thomas P. Green
Use of Drugs to Augment Renal Function, 779
Effect of Renal Insufficiency on Therapeutics, 783
Nephrotoxicity of Drugs, 785
Section E Metabolism and Endocrinology
66 CELLULAR METABOLIC MACHINERY
AND ENERGY METABOLISM, 788
Gregory A. Hollman, Waldemar E. Storm,
Jerry J. Zimmerman
General Cellular Metabolism, 788
Central Metabolic Pathways, 789
Oxidation of Nutrient Molecules, 794
Regulation of Cellular Metabolism, 795
Anaerobic Metabolism, 796
67 NUTRIENT METABOLISM IN RELATION
TO THE SYSTEMIC STRESS RESPONSE, 799
John R. Wesley
Altered Metabolic (Nutrient) Equilibrium in Critical Illness, 799
Starvation: Overall Fuel Conservation, 799
Effect of Stress (Trauma, Surgery, Burns, Sepsis), 801
Functional Consequences of Malnutrition, 807
Altered Substrate Utilization, 811
Energy Requirements, 813
Nutritional Support of the Critically 111 Child: Advantages
and Limitations, 815
68 DISORDERS/DISEASES OF INBORN ERRORS
OF METABOLISM THAT PRODUCE CRITICAL
ILLNESS, 820
Jon A. Wolff, Enid Gilbert Barness. Lewis A. Barness
Presentation and Evaluation, 820
Disorders of Amino Acid Metabolism, 822
Organic Acidemias, 823
Lipid Disorders, 824
Carbohydrate Disorders, 824
Other Enzyme Disorders, 825
Inborn Errors that Do Not Usually Produce Critical Illness, 825
xxviii Contents
69 DISORDERS OF THE ENDOCRINE SYSTEM
RELEVANT TO PEDIATRIC CRITICAL ILLNESS,
826
David B. Allen
Adrenal Cortical Insufficiency, 826
Adrenal Medullary Hyperfunction: Pheochromocytoma, 829
Thyroid Disorders and Responses to Critical Illness, 831
Thyrotoxic Crisis (Thyroid Storm), 832
Euthyroid Sick Syndrome and Hypothyroidism, 833
Glucose Homeostasis: Initial Evaluation and Treatment of
Hypoglycemia, 834
Disorders of Calcium Homeostasis, 838
Hypocalcemia, 838
Hypercalcemia, 840
Anabolic Hormone Therapy: Human Growth Hormone and
Insulin Like Growth Factor 1, 841
70 DIABETIC KETOACIDOSIS, 844
Ram K. Menon, Mark A. Sperling
Definition, 844
Biochemical Pathophysiology, 844
Section F Hematology
71 STRUCTURE AND FUNCTION
OF HEMATOPOIETIC ORGANS, 853
Seth J. Corey, Julie Blatt
Structure and Function of the Bone Marrow, 853
Hematopoiesis, 854
Structure and Function of the Secondary Lymphoreticular
System, 861
72 HEMATOLOGY ONCOLOGY PROBLEMS
IN THE INTENSIVE CARE UNIT, 863
Diane J. Nugent, Michael D. Tarantino
Anemia, 863
Hematological Malignancies, 869
Thrombocytopenia, 871
73 BASICS OF TRANSFUSION MEDICINE, 877
Kurt C. Gunter, Naomi L.C. Luban
Anticoagulants and the Storage Lesion, 877
Components and Derivatives, 878
Specialized Blood Products, 884
Risks of Transfusion Transmitted Diseases, 886
Choice of Resuscitation Fluids, 886
Erythropoietin, 887
Alternative Products, 887
74 HEMATOPOIETIC STEM CELL
TRANSPLANTATION, 890
Ralph R. Quinones
Fundamentals of BMT, 890
Complications, 895
Conclusions, 901
Section G Gastroenterology
75 GASTROINTESTINAL STRUCTURE
AND FUNCTION, 904
David M. Steinhorn
Nutrition, Digestion, and Absorption, 904
Regulation of Electrolyte and Water Movement, 908
Pancreas, 909
Hepatobiliary System, 910
Host Defense Mechanisms of the Gut: Immunology and
Microbiology, 913
Testing of the Gastrointestinal Tract in the ICU, 915
76 DISORDERS AND DISEASES OF THE
GASTROINTESTINAL TRACT AND LIVER, 919
Samuel A. Kocoshis, Philip E. Putnam
Gastrointestinal Evaluation of the Critically 111 Child, 919
Life Threatening Complications of Gastrointestinal Disorders,
923
77 LIVER TRANSPLANTATION, 933
Jerril Green, Joe Carcillo, Jorges Reyes
Indications for Liver Transplantation in Children, 933
Preoperative Management, 934
Surgical Procedure, 935
Reduced Size Grafts, Split Liver Grafts, and Living Related
Donor Transplantation, 937
Postoperative Management, 938
Neurological Complications, 941
Immunosuppression, 943
Long Term Critical Complications of Liver Transplantation, 944
Conclusion, 945
Section H Organ Systems and Failure
78 MOLECULAR ORIGINS OF CELLULAR INJURY,
946
Michael Vespasiano, Jerry J. Zimmerman
General Origins of Cellular Injury, 946
Cellular Stress Responses, 946
Paramount Role of Oxyradical Species, 948
Secondary Injury Caused by Inflammation, 950
Alterations in ATP Synthesis, 950
Histopathological Manifestations, 950
Disrupted Calcium Homeostasis, 950
Lysis vs. Apoptosis, 952
79 MULTIPLE ORGAN DYSFUNCTION SYNDROME,
955
David M. Steinhorn, Frank B. Cerra
Historical Perspective, 955
Clinical Epidemiology, 956
Pathogenesis, 958
Systemic Physiology, 959
Metabolic Manifestations, 960
Microbiology, 962
Current Therapy and Future Directions, 962
Section I Immunity and Infectious Disease
80 STRUCTURE AND FUNCTION OF THE IMMUNE
SYSTEM, 966
Richard Hong
Elements of the Immune System, 966
Functions of the Peripheral Lymphoid Tissue, 971
Functions of the Central Lymphoid Tissue, 975
Control of the Immune Response, 976
Summary, 977
81 INFECTION AND THE HOST RESPONSE, 979
M. Michele Mariscalco
Definitions and Historical Perspective, 979
Recognition of Antigen, 979
Soluble Components of Inflammation, 980
Phagocytic Cells, 985
Other Cells Important to Host Defense, 988
Control of Inflammation, 988
82 CONGENITAL IMMUNODEFICIENCY, 995
Sheldon D. Horowitz
T Cell Deficiency, 995
Other T Lymphocyte Related Immunodeficiency Diseases, 997
B Cell Deficiency, 997
Complement Deficiency, 999
Neutrophil Deficiency, 1000
Summary, 1001
83 PEDIATRIC AIDS IN THE ICU, 1004
Gwenn E. McLaughlin, G. Patricia Cantwell
Diagnosis and Classification, 1004
Epidemiology, 1005
Pulmonary Complications and Respiratory Failure, 1005
Cardiovascular Complications, 1008
Septic Shock, 1009
Renal Failure, 1009
Abdominal Complications, 1010
Malignancies, 1012
Neurological Complications, 1012
Ethical Issues, 1013
84 IMMUNOLOGICAL MANAGEMENT OF CHILDREN
UNDERGOING SOLID ORGAN
TRANSPLANTATION, 1018
Allan D. Kirk, Stephen C. Rayhill, Jon S. Odorico,
Munci Kalayoglu, Stuart J. Knechtle, John D. Pirsch,
Hans W. Sollinger, Robert B. Love,
Anthony M. D Alessandro
Mechanisms of Allograft Rejection, 1018
Immunosuppressive Strategy, 1020
Specific Immunosuppressive Agents, 1020
New Immunosuppressive Agents, 1026
Complications of Immunosuppression, 1027
Clinical Transplant Immunosuppression, 1028
Conclusion, 1032
Contents xxix
85 NOSOCOMIAL INFECTIONS IN THE PICU, 1035
Jacques Lacroix, Peter Skippen, Peter Cox, Joanne M.
Langley, Anne Matlow, Geoffrey Barker, E. Lee Ford Jones
Morbidity, Mortality, and Cost of Nosocomial Infections, 1035
Epidemiology, 1035
Predisposing Factors in Critically 111 Patients, 1040
Site Specific Infections, 1042
Nosocomial Respiratory Tract Infections, 1045
Wound Infection and Surgical Prophylaxis, 1051
Urinary Tract Infection Associated with Catheterization, 1052
Other Infections, 1052
Infection Control Measures, 1053
86 ANTIMICROBIAL USE IN PEDIATRIC CRITICAL
CARE, 1060
Michael Radetsky
Antimicrobials, 1060
Synopsis of Infectious Disease Syndromes, 1062
87 SEPSIS/SEPTIC SHOCK, 1088
Jerry J. Zimmerman
Epidemiology, 1088
Definitions, 1088
Biochemical Pathogenesis, 1089
Pathophysiology, 1092
Therapeutic Intervention, 1094
88 PEDIATRIC INFECTIOUS DISEASE, 1101
P. Joan Chesney
Toxic Shock Syndrome, 1101
Severe Invasive Group A Streptococcal Disease, 1104
Rocky Mountain Spotted Fever, 1105
Hemorrhagic Shock and Encephalopathy Syndrome, 1107
Reye s Syndrome, 1107
Multidrug Resistant Bacteria and Invasive Infections, 1108
Hantavirus Pulmonary Syndrome, 1110
Ehrlichiosis, 1110
Cat Scratch Disease: Encephalopathy and Hepatosplenic
Involvement, 1111
89 COLLAGEN VASCULAR DISEASE, 1115
Michael L. Miller
Systemic Lupus Erythematosus, 1115
Juvenile Rheumatoid Arthritis, 1120
Dermatomyositis, 1122
Other Rheumatic Conditions, 1124
90 ANAPHYLAXIS, 1129
Michael Ritter, Robert F. Lemanske, Jr.
Epidemiology, 1129
Clinical Features, 1130
Pathogenesis, 1131
Differential Diagnosis, 1136
Treatment, 1136
Summary, 1138
xxx Contents
PART III Environmental Hazards
91 PRINCIPLES OF TOXIN ASSESSMENT
AND SCREENING, 1142
Alan D. Woolf, Frederick H. Lovejoy, Jr.
Epidemiology, 1142
Common Agents Involved, 1142
Resources for the Clinician, 1142
General Assessment of the Poisoned Patient, 1143
92 PRINCIPLES AND TECHNIQUES
OF DETOXIFICATION, 1150
Alan D. Woolf, Frederick H. Lovejoy, Jr.
Stabilization, 1150
Efforts to Reduce Absorption of Toxins, 1151
Enhancing Elimination, 1152
Antidotal Therapies, 1155
93 INTERVENTION FOR SPECIFIC TOXINS, 1157
Donald D. Vernon, William Banner, Jr.
Analgesics, 1157
Salicylates, 1158
Anticholinergics, 1158
Cyclic Antidepressants, 1159
Alcohols, 1160
Narcotics, 1161
Cocaine, 1162
Anticonvulsants, 1162
Insecticides, 1163
Hydrocarbons, 1164
Cardiac Agents, 1164
Toxins Producing Methemoglobin, 1165
Iron, 1166
Theophylline/Caffeine, 1166
94 SNAKE ENVENOMATIONS, 1171
John B. Sullivan, Jr., Leslie Boyer
Crotalidae (Pet Vipers), 1171
Envenomation Syndromes, 1173
Management of Crotalidae Envenomation, 1173
Snakebite in Pregnancy, 1178
Avoiding Pitfalls and Errors, 1178
Elapidae, 1178
Clinical Syndrome of Coral Snake Venom Poisoning, 1179
95 ENVIRONMENTAL HEAT AND COLD INJURIES,
1181
Julie A. Kiley, Mel D. Robinson
Cold Injury, 1181
Heat Injury, 1184
96 NEAR DROWNING, 1190
Ashok P. Sarnaik, Mary W. Lieh Lai
Definitions, 1190
Epidemiology, 1190
Pathophysiological Considerations, 1190
Management, 1193
Prognosis, 1196
97 BURN AND INHALATION INJURIES, 1198
Hugo F. Carvajal, James A. Griffith
Pathogenesis and Pathophysiology, 1198
Treatment, 1201
PART IV Trauma
98 EVALUATION, STABILIZATION, AND INITIAL
MANAGEMENT AFTER MULTIPLE TRAUMA, 1212
Grace M. Young, Martin R. Eichelberger
The Pediatric Trauma Center, 1212
The Pediatric Trauma Response Team, 1214
Primary Survey, 1214
Secondary Survey, 1218
Definitive Care Phase, 1219
99 EVALUATION AND MANAGEMENT
OF PEDIATRIC HEAD TRAUMA, 1221
Mark S. Dias, John Borchers, Lynn J. Hernan,
Micam W. Tullous
Pathophysiology of Brain Injury, 1221
Assessment and Initial Management, 1223
Clinical Features of Head Trauma, 1227
Special Problems in Childhood Head Injuries, 1234
Acute Management of Elevated Intracranial Pressure, 1237
100 THORACIC INJURIES IN CHILDREN, 1249
Michael G. Caty, Victor F. Garcia, Martin R. Eichelberger,
Richard G. Azizkhan
Epidemiology, 1249
Diagnosis and Immediate Management of the Child with Chest
Injuries, 1249
Fractures of the Bony Thorax, 1250
Pulmonary Contusion, 1251
Pneumothorax/Hemothorax ,1251
Cardiac Injuries, 1253
Aortic and Great Vessel Injuries, 1253
Other Injuries, 1254
Summary, 1254
101 ABDOMINAL TRAUMA IN PEDIATRIC CRITICAL
CARE, 1256
James C. Gilbert, Patrick V. Bailey
Mechanisms and Patterns of Injury, 1256
Evaluation and Resuscitation, 1256
Penetrating Abdominal Trauma, 1258
Definitive Radiographic Assessment in Pediatric Abdominal
Trauma, 1258
ICU Nonoperative Management Strategies, 1259
Specific Organ Injuries and Management, 1259
PART V Pharmacology
102 PRINCIPLES OF DRUG DISPOSITION IN THE
CRITICALLY ILL CHILD, 1268
Jeffrey L. Blumer
Children, the Therapeutic Orphans, 1268
Drug Disposition in Infants and Children, 1269
Pharmacokinetic Principles, 1278
Critical Care Therapeutics, 1281
103 RECEPTOR PHYSIOLOGY, SIGNAL
TRANSDUCTION, AND SECOND
MESSENGERS, 1286
Kathryn L. Weise
General Principles, 1286
Signal Transduction Mechanisms, 1288
Clinical Manifestations of Receptor Physiology, 1292
104 DRUG DRUG INTERACTIONS, 1301
Brian L. LaRowe
Absorption, 1301
Complex Formation, 1302
Distribution, 1305
Receptor Sites, 1307
Metabolism, 1308
Excretion, 1311
105 PHARMACOLOGICAL IATROGENIA (ADVERSE
DRUG REACTIONS), 1314
Timothy D. Wolf
Definitions, 1314
Hepatotoxicity, 1314
Adverse Pulmonary Reactions, 1315
Nephrotoxicity, 1316
Pancreatic Toxicity, 1317
Blood Dyscrasias, 1318
PART VI Anesthesia/Analgesia Aspects
of Pediatric Critical Care
106 ORGAN SYSTEM CONSIDERATIONS THAT
AFFECT ANESTHETIC MANAGEMENT, 1324
Peter J. Davis, Joel B. Sarner
Cardiovascular Performance, 1324
Anemia and Transfusion, 1325
Respiratory Failure, 1326
Neurologic Injury, 1327
Hepatic Dysfunction, 1329
Intravenous Alimentation, 1331
Summary, 1331
107 NEUROMUSCULAR BLOCKING AGENTS, 1334
D. Ryan Cook
Neuromuscular Junction and Neuromuscular Transmission, 1334
Contents xxxi
Structural and Functional Development of Neuromuscular
System, 1337
Dose Response Relationships, 1338
Characteristics of Specific Agents, 1341
Modes of Evaluation of Neuromuscular Transmission, 1349
Myoneuropathies, 1349
Reversal of Neuromuscular Blockade, 1349
108 ANESTHETIC PRINCIPLES AND OPERATING
ROOM ANESTHESIA REGIMENS, 1353
John H. Arnold, James C. Fackler
Anesthetic Agents, 1353
Anesthetic Techniques, 1358
Specific Anesthetic Considerations, 1359
109 ANALGESIA AND SEDATION IN PEDIATRIC
CRITICAL CARE, 1363
Gregory A. Hollman
Approach to Comfort Control in the PICU, 1363
Drugs for Sedation, 1364
Other Sedatives, 1367
Drugs for Sedation and Analgesia, 1369
Tolerance and Dependence, 1375
Conclusions, 1375
110 MALIGNANT HYPERTHERMIA, 1380
Barbara W. Brandom
Pathophysiology, 1380
Porcine Model, 1380
Clinical Recognition of an Episode in Humans, 1382
Factors that Trigger MH in Humans, 1384
The Course of a Clinical Episode of MH in Humans, 1384
Treatment of an Episode of MH, 1384
Symptomatic Treatment, 1385
Recrudescence, 1386
Potential Systemic Complications, 1386
Identification of Patients at Risk, 1386
The Safe Anesthetic, 1387
Dantrolene, 1387
In Vitro Caffeine Halothane Contracture Testing, 1387
Noninvasive Tests of MH Susceptibility, 1388
Neuroleptic Malignant Syndrome, 1388
111 POSTANESTHESIA RECOVERY IN THE
PEDIATRIC INTENSIVE CARE UNIT, 1391
/. David Todres
Recovery from Anesthesia, 1391
Transport to the Pediatric Intensive Care Unit, 1393
Arrival in the Intensive Care Unit, 1393
Recovery Problems, 1393
PART VII Cardiopulmonary Resuscitation
112 PHYSIOLOGICAL FOUNDATIONS OF
CARDIOPULMONARY RESUSCITATION, 1400
Charles L. Schleien, John W. Kuluz
xxxii Contents
Mechanisms of Blood Flow, 1400
Newer CPR Techniques, 1404
Pharmacology, 1407
113 THE PERFORMANCE OF CPR IN INFANTS
AND CHILDREN, 1420
Judith E. Brill
Epidemiology of Cardiac Arrest, 1420
Performance of CPR, 1421
Resuscitation Procedures, 1422
Airway Management, 1424
Rescue Breathing and Artificial Ventilation, 1425
Supporting the Circulation, 1426
Vascular Access for Resuscitation, 1428
Endotracheal Drug Administration, 1428
Fluid Administration During CPR, 1429
Drug Therapy for Resuscitation, 1429
Defibrillation, 1432
Special Issues and Procedures in Resuscitation, 1433
Complications of CPR, 1434
Summary, 1436
|
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| ctrlnum | (OCoLC)39223857 (DE-599)BVBBV011953799 |
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| id | DE-604.BV011953799 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:19:06Z |
| institution | BVB |
| isbn | 0815125364 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008082093 |
| oclc_num | 39223857 |
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| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XXXII, 1438 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Mosby |
| record_format | marc |
| spelling | Pediatric critical care Bradley P. Fuhrman ; Jerry J. Zimmerman 2. ed. St. Louis [u.a.] Mosby 1998 XXXII, 1438 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Intensive care gtt Kinderen gtt Kind Child Critical Care Infant Pediatric intensive care Fuhrman, Bradley P. Sonstige oth Zimmerman, Jerry J. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008082093&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pediatric critical care Intensive care gtt Kinderen gtt Kind Child Critical Care Infant Pediatric intensive care |
| title | Pediatric critical care |
| title_auth | Pediatric critical care |
| title_exact_search | Pediatric critical care |
| title_full | Pediatric critical care Bradley P. Fuhrman ; Jerry J. Zimmerman |
| title_fullStr | Pediatric critical care Bradley P. Fuhrman ; Jerry J. Zimmerman |
| title_full_unstemmed | Pediatric critical care Bradley P. Fuhrman ; Jerry J. Zimmerman |
| title_short | Pediatric critical care |
| title_sort | pediatric critical care |
| topic | Intensive care gtt Kinderen gtt Kind Child Critical Care Infant Pediatric intensive care |
| topic_facet | Intensive care Kinderen Kind Child Critical Care Infant Pediatric intensive care |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008082093&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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