Advances in animal alternatives for safety and efficacy testing:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, DC [u.a.]
Taylor & Francis
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Frühere Ausg. u.d.T.: Animal test alternatives |
| Beschreibung: | XX, 450 S. Ill., zahlr. graph. Darst. |
| ISBN: | 1560326239 |
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| 650 | 4 | |a Ethik | |
| 650 | 4 | |a Animal Testing Alternatives | |
| 650 | 4 | |a Drug Evaluation | |
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Datensatz im Suchindex
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TABLE OF CONTENTS
Contributors xiii
Preface xix
Part I
DERMAL TOXICITY
CHAPTER 1
Pseudo Epidermis: An In Vitro Surrogate for the Study of Cutaneous Sulfur
Mustard Toxicity 3
/. A. Bernstein, L. I. Bernstam, E. Gasiciel, A. Kotlyar, P. P. Lin, Y. P. Pu,
F. L. Vaughan, and Y. Yang
CHAPTER 2
Refinement of an Endpoint for Measuring Skin Decontaminant Efficacy 21
J. A. Blank, Ronald G. Menton, C. T. Olson, D. W. Hobson, T. H. Snider,
and D. W. Korte, Jr.
CHAPTER 3
An In Vitro Model for Skin Reconstruction 27
R. Fleischmajer, E. D. MacDonald, P. Contard, and J. S. Perlish
CHAPTER 4
Critique of Cell Culture Methods in Skin Permeability Assessment 37
Gordon L. Flynn
CHAPTER 5
The Local Lymph Node Assay and Other Approaches to the Evaluation of Skin
Sensitizing Potential 49
Ian Kimber
CHAPTER 6
The Alternative to Animals for Assessing Topical Irritants Is Humans 55
Albert M. Kligman
CHAPTER 7
Hexose Monophosphate Shunt Activity in Human Epidermal Keratinocytes
Exposed to Sulfur Mustard 59
Margaret E. Martens
vii
viii Table of Contents
CHAPTER 8
What Is Irritant Dermatitis? A Biological Approach 65
Sunita Patil, K. Lamintausta, and Howard I. Maibach
CHAPTER 9
Skin2: An In Vitro Tissue Model for Assessment of Cutaneous Safety and
Efficacy Needs 89
Lawrence A. Rheins, Tracy A. Donnelly, and Susan M. Edwards
CHAPTER 10
Biochemical and Flow Cytometric Studies of the Mechanism of Action of Sulfur
Mustard Using Human Cells In Culture 99
William J. Smith, Margaret E. Martens, Clark L. Gross, Offie E. Clark,
and Fred M. Cowan
CHAPTER 11 i
A Multiphase Screen for the Evaluation of Topical Skin Protectants Against
Chemical Warfare Agents 103
T. H. Snider, Ronald G. Menton, D. W. Hobson, and D. W. Korte, Jr.
Part II
DEVELOPMENTAL/REPRODUCTIVE TOXICITY
CHAPTER 12
Induction of Low Molecular Weight Heat Shock Proteins in Drosophila and
Human Embryonic Lineage Cells After Teratogen Exposure 111
Nicole Bournias Vardiabasis, Kuyng Won Huh, Keri Hopkins,
and Tae Wook Chun
CHAPTER 13
Using Invariants of Swimming Motion in Biotoxicity Testing via
Computerized Microscopy 125
David K. Cohoon, R. James Swanson, and Ronald J. Young
CHAPTER 14
Computation of Developmental Toxicity Potential by QSTR Models in the
TOPKAT Program 159
Kurt Enslein, Vijay K. Gombar, Benjamin W. Blake, and James R. Carter
CHAPTER 15
Activity Profiles of Developmental Toxicity 169
Robert J. Kavlock
CHAPTER 16
Screening of Populations of Women at Risk for Reproductive Failure Using
Cultured Rodent Embryos 175
Norman W. Klein
I Table of Contents ix
f CHAPTER 17
| Continued Evaluation and Application of a Bioluminescent Bacterial
| Genotoxicity Test 181
] W. D. Wang, T. S. C. Sun, and H. M. Stahr
I
Part III
IMMUNOTOXICITY
CHAPTER 18
Cytokine Gene Expression and Allergic Contact Dermatitis 193
j Craig A. Elmets
I CHAPTER 19
I Strategies for Developing Alternative Methods to Assess Contact Allergens 199
{ Anthony A. Gaspari
Part IV
NEUROTOXICITY
CHAPTER 20
Astrocytes as Target Site for Neurotoxicity 209
Michael Aschner
CHAPTER 21
Altered Angiotensin Induced Drinking as a Noninvasive Behavioral Biomarker
of Neonatal Glutamic Acid Neurotoxicity in the Rat 223
Florence A. Caputo and Andrew C. Scallet
CHAPTER 22
Cell Cultures for Screening of Antiesterase Compounds 229
Marion Ehrich
CHAPTER 23
Mechanistic Neurotoxicity Studies Using PC 12 Cells 235
Gary E. horn, A. G. Kanthasamy, and J. L. Borowitz
CHAPTER 24
MDCK: An Epithelial Cell Line Model of the Blood Brain Barrier and Its
Response to Cholinesterase Inhibitors 243
Bellina Veronesi and Marion Ehrich
Part V
ORAL/DERMAL/OCULAR VALIDATION
CHAPTER 25
The Blood Perfused Pig Ear: A Potential In Vitro Alternative for Dermal
Permeation and Toxicity Studies 251
Piet Bruijnzeel, Jan de Lange, Govert van der Schans, and Graham Elliott
x Table of Contents
CHAPTER 26
Bovine Corneal Opacity and Permeability Test Validation as an Alternative to j
the Draize Eye Irritation Assay 261 I
D. Cerven and O. Moreno
CHAPTER 27
Metabolism of Humans and Animals Compared by Organ Cultures 269
Byong Han (Paul) Chin
CHAPTER 28 I
Sulfur Mustard Increased Proteolysis in Cultured Human Cells 277 ;
Fred M. Cowan, Clarence A. Broomfield, and William J. Smith
CHAPTER 29
Evaluation of Two In Vitro Human Skin Equivalents (Epiderm™ and Skin2™
Model ZK1300) for Assessing the Skin Irritation Potential of Personal Care
Products and Chemicals 285
Joanna M. Doyle, William E. Dressier, and S. R. Rachui
CHAPTER 30
Strategies of Applications of In Vitro Methods to the Development of
Pharmaceuticals and Devices 293
Shayne C. Gad
CHAPTER 31
A Modular Approach to Validation—A Work in Progress 303
Alan M. Goldberg, Leonardo D. Epstein, and Joanne Zurlo
CHAPTER 32
Evaluation of the CORROSITEX Method to Determine the Corrosivity Potential
of Surfactants, Surfactant Based Formulations, Chemicals, and Mixtures 309
Virginia C. Gordon, Soheila Mirhashemi, and Rosalind Wei
CHAPTER 33
Comparison Study of In Vitro and In Vivo Results on Textile Fabric Extracts for
Assessing Dermal Irritancy Potential to Industrial Workers 331
Virginia C. Gordon, K. Harris, Howard I. Maibach, and Sunita Patil
CHAPTER 34
Validation Issues for Alternatives Testing 339
Stanley B. Gross
CHAPTER 35
Intra and Interlaboratory Reproducibility of EpiDerm, an In Vitro Model for
Dermal Irritancy Testing 347
M. Klausner, P. J. Neal, C. L. Cannon, J. Kubilus, R. D. Curren,
and J. W. Harbell
Table of Contents xi
CHAPTER 36
Primary Human Hepatocytes as an In Vitro Toxicology System 359
Albert P. Li, Dale J. Beck, Linda J. Loretz, Lilly Xu, Asenath Rasmussen,
Jill C. Merrill, and Donald L. Kaminski
CHAPTER 37
Review of the Up and Down Method for Acute Toxicity Determination 369
Robert L. Lipnick, Joseph A. Cotruvo, Richard N. Hill, Robert D. Bruce,
Katherine A. Stitzel, Arthur P. Walker, Ih Chu, Michael J. Goddard,
Larry M. Segal, Janet A. Springer, and Roy C. Myers
CHAPTER 38
Skin Partitions as a Screen for Dermal Permeability 375
D. R. Mattie and James N. McDougal
CHAPTER 39
Reduction of Animal Utilization in Dermal Toxicologic Studies 381
Ronald G. Menton, J. A. Blank, T. H. Snider, C. T. Olson, and D. W. Korte, Jr.
CHAPTER 40
Computerized In Vitro Test for Chemical Toxicity Based on Tetrahymena
Swimming Patterns 387
David A. Noever, Helen C. Matsos, Raymond J. Cronise, Loren L Looger,
Rachna A. Relwani, and Jacqueline U. Johnson
CHAPTER 41
Renal Alterations Following Sublethal Mercury Toxicity: A Fish Model for
Aquatic Environmental Contamination 399
R. Reimschuessel and C. M. Gonzalez
CHAPTER 42
A Nonlethal, Anesthetized Canine Model Used to Reduce the Number of Animals
Required to Evaluate the Effectiveness of Pretreatment Compounds Challenged
with Toxic Concentrations of Cyanide 403
/ A. Vick, M. T. Marino, L. D. Brown, A. Kaminskis, J. von Bredow,
and T. Brewer
CHAPTER 43
Confocal Microscopy and Calcium Images of Keratinocytes Exposed to Sulfur
Mustard 409
Robert J. Werrlein, J. S. Madren Whalley, S. D. Kirby, and M. A. E. Mol
CHAPTER 44
Inherited and Acquired Enzyme Defects in Multiple Chemical Sensitivity 417
Patricia P. Wilcox
CHAPTER 45
An In Vitro Method for Detecting Toxicants by Changes in the Pattern of Polarized
Light Scattered from Bacteria 427
B. V. Bronk, Zhao Z. Li, J. Czege, and W. P. Van De Merwe
xii Table of Contents I
CHAPTER 46 i
Attaining a Rational Refinement and Reduction in the Use of Live Animals:
Studies on Cyanide Toxicity 433
Edward U. Maduh, Steven I. Baskin, and Harry Salem
CHAPTER 47
Integration of Alternative Tests into a Toxicology Research Program !
Sidney Green and Saura C. Sahu 437 1
Index 445
j
r
I
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| spelling | Advances in animal alternatives for safety and efficacy testing ed. by Harry Salem ... Washington, DC [u.a.] Taylor & Francis 1998 XX, 450 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frühere Ausg. u.d.T.: Animal test alternatives Alternatieven gtt Dierproeven gtt Ethische aspecten gtt Toxiciteit gtt Ethik Animal Testing Alternatives Drug Evaluation Toxicity testing In vitro Alternative (DE-588)4138905-0 gnd rswk-swf Zellkultur (DE-588)4067547-6 gnd rswk-swf Toxizitätstest (DE-588)4060540-1 gnd rswk-swf Tierversuch (DE-588)4060137-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zellkultur (DE-588)4067547-6 s Toxizitätstest (DE-588)4060540-1 s Tierversuch (DE-588)4060137-7 s Alternative (DE-588)4138905-0 s DE-604 Salem, Harry Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007932762&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Advances in animal alternatives for safety and efficacy testing Alternatieven gtt Dierproeven gtt Ethische aspecten gtt Toxiciteit gtt Ethik Animal Testing Alternatives Drug Evaluation Toxicity testing In vitro Alternative (DE-588)4138905-0 gnd Zellkultur (DE-588)4067547-6 gnd Toxizitätstest (DE-588)4060540-1 gnd Tierversuch (DE-588)4060137-7 gnd |
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| title | Advances in animal alternatives for safety and efficacy testing |
| title_auth | Advances in animal alternatives for safety and efficacy testing |
| title_exact_search | Advances in animal alternatives for safety and efficacy testing |
| title_full | Advances in animal alternatives for safety and efficacy testing ed. by Harry Salem ... |
| title_fullStr | Advances in animal alternatives for safety and efficacy testing ed. by Harry Salem ... |
| title_full_unstemmed | Advances in animal alternatives for safety and efficacy testing ed. by Harry Salem ... |
| title_short | Advances in animal alternatives for safety and efficacy testing |
| title_sort | advances in animal alternatives for safety and efficacy testing |
| topic | Alternatieven gtt Dierproeven gtt Ethische aspecten gtt Toxiciteit gtt Ethik Animal Testing Alternatives Drug Evaluation Toxicity testing In vitro Alternative (DE-588)4138905-0 gnd Zellkultur (DE-588)4067547-6 gnd Toxizitätstest (DE-588)4060540-1 gnd Tierversuch (DE-588)4060137-7 gnd |
| topic_facet | Alternatieven Dierproeven Ethische aspecten Toxiciteit Ethik Animal Testing Alternatives Drug Evaluation Toxicity testing In vitro Alternative Zellkultur Toxizitätstest Tierversuch Aufsatzsammlung |
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