Introduction to the cellular and molecular biology of cancer:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
1997
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXI, 458 S. Ill., graph. Darst. |
| ISBN: | 0198548559 0198548540 |
Internformat
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| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 1997 | |
| 300 | |a XXI, 458 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Cancérogenèse |2 ram | |
| 650 | 7 | |a Carcinogenese |2 gtt | |
| 650 | 7 | |a Celbiologie |2 gtt | |
| 650 | 7 | |a Chemotherapie |2 gtt | |
| 650 | 7 | |a Immunotherapie |2 gtt | |
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| 650 | 7 | |a Tumoren |2 gtt | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cancer cells | |
| 650 | 4 | |a Cancer |x Molecular aspects | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Cell Transformation, Neoplastic | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Neoplasms | |
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Datensatz im Suchindex
| _version_ | 1804126291124813824 |
|---|---|
| adam_text | Contents */*
. : i:.
List of contributors xv
Abbreviations xvii
1 What is cancer? l. m. franks 1
1.1 Introduction 1
1.2 Normal cells and tissues 2
1.3 Control of growth in normal cells 3
1.4 The cell cycle 3
1.5 Tumour growth or neoplasia 4
1.6 The process of carcinogenesis 4
1.7 Factors influencing the development of cancers 6
1.8 The natural history of cancer or tumour progression 7
1.9 The diagnosis of tumours 9
1.10 The names of tumours (nomenclature) and the need for tissue
diagnosis 11
1.11 Tumour staging and the spread of tumours—metastasis 14
1.12 How tumours present—some effects of tumours on the body 15
1.13 How does cancer kill? 16
1.14 Treatment of cancer 16
1 1.15 Cancer prevention and screening 16
I 1.16 Experimental methods in cancer research 17
1.17 Experimental methods for tumour identification 18
1.18 Conclusions 19
References and further reading 19
The spread of tumours i. r. hart 21
2.1 Introduction 21
2.2 Tumour angiogenesis 22
2.3 Mechanisms of tumour invasion 23
2.4 Dissemination of tumour cells via lymphatics and/or blood vessels 25
2.5 Patterns of metastatic spread 27
2.6 The role of the immune system in modulating metastasis 28
2.7 Tumour cell heterogeneity 29
2.8 Experimental models/approaches to metastasis 31
2.9 Summary 32
References and further reading 32
Contents ix
3. Epidemiology of cancer t. key, d. forman, and m. c. pike 34
3.1 Introduction 34
3.2 Descriptive epidemiology 34
3.3 Analytical epidemiology 38
3.4 Identifying the causes 39
3.5 Risk factors 50
References and further reading 59
4. Inherited susceptibility to cancer
H. S. WASAN AND W. F. BODMER 60
4.1 Introduction: the cellular genetic basis for cancer 60
4.2 Evidence for a genetic basis 61
4.3 Genetic markers, DNA polymorphisms, and genetic
linkage 64
4.4 Dominant inherited susceptibility and recessive
genetic changes in tumours 69
4.5 Systemic inherited susceptibilities 83
4.6 Types of family data and their interpretation 86
4.7 Conclusions and future prospects 88
References and further reading 90
5. Structure of DNA and its relationship to carcinogenesis
BEVERLY E. GRIFFIN 92
5.1 Introduction 92
5.2 Components of DNA 93
5.3 The genetic material 97
5.4 Informational DNA 100
5.5 DNA damage 101
5.6 DNA manipulation 103
5.7 Conclusion 104
References and further reading 105
h Chemical carcinogenesis
RAYMOND THNNANT. CAROLINE WIGLEY, AND ALAN BALMAIN 106
6.1 The role of chemical carcinogens and mutation in
human cancer 106
6.2 Epidemiological evidence 107
6.3 Evidence from animal studies 111
6.4 Molecular evidence 111
6.5 Experimental approaches to the study of
carcinogenesis by chemicals 113
6.6 The role of tumour promotion in human cancer 119
6.7 Screening for carcinogens 120
I
x Contents
6.8 Prospects 126
6.9 Summary 127
References and further reading 128
1, Radiation carcinogenesis g. e. adams and r. cox 130
7.1 Introduction 130
7.2 Radiation and human cancer 133
7.3 Cellular and molecular processes 139
References and further reading 148
8 Viruses and cancer john wyke 151
8.1 Introduction 151
8.2 The history of tumour virology 151
8.3 Implicating viruses in experimental and natural
cancers 154
8.4 Risk factors predisposing to virus associated
neoplasia 154
8.5 Important tumour viruses of animals and humans 157
8.6 Prophylaxis and therapy of virus associated
neoplasia 161
8.7 The mechanisms of virus induced neoplasia 162
8.8 Conclusions 167
References and further reading 167
n. Oncogenes and cancer natalie m. teich 169
9.1 What is an oncogene? 169
9.2 Identification of viral and cellular oncogene
products 178
9.3 Tumour suppressor genes 185
9.4 Interactions between oncogenes 194
9.5 Protooncogene expression in normal development
and differentiation 197
9.6 Lessons learned from oncogenes 198
References and further reading 201
Chromosomes and cancer denise sheer 202
10.1 Introduction 202
10.2 Methodology 203
10.3 Terminology and types of chromosome aberrations
in tumours 204
10.4 Molecular consequences of chromosome
aberrations in tumours 205
10.5 Chromosomes in leukaemias and lymphomas 207
10.6 Chromosomes in solid tumours 215
Contents xi
10.7 Conclusions and future prospects 224
References and further reading 225
11. Growth factor signalling pathways in cancer
ALASTAIR D. REITH AND GEORGE PANAYOTOU 230
11.1 Structural and functional diversity of growth factors 230
11.2 Structure and diversity of growth factor receptors 232
11.3 Intracellular signalling by activated growth factor
receptors 238
11.4 Oncogenic activation of signalling molecules 242
11.5 Signal transduction pathways and cancer 245
11.6 Abnormal growth control in cancer—a summary 248
References and further reading 249
12. Stem cells, haemopoiesis, and leukaemia mel greaves 251
12.1 Introduction 251
12.2 Haemopoietic regulation 251
12.3 Leukaemia as a clonal disorder of haemopoiesis 254
12.4 Gene culprits 256
12.5 Origin of mutations and the natural history of
leukaemia 257
12.6 Target cells in leukaemia 257
12.7 Clinical and epidemiological implications of
leukaemic cell and molecular biology 259
References and further reading 263
13. The molecular pathology of cancer
NICHOLAS R. LEMOINE AND GORDON STAMP 264
13.1 Introduction 264
13.2 Morphological analysis of tumour tissue 264
13.3 Immunohistochemistry and immunocytochemistry 266
13.4 Nucleic acid changes using in situ hybridization 268
13.5 Genetic abnormalities in neoplasia 270
13.6 Tumour markers 272
References and further reading 272
14 Hormones and cancer m. g. parker and l. m. franks 274
14.1 Introduction 274
14.2 Basic endocrinology 275
14.3 Molecular mechanisms of hormone action; nuclear
receptors 277
14.4 Hormones and carcinogenesis 282
14.5 The mode of action of hormones in carcinogenesis 285
j
xii Contents
14.6 Types and nature of hormone sensitive and
hormone producing tumours 293
14.7 Treatment of hormone sensitive human cancers 295
14.8 Conclusions and future prospects 296
References and further reading 297
15, The neuroendocrine system and its tumours
J. M. POLAK AND S. R. BLOOM 299
15.1 Morphological features of peptide containing
endocrine cells and nerves 299
15.2 Techniques for the visualization of the diffuse
neuroendocrine system 300
15.3 Neuroendocrine tumours 304
15.4 Individual tumours 305
15.5 Conclusions 309
References and further reading 310
16, Immunology of cancer peter beverley 311
16.1 Introduction to the immune system 311
16.2 Organization of the immune system 311
16.3 The immune system and cancer 317
16.4 Cell mediated immune responses to cancer 319
16.5 Human tumour antigens detected by antibodies 322
16.6 Immunodiagnosis 325
16.7 Immunotherapy and immune escape mechanisms 325
16.8 Conclusions 328
References and further reading 329
The local treatment of cancer ian fentiman 330
17.1 How tumours present 330
17.2 Screening 330
17.3 Diagnosis 332
17 A Staging 336
17.5 Treatment 338
17.6 Problem areas 341
References and further reading 342
Chemotherapy j. s. malpas 343
18.1 Introduction 343
18.2 Classification of chemotherapeutic drugs 344
18.3 Pharmacokinetic principles 345
18.4 Pharmacology of the main classes of agents 346
18.5 Drug toxicity 347
Contents xiii
18.6 Principles of chemotherapy 347
18.7 Administration of anticancer drugs 348
18.8 Drug resistance 349
18.9 Clinical trials 351
18.10 Supportive care 351
18.11 Conclusion 351
References and further reading 352
19. Monoclonal antibodies and therapy philip e. thorpe,
EDWARD J. WAWRZYNCZAK AND FRANCIS J. BURROWS 353
19.1 Introduction 353
19.2 Tumour associated antigens 358
19.3 Tumour imaging 362
19.4 Immunotherapy 365
19.5 Targeting of cytotoxic agents 370
19.6 Bone marrow transplantation 376
19.7 Conclusion 377
References and further reading 378
20. Cytokines and cancer Frances r. balk will 380
20.1 Cytokines and the cytokine network 380
20.2 Cytokine networks in cancer 383
20.3 Cytokine treatment of cancer 386
References and further reading 390
21. Screening and chemoprevention jack cuzick 392
21.1 Types of screening tests 393
21.2 Safety and acceptability 393
21.3 Who should be screened? 394
21.4 Evaluation of screening 394
21.5 Screening for specific cancers 396
21.6 The need for DNA sequencing in epidemiology 409
21.7 Conclusion 409
References and further reading 410
22. Some conclusions and prospects robin a. weiss 415
22.1 Understanding carcinogenesis 415
22.2 Prospects for prevention and screening 417
22.3 Prospects for new treatment 419
22.4 Prospects for gene therapy 420
22.5 Conclusion 425
References and further reading 425
I
xiv Contents
Glossary 427
Index 443
Hitter
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| id | DE-604.BV011748451 |
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| indexdate | 2024-07-09T18:15:07Z |
| institution | BVB |
| isbn | 0198548559 0198548540 |
| language | English |
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| physical | XXI, 458 S. Ill., graph. Darst. |
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| spelling | Introduction to the cellular and molecular biology of cancer ed. by L. M. Franks ... 3. ed. Oxford [u.a.] Oxford Univ. Press 1997 XXI, 458 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Cancer - Manuels d'enseignement supérieur ram Cancérogenèse ram Carcinogenese gtt Celbiologie gtt Chemotherapie gtt Immunotherapie gtt Moleculaire biologie gtt Tumoren gtt Cancer Cancer cells Cancer Molecular aspects Carcinogenesis Cell Transformation, Neoplastic Molecular Biology Neoplasms Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Carcinogenese (DE-588)4069853-1 s DE-604 Krebs Medizin (DE-588)4073781-0 s Molekularbiologie (DE-588)4039983-7 s Pathophysiologie (DE-588)4044898-8 s 1\p DE-604 Franks, Leonard M. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007927132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Introduction to the cellular and molecular biology of cancer Cancer - Manuels d'enseignement supérieur ram Cancérogenèse ram Carcinogenese gtt Celbiologie gtt Chemotherapie gtt Immunotherapie gtt Moleculaire biologie gtt Tumoren gtt Cancer Cancer cells Cancer Molecular aspects Carcinogenesis Cell Transformation, Neoplastic Molecular Biology Neoplasms Krebs Medizin (DE-588)4073781-0 gnd Pathophysiologie (DE-588)4044898-8 gnd Molekularbiologie (DE-588)4039983-7 gnd Carcinogenese (DE-588)4069853-1 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4044898-8 (DE-588)4039983-7 (DE-588)4069853-1 |
| title | Introduction to the cellular and molecular biology of cancer |
| title_auth | Introduction to the cellular and molecular biology of cancer |
| title_exact_search | Introduction to the cellular and molecular biology of cancer |
| title_full | Introduction to the cellular and molecular biology of cancer ed. by L. M. Franks ... |
| title_fullStr | Introduction to the cellular and molecular biology of cancer ed. by L. M. Franks ... |
| title_full_unstemmed | Introduction to the cellular and molecular biology of cancer ed. by L. M. Franks ... |
| title_short | Introduction to the cellular and molecular biology of cancer |
| title_sort | introduction to the cellular and molecular biology of cancer |
| topic | Cancer - Manuels d'enseignement supérieur ram Cancérogenèse ram Carcinogenese gtt Celbiologie gtt Chemotherapie gtt Immunotherapie gtt Moleculaire biologie gtt Tumoren gtt Cancer Cancer cells Cancer Molecular aspects Carcinogenesis Cell Transformation, Neoplastic Molecular Biology Neoplasms Krebs Medizin (DE-588)4073781-0 gnd Pathophysiologie (DE-588)4044898-8 gnd Molekularbiologie (DE-588)4039983-7 gnd Carcinogenese (DE-588)4069853-1 gnd |
| topic_facet | Cancer - Manuels d'enseignement supérieur Cancérogenèse Carcinogenese Celbiologie Chemotherapie Immunotherapie Moleculaire biologie Tumoren Cancer Cancer cells Cancer Molecular aspects Carcinogenesis Cell Transformation, Neoplastic Molecular Biology Neoplasms Krebs Medizin Pathophysiologie Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007927132&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT franksleonardm introductiontothecellularandmolecularbiologyofcancer |