Oxidants, antioxidants, and free radicals:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, DC [u.a.]
Taylor & Francis
1997
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 364 S. Ill., zahlr. graph. Darst. |
| ISBN: | 1560326441 |
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| 300 | |a XXIV, 364 S. |b Ill., zahlr. graph. Darst. | ||
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| 650 | 4 | |a Antioxidants |x Physiological effect | |
| 650 | 4 | |a Antioxidants |x metabolism |v Congresses | |
| 650 | 4 | |a Free Radicals |v Congresses | |
| 650 | 4 | |a Free radicals (Chemistry) |x Pathophysiology | |
| 650 | 4 | |a Lipid Peroxidation |x physiology |v Congresses | |
| 650 | 4 | |a Lipids |x Peroxidation | |
| 650 | 4 | |a Oxidants |x metabolism |v Congresses | |
| 650 | 4 | |a Oxidation, Physiological | |
| 650 | 4 | |a Oxidative Stress |x drug effects |v Congresses | |
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Datensatz im Suchindex
| _version_ | 1804126356591607808 |
|---|---|
| adam_text | CONTENTS
Foreword xv
Preface xvii
Contributors xix
About the Editors xxiii
CHAPTER 1
Redox, Radicals, and Antioxidants 1
Andrew L. Ternay Jr. and Viktor Sorokin
The Language of Redox 1
Radicals 3
Oxygen and Its Derivatives 5
Antioxidants 6
L Ascorbic Acid (Vitamin C) 6
P Carotene and Carotenoids 7
Ubiquinone Ubiquinol 10
Chain Reactions and the Role of Antioxidants 11
P Carotene 13
L Ascorbic Acid 13
Vitamin E 14
Ubiquinone 15
Summary 16
References 16
CHAPTER 2
The Analysis of Free Radicals, Their Reaction Products, and Antioxidants 23
Ian N. Acworth, Douglas R. McCabe, and Timothy J. Maher
Review of Chemistry and Measurement of Reactive Oxygen and Nitrogen Species 26
Reactive Oxygen Species 26
Reactive Nitrogen Species 35
ROS and RNS Reaction Products: Introduction and Measurement 40
DNA Damage 40
Protein and Amino Acid Damage 44
Lipid Damage 46
The Antioxidants: Introduction and Measurement 49
Ascorbic Acid 50
Uric Acid 50
Vitamin E 51
Ubiquinone 52
vii
viii Contents
Thiols, Disulfides, and Related Compounds 52
Carotenoids, Retinoids, and Related Compounds 55
Other Phytochemicals as Antioxidants 56
a Ketoacids 57
Melatonin 59
Conclusions 60
References 61
CHAPTER 3
Vitamin E 79
Sharon Landvik
Absorption and Transport 79
Clinical Deficiency 80
Functions 80
Sources 80
Requirements 80
Cardiovascular Disease 81 ,
Cancer 83
Cataract 86
Air Pollution 87
Safety 88
Summary 88
References 88 *
CHAPTER 4
Vitamin E and Polyunsaturated Fats: Antioxidant and Pro oxidant Relationship 95
Melanie A. Banks
Introduction 95
Vitamin E 95
Polyunsaturated Fats and Lipid Peroxidation 99
Roles of Dietary Fat and Vitamin E in Chronic Diseases 102
Coronary Heart Disease 102
Cancer 104
Respiratory Disease 105
Diabetes 106
Other Chronic Diseases 106
Absorption, Transport, and Distribution of Vitamin E 107
Suggested Areas for Further Research 107
References 108
CHAPTER 5
a Tocopherol, (3 Carotene, and Oxidative Modification of Human
Low Density Lipoprotein 113
Hazel T. Bowen and Stanley T. Omaye
Clinical Data 113
Oxidized LDL and Atherosclerosis 115
Effect of Antioxidant Vitamins on Oxidative Modification of LDL 116
Conclusions 120
References 120
Contents ix
CHAPTER 6
Response of Antioxidant System to Physical and Chemical Stress 125
Satu M. Somani, Kazim Husain, and Eric C. Schlorff
Pathways and Components of the Antioxidant System 125
Endogenous Nonezymatic Antioxidants 126
Endogenous Enzymatic Antioxidants 127
Antioxidants Response to Exercise 129
Endogenous Antioxidant Compounds 129
Antioxidant Enzymes 130
Adenosine Generation During Exercise 132
Endogenous Activation of Antioxidant Enzymes by Adenosine 132
Adenosine and Antioxidant Enzyme in Exercise 134
Interaction of Exercise and Chemicals on Antioxidant System 135
Future Perspectives 135
Summary 137
References 137
CHAPTER 7
Zinc as a Cardioprotective Antioxidant 143
Saul R. Powell
A Role for the Redox Active Metals in Post Ischemic Oxidative Cardiac Injury 143
Redox Active Transition Metals as Catalysts 143
Redox Active Metals and Oxidative Tissue Injury 144
Redox Active Metals and Post Ischemic Cardiac Oxidative Injury 145
Zinc and Site Specific Formation of Reactive Oxygen Intermediates ( Push vs. Pull ) 147
Site Specific Formation of Radicals 147
Push vs. Pull 147
Zinc as a Cardioprotective Antioxidant 150
The Anti Arrhythmic Effect of Zinc 150
Effect on Post Ischemic or Post Arrest Cardiac Function 150
Evidence of Inhibition of Transition Metal Mediated Oxidative Stress 156
Summary and Conclusions 157
References 161
CHAPTER 8
Ascorbic Acid, Melatonin, and the Adrenal Gland: A Commentary 167
Madeline M. Hall, Harry Van Keulen, and James M. Willard
References 169
CHAPTER 9
Antioxidant Properties of Glutathione and its Role in Tissue Protection 171
Alfred M. Sciuto
Historical Background 171
Biosynthesis of GSH 171
Antioxidant Properties 175
Tissue Protection and Response to Stress 177
Environmental Stress 177
Physiological Effects 177
x Contents
Prophylactic and Therapeutic Up Regulation of GSH 184
The Toxicity of GSH Metabolism 185
Conclusion 186
References 186
CHAPTER 10
Antioxidant Effects of Hypotaurine and Taurine 193
Steven I. Baskin, Kokiku Wakayama, Melanie A. Banks, Dale W. Porter,
and Harry Salem
References 200
CHAPTER 11
Antoxidative Activity of Ergothioneine and Ovothiol 203
Robert D. Short Jr. and Steven I. Baskin
Ergothionine 203
Background 203
Occurrence 203
Biological Activity in Whole Animals 204
Biological Activity in Organ, Tissue, or Culture Systems 204
What are the Roles of ET in Biological Systems? 205
Potential Clinical Applications 205
Ovothiols 205
Background 205
Occurrence 205
Biological Activity 205
References 206
CHAPTER 12
The Toxicology of Antioxidants 207
Harry Salem and Steven I. Baskin
Toxicology 207
Vitamin A 209
Acute Human Toxicity 209
Chronic Human Toxicity 210
Animal Toxicology: Acute Toxicity 212
Animal Toxicity: Repeat Dose 212
Animal Reproductive Studies 213
Mutagenicity 214
Vitamin C 214
Human Toxicity 215
Toxicology—Animals 215
Vitamin E 216
Human Toxicity 217
Copper 218
Manganese 218
Selenium 219
Animal Toxicology 220
Zinc 220
References 222
Contents xi
CHAPTER 13
Toxicity of Oxygen and Ozone 227
Harry Salem and Steven I. Baskin
Oxygen 227
Oxidative Stress 228
Oxygen Injury 229
Ozone Injury 229
Comparison of Models 233
References 233
CHAPTER 14
Peroxidation of Lipids and Liver Damage 237
Pablo Muriel
From Free Radicals to Lipid Peroxidation 237
Oxygen Toxicity 237
Properties of Free Radicals 237
Peroxidation of Lipids 237
Peroxidation of Lipids and Alcohol Induced Liver Damage 239
Alcohol and Liver Diseases 239
Role of Peroxidation of Lipids 239
Promotion of Lipid Peroxidation through Interactions with Cysteine, Glutathione,
Vitamin E, and Iron 240
Lipid Peroxidation in Other Types of Liver Injury 241
Paracetamol Induced Liver Necrosis and Lipid Peroxidation 241
Liver Damage Induced by Carbon Tetrachloride 244
Biliary Obstruction Induced Liver Damage 247
Naproxen Induced Lipid Peroxidation 247
Halothane and Sevoflurane 250
Conclusions 251
References 252
CHAPTER 15
Role of Free Radicals in Alcohol Induced Tissue Injury 259
Carol A. Colton and Samir Zakhari
ROI and RNI 259
Cellular Sources of ROI and RNI 259
Reactions Involving ROI and RNI 260
Protective Mechanisms 262
Ethanol Induced ROI 262
Increased Production of ROI 262
Possible Sources of Alcohol Induced ROI 263
Role of ROI in Alcohol Induced Tissue Injury 264
Liver Damage 264
Macrophages 265
Fetal Alcohol Syndrome 265
Brain Damage 266
Mechanisms of ROI Induced Tissue Injury 266
Increased Extracellular LPS 266
Altered Intracellular Signal Transduction 266
Fatty Acid Oxygenases and Eicosanoids 266
x Contents
Altered Nuclear Transcription and Gene Expression 267
Loss of Antioxidant Protection 267
References 267
CHAPTER 16
Oxidant Injury from Inhaled Paniculate Matter 273
James J. McGrath
Particles 273
Atmospheric Concentrations 273
Particle Composition 273
Indoor Concentrations 274
Epidemiologic Studies 274
Recent Studies 274
Physiological Response 275
Particle Deposition 276
Particle Clearance 276
Classes of Particles 279
Metals 279
Ultrafines 2« 1
Lung Overload 282
Oxidative Lung Injury Caused by Reactive Oxygen Species 284
Reactive Oxygen Species Generation and Secretion 284
Summary and Conclusions 286
References 2g7
CHAPTER 17
Edemagenic Gases Cause Lung Toxicity by Generating Reactive
Intermediate Species 291
Carmen M. Arroyo and Jill R. Keeler
Phosgene (OCC12) 291
Materials and Methods 291
Results and Discussion 292
Bis(TrifluoromethyI)Disulfide (TFD) 295
Materials and Methods 296
Results 296
Discussion 303
Perfluoroisobutylene (PFIB) 306
Experimental Procedures 3q7
Results ™7
Discussion .j
References ,.
CHAPTER 18
Lipid Peroxidation and Antioxidant Depletion Induced by Blast Overpressure 315
Nabil M. Elsayed
Introduction
Experimental ,.„
Results and Discussion ..q
Summary
Acknowledgments ..„
Contents xiii
Disclaimer 325
References 325
CHAPTER 19
Food Antioxidants: Their Dual Role in Carcinogenesis 327
Saura C. Sahu and Sidney Green
Introduction 327
Diet, Oxygen, and Cancer 327
Antioxidants as Anticarcinogens 329
Antioxidants as Carcinogens 330
Interactions of Antioxidants 332
Antioxidants as Pro Oxidants 332
Free Radical Mechanisms of Antioxidant Carcinogenicity 333
Antioxidants as Double Edged Biological Swords 333
Summary 334
References 334
CHAPTER 20
Anticarcinogenic Effects of Synthetic Phenolic Antioxidants 341
Gary M. Williams and Michael latropoulos
Introduction 341
Materials and Methods 342
Experiment I 342
Experiment II 342
Experiment III 342
Experiment IV 342
Morphology 3 * 2
Statistical Analysis M1
Results and Discussion 343
Experiment I 343
Experiment II 344
Experiment III 345
Experiment IV 345
Conclusions 34K
References 4H
Index ^ I
|
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| dewey-sort | 3616.07 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV011811117 |
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| indexdate | 2024-07-09T18:16:09Z |
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| publisher | Taylor & Francis |
| record_format | marc |
| spelling | Oxidants, antioxidants, and free radicals ed. by Steven I. Baskin ... Washington, DC [u.a.] Taylor & Francis 1997 XXIV, 364 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Radicalen (chemie) gtt Antioxidants Physiological effect Antioxidants metabolism Congresses Free Radicals Congresses Free radicals (Chemistry) Pathophysiology Lipid Peroxidation physiology Congresses Lipids Peroxidation Oxidants metabolism Congresses Oxidation, Physiological Oxidative Stress drug effects Congresses Vitamins therapeutic use Congresses Freies Radikal (DE-588)4137149-5 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Pathobiochemie (DE-588)4044888-5 gnd rswk-swf Oxidans (DE-588)4202009-8 gnd rswk-swf Sauerstoffradikal (DE-588)4179211-7 gnd rswk-swf Antioxidans (DE-588)4142729-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Antioxidans (DE-588)4142729-4 s Pharmakologie (DE-588)4045687-0 s DE-604 Sauerstoffradikal (DE-588)4179211-7 s Pathobiochemie (DE-588)4044888-5 s Biochemie (DE-588)4006777-4 s Oxidans (DE-588)4202009-8 s Freies Radikal (DE-588)4137149-5 s Baskin, Steven I. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007975626&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Oxidants, antioxidants, and free radicals Radicalen (chemie) gtt Antioxidants Physiological effect Antioxidants metabolism Congresses Free Radicals Congresses Free radicals (Chemistry) Pathophysiology Lipid Peroxidation physiology Congresses Lipids Peroxidation Oxidants metabolism Congresses Oxidation, Physiological Oxidative Stress drug effects Congresses Vitamins therapeutic use Congresses Freies Radikal (DE-588)4137149-5 gnd Biochemie (DE-588)4006777-4 gnd Pharmakologie (DE-588)4045687-0 gnd Pathobiochemie (DE-588)4044888-5 gnd Oxidans (DE-588)4202009-8 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Antioxidans (DE-588)4142729-4 gnd |
| subject_GND | (DE-588)4137149-5 (DE-588)4006777-4 (DE-588)4045687-0 (DE-588)4044888-5 (DE-588)4202009-8 (DE-588)4179211-7 (DE-588)4142729-4 (DE-588)4143413-4 (DE-588)1071861417 |
| title | Oxidants, antioxidants, and free radicals |
| title_auth | Oxidants, antioxidants, and free radicals |
| title_exact_search | Oxidants, antioxidants, and free radicals |
| title_full | Oxidants, antioxidants, and free radicals ed. by Steven I. Baskin ... |
| title_fullStr | Oxidants, antioxidants, and free radicals ed. by Steven I. Baskin ... |
| title_full_unstemmed | Oxidants, antioxidants, and free radicals ed. by Steven I. Baskin ... |
| title_short | Oxidants, antioxidants, and free radicals |
| title_sort | oxidants antioxidants and free radicals |
| topic | Radicalen (chemie) gtt Antioxidants Physiological effect Antioxidants metabolism Congresses Free Radicals Congresses Free radicals (Chemistry) Pathophysiology Lipid Peroxidation physiology Congresses Lipids Peroxidation Oxidants metabolism Congresses Oxidation, Physiological Oxidative Stress drug effects Congresses Vitamins therapeutic use Congresses Freies Radikal (DE-588)4137149-5 gnd Biochemie (DE-588)4006777-4 gnd Pharmakologie (DE-588)4045687-0 gnd Pathobiochemie (DE-588)4044888-5 gnd Oxidans (DE-588)4202009-8 gnd Sauerstoffradikal (DE-588)4179211-7 gnd Antioxidans (DE-588)4142729-4 gnd |
| topic_facet | Radicalen (chemie) Antioxidants Physiological effect Antioxidants metabolism Congresses Free Radicals Congresses Free radicals (Chemistry) Pathophysiology Lipid Peroxidation physiology Congresses Lipids Peroxidation Oxidants metabolism Congresses Oxidation, Physiological Oxidative Stress drug effects Congresses Vitamins therapeutic use Congresses Freies Radikal Biochemie Pharmakologie Pathobiochemie Oxidans Sauerstoffradikal Antioxidans Aufsatzsammlung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007975626&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT baskinsteveni oxidantsantioxidantsandfreeradicals |